Annona cherimola, Annona macrocarpa, Annona muricata, Brazilian Cherimoya, Brazilian Paw Paw, Corossol, Corossol Épineux, Corossolier, Durian Benggala, Ekitafeli, Guanabana, Guanábana, Guanavana, Nangka Blanda, Nangka Londa, Omusitafeli, Paw-Paw, Sirsak, Soursop, Sour Sop, Toge-Banreisi.


Overview Information

Graviola is a small evergreen tree. The leaves, fruit, seeds, root, and stem are used to make medicine.

Some people take graviola by mouth for infections caused by bacteria and parasites, cancer, diabetes, and to cause vomiting. Some people apply graviola directly to the skin for use as an insect repellent, but there is no good scientific evidence to support any of these uses.

In foods, graviola is used in cooking and beverages.

How does it work?

Graviola contains many chemicals that may be active against cancer, as well as disease-causing agents such as bacteria, viruses, and parasites.


Uses & Effectiveness?

Insufficient Evidence for

  • Human papilloma virus (HPV). High-risk HPV is linked with cancer of the cervix. Taking graviola with ellagic acid for 6 months has antiviral activity against high-risk HPV. It might also prevent precancerous cells from becoming worse in women with high-risk HPV.
  • An infection caused by sand fleas (leishmaniasis).
  • Bacterial infections.
  • Cancer.
  • Diabetes.
  • Causing relaxation.
  • Causing vomiting.
  • Coughs.
  • Emptying the bowels.
  • Herpes.
  • Inflammation of the nose and throat.
  • Parasitic infections.
  • Other conditions.
More evidence is needed to rate the effectiveness of graviola for these uses.

Side Effects

Side Effects & Safety

Graviola is POSSIBLY UNSAFE when taken by mouth. It can kill nerve cells in the brain and other parts of the body. It may cause movement disorders similar to Parkinson's disease. However, more research is needed to confirm this.

Special Precautions & Warnings:

Pregnancy or breast-feeding: Do not use graviola. It is POSSIBLY UNSAFE when taken by mouth.

Parkinson's disease: Graviola might make the symptoms of Parkinson's disease worse.



We currently have no information for GRAVIOLA Interactions.



The appropriate dose of graviola depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for graviola. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References


  • Champy, P., Hoglinger, G. U., Feger, J., Gleye, C., Hocquemiller, R., Laurens, A., Guerineau, V., Laprevote, O., Medja, F., Lombes, A., Michel, P. P., Lannuzel, A., Hirsch, E. C., and Ruberg, M. Annonacin, a lipophilic inhibitor of mitochondrial complex I, induces nigral and striatal neurodegeneration in rats: possible relevance for atypical parkinsonism in Guadeloupe. J.Neurochem. 2004;88(1):63-69. View abstract.
  • Hernandez, L., Munoz, R. A., Miro, G., Martinez, M., Silva-Parra, J., and Chavez, P. I. Use of medicinal plants by ambulatory patients in Puerto Rico. Am J Hosp.Pharm 1984;41(10):2060-2064. View abstract.
  • Lannuzel, A., Hoglinger, G. U., Champy, P., Michel, P. P., Hirsch, E. C., and Ruberg, M. Is atypical parkinsonism in the Caribbean caused by the consumption of Annonacae? J.Neural Transm.Suppl 2006;(70):153-157. View abstract.
  • Atlas RO, Lemus J, Reed J 3rd, Atkins D, Alger LS. Second trimester abortion using prostaglandin E2 suppositories with or without intracervical Laminaria japonica: a randomized study. Obstet Gynecol. 1998 Sep;92(3):398-402 View abstract.
  • Bonneau N, Le Ven J, Schmitz-Afonso I, et al. Annonaceous acetogenins as environmental neurotoxins: Human exposure from edible Annona fruits. Planta Med. 2012;78:PH25. Abstract only.
  • Caparros-Lefebvre D, Elbaz A. Possible relation of atypical parkinsonism in the French West Indies with consumption of tropical plants: a case-control study. Caribbean Parkinsonism Study Group. Lancet 1999;354:281-6. View abstract.
  • dos Santos AF, Sant'Ana AE. Molluscicidal properties of some species of Annona. Phytomedicine 2001;8:115-20.. View abstract.
  • Gavamukulya Y, Wamunyokoli F, El-Shemy HA. Annona muricata: Is the natural therapy to most disease conditions including cancer growing in our backyard? A systematic review of its research history and future prospects. Asian Pac J Trop Med. 2017;10(9):835-48. View abstract.
  • Hansra DM, Silva O, Mehta A, Ahn E. Patient with metastatic breast cancer achieves stable disease for 5 years on graviola and xeloda after progressing on multiple lines of therapy. Adv Breast Cancer Res. 2014;3:84-7.
  • Indrawati L, Ascobat P, Bela B, Abdullah M, Surono IS. The effect of an Annona muricata leaf extract on nutritional status and cytotoxicity in colorectal cancer: a randomized controlled trial. Asia Pac J Clin Nutr. 2017;26(4):606-12.View abstract.
  • Jaramillo MC, Arango GJ, Gonzalez MC, et al. Cytotoxicity and antileishmanial activity of Annona muricata pericarp. Fitoterapia 2000;71:183-6. View abstract.
  • Lannuzel A, Michel PP, Caparros-Lefebvre D, et al. Toxicity of Annonaceae for dopaminergic neurons: potential role in atypical parkinsonism in Guadeloupe. Mov Disord 2002;17:84-90. View abstract.
  • Le Donne M, Lentini M, Alibrandi A, et al. Antiviral activity of Ellagic acid and Annona Muricata in cervical HPV related pre-neoplastic lesions: A randomized trial. J Funct Food 2017;35:549-54.
  • Moghadamtousi SZ, Fadaeinasab M, Nikzad S, Mohan G, Ali HM, Kadir HA. Annona muricata (Annonaceae): A Review of Its Traditional Uses, Isolated Acetogenins and Biological Activities. Int J Mol Sci. 2015 Jul 10;16(7):15625-58. doi: 10.3390/ijms160715625. View abstract.
  • Oberlies NH, Chang CJ, McLaughlin JL. Structure-activity relationships of diverse Annonaceous acetogenins against multidrug resistant human mammary adenocarcinoma (MCF-7/Adr) cells. J Med Chem 1997;40:2102-6. View abstract.
  • Padma P, Pramod NP, Thyagarajan SP, Khosa RL. Effect of the extract of Annona muricata and Petunia nyctaginiflora on Herpes simplex virus. J Ethnopharmacol 1998;61:81-3. View abstract.
  • Raveloson Ravaomanarivo LH, Andrianiaina Razafindraleva H, Raharimalala FN, Rasoahantaveloniaina B, Ravelonandro PH, Mavingui P. Efficacy of seed extracts of Annona squamosa and Annona muricata (Annonaceae) for the control of Aedes albopictus and Culex quinquefasciatus (Culicidae). Asian Pac J Trop Biomed. 2014;4(10):798-806.
  • Roman G. Tropical myeloneuropathies revisited. Curr Opin Neurol 1998;11:539-44. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
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