Bambou Japonais, Bambou Mexicain, Extrait de Hu Zhang, Fallopia japonica, Fleece Flower, Giant Knotweed, He Shou Wu, Hojang-geun, Huzhang, Hu Zhang Extract, Hu Zhang Root, Itadori, Itadori-Kon, Japanese Bamboo, Japanese Knotweed, Japanese Knotwood, Mexican Bamboo, PCWE, Persicaire Cuspidée, Polygoni Multiflora, Polygonum cuspidatum, Racine de Hu Zhang, Renouée à Feuilles Pointues, Renouée du Japon, Renouée Japonaise, Reynoutria japonica, Tiger Cane.
Overview InformationHu zhang is the Chinese name given to a plant with the scientific name of Polygonum cuspidatum. The root is used as medicine.
Hu zhang is commonly used by mouthy for conditions of the heart, liver, and digestive system and to reduce symptoms of menopause. It is also applied to the skin to help speed wound healing. But there is no good scientific research to support these or other uses.
How does it work?There is not enough known about how hu zhang might work. Some chemicals in hu zhang might decrease how fast some cells grow. Also, some chemicals may prevent swelling and injury to cells.
Uses & Effectiveness
Insufficient Evidence for
- Menstrual problems.
- Hot flashes.
- Heart disease.
- High cholesterol.
- Skin burns.
- Skin infections.
- Wound healing.
- Snake bites.
- Liver disease.
- Other conditions.
Side Effects & SafetyThere is not enough information available to know if hu zhang is safe to take for medical conditions.
Special Precautions & Warnings:Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking hu zhang if you are pregnant or breast feeding. Stay on the safe side and avoid use.
Bleeding disorders: Hu zhang contains resveratrol. Resveratrol is a chemical that might slow blood clotting. Taking hu zhang might slow clotting and increase the chances of bruising and bleeding in people with bleeding disorders.
Hormone-sensitive conditions such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: There is some developing evidence that hu zhang might act like estrogen. If you have any condition that might be made worse by exposure to estrogen, don't use hu zhang until more is known.
Surgery: Hu zhang contains resveratrol. Resveratrol is a chemical that might slow blood clotting. Hu zhang might increase the risk of bleeding during and after surgery. Stop using hu zhang at least 2 weeks before a scheduled surgery.
Be cautious with this combination
Estrogens interacts with HU ZHANG
Hu zhang seems to have some of the same effects as estrogen. Taking hu zhang along with estrogens might decrease the effects of estrogens.
Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol, and others.
Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with HU ZHANG
Some medications are changed and broken down by the liver.
Hu zhang contains a chemical called resveratrol. Resveratrol might decrease how quickly the liver breaks down some medications. Taking hu zhang along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking hu zhang, talk to your healthcare provider if you are taking any medications that are changed by the liver.
Some medications changed by the liver include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and many others.
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with HU ZHANG
Hu zhang contains a chemical called resveratrol. Resveratrol might slow blood clotting. Taking hu zhang along with medications that also slow clotting might increase the chances of bruising and bleeding.
Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.
The appropriate dose of hu zhang depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for hu zhang. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
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- Chang, T. K., Lee, W. B., and Ko, H. H. Trans-resveratrol modulates the catalytic activity and mRNA expression of the procarcinogen-activating human cytochrome P450 1B1. Can.J.Physiol Pharmacol. 2000;78(11):874-881. View abstract.
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- Kim, J. R., Oh, D. R., Cha, M. H., Pyo, B. S., Rhee, J. H., Choy, H. E., Oh, W. K., and Kim, Y. R. Protective effect of polygoni cuspidati radix and emodin on Vibrio vulnificus cytotoxicity and infection. J Microbiol. 2008;46(6):737-743. View abstract.
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- Xing, W. W., Wu, J. Z., Jia, M., Du, J., Zhang, H., and Qin, L. P. Effects of polydatin from Polygonum cuspidatum on lipid profile in hyperlipidemic rabbits. Biomed.Pharmacother. 2009;63(7):457-462. View abstract.
- Yang, Y. M., Wang, X. X., Chen, J. Z., Wang, S. J., Hu, H., and Wang, H. Q. Resveratrol attenuates adenosine diphosphate-induced platelet activation by reducing protein kinase C activity. Am J Chin Med 2008;36(3):603-613. View abstract.
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- Chueh FS, Lin JJ, Lin JH, Weng SW, Huang YP, Chung JG. Crude extract of Polygonum cuspidatum stimulates immune responses in normal mice by increasing the percentage of Mac-3-positive cells and enhancing macrophage phagocytic activity and natural killer cell cytotoxicity. Mol Med Rep 2015;11(1):127-32. View abstract.
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- Lin CJ, Lin HJ, Chen TH, et al. Polygonum cuspidatum and its active components inhibit replication of the influenza virus through toll-like receptor 9-induced interferon beta expression. PLoS One 2015;10(2):e0117602. View abstract.
- Lin HW, Sun MX, Wang YH, et al. Anti-HIV activities of the compounds isolated from Polygonum cuspidatum and Polygonum multiflorum. Planta Med 2010;76(9):889-92. View abstract.
- Lin SP, Chu PM, Tsai SY, Wu MH, Hou YC. Pharmacokinetics and tissue distribution of resveratrol, emodin and their metabolites after intake of Polygonum cuspidatum in rats. J Ethnopharmacol 2012;144(3):671-6. View abstract.
- Matsuda H, Shimoda H, Morikawa T, Yoshikawa M. Phytoestrogens from the roots of Polygonum cuspidatum (Polygonaceae): structure-requirement of hydroxyanthraquinones for estrogenic activity. Bioorg Med Chem Lett 2001;11:1839-42. View abstract.
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- Pace-Asciak CR, Rounova O, Hahn SE, et al. Wines and grape juices as modulators of platelet aggregation in healthy human subjects. Clin Chim Acta 1996;246:163-82. View abstract.
- Park CS, Lee YC, Kim JD, et al. Inhibitory effects of Polygonum cuspidatum water extract (PCWE) and its component resveratrol on acyl-coenzyme A-cholesterol acyltransferase activity for cholesteryl ester synthesis in HepG2 cells. Vascul Pharmacol 2004;40:279-84. View abstract.
- Pervaiz S. Resveratrol: from grapevines to mammalian biology. FASEB J 2003;17:1975-85. View abstract.
- Piver B, Berthou F, Dreano Y, Lucas D. Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components. Toxicol Lett 2001;125:83-91. View abstract.
- Sohn E, Kim J, Kim CS, Jo K, Kim JS. Extract of rhizoma Polygonum cuspidatum reduces early renal podocyte injury in streptozotocin induced diabetic rats and its active compound emodin inhibits methylglyoxal mediated glycation of proteins. Mol Med Rep 2015;12(4):5837-45. View abstract.
- Sohn E, Kim J, Kim CS, Lee YM, Kim JS. Extract of Polygonum cuspidatum attenuates diabetic retinopathy by inhibiting the high-mobility group box-1 (HMGB1) signaling pathway in streptozotocin-induced diabetic rats. Nutrients 2016;8(3):140. View abstract.
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- Wang C, Yang S, Lu H, et al. A natural product from Polygonum cuspidatum Sieb. et Zucc. promotes Tat-dependent HIV latency reversal through triggering P-TEFb's release from 7SK snRNP. PLoS One 2015;10(11):e0142739. View abstract.
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- Wu XB, Luo XQ, Gu SY, Xu JH. The effects of Polygonum cuspidatum extract on wound healing in rats. J Ethnopharmacol 2012;141(3):934-7. View abstract.
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- Zahedi HS, Jazayeri S, Ghiasvand R, Djalali M, Eshraghian MR. Effects of Polygonum cuspidatum containing resveratrol on inflammation in male professional basketball players. Int J Prev Med 2013;4(Suppl 1):S1-4. View abstract.
- Zhang CZ, Wang SX, Zhang Y, et al. In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms. J Ethnopharmacol 2005;98:295-300. View abstract.
- Zhang H, Li C, Kwok ST, Zhang QW, Chan SW. A review of the pharmacological effects of the dried root of Polygonum cuspidatum (hu zhang) and its constituents. Evid Based Complement Alternat Med 2013;2013:208349. View abstract.
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