PANTETHINE: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Pantethine is chemical that occurs naturally in the body. It's related to vitamin B5 (pantothenic acid).

Pantethine might increase concentrations of some chemicals that lower blood cholesterol and triglycerides in the body.

People use pantethine for lowering levels of cholesterol and triglycerides. It is also used for athletic performance and other purposes, but there is no good scientific evidence to support these uses.

In Japan and China, pantethine is available as a prescription drug for hyperlipidemia. Don't confuse pantethine with pantothenic acid. These are not the same.

Uses & Effectiveness ?

Possibly Effective for

High levels of lipoproteins in the blood (hyperlipoproteinemia). Taking pantethine by mouth might modestly lower triglycerides, total cholesterol, and low-density lipoprotein (LDL or "bad") cholesterol, and raise high-density lipoprotein (HDL or "good") cholesterol, in people with this inherited condition. But it doesn't seem to work as well as conventional drugs.

There is interest in using pantethine for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful.

Side Effects

When taken by mouth: Pantethine is possibly safe when used in doses of up to 1000 mg daily for up to 48 weeks. It might cause nausea, diarrhea, and stomach discomfort in some people.

Special Precautions and Warnings

When taken by mouth: Pantethine is possibly safe when used in doses of up to 1000 mg daily for up to 48 weeks. It might cause nausea, diarrhea, and stomach discomfort in some people.

Pregnancy and breast-feeding: There isn't enough reliable information to know if pantethine is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Bleeding disorders: Pantethine might slow blood clotting. This might increase the risk of severe bleeding in patients with bleeding disorders. If you have a bleeding disorder, talk to your healthcare provider before starting pantethine.

Surgery: Pantethine might slow blood clotting. This might increase the risk of bleeding during and after surgery. Stop using pantethine at least 2 weeks before a scheduled surgery.

Interactions ?

Moderate Interaction

Be cautious with this combination

Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with PANTETHINE
Pantethine might slow blood clotting. Taking pantethine along with medications that also slow blood clotting might increase the risk of bruising and bleeding.

Dosing

Pantethine has most often been used by adults in doses of 600-900 mg by mouth daily for 2-3 months. Speak with a healthcare provider to find out what dose might be best for a specific condition.

View References

REFERENCES:

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Angelica M, Pinto G Ciaccheri C et al. Improvement in serum lipid profile in hyperlipoproteinemia patients after treatment with pantethine: a cross-over double-blind trial versus placebo. Curr Ther Res 1983;33:1091-1097.

Angelico, M., Pinto, G., Ciaccheri, C., Alvaro, D., and De Santis, A. Improvement in serum lipid profile in hyperlipoproteinemic patients after treatment with pantethine: crossover, double blind trial versus placebo. Current Therapeutic Research 1983;33(June Sec 2):1091-1097.

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Maioli M, Pacifico A Cherchi G. Effect of pantethine on the subfractions of HDL in dyslipidemic patients. Curr Ther Res 1984;35:307-311.

Maioli, M., Pacifico, A., and Cherchi, G. M. Effect of pantethine on the subfractions of HDL in dislipidemic patients. Current Therapeutic Research 1984;35(Feb):307-311.

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Rumberger, J. A., Napolitano, J., Azumano, I., Kamiya, T., and Evans, M. Pantethine, a derivative of vitamin B(5) used as a nutritional supplement, favorably alters low-density lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk North American subjects: a triple-blinded placebo and diet-controlled investigation. Nutr.Res. 2011;31(8):608-615. View abstract.

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Vignola, D., Fanini, A., and Biffignandi, P. [Effects of D(+)-bis-(N-pantothenyl-amidoethyl)-disulphur on the blood lipid profile and apoproteins A and B levels]. Clin.Ter. 6-30-1985;113(6):479-483. View abstract.

Wittwer, C. T., Gahl, W. A., Butler, J. D., Zatz, M., and Thoene, J. G. Metabolism of pantethine in cystinosis. J.Clin.Invest 1985;76(4):1665-1672. View abstract.

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Angelica M, Pinto G, Ciaccheri C, et al. Improvement in serum lipid profile in hyperlipoproteinemia patients after treatment with pantethine: a cross-over double-blind trial versus placebo. Curr Ther Res 1983;33:1091-7.

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Coronel F, Tornero F, Torrente J, et al. Treatment of hyperlipemia in diabetic patients on dialysis with a physiological substance. Am J Nephrol 1991;11:32-6.. View abstract.

Da Col PG, Cattin L, Fonda M, et al. Pantethine in the treatment of hypercholesterolemia: a randomized double-blind trial versus tiadenol. Curr Ther Res 1984;36:314-22.

Donati C, Barbi G, Cairo G, et al. Pantethine improves the lipid abnormalities of chronic hemodialysis patients: results of a multicenter clinical trial. Clin Nephrol 1986;25:70-4.. View abstract.

Evans M, Rumberger JA, Azumano I, Napolitano JJ, Citrolo D, Kamiya T. Pantethine, a derivative of vitamin B5, favorably alters total, LDL and non-HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy: a triple-blinded placebo and diet-controlled investigation. Vasc Health Risk Manag. 2014;10:89-100. View abstract.

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Ranganathan S, Jackson RL, Harmony JA. Effect of pantethine on the biosynthesis of cholesterol in human skin fibroblasts. Atherosclerosis 1982;44:261-73.. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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