SCHIZONEPETA: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Schizonepeta is a plant. The parts that grow above the ground are used to make medicine.

Schizonepeta is used for the common cold, fever, sore throat, pain, eczema (atopic dermatitis), psoriasis, and many other conditions, but there is no good scientific evidence to support these uses.

How does it work ?

Schizonepeta contains chemicals that might reduce swelling and allergic reactions.

Interactions ?

Moderate Interaction

Be cautious with this combination

Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with SCHIZONEPETA
Some medications are changed and broken down by the liver. Schizonepeta might decrease how quickly the liver breaks down some medications. Taking schizonepeta along with some medications that are changed by the liver may increase the effects and side effects of some medications. Before taking schizonepeta, talk to your healthcare provider if you take any medications that are changed by the liver.

Some of these medications that are changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline, zileuton (Zyflo), zolmitriptan (Zomig), and others.
Medications changed by the liver (Cytochrome P450 2D6 (CYP2D6) substrates) interacts with SCHIZONEPETA
Some medications are changed and broken down by the liver. Schizonepeta might decrease how quickly the liver breaks down some medications. Taking schizonepeta along with some medications that are changed by the liver may increase the effects and side effects of some medications. Before taking schizonepeta talk to your healthcare provider if you take any medications that are changed by the liver.

Some medications that are changed by the liver include amitriptyline (Elavil), codeine, desipramine (Norpramin), flecainide (Tambocor), haloperidol (Haldol), imipramine (Tofranil), metoprolol (Lopressor, Toprol XL), ondansetron (Zofran), paroxetine (Paxil), risperidone (Risperdal), tramadol (Ultram), venlafaxine (Effexor), and others.
Medications changed by the liver (Cytochrome P450 2E1 (CYP2E1) substrates) interacts with SCHIZONEPETA
Some medications are changed and broken down by the liver. Schizonepeta might decrease how quickly the liver breaks down some medications. Taking schizonepeta along with some medications that are broken down by the liver may increase the effects and side effects of some medications. Before taking schizonepeta talk to your healthcare provider if you take any medications that are changed by the liver.

Some medications changed by the liver include acetaminophen, chlorzoxazone (Parafon Forte), ethanol, theophylline, and anesthetics such as enflurane (Ethrane), halothane (Fluothane), isoflurane (Forane), methoxyflurane (Penthrane).
Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with SCHIZONEPETA
Some medications are changed and broken down by the liver. Schizonepeta might increase how quickly the liver breaks down some medications. Taking schizonepeta along with some medications that are broken down by the liver may decrease the effects of some medications. Before taking schizonepeta talk to your healthcare provider if you take any medications that are changed by the liver.

Some medications changed by the liver include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and many others.

View References

REFERENCES:

Bao B, Geng T, Cao Y, et al. Effects of schizonepetin on activity of mRNA expression of cytochrome P450 enzymes in rats. Int J Mol Sci. 2012;13(12):17006-18. View abstract.

Choi YY, Kim MH, Kim JH, et al. Schizonepeta tenuifolia inhibits the development of atopic dermatitis in mice. Phytother Res. 2013;27(8):1131-5. View abstract.

Ding AW, Wu H, Kong LD, et al. [Research on hemostatic mechanism of extracts from carbonized Schizonepeta tenuifolia Brig]. Zhongguo Zhong Yao Za Zhi 1993;18:598-600, 638. View abstract.

Fung AY, Look PC, Chong LY, et al. A controlled trial of traditional Chinese herbal medicine in Chinese patients with recalcitrant atopic dermatitis. Int J Dermatol 1999;38:387-92 . View abstract.

Fung D, Lau CB. Schizonepeta tenuifolia: chemistry, pharmacology, and clinical applications. J Clin Pharmacol 2002;42:30-6. View abstract.

Kirby AJ, Schmidt RJ. The antioxidant activity of Chinese herbs for eczema and of placebo herbs--I. J Ethnopharmacol 1997;56:103-8. View abstract.

Lin R, Tian J, Huang G, et al. Analysis of menthol in three traditional Chinese medicinal herbs and their compound formulation by GC-MS. Biomed Chromatogr 2002;16:229-33. View abstract.

Liu HN, Jaw SK, Wong CK. Chinese herbs and atopic dermatitis. Lancet 1993;342:1175-6.

Shan MQ, Qian Y, Yu S, et al. Anti-inflammatory effect of volatile oil from Schizonepeta tenuifolia on carrageenin-induced pleurisy in rats and its application to study of appropriate harvesting time coupled with multi-attribute comprehensive index method. J Ethnopharmacol. 2016;194:580-6. View abstract.

Sheehan M, Rustin MHA, Atherton DJ, et al. Efficacy of traditional Chinese herbal therapy in adult atopic dermatitis. Lancet 1992;340:13-17. View abstract.

Sheehan MP, Stevens H, Ostlere LS, et al. Follow-up of adult patients with atopic eczema treated with Chinese herbal therapy for 1 year. Clin Exp Dermatol. 1995;20:136-40. View abstract.

Shin TY, Jeong HJ, Jun SM, et al. Effect of Schizonepeta tenuifolia extract on mast cell-mediated immediate-type hypersensitivity in rats. Immunopharmacol Immunotoxicol 1999;21:705-15. View abstract.

Tohda C, Kakihara Y, Komatsu K, Kuraishi Y. Inhibitory effects of methanol extracts of herbal medicines on substance P-induced itch-scratch response. Biol Pharm Bull 2000;23:599-601. View abstract.

Wang BS, Huang GJ, Tai HM, Huang MH. Antioxidant and anti-inflammatory activities of aqueous extracts of Schizonepeta tenuifolia Briq. Food Chem Toxicol. 2012;50(3-4):526-31. View abstract.

Zhang W, Leonard T, Bath-Hextall F, et al. Chinese herbal medicine for atopic eczema. Cochrane Database Syst Rev 2004;4:CD002291. [RETRACTED]. View abstract.

Zhou S, Koh HL, Gao Y, et al. Herbal bioactivation: the good, the bad and the ugly. Life Sci 2004;74:935-68. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.

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SCHIZONEPETA - Uses, Side Effects, and More

Overview

How does it work ?

Uses & Effectiveness ?

Insufficient Evidence for

Side Effects

Special Precautions and Warnings

Interactions ?

Moderate Interaction

Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with SCHIZONEPETA

Medications changed by the liver (Cytochrome P450 2D6 (CYP2D6) substrates) interacts with SCHIZONEPETA

Medications changed by the liver (Cytochrome P450 2E1 (CYP2E1) substrates) interacts with SCHIZONEPETA

Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with SCHIZONEPETA

Dosing

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