TREE TURMERIC

OTHER NAME(S):

Berberis aristata, Berberis chitria, Berberis coriaria, Bérbero Indio, Chitra, Citra, Darhahed, Darhald, Daruhaldi, Daruharidra, Darurajani, Darvi, Épine-Vinette Aristée, Hint Amberparisi, Indian Barberry, Indian Berberry, Indian Lycium, Indian Ophthalmic Barberry, Nepal Barberry, Nepalese Barberry, Ophthalmic Barberry.<br/><br/>

Overview

Overview Information

Tree turmeric is a plant. The fruit, stems, leaves, wood, root, and root bark are used to make medicine.

People take tree turmeric for diabetes, high cholesterol, heart failure, liver disease, malaria, an eye infection called trachoma, skin diseases, heavy menstrual periods, swelling of the stomach and intestines (gastroenteritis), diarrhea, and yellowed skin (jaundice).

Tree turmeric is sometimes applied directly to the skin to treat burns and wounds.

How does it work?

The chemicals in tree turmeric might reduce blood sugar and cholesterol levels. They might also cause stronger heartbeats and be able to fight bacteria.

Uses

Uses & Effectiveness?

Possibly Effective for

  • Diabetes. Taking a specific product containing tree turmeric extract and milk thistle extract (Berberol by PharmExtracta) along with antidiabetes drugs seems to decrease blood sugar levels before meals in people with diabetes. It also seems to decrease average blood sugar levels in these people. It might take more than 3 months for this product to show benefit.

Insufficient Evidence for

  • High cholesterol. Taking tree turmeric extract along with milk thistle extract seems to prevent cholesterol levels from increasing in people with high cholesterol who are taking statins but who require their statin dose to be lowered. Taking this product also seems to help lower cholesterol when used alone or along with low-dose statins or ezetimibe in people with high cholesterol who can't tolerate high dose statin treatment. It's unclear if these benefits are due to tree turmeric, milk thistle, or the combination. There is also evidence that taking a similar product containing milk thistle, tree turmeric, and chemicals called monacolins also helps to lower cholesterol levels. Monacolins are chemicals similar to statin drugs. So, it's not clear if the cholesterol reduction is due to milk thistle or the statin-like chemicals.
  • An eye infection that can cause blindness (trachoma).
  • Burns, when applied directly to the skin.
  • Diarrhea.
  • Heart failure.
  • Heavy menstrual periods.
  • Liver disease.
  • Malaria.
  • Yellowed skin (jaundice).
  • Other conditions.
More evidence is needed to rate the effectiveness of tree turmeric for these uses.

Side Effects

Side Effects & Safety

Tree turmeric is POSSIBLY SAFE when taken as a specific product that also contains milk thistle (Berberol, PharmExtracta). The most common side effects are nausea and other stomach problems. There is not enough information to know if other forms of tree turmeric are safe for adults in medicinal amounts.

Special Precautions & Warnings:

Children: Tree turmeric is LIKELY UNSAFE in newborn infants. It contains a chemical called berberine that can cause kernicterus, a rare type of brain damage that can occur in newborns who have severe jaundice. Jaundice is yellowing of the skin caused by too much bilirubin in the blood. Bilirubin is a chemical that is produced when the old red cells break down. Bilirubin is normally removed by the liver. Berberine may keep the liver from removing bilirubin fast enough.

Pregnancy and breast-feeding: It's LIKELY UNSAFE to take tree tumeric if you are pregnant because it contains a chemical called berberine. Researchers believe berberine can cross the placenta and might cause harm to the fetus. Kernicterus, a type of brain damage, has developed in newborn infants exposed to berberine.

It's also LIKELY UNSAFE to take tree tumeric if you are breast-feeding, because it contains a chemical called berberine. Berberine can be transferred to the infant through breast milk, and it might cause harm.

Diabetes: Tree turmeric might lower blood sugar levels. Watch for signs of low blood sugar (hypoglycemia) and monitor your blood sugar carefully if you have diabetes and use tree turmeric.

Interactions

Interactions?

Major Interaction

Do not take this combination

!
  • Cyclosporine (Neoral, Sandimmune) interacts with TREE TURMERIC

    The body breaks down cyclosporine (Neoral, Sandimmune) to get rid of it. Tree turmeric might decrease how fast the body breaks down cyclosporine (Neoral, Sandimmune). This might cause there to be too much cyclosporine (Neoral, Sandimmune) in the body and potentially cause side effects.

Moderate Interaction

Be cautious with this combination

!
  • Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with TREE TURMERIC

    Some medications are changed and broken down by the liver.<br><nb>Tree turmeric might decrease how quickly the liver breaks down some medications. Taking tree turmeric along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking tree turmeric, talk to your healthcare provider if you are taking any medications that are changed by the liver.<br><nb>Some medications changed by the liver include lovastatin (Mevacor), clarithromycin (Biaxin), indinavir (Crixivan), sildenafil (Viagra), triazolam (Halcion), and many others.

Dosing

Dosing

BY MOUTH:

  • Diabetes: A specific product (Berberol, PharmExtracta) containing 1176 mg of tree turmeric extract and 210 mg of milk thistle extract has been taken daily for 3-12 months.

View References

REFERENCES:

  • Amin AH, Subbaiah TV, Abbasi KM. Berberine sulfate: antimicrobial activity, bioassay, and mode of action. Can J Microbiol 1969;15:1067-76. View abstract.
  • Ang ES, Lee ST, Gan CS, et al. Evaluating the role of alternative therapy in burn wound management: randomized trial comparing moist exposed burn ointment with conventional methods in the management of patients with second-degree burns. MedGenMed 2001;3:3. View abstract.
  • Anis KV, Rajeshkumar NV, Kuttan R. Inhibition of chemical carcinogenesis by berberine in rats and mice. J Pharm Pharmacol 2001;53:763-8. . View abstract.
  • Chan E. Displacement of bilirubin from albumin by berberine. Biol Neonate 1993;63:201-8. View abstract.
  • Derosa G, D'Angelo A, Maffioli P. The role of a fixed Berberis aristata/Silybum marianum combination in the treatment of type 1 diabetes mellitus. Clin Nutr. 2016;35(5):1091-5. View abstract.
  • Derosa G, D'Angelo A, Romano D, Maffioli P. Effects of a combination of Berberis aristata, Silybum marianum and monacolin on lipid profile in subjects at low cardiovascular risk; A double-blind, randomized, placebo-controlled trial. Int J Mol Sci. 2017;18(2). pii: E343. View abstract.
  • Derosa G, Romano D, D'Angelo A, Maffioli P. Berberis aristata/Silybum marianum fixed combination (Berberol(®)) effects on lipid profile in dyslipidemic patients intolerant to statins at high dosages: a randomized, placebo-controlled, clinical trial. Phytomedicine. 2015;22(2):231-7. View abstract.
  • Di Pierro F, Bellone I, Rapacioli G, Putignano P. Clinical role of a fixed combination of standardized Berberis aristata and Silybum marianum extracts in diabetic and hypercholesterolemic patients intolerant to statins. Diabetes Metab Syndr Obes. 2015;8:89-96. View abstract.
  • Di Pierro F, Villanova N, Agostini F, Marzocchi R, Soverini V, Marchesini G. Pilot study on the additive effects of berberine and oral type 2 diabetes agents for patients with suboptimal glycemic control. Diabetes Metab Syndr Obes. 2012;5:213-7. View abstract.
  • Fukuda K, Hibiya Y, Mutoh M, et al. Inhibition by berberine of cyclooxygenase-2 transcriptional activity in human colon cancer cells. J Ethnopharmacol 1999;66:227-33. View abstract.
  • Gilani AH, Janbaz KH, Aziz N, et al. Possible mechanism of selective inotropic activity of the n-butanolic fraction from Berberis aristata fruit. Gen Pharmacol 1999;33:407-14. . View abstract.
  • Guarino G, Strollo F, Carbone L, et al. Bioimpedance analysis, metabolic effects and safety of the association Berberis aristata/Bilybum marianum: a 52-week double-blind, placebo-controlled study in obese patients with type 2 diabetes. J Biol Regul Homeost Agents. 2017;31(2):495-502. View abstract.
  • Gupte S. Use of berberine in treatment of giardiasis. Am J Dis Child 1975;129:866. View abstract.
  • Hsiang CY, Wu SL, Cheng SE, Ho TY. Acetaldehyde-induced interleukin-1beta and tumor necrosis factor-alpha production is inhibited by berberine through nuclear factor-kappaB signaling pathway in HepG2 cells. J Biomed Sci 2005;12:791-801. View abstract.
  • Janbaz KH, Gilani AH. Studies on preventive and curative effects of berberine on chemical-induced hepatotoxicity in rodents. Fitoterapia 2000;71:25-33.. View abstract.
  • Kaneda Y, Torii M, Tanaka T, Aikawa M. In vitro effects of berberine sulphate on the growth and structure of Entamoeba histolytica, Giardia lamblia and Trichomonas vaginalis. Ann Trop Med Parasitol 1991;85:417-25. View abstract.
  • Kim SH, Shin DS, Oh MN, et al. Inhibition of the bacterial surface protein anchoring transpeptidase sortase by isoquinoline alkaloids. Biosci Biotechnol Biochem 2004;68:421-4.. View abstract.
  • Li B, Shang JC, Zhou QX. [Study of total alkaloids from rhizoma coptis chinensis on experimental gastric ulcers]. Chin J Integr Med 2005;11:217-21. View abstract.
  • Rathi B, Sahu J, Koul S, Kosha RL. Detailed pharmacognostical studies on Berberis aristata DC plant. Anc Sci Life. 2013;32(4):234-40. View abstract.
  • Rehman J, Dillow JM, Carter SM, et al. Increased production of antigen-specific immunoglobulins G and M following in vivo treatment with the medicinal plants Echinacea angustifolia and Hydrastis canadensis. Immunol Lett 1999;68:391-5. View abstract.
  • Scazzocchio F, Corneta MF, Tomassini L, Palmery M. Antibacterial activity of Hydrastis canadensis extract and its major isolated alkaloids. Planta Med 2001;67:561-4. View abstract.
  • Sun D, Courtney HS, Beachey EH. Berberine sulfate blocks adherence of Streptococcus pyogenes to epithelial cells, fibronectin, and hexadecane. Antimicrob Agents Chemother 1988;32:1370-4. View abstract.
  • Tsai PL, Tsai TH. Hepatobiliary excretion of berberine. Drug Metab Dispos 2004;32:405-12. . View abstract.
  • Wu X, Li Q, Xin H, Yu A, Zhong M. Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study. Eur J Clin Pharmacol 2005;61:567-72. View abstract.
  • Zeng XH, Zeng XJ, Li YY. Efficacy and safety of berberine for congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol 2003;92:173-6. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2018.