HU ZHANG: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Hu zhang (Polygonum cuspidatum) is a plant native to Asia. The root is commonly used as part of traditional medicine in countries throughout Asia.

Hu zhang contains chemicals that might reduce symptoms of allergies. It also contains chemicals that might have anti-inflammatory and antioxidant effects.

People use hu zhang for hay fever, diabetes, gout, wound healing, and many other conditions, but there is no good scientific evidence to support these uses.

Uses & Effectiveness ?

We currently have no information for HU ZHANG overview.

Side Effects

When taken by mouth: There isn't enough reliable information to know if hu zhang is safe or what the side effects might be.

Special Precautions and Warnings

When taken by mouth: There isn't enough reliable information to know if hu zhang is safe or what the side effects might be. Pregnancy and breast-feeding: There isn't enough reliable information to know if hu zhang is safe to use when pregnant or breast feeding. Stay on the safe side and avoid use.

Hormone-sensitive conditions such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Hu zhang might act like estrogen. If you have any condition that might be made worse by exposure to estrogen, don't use hu zhang until more is known.

Surgery: Hu zhang contains resveratrol. Resveratrol is a chemical that might slow blood clotting. Hu zhang might increase the risk of bleeding during and after surgery. Stop using hu zhang at least 2 weeks before a scheduled surgery.

Interactions ?

Moderate Interaction

Be cautious with this combination

Estrogens interacts with HU ZHANG
Hu zhang seems to have some of the same effects as estrogen. Taking hu zhang along with estrogens might decrease the effects of estrogens.
Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with HU ZHANG
Some medications are changed and broken down by the liver. Hu zhang might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with HU ZHANG
Hu zhang might slow blood clotting. Taking hu zhang along with medications that also slow blood clotting might increase the risk of bruising and bleeding.
Medications changed by the liver (Cytochrome P450 1A1 (CYP1A1) substrates) interacts with HU ZHANG
Some medications are changed and broken down by the liver. Hu zhang might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with HU ZHANG
Some medications are changed and broken down by the liver. Hu zhang might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications changed by the liver (Cytochrome P450 1B1 (CYP1B1) substrates) interacts with HU ZHANG
Some medications are changed and broken down by the liver. Hu zhang might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications changed by the liver (Cytochrome P450 2C19 (CYP2C19) substrates) interacts with HU ZHANG
Some medications are changed and broken down by the liver. Hu zhang might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications changed by the liver (Cytochrome P450 2E1 (CYP2E1) substrates) interacts with HU ZHANG
Some medications are changed and broken down by the liver. Hu zhang might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.

Minor Interaction

Be watchful with this combination

Carbamazepine (Tegretol) interacts with HU ZHANG
Hu zhang might slow down how quickly the body breaks down carbamazepine. This might increase the amount of carbamazepine in the body and increase the risk of side effects. If you take carbamazepine, talk to your healthcare provider before taking hu zhang.

Dosing

There isn't enough reliable information to know what an appropriate dose of hu zhang might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.

View References

REFERENCES:

Bralley, E. E., Greenspan, P., Hargrove, J. L., Wicker, L., and Hartle, D. K. Topical anti-inflammatory activity of Polygonum cuspidatum extract in the TPA model of mouse ear inflammation. J Inflamm.(Lond) 2008;5:1. View abstract.

Chang, T. K., Lee, W. B., and Ko, H. H. Trans-resveratrol modulates the catalytic activity and mRNA expression of the procarcinogen-activating human cytochrome P450 1B1. Can.J.Physiol Pharmacol. 2000;78(11):874-881. View abstract.

Ciolino, H. P. and Yeh, G. C. Inhibition of aryl hydrocarbon-induced cytochrome P-450 1A1 enzyme activity and CYP1A1 expression by resveratrol. Mol.Pharmacol. 1999;56(4):760-767. View abstract.

Dobrydneva, Y., Williams, R. L., and Blackmore, P. F. trans-Resveratrol inhibits calcium influx in thrombin-stimulated human platelets. Br.J.Pharmacol. 1999;128(1):149-157. View abstract.

Kim, J. R., Oh, D. R., Cha, M. H., Pyo, B. S., Rhee, J. H., Choy, H. E., Oh, W. K., and Kim, Y. R. Protective effect of polygoni cuspidati radix and emodin on Vibrio vulnificus cytotoxicity and infection. J Microbiol. 2008;46(6):737-743. View abstract.

Kimura, Y., Okuda, H., and Kubo, M. Effects of stilbenes isolated from medicinal plants on arachidonate metabolism and degranulation in human polymorphonuclear leukocytes. J Ethnopharmacol. 1995;45(2):131-139. View abstract.

Kirk, R. I., Deitch, J. A., Wu, J. M., and Lerea, K. M. Resveratrol decreases early signaling events in washed platelets but has little effect on platalet in whole food. Blood Cells Mol.Dis. 2000;26(2):144-150. View abstract.

Lee, J. E. and Safe, S. Involvement of a post-transcriptional mechanism in the inhibition of CYP1A1 expression by resveratrol in breast cancer cells. Biochem.Pharmacol. 10-15-2001;62(8):1113-1124. View abstract.

Lim, B. O., Lee, J. H., Ko, N. Y., Mun, S. H., Kim, J. W., Kim, do K., Kim, J. D., Kim, B. K., Kim, H. S., Her, E., Lee, H. Y., and Choi, W. S. Polygoni cuspidati radix inhibits the activation of Syk kinase in mast cells for antiallergic activity. Exp.Biol.Med (Maywood.) 2007;232(11):1425-1431. View abstract.

Ma, Z. H. and Ma, Q. Y. Resveratrol: a medical drug for acute pancreatitis. World J Gastroenterol. 6-7-2005;11(21):3171-3174. View abstract.

Mi, Z., Chen, H., Zhang, X., Li, Z., Chen, W., and Shao, X. [Screening of antiviral agents from medicinal herbs by means of Hepadnaviruses models]. Zhongguo Zhong.Yao Za Zhi. 1997;22(1):43-5, 63. View abstract.

Olas, B., Wachowicz, B., Saluk-Juszczak, J., and Zielinski, T. Effect of resveratrol, a natural polyphenolic compound, on platelet activation induced by endotoxin or thrombin. Thromb.Res 8-15-2002;107(3-4):141-145. View abstract.

Pendurthi, U. R., Williams, J. T., and Rao, L. V. Resveratrol, a polyphenolic compound found in wine, inhibits tissue factor expression in vascular cells : A possible mechanism for the cardiovascular benefits associated with moderate consumption of wine. Arterioscler.Thromb.Vasc.Biol 1999;19(2):419-426. View abstract.

Wang, D., Xu, Y., and Liu, W. Tissue distribution and excretion of resveratrol in rat after oral administration of Polygonum cuspidatum extract (PCE). Phytomedicine. 2008;15(10):859-866. View abstract.

Xing, W. W., Wu, J. Z., Jia, M., Du, J., Zhang, H., and Qin, L. P. Effects of polydatin from Polygonum cuspidatum on lipid profile in hyperlipidemic rabbits. Biomed.Pharmacother. 2009;63(7):457-462. View abstract.

Yu, C., Shin, Y. G., Kosmeder, J. W., Pezzuto, J. M., and van Breemen, R. B. Liquid chromatography/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate. Rapid Commun.Mass Spectrom. 2003;17(4):307-313. View abstract.

Zbikowska, H. M. and Olas, B. Antioxidants with carcinostatic activity (resveratrol, vitamin E and selenium) in modulation of blood platelet adhesion. J Physiol Pharmacol. 2000;51(3):513-520. View abstract.

Bedada SK, Neerati P. Resveratrol Pretreatment Affects CYP2E1 Activity of Chlorzoxazone in Healthy Human Volunteers. Phytother Res. 2016;30(3):463-8. View abstract.

Bertelli A, Bertelli AA, Gozzini A, Giovannini L. Plasma and tissue resveratrol concentrations and pharmacological activity. Drugs Exp Clin Res 1998;24:133-8. View abstract.

Bertelli AA, Giovannini L, Bernini W, et al. Antiplatelet activity of cis-resveratrol. Drugs Exp Clin Res 1996;22:61-3. View abstract.

Bertelli AA, Giovannini L, Giannessi D, et al. Antiplatelet activity of synthetic and natural resveratrol in red wine. Int J Tissue React 1995;17:1-3. View abstract.

Chachay VS, Macdonald GA, Martin JH, Whitehead JP, O'Moore-Sullivan TM, Lee P, Franklin M, Klein K, Taylor PJ, Ferguson M, Coombes JS, Thomas GP, Cowin GJ, Kirkpatrick CM, Prins JB, Hickman IJ. Resveratrol does not benefit patients with nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol. 2014 Dec;12(12):2092-103.e1-6. View abstract.

Chang, T. K., Chen, J., and Lee, W. B. Differential inhibition and inactivation of human CYP1 enzymes by trans-resveratrol: evidence for mechanism-based inactivation of CYP1A2. J.Pharmacol.Exp.Ther. 2001;299(3):874-882. View abstract.

Chi YC, Lin SP, Hou YC. A new herb-drug interaction of Polygonum cuspidatum, a resveratrol-rich nutraceutical, with carbamazepine in rats. Toxicol Appl Pharmacol 2012;263(3):315-22. View abstract.

Chueh FS, Lin JJ, Lin JH, Weng SW, Huang YP, Chung JG. Crude extract of Polygonum cuspidatum stimulates immune responses in normal mice by increasing the percentage of Mac-3-positive cells and enhancing macrophage phagocytic activity and natural killer cell cytotoxicity. Mol Med Rep 2015;11(1):127-32. View abstract.

Jayasuriya H, Koonchanok NM, Geahlen RL, et al. Emodin, a protein tyrosine kinase inhibitor from Polygonum cuspidatum. J Nat Prod 1992;55:696-8. View abstract.

Jayatilake GS, Jayasuriya H, Lee ES, et al. Kinase inhibitors from Polygonum cuspidatum. J Nat Prod 1993;56:1805-10. View abstract.

Kong LD, Cai Y, Huang WW, et al. Inhibition of xanthine oxidase by some Chinese medicinal plants used to treat gout. J Ethnopharmacol 2000;73:199-207. View abstract.

Lee H, Tsai SJ. Effect of emodin on cooked-food mutagen activation. Food Chem Toxicol 1991;29:765-70. View abstract.

Lin CJ, Lin HJ, Chen TH, et al. Polygonum cuspidatum and its active components inhibit replication of the influenza virus through toll-like receptor 9-induced interferon beta expression. PLoS One 2015;10(2):e0117602. View abstract.

Lin HW, Sun MX, Wang YH, et al. Anti-HIV activities of the compounds isolated from Polygonum cuspidatum and Polygonum multiflorum. Planta Med 2010;76(9):889-92. View abstract.

Lin SP, Chu PM, Tsai SY, Wu MH, Hou YC. Pharmacokinetics and tissue distribution of resveratrol, emodin and their metabolites after intake of Polygonum cuspidatum in rats. J Ethnopharmacol 2012;144(3):671-6. View abstract.

Matsuda H, Shimoda H, Morikawa T, Yoshikawa M. Phytoestrogens from the roots of Polygonum cuspidatum (Polygonaceae): structure-requirement of hydroxyanthraquinones for estrogenic activity. Bioorg Med Chem Lett 2001;11:1839-42. View abstract.

Nawrot-Hadzik I, Matkowski A, Pitulaj A, et al. In vitro gingival wound healing activity of extracts from Reynoutria japonica Houtt rhizomes. Pharmaceutics 2021;13(11):1764. View abstract.

Pace-Asciak CR, Hahn S, Diamandis EP, et al. The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease. Clin Chim Acta 1995;235:207-19. View abstract.

Pace-Asciak CR, Rounova O, Hahn SE, et al. Wines and grape juices as modulators of platelet aggregation in healthy human subjects. Clin Chim Acta 1996;246:163-82. View abstract.

Park CS, Lee YC, Kim JD, et al. Inhibitory effects of Polygonum cuspidatum water extract (PCWE) and its component resveratrol on acyl-coenzyme A-cholesterol acyltransferase activity for cholesteryl ester synthesis in HepG2 cells. Vascul Pharmacol 2004;40:279-84. View abstract.

Pervaiz S. Resveratrol: from grapevines to mammalian biology. FASEB J 2003;17:1975-85. View abstract.

Piver B, Berthou F, Dreano Y, Lucas D. Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components. Toxicol Lett 2001;125:83-91. View abstract.

Sohn E, Kim J, Kim CS, Jo K, Kim JS. Extract of rhizoma Polygonum cuspidatum reduces early renal podocyte injury in streptozotocin induced diabetic rats and its active compound emodin inhibits methylglyoxal mediated glycation of proteins. Mol Med Rep 2015;12(4):5837-45. View abstract.

Sohn E, Kim J, Kim CS, Lee YM, Kim JS. Extract of Polygonum cuspidatum attenuates diabetic retinopathy by inhibiting the high-mobility group box-1 (HMGB1) signaling pathway in streptozotocin-induced diabetic rats. Nutrients 2016;8(3):140. View abstract.

Soleas GJ, Diamandis EP, Goldberg DM. Resveratrol: a molecule whose time has come? And gone? Clin Biochem 1997;30:91-113. View abstract.

Wang C, Yang S, Lu H, et al. A natural product from Polygonum cuspidatum Sieb. et Zucc. promotes Tat-dependent HIV latency reversal through triggering P-TEFb's release from 7SK snRNP. PLoS One 2015;10(11):e0142739. View abstract.

Wang S, Zheng Z, Weng Y, et al. Angiogenesis and anti-angiogenesis activity of Chinese medicinal herbal extracts. Life Sci 2004;74:2467-78. View abstract.

Wu M, Yang S, Liu G, et al. Treating unstable angina with detoxifying and blood-activating formulae: a randomized controlled trial. J Ethnopharmacol 2021;281:114530. View abstract.

Wu XB, Luo XQ, Gu SY, Xu JH. The effects of Polygonum cuspidatum extract on wound healing in rats. J Ethnopharmacol 2012;141(3):934-7. View abstract.

Yeh SF, Chou TC, Liu TS. Effects of anthraquinones of Polygonum cuspidatum on HL-60 cells. Planta Med 1988;54:413-4.

Zahedi HS, Jazayeri S, Ghiasvand R, Djalali M, Eshraghian MR. Effects of Polygonum cuspidatum containing resveratrol on inflammation in male professional basketball players. Int J Prev Med 2013;4(Suppl 1):S1-4. View abstract.

Zhang CZ, Wang SX, Zhang Y, et al. In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms. J Ethnopharmacol 2005;98:295-300. View abstract.

Zhang H, Li C, Kwok ST, Zhang QW, Chan SW. A review of the pharmacological effects of the dried root of Polygonum cuspidatum (hu zhang) and its constituents. Evid Based Complement Alternat Med 2013;2013:208349. View abstract.

Zhang H, Zhang QW, Wang L, Zhang XQ, Ye WC, Wang YT. Two new anthraquinone malonylglucosides from Polygonum cuspidatum. Nat Prod Res 2012;26(14):1323-7. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.

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HU ZHANG - Uses, Side Effects, and More

Overview

Uses & Effectiveness ?

Side Effects

Special Precautions and Warnings

Interactions ?

Moderate Interaction

Estrogens interacts with HU ZHANG

Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with HU ZHANG

Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with HU ZHANG

Medications changed by the liver (Cytochrome P450 1A1 (CYP1A1) substrates) interacts with HU ZHANG

Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with HU ZHANG

Medications changed by the liver (Cytochrome P450 1B1 (CYP1B1) substrates) interacts with HU ZHANG

Medications changed by the liver (Cytochrome P450 2C19 (CYP2C19) substrates) interacts with HU ZHANG

Medications changed by the liver (Cytochrome P450 2E1 (CYP2E1) substrates) interacts with HU ZHANG

Minor Interaction

Carbamazepine (Tegretol) interacts with HU ZHANG

Dosing

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