HOODIA

OTHER NAME(S):

Cactus, Cactus Hoodia, Cactus du Kalahari, Extrait de Hoodia, Hoodia Cactus, Hoodia Extract, Hoodia Gordonii, Hoodia Gordonii Cactus, Hoodia P57, Kalahari Cactus, Kalahari Diet, P57, Xhoba.

Overview

Overview Information

Hoodia is a cactus-type plant from the Kalahari Desert in Africa.

People use hoodia to curb their appetite so they can lose weight. According to some claims, San bushmen in Africa eat hoodia to fight off hunger during long hunts.

Be careful when buying hoodia products. According to news reports, some samples of hoodia sold on the Internet do not contain any hoodia at all. You might not get what's listed on the label. Also, a certain hoodia product (P57 Hoodia, Huikng Pharmaceuticals) has been shown to contain sibutramine. Sibutramine is a substance removed from the US market in 2010 due to its potential to increase blood pressure and heart rate.

How does it work?

One chemical in hoodia called P57 is thought to decrease feelings of hunger. But it's not clear how P57 causes this effect. Another chemical in hoodia called gordonoside F is thought to decrease feelings of hunger by increasing the production of insulin.

Uses

Uses & Effectiveness?

Insufficient Evidence for

  • Weight loss. Drinking a raspberry-flavored yogurt drink containing hoodia extract for 15 days does not seem to reduce food intake or increase weight loss in overweight women.
More evidence is needed to rate the effectiveness of hoodia for this use.
Side Effects

Side Effects & Safety

There isn't enough information to know if hoodia is safe. There is some evidence that hoodia might cause minor side effects such as headache, dizziness, giddiness, nausea, and unusual skin sensations. Also, there is concern that hoodia might increase blood pressure and heart rate.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Not enough is known about the use of hoodia during pregnancy and breast-feeding. Stay on the safe side and avoid use.

Diabetes: Hoodia might lower blood sugar by increasing the production of insulin. Watch for signs of low blood sugar (hypoglycemia) and monitor your blood sugar carefully if you are being treated for diabetes and use hoodia.

High blood pressure: Hoodia might increase blood pressure. This might cause blood pressure to become too high in people already at risk for high blood pressure.

Interactions

Interactions?

We currently have no information for HOODIA Interactions.

Dosing

Dosing

The appropriate dose of hoodia depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for hoodia. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

  • MacLean, D. B. and Luo, L. G. Increased ATP content/production in the hypothalamus may be a signal for energy-sensing of satiety: studies of the anorectic mechanism of a plant steroidal glycoside. Brain Res 9-10-2004;1020(1-2):1-11. View abstract.
  • Anon. Protecting traditional knowledge: the San and hoodia. Bull World Health Organ 2006;84:345. View abstract.
  • Blom WA, Abrahamse SL, Bradford R, et al. Effects of 15-d repeated consumption of Hoodia gordonii purified extract on safety, ad libitum energy intake, and body weight in healthy, overweight women: a randomized controlled trial. Am J Clin Nutr 2011;94(5):1171-81. View abstract.
  • Citó MCO, Silva MIG, Santos LKX, et al. Antidepressant-like effect of Hoodia gordonii in a forced swimming test in mice: evidence for involvement of the monoaminergic system. Braz J Med Biol Res. 2015;48(1):57-64. View abstract.
  • Dent MP, Wolterbeek APM, Russell PJ, Bradford R. Safety profile of Hoodia gordonii extract: mouse prenatal developmental toxicity study. Food Chem Toxicol. 2012;50 Suppl 1:S20-5. View abstract.
  • Dent MP, Wolterbeek APM, Russell PJ, Bradford R. Safety profile of Hoodia gordonii extract: rabbit prenatal developmental toxicity study. Food Chem Toxicol. 2012;50 Suppl 1:S26-33. View abstract.
  • Mangold T. Sampling the Kalahari cactus diet. BBC News; May 30, 2003. Available at: https://news.bbc.co.uk/2/hi/programmes/correspondent/2947810.stm.
  • Pfizer returns rights of P57. Phytopharm Press Release; July 30, 2003.
  • Phytopharm plc successful completion of proof of principle clinical study of P57 for Obesity. Phytopharm Press Release; December 5, 2001.
  • Roza O, Lovász N, Zupkó I, Hohmann J, Csupor D. Sympathomimetic activity of a Hoodia gordonii product: a possible mechanism of cardiovascular side effects. Biomed Res Int. 2013;2013:171059. View abstract.
  • Scott AD, Orsi A, Ward C, Bradford R. Genotoxicity testing of a Hoodia gordonii extract. Food Chem Toxicol. 2012;50 Suppl 1:S34-40. View abstract.
  • Stafford L. Phytopharm Returns Hoodia Gordonii Rights to South African R&D Company. HerbalEGram: Volume 8, Number 3, March 2011. Available at: https://cms.herbalgram.org/heg/volume8/03March/PhytopharmHoodiaTransfer.html?ts=1462301010&signature=716cdaf3800bde68aa9c14eda009a074.
  • Zhang S, Ma Y, Li J, et al. Molecular matchmaking between the popular weight-loss herb Hoodia gordonii and GPR119, a potential drug target for metabolic disorder. Proc Natl Acad Sci U S A. 2014;111(40):14571-6. View abstract.
  • Zhang S, Ma Y, Li J, et al. Molecular matchmaking between the popular weight-loss herb Hoodia gordonii and GPR119, a potential drug target for metabolic disorder. Proc Natl Acad Sci U S A. 2014;111(40):14571-6. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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