JAPANESE PERSIMMON

OTHER NAME(S):

Caqui, Chinese Persimmon, Chinese Plum, Coing de Chine, Diospyros chinensis, Diospyros kaki, Diospyroskaki, Dried Persimmon, Figuier Caque, Fuyu, Hachiya, Hachiya Persimmon, Hanagosho, Jiro, Kaki, Kaki du Japon, Kaki Persimmon, Korean Persimmon, Oriental Persimmon, Persimmon, Persimmon Fruit, Persimmon Japonais, Persimmon Juice, Persimmon Punch, Plaqueminier, Plaqueminier de Chine, Plaqueminier du Japon, Plaqueminier Kaki, Sharon Fruit.

Overview

Overview Information

Japanese persimmon is a tree. People eat the fruit. The fruit and leaf are used for medicine.

Japanese persimmon is used for high blood pressure, fluid retention, constipation, and other conditions, but there is no good scientific evidence to support many of these uses.

How does it work?

Japanese persimmon contains chemicals that might lower blood pressure. There isn't enough information to know how Japanese persimmon works for other conditions.

Uses

Uses & Effectiveness?

Insufficient Evidence for

  • High levels of cholesterol or other fats (lipids) in the blood (hyperlipidemia). Early research shows that eating fiber from unripe Japanese persimmon fruit may lower lipid levels in the blood.
  • Prediabetes. Early research in people with prediabetes shows that taking Japanese persimmon leaf extract might lower blood sugar.
  • High blood pressure.
  • Constipation.
  • Hiccough.
  • Stroke.
  • Fluid retention.
  • Improving blood flow.
  • Reducing body temperature.
  • Other conditions.
More evidence is needed to rate Japanese persimmon for these uses.

Side Effects

Side Effects & Safety

When taken by mouth: Japanese persimmon is POSSIBLY SAFE when taken as a medicine. It has been used in clinical research without reported adverse effects. The fruit might cause allergic reactions in some people, but this is uncommon. Eating the fruit in very large amounts might cause blockage of the intestines.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Not enough is known about the use of Japanese persimmon during pregnancy and breast-feeding. Stay on the safe side and avoid use.

Bleeding disorders: Taking Japanese persimmon might slow blood clotting. This might increase the risk of bruising and bleeding in people with bleeding disorders.

Low blood pressure: Japanese persimmon might lower blood pressure. There is some concern that it might make low blood pressure worse or interfere with treatment intended to raise low blood pressure.

Surgery: Japanese persimmon might lower blood pressure or slow blood clotting. This might interfere with blood pressure control or increase the chance of excessive bleeding during and after surgery. Stop using Japanese persimmon at least 2 weeks before a scheduled surgery.

Interactions

Interactions?

Moderate Interaction

Be cautious with this combination

!
  • Medications for high blood pressure (Antihypertensive drugs) interacts with JAPANESE PERSIMMON

    Japanese persimmon seems to decrease blood pressure. Taking Japanese persimmon along with medications for high blood pressure might cause your blood pressure to go too low.
    Some medications for high blood pressure include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), amlodipine (Norvasc), hydrochlorothiazide (HydroDiuril), furosemide (Lasix), and many others.

Dosing

Dosing

The appropriate dose of Japanese persimmon depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for Japanese persimmon. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

  • Akdoğan RA, Türkyilmaz S, Sipahi T, Uzun DY, Ozgür O. Gastric outlet syndrome caused by persimmon (Diospyros kaki) bezoars. Turk J Gastroenterol. 2009;20(1):72-4. View abstract.
  • An BJ, Kwak JH, Park JM, et al. Inhibition of enzyme activities and the antiwrinkle effect of polyphenol isolated from the persimmon leaf (Diospyros kaki folium) on human skin. Dermatol Surg. 2005;31(7 Pt 2):848-54; discussion 854. View abstract.
  • Anliker MD, Reindl J, Vieths S, Wuthrich B. Allergy caused by ingestion of persimmon (Diospyros kaki): detection of specific IgE and cross-reactivity to profilin and carbohydrate determinants. J Allergy Clin Immunol 2001;107:718-23. View abstract.
  • Duan J, Wang X, Dong Q, et al. Structural features of a pectic arabinogalactan with immunological activity from the leaves of Diospyros kaki. Carbohydr Res 2003;338:1291-7.. View abstract.
  • Gato N, Kadowaki A, Hashimoto N, Yokoyama S, Matsumoto K. Persimmon fruit tannin-rich fiber reduces cholesterol levels in humans. Ann Nutr Metab. 2013;62(1):1-6. View abstract.
  • Han J, Kang S, Choue R, et al. Free radical scavenging effect of Diospyros kaki, Laminaria japonica and Undaria pinnatifida. Fitoterapia 2002;73:710-2.. View abstract.
  • Hibino G, Nadamoto T, Fujisawa F, Fushiki T. Regulation of the peripheral body temperature by foods: a temperature decrease induced by the Japanese persimmon (kaki, Diospyros kaki). Biosci Biotechnol Biochem 2003;67:23-8. . View abstract.
  • Hwang YH, Ha H, Kim R, et al. Anti-Osteoporotic Effects of Polysaccharides Isolated from Persimmon Leaves via Osteoclastogenesis Inhibition. Nutrients. 2018;10(7). pii: E901. View abstract.
  • Kawase M, Motohashi N, Satoh K, et al. Biological activity of persimmon (Diospyros kaki) peel extracts. Phytother Res 2003;17:495-500. . View abstract.
  • Kazzem M, Sun YT, Low M, et al. Chromatographic Analysis and Anti-Oxidative Property of Naoxinqing Tablet, a Proprietary Preparation of Diospyros Kaki Leaves. Molecules. 2019;24(6). pii: E1101. View abstract.
  • Khan MM, Tran BQ, Jang YJ, et al. Assessment of the Therapeutic Potential of Persimmon Leaf Extract on Prediabetic Subjects. Mol Cells. 2017;40(7):466-475. View abstract.
  • Kim HH, Kim DS, Kim SW, et al. Inhibitory effects of Diospyros kaki in a model of allergic inflammation: role of cAMP, calcium and nuclear factor-κB. Int J Mol Med. 2013;32(4):945-51. View abstract.
  • Kim KA, Kang SW, Ahn HR, Song Y, Yang SJ, Jung SH. Leaves of Persimmon (Diospyros kaki Thunb.) Ameliorate N-Methyl-N-nitrosourea (MNU)-Induced Retinal Degeneration in Mice. J Agric Food Chem. 2015;63(35):7750-9. View abstract.
  • Lee YA, Cho EJ, Yokozawa T. Protective effect of persimmon (Diospyros kaki) peel proanthocyanidin against oxidative damage under H2O2-induced cellular senescence. Biol Pharm Bull. 2008;31(6):1265-9. View abstract.
  • Ma Y, Ma B, Shang Y, et al. Flavonoid-rich ethanol extract from the leaves of Diospyros kaki attenuates cognitive deficits, amyloid-beta production, oxidative stress, and neuroinflammation in APP/PS1 transgenic mice. Brain Res. 2018;1678:85-93. View abstract.
  • Martinez JC, Armentia A, Bartolome B, et al. Anaphylaxis after ingestion of Sharon fruit. Allergol Immunoplathol (Madr) 2001;29:69-71. View abstract.
  • Matsumoto M, Kotani M, Fujita A, et al. Oral administration of persimmon leaf extract ameliorates skin symptoms and transepidermal water loss in atopic dermatitis model mice, NC/Nga. Br J Dermatol 2002;146:221-7. . View abstract.
  • Sa YS, Kim SJ, Choi HS. The anticoagulant fraction from the leaves of Diospyros kaki L. has an antithrombotic activity. Arch Pharm Res. 2005;28(6):667-74. View abstract.
  • Ueda K, Kawabata R, Irie T, Nakai Y, Tohya Y, Sakaguchi T. Inactivation of pathogenic viruses by plant-derived tannins: strong effects of extracts from persimmon (Diospyros kaki) on a broad range of viruses. PLoS One. 2013;8(1):e55343. View abstract.
  • Yamagata Y, Saito K, Hirano K, et al. Obstruction in the third portion of the duodenum due to a diospyrobezoar: a case report. BMC Surg. 2017;17(1):117. View abstract.
  • Yang SJ, Jo H, Kim KA, et al. Diospyros kaki Extract Inhibits Alkali Burn-Induced Corneal Neovascularization. J Med Food. 2016;19(1):106-9. View abstract.
  • Yin MH, Kang DG, Choi DH, et al. Screening of vasorelaxant activity of some medicinal plants used in Oriental medicines. J Ethnopharmacol 2005;99:113-7.. View abstract.
  • Zhou Z, Huang Y, Liang J, Ou M, Chen J, Li G. Extraction, purification and anti-radiation activity of persimmon tannin from Diospyros kaki L.f. J Environ Radioact. 2016;162-163:182-188. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
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