AMK, ATR, Atractylenolide, Atractylénolide, Atractylis lancea, Atractylis ovata, Atractylode Blanc, Atractylode Gris, Atractylodes chinensis, Atractylodes japonica, Atractylodes lancea, Atractylodes macrocephala, Atractylodes ovata, Atractylodis Radix, Bai Zhu, Bai-Zhu Atractylodes, Byaki-Jutsu, Cang Zhu, Cangzhu, Chang Zhe, Jutsu, Khod Kha Mao, Largehead Atractylodes, Paekch'ul, Red Atractylodes, Rhizoma Atractylodis, Rhizoma Atractylodis Macroce, Rhizoma Atractylodis Macrocephalae, Rhizome d'Atractylode, So-Jutsu, White Atractylodes, White Atractylodis.


Overview Information

Atractylodes is a plant. People use the root to make medicine.

Atractylodes is used for obesity, indigestion, stomach ache, bloating, fluid retention, diarrhea, loss of appetite, sweating, night blindness, weight loss due to cancer, allergies to dust mites, and joint pain (rheumatism). It is also used for colds, flu, and fever.

Atractylodes is used with other herbs in traditional Chinese medicine (TCM) for treating lung cancer and for treating complications of dialysis, a mechanical method for "cleaning the blood" when the kidneys have failed.

How does it work?

Chemicals in atractylodes might improve the function of the digestive tract and reduce pain and swelling (inflammation). Some chemicals might also prevent cancer cells from growing.


Uses & Effectiveness?

Insufficient Evidence for

  • Loss of appetite. Early research in people with stomach cancer shows that taking atractylenolide, a purified atractylodes ingredient, seems to improve appetite in people who have lost weight.
  • Joint pain (rheumatism).
  • Indigestion.
  • Stomach ache.
  • Bloating.
  • Obesity.
  • Colds and flu.
  • Fever.
  • Edema.
  • Diarrhea.
  • Other conditions.
More evidence is needed to rate the effectiveness of atractylodes for these uses.

Side Effects

Side Effects & Safety

There isn't enough information available to know if atractylodes is safe to take for medical conditions.

Special Precautions & Warnings:

Pregnancy: Atractylodes is POSSIBLY UNSAFE when used orally. In animals, it has caused death or harm in unborn babies. Stay on the safe side and avoid use.

Breastfeeding: Not enough is known about the use of atractylodes during breastfeeding. Stay on the safe side and avoid use.

Allergy to ragweed and related plants: Atractylodes may cause an allergic reaction in people who are sensitive to the Asteraceae/Compositae family. Members of this family include ragweed, chrysanthemums, marigolds, daisies, and many others. If you have allergies, be sure to check with your healthcare provider before taking atractylodes.

BLEEDING DISORDERS: Atractylodes might slow blood clotting. In theory, atractylodes might increase the risk of bruising and bleeding in people with bleeding disorders.

SURGERY: Atractylodes might slow blood clotting. There is concern that it might cause extra bleeding during and after surgery. Stop using atractylodes at least 2 weeks before a scheduled surgery.



We currently have no information for ATRACTYLODES Interactions.



The appropriate dose of atractylodes depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for atractylodes. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References


  • 94305 Wang KT, Chen LG, Chou DS, Liang WL, Wang CC. Anti-Oxidative Abilities of Essential Oils from Atractylodes ovata Rhizome. Evid Based Complement Alternat Med. 2011;2011:204892. View abstract.
  • Chen Y, Yang W, Guo L, Wu X, Zhang T, Liu J, Zhang J. Atractylodes lactone compounds inhibit platelet activation. Platelets. 2017 Mar;28(2):194-202. View abstract.
  • Han Y, Jung HW, Park YK. The roots of Atractylodes japonica Koidzumi promote adipogenic differentiation via activation of the insulin signaling pathway in 3T3-L1 cells. BMC Complement Altern Med. 2012 Sep 14;12:154. View abstract.
  • Inagaki K, Komatsu Y, Sasaki H, et al. Acidic polysaccharides from rhizomes of Atractylodes lancea as protective principle in Candida-infected mice. Planta Med 2001;67:428-31. View abstract.
  • Jang MH, Shin MC, Kim YJ, et al. Atractylodes japonica suppresses lipopolysaccharide-stimulated expressions of inducible nitric oxide synthase and cyclooxygenase-2 in RAW 264.7 macrophages. Biol Pharm Bull 2004;27:324-7. View abstract.
  • Jeong SI, Kim SY, Kim SJ, Hwang BS, Kwon TH, Yu KY, Hang SH, Suzuki K, Kim KJ. Antibacterial activity of phytochemicals isolated from Atractylodes japonica against methicillin-resistant Staphylococcus aureus. Molecules. 2010 Oct 21;15(10):7395-402. View abstract.
  • Jiang H, Shi J, Li Y. Screening for compounds with aromatase inhibiting activities from Atractylodes macrocephala Koidz. Molecules. 2011 Apr 14;16(4):3146-51. View abstract.
  • Kamei T, Kumano H, Iwata K, et al. The effect of a traditional Chinese prescription for a case of lung carcinoma. J Altern Complement Med 2000;6:557-9. View abstract.
  • Kim HK, Yun YK, Ahn YJ. Toxicity of atractylon and atractylenolide III identified in Atractylodes ovata rhizome to Dermatophagoides farinae and Dermatophagoides pteronyssinus. J Agric Food Chem 2007;55:6027-31. View abstract.
  • Kitajima J, Kamoshita A, Ishikawa T, et al. Glycosides of Atractylodes japonica. Chem Pharm Bull (Tokyo) 2003;51:152-7. View abstract.
  • Kitajima J, Kamoshita A, Ishikawa T, et al. Glycosides of Atractylodes lancea. Chem Pharm Bull (Tokyo) 2003;51:673-8. View abstract.
  • Kitajima J, Kamoshita A, Ishikawa T, et al. Glycosides of Atractylodes ovata. Chem Pharm Bull (Tokyo) 2003;51:1106-8. View abstract.
  • Koonrungsesomboon N, Na-Bangchang K, Karbwang J. Therapeutic potential and pharmacological activities of Atractylodes lancea (Thunb.) DC. Asian Pac J Trop Med. 2014 Jun;7(6):421-8. View abstract.
  • Lee JC, Lee KY, Son YO, et al. Stimulating effects on mouse splenocytes of glycoproteins from the herbal medicine Atractylodes macrocephala Koidz. Phytomedicine 2007;14:390-5. View abstract.
  • Li CQ, He LC, Jin JQ. Atractylenolide I and atractylenolide III inhibit Lipopolysaccharide-induced TNF-alpha and NO production in macrophages. Phytother Res 2007;21:347-53. View abstract.
  • Li L, Tang LY, Man GC, Yeung BH, Lau CB, Leung PC, Wang CC. Potential reproductive toxicity of Largehead Atractylodes Rhizome, the most commonly used Chinese medicine for threatened miscarriage. Hum Reprod. 2011 Dec;26(12):3280-8. View abstract.
  • Liambo W, Baotian C, Rengao Y, Huiqun L. Treatment of complications due to peritoneal dialysis for chronic renal failure with traditional Chinese medicine. J Trad Chinese Med 1999;19:3-9. View abstract.
  • Liu Y, Jia Z, Dong L, et al. A randomized pilot study of atractylenolide I on gastric cancer cachexia patients. Evid Based Complement Alternat Med 2008;5:337-44. View abstract.
  • Min BS, Kim YH, Tomiyama M, et al. Inhibitory effects of Korean plants on HIV-1 activities. Phytother Res 2001;15:481-6. View abstract.
  • Nakai Y, Kido T, Hashimoto K, et al. Effect of the rhizomes of Atractylodes lancea and its constituents on the delay of gastric emptying. J Ethnopharmacol 2003;84:51-5. View abstract.
  • Nogami M, Moriura T, Kubo M, Tani T. Studies on the origin, processing and quality of crude drugs. II. Pharmacological evaluation of the Chinese crude drug "zhu" in experimental stomach ulcer. (2). Inhibitory effect of extract of Atractylodes lancea on gastric secretion. Chem Pharm Bull (Tokyo) 1986;34:3854-60. View abstract.
  • Prieto JM, Recio MC, Giner RM, et al. Influence of traditional Chinese anti-inflammatory medicinal plants on leukocyte and platelet functions. J Pharm Pharmacol 2003;55:1275-82. View abstract.
  • Resch M, Heilmann J, Steigel A, Bauer R. Further phenols and polyacetylenes from the rhizomes of Atractylodes lancea and their anti-inflammatory activity. Planta Med 2001;67:437-42. View abstract.
  • Resch M, Steigel A, Chen ZL, Bauer R. 5-Lipoxygenase and cyclooxygenase-1 inhibitory active compounds from Atractylodes lancea. J Nat Prod 1998;61:347-50. View abstract.
  • Sakurai T, Sugawara H, Saito K, Kano Y. Effects of the acetylene compound from Atractylodes rhizome on experimental gastric ulcers induced by active oxygen species. Biol Pharm Bull 1994;17:1364-8. View abstract.
  • Tsuneki H, Kobayashi S, Sekizaki N, et al. Antiangiogenic activity of beta-eudesmol in vitro and in vivo. Eur J Pharmacol 2005;512:105-15. View abstract.
  • Wang CC, Chen LG, Yang LL. Cytotoxic activity of sesquiterpenoids from Atractylodes ovata on leukemia cell lines. Planta Med 2002;68:204-8. View abstract.
  • Wang CC, Lin SY, Cheng HC, Hou WC. Pro-oxidant and cytotoxic activities of atractylenolide I in human promyeloleukemic HL-60 cells. Food Chem Toxicol 2006;44:1308-15. View abstract.
  • Wang KT, Chen LG, Yang LL, et al. Analysis of the sesquiterpenoids in processes Atractylodes rhizome. Chem Pharm Bull 2007;55:50-6. View abstract.
  • Yamahara J, Matsuda H, Huang Q, Li Y, Fujimura H. Intestinal motility enhancing effect of Atractylodes lancea rhizome. J Ethnopharmacol 1990;29:341-4.
  • Yu KW, Kiyohara H, Matsumoto T, et al. Intestinal immune system modulating polysaccharides from rhizomes of Atractylodes lancea. Planta Med 1998;64:714-9. View abstract.
  • Zhou J, Qu F, Yu Y. Chemical and ecological evaluation of a genuine Chinese medicine: Atractylodes macrocephala Koidz. Afr J Tradit Complement Altern Med.2011;8(4):405-11. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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