Bambou Japonais, Bambou Mexicain, Extrait de Hu Zhang, Fallopia japonica, Fleece Flower, Giant Knotweed, He Shou Wu, Hu Zhang Extract, Hu Zhang Root, Itadori, Japanese Bamboo, Japanese Knotweed, Japanese Knotwood, Mexican Bamboo, PCWE, Persicaire Cuspidée, Polygoni Multiflora, Polygonum cuspidatum, Racine de Hu Zhang, Renouée à Feuilles Pointues, Renouée du Japon, Renouée Japonaise, Reynoutria japonica, Tiger Cane.<br/><br/>


Overview Information

Hu zhang is the Chinese name given to a plant with the scientific name of Polygonum cuspidatum. North American varieties are often referred to as “Mexican bamboo.” The root is used as medicine.

Hu zhang is used for conditions of the heart and blood vessels including “hardening of the arteries” (atherosclerosis), high cholesterol, and heart disease; and for digestion problems including constipation, liver disease (hepatitis), and gallstones. It is also used for cancer, skin burns, pain and swelling of the bone (osteomyelitis) and gout.

Women sometimes use hu zhang for painful menstrual periods and menopausal symptoms such as hot flashes.

How does it work?

There is not enough known about how hu zhang might work. Some chemicals in hu zhang might decrease how fast some cells grow.


Uses & Effectiveness?

Insufficient Evidence for

More evidence is needed to rate the effectiveness of hu zhang for these uses.

Side Effects

Side Effects & Safety

There is not enough information available to know if hu zhang is safe to take for medical conditions.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking hu zhang if you are pregnant or breast feeding. Stay on the safe side and avoid use.

Bleeding disorders: Hu zhang contains resveratrol. Resveratrol is a chemical that might slow blood clotting. Taking hu zhang might slow clotting and increase the chances of bruising and bleeding in people with bleeding disorders.

Hormone-sensitive conditions such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: There is some developing evidence that hu zhang might act like estrogen. If you have any condition that might be made worse by exposure to estrogen, don’t use hu zhang until more is known.

Surgery: Hu zhang contains resveratrol. Resveratrol is a chemical that might slow blood clotting. Hu zhang might increase the risk of bleeding during and after surgery. Stop using hu zhang at least 2 weeks before a scheduled surgery.



Moderate Interaction

Be cautious with this combination

  • Estrogens interacts with HU ZHANG

    Hu zhang seems to have some of the same effects as estrogen. Taking hu zhang along with estrogens might decrease the effects of estrogens.<br /> Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol, and others.

  • Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with HU ZHANG

    Some medications are changed and broken down by the liver.<br /><br /> Hu zhang contains a chemical called resveratrol. Resveratrol might decrease how quickly the liver breaks down some medications. Taking hu zhang along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking hu zhang, talk to your healthcare provider if you are taking any medications that are changed by the liver.<br /><br /> Some medications changed by the liver include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and many others.

  • Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with HU ZHANG

    Hu zhang contains a chemical called resveratrol. Resveratrol might slow blood clotting. Taking hu zhang along with medications that also slow clotting might increase the chances of bruising and bleeding.<br /><br /> Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.



The appropriate dose of hu zhang depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for hu zhang. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References


  • Bagchi, D., Das, D. K., Tosaki, A., Bagchi, M., and Kothari, S. C. Benefits of resveratrol in women's health. Drugs Exp.Clin Res 2001;27(5-6):233-248. View abstract.
  • Banerjee, S., Bueso-Ramos, C., and Aggarwal, B. B. Suppression of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: role of nuclear factor-kappaB, cyclooxygenase 2, and matrix metalloprotease 9. Cancer Res 9-1-2002;62(17):4945-4954. View abstract.
  • Benova, B., Adam, M., Onderkova, K., Kralovsky, J., and Krajicek, M. Analysis of selected stilbenes in Polygonum cuspidatum by HPLC coupled with CoulArray detection. J Sep.Sci 2008;31(13):2404-2409. View abstract.
  • Bralley, E. E., Greenspan, P., Hargrove, J. L., Wicker, L., and Hartle, D. K. Topical anti-inflammatory activity of Polygonum cuspidatum extract in the TPA model of mouse ear inflammation. J Inflamm.(Lond) 2008;5:1. View abstract.
  • Cao, Y., Zhang, M., Yu, H., Li, G., Du, Y., and Xiao, L. [Effects of meteorological factors and mineral elements on the content of resveratrol in Polygonum cuspidatum rootstalk]. Ying.Yong.Sheng Tai Xue.Bao. 2004;15(7):1143-1147. View abstract.
  • Chang, C. J., Ashendel, C. L., Geahlen, R. L., McLaughlin, J. L., and Waters, D. J. Oncogene signal transduction inhibitors from medicinal plants. In Vivo 1996;10(2):185-190. View abstract.
  • Chang, J. S., Liu, H. W., Wang, K. C., Chen, M. C., Chiang, L. C., Hua, Y. C., and Lin, C. C. Ethanol extract of Polygonum cuspidatum inhibits hepatitis B virus in a stable HBV-producing cell line. Antiviral Res 2005;66(1):29-34. View abstract.
  • Chang, T. K., Lee, W. B., and Ko, H. H. Trans-resveratrol modulates the catalytic activity and mRNA expression of the procarcinogen-activating human cytochrome P450 1B1. Can.J.Physiol Pharmacol. 2000;78(11):874-881. View abstract.
  • Chen, L., Han, Y., Yang, F., and Zhang, T. High-speed counter-current chromatography separation and purification of resveratrol and piceid from Polygonum cuspidatum. J Chromatogr.A 1-12-2001;907(1-2):343-346. View abstract.
  • Chen, Y. B., Sun, B. X., and Chen, J. X. [Study on the stability of resveratrol in rhizoma polygoni cuspidati]. Zhong.Yao Cai. 2007;30(7):805-807. View abstract.
  • Ciolino, H. P. and Yeh, G. C. Inhibition of aryl hydrocarbon-induced cytochrome P-450 1A1 enzyme activity and CYP1A1 expression by resveratrol. Mol.Pharmacol. 1999;56(4):760-767. View abstract.
  • Dobrydneva, Y., Williams, R. L., and Blackmore, P. F. trans-Resveratrol inhibits calcium influx in thrombin-stimulated human platelets. Br.J.Pharmacol. 1999;128(1):149-157. View abstract.
  • Du, F. Y., Xiao, X. H., and Li, G. K. Application of ionic liquids in the microwave-assisted extraction of trans-resveratrol from Rhizma Polygoni Cuspidati. J Chromatogr.A 1-26-2007;1140(1-2):56-62. View abstract.
  • Feng, L., Zhang, L. F., Yan, T., Jin, J., and Tao, W. Y. [Studies on active substance of anticancer effect in Polygonum cuspidatum]. Zhong.Yao Cai. 2006;29(7):689-691. View abstract.
  • Gu, M., Su, Z. G., and Janson, J. C. One-Step Purification of Resveratrol and Polydatin from Polygonum cuspidatum (Sieb. & Zucc.) by Isocratic Hydrogen Bond Adsorption Chromatography on Cross-Linked 12% Agarose. Chromatographia 2006;64(11-12):701-704.
  • Hegde, V. R., Pu, H., Patel, M., Black, T., Soriano, A., Zhao, W., Gullo, V. P., and Chan, T. M. Two new bacterial DNA primase inhibitors from the plant Polygonum cuspidatum. Bioorg.Med Chem.Lett. 5-3-2004;14(9):2275-2277. View abstract.
  • Hsu, C. Y., Chan, Y. P., and Chang, J. Antioxidant activity of extract from Polygonum cuspidatum. Biol.Res 2007;40(1):13-21. View abstract.
  • Jiang, Q., Li, Y., Pan, J., Ma, J., Xu, B., Yang, H., Zhang, J., and He, M. [TNF-alpha gene expression of NAFLD rat intervened by the extracts of Rizoma Polygoni Cuspidati]. Zhong.Yao Cai. 2005;28(10):917-920. View abstract.
  • Kim, J. R., Oh, D. R., Cha, M. H., Pyo, B. S., Rhee, J. H., Choy, H. E., Oh, W. K., and Kim, Y. R. Protective effect of polygoni cuspidati radix and emodin on Vibrio vulnificus cytotoxicity and infection. J Microbiol. 2008;46(6):737-743. View abstract.
  • Kim, K. W., Ha, K. T., Park, C. S., Jin, U. H., Chang, H. W., Lee, I. S., and Kim, C. H. Polygonum cuspidatum, compared with baicalin and berberine, inhibits inducible nitric oxide synthase and cyclooxygenase-2 gene expressions in RAW 264.7 macrophages. Vascul.Pharmacol 2007;47(2-3):99-107. View abstract.
  • Kimura, Y., Okuda, H., and Kubo, M. Effects of stilbenes isolated from medicinal plants on arachidonate metabolism and degranulation in human polymorphonuclear leukocytes. J Ethnopharmacol. 1995;45(2):131-139. View abstract.
  • Kirk, R. I., Deitch, J. A., Wu, J. M., and Lerea, K. M. Resveratrol decreases early signaling events in washed platelets but has little effect on platalet in whole food. Blood Cells Mol.Dis. 2000;26(2):144-150. View abstract.
  • Kong, L. D., Yang, C., and Qiu, X. [Effects of processing on antioxidation of Radix et Rhizoma Rhei and Rhizoma Polygoni Cuspidati]. Zhongguo Zhong.Yao Za Zhi. 2001;26(6):388-391. View abstract.
  • Kumar, A., Dhawan, S., and Aggarwal, B. B. Emodin (3-methyl-1,6,8-trihydroxyanthraquinone) inhibits TNF-induced NF-kappaB activation, IkappaB degradation, and expression of cell surface adhesion proteins in human vascular endothelial cells. Oncogene 8-20-1998;17(7):913-918. View abstract.
  • Lee, J. E. and Safe, S. Involvement of a post-transcriptional mechanism in the inhibition of CYP1A1 expression by resveratrol in breast cancer cells. Biochem.Pharmacol. 10-15-2001;62(8):1113-1124. View abstract.
  • Lee, S. H., Ryu, S. Y., Kim, H. B., Kim, M. Y., and Chun, Y. J. Induction of apoptosis by 3,4'-dimethoxy-5-hydroxystilbene in human promyeloid leukemic HL-60 cells. Planta Med 2002;68(2):123-127. View abstract.
  • Leu, Y. L., Hwang, T. L., Hu, J. W., and Fang, J. Y. Anthraquinones from Polygonum cuspidatum as tyrosinase inhibitors for dermal use. Phytother.Res 2008;22(4):552-556. View abstract.
  • Lim, B. O., Lee, J. H., Ko, N. Y., Mun, S. H., Kim, J. W., Kim, do K., Kim, J. D., Kim, B. K., Kim, H. S., Her, E., Lee, H. Y., and Choi, W. S. Polygoni cuspidati radix inhibits the activation of Syk kinase in mast cells for antiallergic activity. Exp.Biol.Med (Maywood.) 2007;232(11):1425-1431. View abstract.
  • Liu, Z. P., Li, W. X., Yu, B., Huang, J., Sun, J., Huo, J. S., and Liu, C. X. Effects of trans-resveratrol from Polygonum cuspidatum on bone loss using the ovariectomized rat model. J Med Food 2005;8(1):14-19. View abstract.
  • Ma, Z. H. and Ma, Q. Y. Resveratrol: a medical drug for acute pancreatitis. World J Gastroenterol. 6-7-2005;11(21):3171-3174. View abstract.
  • Manna, S. K., Mukhopadhyay, A., and Aggarwal, B. B. Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. J Immunol. 6-15-2000;164(12):6509-6519. View abstract.
  • Mi, Z., Chen, H., Zhang, X., Li, Z., Chen, W., and Shao, X. [Screening of antiviral agents from medicinal herbs by means of Hepadnaviruses models]. Zhongguo Zhong.Yao Za Zhi. 1997;22(1):43-5, 63. View abstract.
  • Olas, B., Wachowicz, B., Saluk-Juszczak, J., and Zielinski, T. Effect of resveratrol, a natural polyphenolic compound, on platelet activation induced by endotoxin or thrombin. Thromb.Res 8-15-2002;107(3-4):141-145. View abstract.
  • Pendurthi, U. R., Williams, J. T., and Rao, L. V. Resveratrol, a polyphenolic compound found in wine, inhibits tissue factor expression in vascular cells : A possible mechanism for the cardiovascular benefits associated with moderate consumption of wine. Arterioscler.Thromb.Vasc.Biol 1999;19(2):419-426. View abstract.
  • Song, J. H., Kim, S. K., Chang, K. W., Han, S. K., Yi, H. K., and Jeon, J. G. In vitro inhibitory effects of Polygonum cuspidatum on bacterial viability and virulence factors of Streptococcus mutans and Streptococcus sobrinus. Arch Oral Biol. 2006;51(12):1131-1140. View abstract.
  • Wang, C., Zhang, D., Ma, H., and Liu, J. Neuroprotective effects of emodin-8-O-beta-D-glucoside in vivo and in vitro. Eur.J Pharmacol 12-22-2007;577(1-3):58-63. View abstract.
  • Wang, D., Xu, Y., and Liu, W. Tissue distribution and excretion of resveratrol in rat after oral administration of Polygonum cuspidatum extract (PCE). Phytomedicine. 2008;15(10):859-866. View abstract.
  • Xing, W. W., Wu, J. Z., Jia, M., Du, J., Zhang, H., and Qin, L. P. Effects of polydatin from Polygonum cuspidatum on lipid profile in hyperlipidemic rabbits. Biomed.Pharmacother. 2009;63(7):457-462. View abstract.
  • Yan, Y., Su, X., Liang, Y., Zhang, J., Shi, C., Lu, Y., Gu, L., and Fu, L. Emodin azide methyl anthraquinone derivative triggers mitochondrial-dependent cell apoptosis involving in caspase-8-mediated Bid cleavage. Mol Cancer Ther 2008;7(6):1688-1697. View abstract.
  • Yang, Y. M., Wang, X. X., Chen, J. Z., Wang, S. J., Hu, H., and Wang, H. Q. Resveratrol attenuates adenosine diphosphate-induced platelet activation by reducing protein kinase C activity. Am J Chin Med 2008;36(3):603-613. View abstract.
  • Yu, C., Shin, Y. G., Kosmeder, J. W., Pezzuto, J. M., and van Breemen, R. B. Liquid chromatography/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate. Rapid Commun.Mass Spectrom. 2003;17(4):307-313. View abstract.
  • Zbikowska, H. M. and Olas, B. Antioxidants with carcinostatic activity (resveratrol, vitamin E and selenium) in modulation of blood platelet adhesion. J Physiol Pharmacol. 2000;51(3):513-520. View abstract.
  • Zhao, K. S., Jin, C., Huang, X., Liu, J., Yan, W. S., Huang, Q., and Kan, W. The mechanism of Polydatin in shock treatment. Clin Hemorheol.Microcirc. 2003;29(3-4):211-217. View abstract.
  • Bertelli A, Bertelli AA, Gozzini A, Giovannini L. Plasma and tissue resveratrol concentrations and pharmacological activity. Drugs Exp Clin Res 1998;24:133-8. View abstract.
  • Bertelli AA, Giovannini L, Bernini W, et al. Antiplatelet activity of cis-resveratrol. Drugs Exp Clin Res 1996;22:61-3. View abstract.
  • Bertelli AA, Giovannini L, Giannessi D, et al. Antiplatelet activity of synthetic and natural resveratrol in red wine. Int J Tissue React 1995;17:1-3. View abstract.
  • Chang, T. K., Chen, J., and Lee, W. B. Differential inhibition and inactivation of human CYP1 enzymes by trans-resveratrol: evidence for mechanism-based inactivation of CYP1A2. J.Pharmacol.Exp.Ther. 2001;299(3):874-882. View abstract.
  • Jayasuriya H, Koonchanok NM, Geahlen RL, et al. Emodin, a protein tyrosine kinase inhibitor from Polygonum cuspidatum. J Nat Prod 1992;55:696-8. View abstract.
  • Jayatilake GS, Jayasuriya H, Lee ES, et al. Kinase inhibitors from Polygonum cuspidatum. J Nat Prod 1993;56:1805-10. View abstract.
  • Kong LD, Cai Y, Huang WW, et al. Inhibition of xanthine oxidase by some Chinese medicinal plants used to treat gout. J Ethnopharmacol 2000;73:199-207. View abstract.
  • Lee H, Tsai SJ. Effect of emodin on cooked-food mutagen activation. Food Chem Toxicol 1991;29:765-70. View abstract.
  • Matsuda H, Shimoda H, Morikawa T, Yoshikawa M. Phytoestrogens from the roots of Polygonum cuspidatum (Polygonaceae): structure-requirement of hydroxyanthraquinones for estrogenic activity. Bioorg Med Chem Lett 2001;11:1839-42. View abstract.
  • Pace-Asciak CR, Hahn S, Diamandis EP, et al. The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease. Clin Chim Acta 1995;235:207-19. View abstract.
  • Pace-Asciak CR, Rounova O, Hahn SE, et al. Wines and grape juices as modulators of platelet aggregation in healthy human subjects. Clin Chim Acta 1996;246:163-82. View abstract.
  • Park CS, Lee YC, Kim JD, et al. Inhibitory effects of Polygonum cuspidatum water extract (PCWE) and its component resveratrol on acyl-coenzyme A-cholesterol acyltransferase activity for cholesteryl ester synthesis in HepG2 cells. Vascul Pharmacol 2004;40:279-84. View abstract.
  • Pervaiz S. Resveratrol: from grapevines to mammalian biology. FASEB J 2003;17:1975-85. View abstract.
  • Piver B, Berthou F, Dreano Y, Lucas D. Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components. Toxicol Lett 2001;125:83-91. View abstract.
  • Soleas GJ, Diamandis EP, Goldberg DM. Resveratrol: a molecule whose time has come? And gone? Clin Biochem 1997;30:91-113. View abstract.
  • Wang S, Zheng Z, Weng Y, et al. Angiogenesis and anti-angiogenesis activity of Chinese medicinal herbal extracts. Life Sci 2004;74:2467-78. View abstract.
  • Yeh SF, Chou TC, Liu TS. Effects of anthraquinones of Polygonum cuspidatum on HL-60 cells. Planta Med 1988;54:413-4.
  • Zhang CZ, Wang SX, Zhang Y, et al. In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms. J Ethnopharmacol 2005;98:295-300. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
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