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    Other Names:

    [(E)-4-[(4-amino-2-methyl-pyrimidin-5-yl)methyl-formyl-amino]-3-[[(E)-2-[(4-amino-2-methylpyrimidin-5-yl)methyl-formylamino]-5-(2-methylpropanoyloxy)pent-2-en-3-yl]disulfanyl]-pent-3-enyl]-2-methylpropanoate, 2-Isobutyryl-thiamine Disulfide, Bis...
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    SULBUTIAMINE Side Effects
    SULBUTIAMINE Interactions
    SULBUTIAMINE Overview Information

    Sulbutiamine is man-made chemical similar to the B vitamin thiamine. Unlike thiamine, which dissolves in water, sulbutiamine dissolves in fats. Sulbutiamine is able to increase thiamine levels in the brain, and thought to be used as a stimulant in athletes.

    People take sulbutiamine by mouth for Alzheimer’s disease, weakness, athletic performance, depression, diabetic nerve damage, erectile dysfunction, fatigue, and memory.

    How does it work?

    It is not fully understood how sulbutiamine works. However, it seems to have various effects on the brain that might improve memory and reduce feelings of weakness.

    SULBUTIAMINE Uses & Effectiveness What is this?

    Possibly Ineffective for:

    • Fatigue caused by an infection. Early research suggests that taking sulbutiamine daily in addition to standard care for an infection over 15 days seems to help reduce weakness and fatigue in people with an infection. However, fatigue does not seem to improve when sulbutiamine is taken for longer periods of time. Other research shows that taking sulbutiamine daily for 28 days does not improve fatigue in people with an infection.

    Insufficient Evidence for:

    • Alzheimer’s disease. Early research suggests that taking sulbutriamine by mouth for 3 months improves attention in people with early stage Alzheimer’s disease. When it is combined with the anti-Alzheimer’s drug donepezil (Aricept) for 3 months, it might also improve memory.
    • Depression. Research suggests that taking sulbutriamine daily for 4 weeks improves one aspect of depression called psycho-behavioral inhibition, but no other measurements of depression.
    • Diabetic nerve pain. Research suggests that taking sulbutiamine (Arcalion) daily for 6 weeks improves how well nerves work in people with nerve damage caused by diabetes. However, it does not seem to improve symptoms of diabetic nerve pain in these patients.
    • Erectile dysfunction (ED). Early evidence shows that taking sulbutiamine for 30 days improves erectile dysfunction in 16 out of 20 men.
    • Fatigue related to multiple sclerosis (MS). Early evidence suggests that taking sulbutiamine for 6 months improves fatigue related to multiple sclerosis.
    • Weakness.
    • Athletic performance.
    • Memory.
    • Other conditions.
    More evidence is needed to rate sulbutiamine for these uses.

    SULBUTIAMINE Side Effects & Safety

    Sulbutiamine is POSSIBLY SAFE when taken by mouth appropriately, short-term. A dose of 600 mg daily has been used safely for up to 4 weeks. A small number of people taking sulbutiamine have reported nausea, headache, tiredness, and inability to sleep.

    There isn’t enough reliable information available about sulbutiamine to know if it is safe to use long-term.

    Special Precautions & Warnings:

    Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking sulbutiamine if you are pregnant or breast feeding. Stay on the safe side and avoid use.

    Psychiatric disorders: People with certain psychiatric disorders, including bipolar disorder, may be more likely to abuse drugs. These individuals may be more likely to abuse sulbutiamine. Until more is known about sulbutiamine, people with psychiatric disorders should use sulbutiamine cautiously. These patients should not discontinue use of their prescribed treatments.

    SULBUTIAMINE Interactions What is this?

    We currently have no information for SULBUTIAMINE Interactions


    The appropriate dose of sulbutiamine depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for sulbutiamine (in children/in adults). Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

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    Conditions of Use and Important Information: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

    This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. © Therapeutic Research Faculty 2009.

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