HU ZHANG

OTHER NAME(S):

Bambou Japonais, Bambou Mexicain, Extrait de Hu Zhang, Fallopia japonica, Fleece Flower, Giant Knotweed, He Shou Wu, Hojang-geun, Huzhang, Hu Zhang Extract, Hu Zhang Root, Itadori, Itadori-Kon, Japanese Bamboo, Japanese Knotweed, Japanese Knotwood, Mexican Bamboo, PCWE, Persicaire Cuspidée, Polygoni Multiflora, Polygonum cuspidatum, Racine de Hu Zhang, Renouée à Feuilles Pointues, Renouée du Japon, Renouée Japonaise, Reynoutria japonica, Tiger Cane.

Overview

Overview Information

Hu zhang is the Chinese name given to a plant with the scientific name of Polygonum cuspidatum. The root is used as medicine.

Hu zhang is commonly used by mouthy for conditions of the heart, liver, and digestive system and to reduce symptoms of menopause. It is also applied to the skin to help speed wound healing. But there is no good scientific research to support these or other uses.

How does it work?

There is not enough known about how hu zhang might work. Some chemicals in hu zhang might decrease how fast some cells grow. Also, some chemicals may prevent swelling and injury to cells.

Uses

Uses & Effectiveness?

Insufficient Evidence for

More evidence is needed to rate the effectiveness of hu zhang for these uses.

Side Effects

Side Effects & Safety

There is not enough information available to know if hu zhang is safe to take for medical conditions.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking hu zhang if you are pregnant or breast feeding. Stay on the safe side and avoid use.

Bleeding disorders: Hu zhang contains resveratrol. Resveratrol is a chemical that might slow blood clotting. Taking hu zhang might slow clotting and increase the chances of bruising and bleeding in people with bleeding disorders.

Hormone-sensitive conditions such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: There is some developing evidence that hu zhang might act like estrogen. If you have any condition that might be made worse by exposure to estrogen, don't use hu zhang until more is known.

Surgery: Hu zhang contains resveratrol. Resveratrol is a chemical that might slow blood clotting. Hu zhang might increase the risk of bleeding during and after surgery. Stop using hu zhang at least 2 weeks before a scheduled surgery.

Interactions

Interactions?

Moderate Interaction

Be cautious with this combination

!
  • Estrogens interacts with HU ZHANG

    Hu zhang seems to have some of the same effects as estrogen. Taking hu zhang along with estrogens might decrease the effects of estrogens.
    Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol, and others.

  • Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with HU ZHANG

    Some medications are changed and broken down by the liver.

    Hu zhang contains a chemical called resveratrol. Resveratrol might decrease how quickly the liver breaks down some medications. Taking hu zhang along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking hu zhang, talk to your healthcare provider if you are taking any medications that are changed by the liver.

    Some medications changed by the liver include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and many others.

  • Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with HU ZHANG

    Hu zhang contains a chemical called resveratrol. Resveratrol might slow blood clotting. Taking hu zhang along with medications that also slow clotting might increase the chances of bruising and bleeding.

    Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.

Dosing

Dosing

The appropriate dose of hu zhang depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for hu zhang. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

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  • Chang, T. K., Lee, W. B., and Ko, H. H. Trans-resveratrol modulates the catalytic activity and mRNA expression of the procarcinogen-activating human cytochrome P450 1B1. Can.J.Physiol Pharmacol. 2000;78(11):874-881. View abstract.
  • Ciolino, H. P. and Yeh, G. C. Inhibition of aryl hydrocarbon-induced cytochrome P-450 1A1 enzyme activity and CYP1A1 expression by resveratrol. Mol.Pharmacol. 1999;56(4):760-767. View abstract.
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  • Sohn E, Kim J, Kim CS, Lee YM, Kim JS. Extract of Polygonum cuspidatum attenuates diabetic retinopathy by inhibiting the high-mobility group box-1 (HMGB1) signaling pathway in streptozotocin-induced diabetic rats. Nutrients 2016;8(3):140. View abstract.
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  • Wu XB, Luo XQ, Gu SY, Xu JH. The effects of Polygonum cuspidatum extract on wound healing in rats. J Ethnopharmacol 2012;141(3):934-7. View abstract.
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  • Zahedi HS, Jazayeri S, Ghiasvand R, Djalali M, Eshraghian MR. Effects of Polygonum cuspidatum containing resveratrol on inflammation in male professional basketball players. Int J Prev Med 2013;4(Suppl 1):S1-4. View abstract.
  • Zhang CZ, Wang SX, Zhang Y, et al. In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms. J Ethnopharmacol 2005;98:295-300. View abstract.
  • Zhang H, Li C, Kwok ST, Zhang QW, Chan SW. A review of the pharmacological effects of the dried root of Polygonum cuspidatum (hu zhang) and its constituents. Evid Based Complement Alternat Med 2013;2013:208349. View abstract.
  • Zhang H, Zhang QW, Wang L, Zhang XQ, Ye WC, Wang YT. Two new anthraquinone malonylglucosides from Polygonum cuspidatum. Nat Prod Res 2012;26(14):1323-7. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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