BURDOCK - Uses, Side Effects, and More

Bever BO and Zahnd GR. Plants with oral hypoglycaemic action. Quart J Crude Drug Res 1979;17:139-196.

Breed, F. B. and Kuwabara, T. Burdock ophthalmia. Arch Ophthalmol 1966;75(1):16-20. View abstract.

Bryson, P. D., Watanabe, A. S., Rumack, B. H., and Murphy, R. C. Burdock root tea poisoning. Case report involving a commercial preparation. JAMA 5-19-1978;239(20):2157. View abstract.

Chan, Y. S., Cheng, L. N., Wu, J. H., Chan, E., Kwan, Y. W., Lee, S. M., Leung, G. P., Yu, P. H., and Chan, S. W. A review of the pharmacological effects of Arctium lappa (burdock). Inflammopharmacology. 2011;19(5):245-254. View abstract.

Dombradi, C. A. and Foldeak, S. Screening report on the antitumor activity of purified Arctium Lappa extracts. Tumori 1966;52(3):173-175. View abstract.

Fan, H., De-Qiang, D., Yu, S., Lin, Z., Hong-Bin, X., and Ting-Guo, K. Plasma pharmacokinetics and tissue distribution of arctiin and its main metabolite in rats by HPLC-UV and LC-MS. Planta Med 2012;78(8):800-806. View abstract.

Farnsworth NR and Segelman AB. Hypoglycemic plants. Tile Till 1971;57:52-56.

Ichihara A. New sesquilignans from Arctium lappa L. The structure of lappaol C, D and E. Agric Biol Chem 1977;41:1813-1814.

Kassler, W. J., Blanc, P., and Greenblatt, R. The use of medicinal herbs by human immunodeficiency virus-infected patients. Arch Intern Med 1991;151(11):2281-2288. View abstract.

Knott, A., Reuschlein, K., Mielke, H., Wensorra, U., Mummert, C., Koop, U., Kausch, M., Kolbe, L., Peters, N., Stab, F., Wenck, H., and Gallinat, S. Natural Arctium lappa fruit extract improves the clinical signs of aging skin. J Cosmet.Dermatol. 2008;7(4):281-289. View abstract.

Lapinina L and Sisoeva T. Investigation of some plants to determine their sugar lowering action. Farmatsevtichnyi Zhurnal 1964;19:52-58.

Morita K. Chemical nature of a desmutagenic factor isolated from burdock (Arctium lappa Linne). Agric Biol Chem 1985;49:925-932.

Morita, K., Kada, T., and Namiki, M. A desmutagenic factor isolated from burdock (Arctium lappa Linne). Mutat.Res 1984;129(1):25-31. View abstract.

Nose, M., Fujimoto, T., Nishibe, S., and Ogihara, Y. Structural transformation of lignan compounds in rat gastrointestinal tract; II. Serum concentration of lignans and their metabolites. Planta Med 1993;59(2):131-134. View abstract.

Sato, A. [Studies on anti-tumor activity of crude drugs. I. The effects of aqueous extracts of some crude drugs in shortterm screening test. (1)]. Yakugaku Zasshi 1989;109(6):407-423. View abstract.

Silver AA and Krantz JC. The effect of the ingestion of burdock root on normal and diabetic individuals: A preliminary report. Ann Int Med 1931;5:274-284.

Swanston-Flatt, S. K., Day, C., Flatt, P. R., Gould, B. J., and Bailey, C. J. Glycaemic effects of traditional European plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice. Diabetes Res 1989;10(2):69-73. View abstract.

Wang, H. Y. and Yang, J. S. [Studies on the chemical constituents of Arctium lappa L]. Yao Xue.Xue.Bao.[Acta Pharmaceutica Sinica] 1993;28(12):911-917. View abstract.

Wang, W., Pan, Q., Han, X. Y., Wang, J., Tan, R. Q., He, F., Dou, D. Q., and Kang, T. G. Simultaneous determination of arctiin and its metabolites in rat urine and feces by HPLC. Fitoterapia 2-1-2013;86C:6-12. View abstract.

<p>Fletcher GF<span>, </span>Cantwell JD. Burdock root tea poisoning. JAMA <span>1978 Oct 6;240(15):1586.</span></p> View abstract.

Carlotto J, de Souza LM, Baggio CH, et al. Polysaccharides from Arctium lappa L.: Chemical structure and biological activity. Int J Biol Macromol. 2016;91:954-60. View abstract.

El-Kott AF and Bin-Meferij MM. Use of Arctium lappa extract against acetaminophen-induced hepatotoxicity in rats. Curr Ther Res Clin Exp. 2015;77:73-8. View abstract.

García F, Rodríguez CA, Palomo ML, et al. Efficacy, acceptability and tolerability of Zelesse for the treatment of non-specific vulvovaginitis in paediatric patients: The NINESSE Study. J Int Med Res. 2018;46(9):3583-3595. View abstract.

Guinot M, Blanco JE, Delgado JL, et al. Acceptability, tolerability, and effects on symptoms and signs of vulvovaginitis of a non-soap, herbal-based intimate hygiene solution (Zelesse). J Int Med Res. 2019;47(6):2626-2636. View abstract.

Ha MS, Yook JS, Lee M, et al. Exercise training and burdock root (Arctium lappa L.) extract independently improve abdominal obesity and sex hormones in elderly women with metabolic syndrome. Sci Rep. 2021;11(1):5175. View abstract.

Han YH, Mun JG, Jeon HD, et al. The Extract of Arctium lappa L. Fruit (Arctii Fructus) Improves Cancer-Induced Cachexia by Inhibiting Weight Loss of Skeletal Muscle and Adipose Tissue. Nutrients. 2020;12(10):3195. View abstract.

Hirose M, Yamaguchi T, Lin C, et al. Effects of arctiin on PhIP-induced mammary, colon and pancreatic carcinogenesis in female Sprague-Dawley rats and MeIQx-induced hepatocarcinogenesis in male F344 rats. Cancer Lett 2000;155:79-88. View abstract.

Holetz FB, Pessini GL, Sanches NR, et al. Screening of some plants used in the Brazilian folk medicine for the treatment of infectious diseases. Mem Inst Oswaldo Cruz 2002;97:1027-31. View abstract.

Iwakami S, Wu JB, Ebizuka Y, Sankawa U. Platelet activating factor (PAF) antagonists contained in medicinal plants: lignans and sesquiterpenes. Chem Pharm Bull (Tokyo) 1992;40:1196-8. View abstract.

Kardosova A, Ebringerova A, Alfoldi J, et al. A biologically active fructan from the roots of Arctium lappa L., var. Herkules. Int J Biol Macromol 2003;33:135-40. View abstract.

Latif A, Fichadiya H, Abid F, Capo G. Herbal Teas and Thrombocytopenia: A Curious Case of Yellow Dock and Burdock-Induced Thrombocytopenia. Eur J Case Rep Intern Med 2022;9(3):003247. View abstract.

Lin CC, Lu JM, Yang JJ, et al. Anti-inflammatory and radical scavenge effects of Arctium lappa. Am J Chin Med 1996;24:127-37. View abstract.

Lin SC, Lin CH, Lin CC, et al. Hepatoprotective effects of Arctium lappa Linne on liver injuries induced by chronic ethanol consumption and potentiated by carbon tetrachloride. J Biomed Sci 2002;9:401-9. View abstract.

Mizuki A, Tatemichi M, Nakazawa A, Tsukada N, Nagata H, Kinoshita Y. Effects of Burdock tea on recurrence of colonic diverticulitis and diverticular bleeding: An open-labelled randomized clinical trial. Sci Rep. 2019;9(1):6793. View abstract.

Predes Fde S, Diamante MA, Foglio MA, Dolder H. Effects of Arctium lappa on cadmium-induced damage to the testis and epididymis of adult wistar rats. Biol Trace Elem Res. 2016;173(2):362-71. View abstract.

Rhoads PM, Tong TG, Banner W Jr, Anderson R. Anticholinergic poisonings associated with commercial burdock root tea. J Toxicol Clin Toxicol 1984-85;22:581-4. View abstract.

Rodriguez P, Blanco J, Juste S, et al. Allergic contact dermatitis due to burdock (Arctium lappa). Contact Dermatitis 1995;33:134-5. View abstract.

Sasaki Y, Kimura Y, Tsunoda T, Tagami H. Anaphylaxis due to burdock. Int J Dermatol 2003;42:472-3. View abstract.

Xie LH, Ahn EM, Akao T, et al. Transformation of arctiin to estrogenic and antiestrogenic substances by human intestinal bacteria. Chem Pharm Bull (Tokyo) 2003;51:378-84. View abstract.

Yang WS, Lee SR, Jeong YJ, et al. Antiallergic activity of ethanol extracts of Arctrium lappa L. undried roots and its active compound, oleamide, in regulating FceRI-mediated and MAPK signaling in RBL-2H3 cells. J Agric Food Chem. 2016;64(18):3564-73.View abstract.

Zick, S. M., Sen, A., Feng, Y., Green, J., Olatunde, S., and Boon, H. Trial of Essiac to ascertain its effect in women with breast cancer (TEA-BC). J Altern Complement Med 2006;12(10):971-980. View abstract.