DIACYLGLYCEROL: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Diacylglycerol is a compound found in small amounts in plant oils. Oils rich in diacylglycerol can be made in the lab and used to replace fats in the diet.

Diacylglycerol might work by increasing energy use and the breakdown of fat. Diacylglycerol-concentrated oils taste and look like regular fats and cooking oils.

People use diacylglycerol for obesity, diabetes, high levels of triglycerides in the blood, and other conditions, but there is no good scientific evidence to support most of these uses.

Uses & Effectiveness ?

Possibly Effective for

Obesity. Taking diacylglycerol by mouth seems to improve weight loss in overweight or obese adults.

There is interest in using diacylglycerol for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful.

Side Effects

When taken by mouth: Diacylglycerol is likely safe for most people. It's usually well tolerated, but might cause some stomach upset similar to other cooking oils.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Diacylglycerol is likely safe when consumed in foods. There isn't enough reliable information to know if diacylglycerol is safe to use in larger amounts when pregnant or breast-feeding. Stay on the safe side and stick to food amounts.

Special Precautions and Warnings

When taken by mouth: Diacylglycerol is likely safe for most people. It's usually well tolerated, but might cause some stomach upset similar to other cooking oils.

Special Precautions & Warnings:

Interactions ?

We currently have no information for DIACYLGLYCEROL overview.

Dosing

Diacylglycerol is a compound naturally found in small amounts in plant oils. Oils such as soybean and rapeseed can be changed to include higher concentrations of diacylglycerol to be used as replacement cooking oils. It's most often been used by adults in doses of 10-20 grams by mouth daily for up to 1 year. Speak with a healthcare provider to find out what dose might be best for a specific condition.

View References

REFERENCES:

Hibi M, Sugiura Y, Yokoyama R, et al. The short-term effect of diacylglycerol oil consumption on total and dietary fat utilization in overweight women. Obesity (Silver Spring). 2011;19(3):536-40. View abstract.

Kawashima H, Takase H, Yasunaga K, et al. One-year ad libitum consumption of diacylglycerol oil as part of a regular diet results in modest weight loss in comparison with consumption of a triacylglycerol control oil in overweight Japanese subjects. J Am Diet Assoc. 2008;108(1):57-66. View abstract.

Li D, Xu T, Takase H, et al. Diacylglycerol-induced improvement of whole-body insulin sensitivity in type 2 diabetes mellitus: a long-term randomized, double-blind controlled study. Clin Nutr. 2008;27(2):203-11. View abstract.

Maki KC, Davidson MH, Tsushima R, et al. Consumption of diacylglycerol oil as part of a reduced-energy diet enhances loss of body weight and fat in comparison with consumption of a triacylglycerol control oil. Am J Clin Nutr 2002;76:1230-6.. View abstract.

Nagao T, Watanabe H, Goto N, et al. Dietary diacylglycerol suppresses accumulation of body fat compared to triacylglycerol in men in a double-blind controlled trial. J Nutr 2000;130:792-7.. View abstract.

Reyes G, Yasunaga K, Rothenstein E, et al. Effects of a 1,3-diacylglycerol oil-enriched diet on postprandial lipemia in people with insulin resistance. J Lipid Res. 2008;49(3):670-8. View abstract.

Saito S, Mori A, Osaki N, Katsuragi Y. Diacylglycerol enhances the effects of alpha-linolenic acid against visceral fat: A double-blind randomized controlled trial. Obesity (Silver Spring). 2017;25(10):1667-1675. View abstract.

Saito S, Takeshita M, Tomonobu K, et al. Dose-dependent cholesterol-lowering effect of a mayonnaise-type product with a main component of diacylglycerol-containing plant sterol esters. Nutrition 2006;22:174-8. View abstract.

Saito S, Tomonobu K, Hase T, Tokimitsu I. Effects of diacylglycerol on postprandial energy expenditure and respiratory quotient in healthy subjects. Nutrition 2006;22:30-5. View abstract.

Taguchi H, Watanabe H, Onizawa K, et al. Double-blind controlled study on the effects of dietary diacylglycerol on postprandial serum and chylomicron triacylglycerol responses in healthy humans. J Am Coll Nutr 2000;19:789-96.. View abstract.

Takase H, Shoji K, Hase T, Tokimitsu I. Effect of diacylglycerol on postprandial lipid metabolism in non-diabetic subjects with and without insulin resistance. Atherosclerosis 2005;180:197-204. View abstract.

Tomonobu K, Hase T, Tokimitsu I. Dietary diacylglycerol in a typical meal suppresses postprandial increases in serum lipid levels compared with dietary triacylglycerol. Nutrition 2006;22:128-35. View abstract.

US Food and Drug Administration. Center for Food Safety & Applied Nutrition. Office of Premarket Approval. Agency Response Letter GRAS Notice No. GRN 00056. DEcember 4, 2000 Available at: https://vm.cfsan.fda.gov/~rdb/opa-g056.html

Wang W, Xu T, Li X, Zhu Q, Cheng A, Du F, Li D. Effect of diacylglycerol supplementation on fasting serum triacylglycerol concentration: a meta-analysis. Lipids. 2010;45(12):1139-46. View abstract.

Watanabe H, Onizawa K, Naito S, et al. Fat-soluble vitamin status is not affected by diacylglycerol consumption. Ann Nutr Metab 2001;45:259-64.. View abstract.

Xu T, Li X, Ma X, Zhang Z, Zhang T, Li D. Effect of diacylglycerol on postprandial serum triacylglycerol concentration: a meta-analysis. Lipids. 2009;44(2):161-8. View abstract.

Yamamoto K, Asakawa H, Tokunaga K, et al. Long-term ingestion of dietary diacylglycerol lowers serum triacylglycerol in type II diabetic patients with hypertriglyceridemia. J Nutr 2001;131:3204-7.. View abstract.

Yamamoto K, Tomonobu K, Asakawa H, et al. Diet therapy with diacylglycerol oil delays the progression of renal failure in type 2 diabetic patients with nephropathy. Diabetes Care 2006;29:417-9. View abstract.

Yanai H, Yoshida H, Tomono Y, et al. Effects of diacylglycerol on glucose, lipid metabolism, and plasma serotonin levels in lean Japanese. Obesity (Silver Spring). 2008;16(1):47-51. View abstract.

Yasunaga K, Glinsmann WH, Seo Y, et al. Safety aspects regarding the consumption of high-dose dietary diacylglycerol oil in men and women in a double-blind controlled trial in comparison with consumption of a triacylglycerol control oil. Food Chem Toxicol 2004;42:1419-29. View abstract.

Yuan Q, Ramprasath VR, Harding SV, Rideout TC, Chan YM, Jones PJH. Diacylglycerol oil reduces body fat but does not alter energy or lipid metabolism in overweight, hypertriglyceridemic women. J Nutr. 2010;140(6):1122-6. View abstract.

Zheng JS, Wang L, Lin M, Yang H, Li D. BMI status influences the response of insulin sensitivity to diacylglycerol oil in Chinese type 2 diabetic patients. Asia Pac J Clin Nutr. 2015;24(1):65-72. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.

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DIACYLGLYCEROL - Uses, Side Effects, and More

Overview

Uses & Effectiveness ?

Possibly Effective for

Side Effects

Special Precautions & Warnings:

Special Precautions and Warnings

Special Precautions & Warnings:

Interactions ?

Dosing

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