EURYCOMA LONGIFOLIA

OTHER NAME(S):

Akar Pasak Bumi, Ali's Umbrella, Ali's Walking Stick, Batang Pasak Bumi, Bedara Pahit, Canne d'Ali, Cay ba binh, Eurycoma, Eurycoma Longifolia Jack, Ginseng de Malaisie, Ian-don, Jelaih, Kayu Dali, Local Ginseng, Long Jack, Longjack, Malaysian Ginseng, Natural Viagra, Pasak Bumi, Payung Ali, Penawar Pahit, Pokok Jelas, Pokok Syurga, Sengkayap, Setunjang Bumi, Tongkat Ali, Tongkat Baginda, Tung Saw, Umpudumaidu, Wonod Mondou.<br/><br/>

Overview

Overview Information

Eurycoma longifolia is a tall, slender evergreen shrub-tree commonly found in Southeast Asia. Malaysian men claim that tea made from this plant improves their sexual abilities and virility. As a result, this plant is in such high demand that it is now considered a “protected” species.

The root and bark of Eurycoma longifolia are used for treating erectile dysfunction (ED), increasing interest in sex, male infertility, boosting athletic performance, body building, and reducing body fat. Eurycoma longifolia is also used for fever, malaria, ulcers, high blood pressure, tuberculosis, bone pain, cough, diarrhea, headache, syphilis, and cancer.

How does it work?

The root of Eurycoma longifolia contains several chemicals that have different effects in the body. Some of the chemicals seem to affect how the body produces the hormone testosterone. Research in animals and humans suggests it might increase testosterone in the body.

Uses

Uses & Effectiveness?

Possibly Effective for

  • Male Infertility. Some evidence suggests that taking a specific Eurycoma longifolia supplement (Phytes Bioteks by Biotropics Malaysia) by mouth can improve the quality and concentration of sperm in infertile men.

Insufficient Evidence for

  • Athletic performance. Early research suggests that taking Eurycoma longifolia by mouth for 7 days does not increase endurance in male athletes.
  • Low testosterone. Early research shows that taking an extract of Eurycoma longifolia by mouth for one month might increase testosterone levels and improve related symptoms in men with low testosterone levels.
  • Muscle strength. Early research suggests that taking Eurycoma longifolia by mouth for 5 weeks helps increase muscle mass and strength in healthy men participating in an intense strength training program.
  • Problems achieving an erection (erectile dysfunction, ED).
  • Increasing interest in sex.
  • Fever.
  • Malaria.
  • Ulcers.
  • High blood pressure.
  • Tuberculosis.
  • Bone pain.
  • Cough.
  • Diarrhea.
  • Headache.
  • Syphilis.
  • Cancer.
  • Other conditions.
More evidence is needed to rate the effectiveness of Eurycoma longifolia for these uses.

Side Effects

Side Effects & Safety

Eurycoma longifolia is POSSIBLY SAFE when taken by mouth in medicinal amounts for up to 9 months.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking Eurycoma longifolia if you are pregnant or breast-feeding. Stay on the safe side and avoid use.

Interactions

Interactions?

We currently have no information for EURYCOMA LONGIFOLIA Interactions.

Dosing

Dosing

The appropriate dose of Eurycoma longifolia depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for Eurycoma longifolia. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

  • Abd Rahman K, Niiyama K, Azizi R, and et al. Species assembly and site preference of tree species in a primary seraya-ridge forest of Peninsular Malaysia. Journal of Tropical Forest Science 2002;14(3):287-303.
  • Ang HH and Cheang HS. Promotion of sexual activity in rats with Eurycoma longifolia Jack. Journal of Herbs, Spices, and Medicinal Plants 1999;6:23-28.
  • Ang HH and HS Cheang. Effects of Eurycoma longifolia Jack on copulatory behavior in middle-aged male rats. Journal of Herbs, Spices & Medicinal Plants 2002;9(1):109-114.
  • Ang HH and KL Lee. Effects of Eurycoma longifolia Jack on masculine copulatory behaviour in middle aged male rats - a comparison study. Natural Product Sciences 2002;8(2):44-47.
  • Ang HH and Sim MK. Aphrodisiac effects of Eurycoma longifolia root in non-copulator male rats. Fitoterapia 1998;69(5)
  • Ang HH and Sim MK. Aphrodisiac evaluation in sexually naive male mice after chronic administration of Eurycoma longifolia Jack. Natural Product Sciences 1998;4(2)
  • Ang HH, Chan KL, Gan EK, and et al. Enhancement of sexual motivation in sexually naive male mice by Eurycoma longifolia. International Journal of Pharmacognosy 1997;35:144-146.
  • Ang LH, Ho WM, Ang TB, and et al. Establishment of a high value timber production area on tin tailings - Tropical forestry research in the new millennium: meeting demands and challenges. 2001;245-253.
  • Ang, H. H. An insight into Malaysian herbal medicines. Trends.Pharmacol.Sci 2004;25(6):297-298. View abstract.
  • Ang, H. H. and Lee, K. L. Effect of Eurycoma longifolia Jack on orientation activities in middle-aged male rats. Fundam.Clin.Pharmacol. 2002;16(6):479-483. View abstract.
  • Ang, H. H. and Sim, M. K. Eurycoma longifolia increases sexual motivation in sexually naive male rats. Arch Pharm.Res 1998;21(6):779-781. View abstract.
  • Ang, H. H. and Sim, M. K. Eurycoma longifolia JACK and orientation activities in sexually experienced male rats. Biol.Pharm.Bull. 1998;21(2):153-155. View abstract.
  • Ang, H. H., Chan, K. L., and Mak, J. W. Effect of 7-day daily replacement of culture medium containing Eurycoma longifolia Jack constituents on the Malaysian Plasmodium falciparum isolates. J Ethnopharmacol. 12-15-1995;49(3):171-175. View abstract.
  • Ang, H. H., Chan, K. L., and Mak, J. W. In vitro antimalarial activity of quassinoids from Eurycoma longifolia against Malaysian chloroquine-resistant Plasmodium falciparum isolates. Planta.Med 1995;61(2):177-178. View abstract.
  • Ang, H. H., Hitotsuyanagi, Y., Fukaya, H., and Takeya, K. Quassinoids from Eurycoma longifolia. Phytochemistry. 2002;59(8):833-837. View abstract.
  • Ang, H. H., Lee, E. L., and Matsumoto, K. Analysis of lead content in herbal preparations in Malaysia. Hum.Exp.Toxicol. 2003;22(8):445-451. View abstract.
  • Ang, H. H., Lee, K. L., and Kiyoshi, M. Eurycoma longifolia Jack enhances sexual motivation in middle-aged male mice. J Basic Clin.Physiol.Pharmacol. 2003;14(3):301-308. View abstract.
  • Ang, H. H., Lee, K. L., and Kiyoshi, M. Sexual arousal in sexually sluggish old male rats after oral administration of Eurycoma longifolia Jack. J Basic Clin.Physiol.Pharmacol. 2004;15(3-4):303-309. View abstract.
  • Ang, H. H., Ngai, T. H., and Tan, T. H. Effects of Eurycoma longifolia Jack on sexual qualities in middle aged male rats. Phytomedicine. 2003;10(6-7):590-593. View abstract.
  • Asiah O, Nurhanan MY, and Mohd IA. Determination of bioactive peptide (4.3 kDa) as an aphrodisiac marker in six Malaysian plants. Journal of Tropical Forest Science 2007;19(1):61-63.
  • Aziz L M.S, Keng ChanLai, and Lim BoeyPeng. Effects of medium constituents on growth and canthinone accumulation in cell suspension cultures of Eurycoma longifolia Jack. Hayati Journal of Biosciences 2009;16(2)
  • Baharuddin S, Adenan J, and Mashhor M. Some medicinal plants from Sungai Kinchin, Pahang, Malaysia. Malayan Nature Journal 1990;43(4)
  • Chan K, Iitaka Y, Noguchi H, and et al. 6a-Hydroxyeurycomalactone, a quassinoid from Eurycoma longifolia. Phytochemistry 1992;31(12):4295-4298.
  • Chan KL, Lee SP, Sam TW, and et al. 13ß,18-dihydroeurycomanol, a quassinoid from Eurycoma longifolia. Phytochemistry 1991;30(9):3138-3141.
  • Chan KL, Lee SP, Sam TW, and et al. A quassinoid glycoside from the roots of Eurycoma longifolia. Phytochemistry 2012;28(10):2857-2859.
  • Chan, K. L., Choo, C. Y., and Abdullah, N. R. Semisynthetic 15-O-acyl- and 1,15-di-O-acyleurycomanones from Eurycoma longifolia as potential antimalarials. Planta.Med 2005;71(10):967-969. View abstract.
  • Chan, K. L., Choo, C. Y., Morita, H., and Itokawa, H. High performance liquid chromatography in phytochemical analysis of Eurycoma longifolia. Planta.Med 1998;64(8):741-745. View abstract.
  • Chan, K. L., Low, B. S., Teh, C. H., and Das, P. K. The effect of Eurycoma longifolia on sperm quality of male rats. Nat.Prod.Commun. 2009;4(10):1331-1336. View abstract.
  • Chan, K. L., O'Neill, M. J., Phillipson, J. D., and Warhurst, D. C. Plants as sources of antimalarial drugs. Part 3. Eurycoma longifolia. Planta.Med 1986;(2):105-107. View abstract.
  • Choo, C. Y. and Chan, K. L. High performance liquid chromatography analysis of canthinone alkaloids from Eurycoma longifolia. Planta.Med 2002;68(4):382-384. View abstract.
  • Chua GLS, Koh BL, Lau SC, and et al. The nutrient status of the plateau heath forest on Gunung Keriong, Pahang, Peninsular Malaysia. Journal of Tropical Forest Science 1995;8(2):240-246.
  • Chua LSL, Kamarudin S, Markandan S, and et al. A preliminary checklist of vascular plants from the Machinchang Range, Pulau Langkawi, Peninsular Malaysia. Malayan Nature Journal 2005;57(2):155-172.
  • Cyranoski, D. Malaysian researchers bet big on home-grown Viagra. Nat.Med 2005;11(9):912. View abstract.
  • Darise M, Kohda H, Mizutani K, and et al. Eurycomanone and eurycomanol, quassinoids from the roots of Eurycoma longifolia [from Indonesia. Phytochemistry 1982;21(8):2091-2093.
  • Darise M, Kohda H, Mizutani K, and et al. Revision of configuration of the 12-hydroxyl group of eurycomanone and eurycomanol, quassinoids from Eurycoma longifolia. Phytochemistry 1983;22(6):1514.
  • Farouk, A. E. and Benafri, A. Antibacterial activity of Eurycoma longifolia Jack. A Malaysian medicinal plant. Saudi.Med J 2007;28(9):1422-1424. View abstract.
  • Frydrychova, S., Opletal, L., Macakova, K., Lustykova, A., Rozkot, M., and Lipensky, J. Effects of herbal preparation on libido and semen quality in boars. Reprod.Domest.Anim 2011;46(4):573-578. View abstract.
  • Hamzah S and A Yusof. The ergogenic effects of Eurycoma longifolia Jack: a pilot study. British Journal of Sports Medicine 2003;37(5):465-466.
  • Hout, S., Chea, A., Bun, S. S., Elias, R., Gasquet, M., Timon-David, P., Balansard, G., and Azas, N. Screening of selected indigenous plants of Cambodia for antiplasmodial activity. J Ethnopharmacol. 8-11-2006;107(1):12-18. View abstract.
  • Husen, R., Pihie, A. H., and Nallappan, M. Screening for antihyperglycaemic activity in several local herbs of Malaysia. J.Ethnopharmacol. 2004;95(2-3):205-208. View abstract.
  • Hussein S, Rusli I, and Kiong LPA. A summary of reported chemical constituents and medicinal uses of Eurycoma longifolia. Journal of Tropical Medicinal Plants 2007;8(1):103-110.
  • Itokawa H, Kishki E, Morita H, and et al. Cytotoxic quassinoids and tirucallane-type triterpenes from the woods of Eurycoma longifolia. Chemical and Pharmaceutical Bulletin 1992;40(4):1053-1055.
  • Itokawa H, Qin XR, Morita H, and et al. C18 and C19 quassinoids from Eurycoma longifolia. Journal of Natural Products 1993;56(10):1766-1771.
  • Jantan I, Zaki ZM, Ahmad AR, and et al. Evaluation of smoke from mosquito coils containing Malaysian plants against Aedes aegypti. Fitoterapia 1999;70(3):327.
  • Jiwajinda, S., Santisopasri, V., Murakami, A., Hirai, N., and Ohigashi, H. Quassinoids from Eurycoma longifolia as plant growth inhibitors. Phytochemistry. 2001;58(6):959-962. View abstract.
  • Kardono, L. B., Angerhofer, C. K., Tsauri, S., Padmawinata, K., Pezzuto, J. M., and Kinghorn, A. D. Cytotoxic and antimalarial constituents of the roots of Eurycoma longifolia. J Nat.Prod. 1991;54(5):1360-1367. View abstract.
  • Kulip, Julius. Medicinal plants of Sabah, Malaysia: potential for agroforestry. JIRCAS Working Report 2009;47-48.
  • Kuo PC, Damu AG, and Wu TS. Characterization of the water soluble fraction from the root extract of Eurycoma longifolia. Chinese Pharmaceutical Journal 2003;55:257-265.
  • Kuo, P. C., Damu, A. G., Lee, K. H., and Wu, T. S. Cytotoxic and antimalarial constituents from the roots of Eurycoma longifolia. Bioorg.Med Chem. 2-1-2004;12(3):537-544. View abstract.
  • Kuo, P. C., Shi, L. S., Damu, A. G., Su, C. R., Huang, C. H., Ke, C. H., Wu, J. B., Lin, A. J., Bastow, K. F., Lee, K. H., and Wu, T. S. Cytotoxic and antimalarial beta-carboline alkaloids from the roots of Eurycoma longifolia. J Nat.Prod. 2003;66(10):1324-1327. View abstract.
  • Le, Van Thoi and Nguyen, Ngoc Suong. Constituents of Eurycoma longifolia Jack. J Org Chem. 1970;35(4):1104-1109. View abstract.
  • Lin LC, Peng CY, Wang HS, and et al. Reinvestigation of the constituents of Eurycoma longifolia. Chinese Pharmaceutical Journal 2011;53:97-106.
  • Low, B. S., Teh, C. H., Yuen, K. H., and Chan, K. L. Physico-chemical effects of the major quassinoids in a standardized Eurycoma longifolia extract (Fr 2) on the bioavailability and pharmacokinetic properties, and their implications for oral antimalarial activity. Nat.Prod.Commun. 2011;6(3):337-341. View abstract.
  • Lufthi MS, Chan LK, and Boey PL. Effect of cell source and pH of culture medium on the production of canthin-6-one alkaloids from the cell cultures of Tongkat Ali (Eurycoma longifolia Jack). Journal of Plant Biotechnology 2004;6(2):125-130.
  • Lugnataweepon I, Pleuktivorapongkul A, Sirithunyalug J, and et al. Effects of herbal powder composition on flow and compaction properties. Proceedings of the Kasetsart University Annual Conference 2011;1:113-120.
  • Mahanem MN, Abu Hassan SMN, and Lukman CH. The effect of Eurycoma longifolia Jack (Tongkat Ali) on sexual behaviour and sperm quality in rats. Malaysian Journal of Pharmaceutical Sciences 2004;2(1):53-60.
  • Malviya, N., Jain, S., Gupta, V. B., and Vyas, S. Recent studies on aphrodisiac herbs for the management of male sexual dysfunction--a review. Acta Pol.Pharm. 2011;68(1):3-8. View abstract.
  • Maziah, M. and Rosli, N. The Production of 9-methoxycanthin-6-one from Callus Cultures of (Eurycoma longifolia Jack) Tongkat Ali. Methods.Mol.Biol. 2009;547:359-369. View abstract.
  • Mitsunaga K, Koike K, Tanaka T, and et al. Canthin-6-one alkaloids from Eurycoma longifolia. Phytochemistry 1994;35(3):799-802.
  • Miyake, K., Li, F., Tezuka, Y., Awale, S., and Kadota, S. Cytotoxic activity of quassinoids from Eurycoma longifolia. Nat.Prod.Commun. 2010;5(7):1009-1012. View abstract.
  • Miyake, K., Tezuka, Y., Awale, S., Li, F., and Kadota, S. Canthin-6-one alkaloids and a tirucallanoid from Eurycoma longifolia and their cytotoxic activity against a human HT-1080 fibrosarcoma cell line. Nat.Prod.Commun. 2010;5(1):17-22. View abstract.
  • Mohamad M, li MW, and hmad A. Modelling for Extraction of Major Phytochemical Components from Eurycoma longifolia. Journal of Applied Sciences 2010;10(21):2572-2577.
  • Mohd NAG, Amran M, and Mohd HT. Sustainable production of medicinal plants through cultivation: the golden hope experience.Towards modernisation of research and technology in herbal industries 2001; Proceedings of the Seminar on Medicinal and Aromatic Plants.
  • Mohd Ridzuan, M. A., Noor, Rain A., Zhari, I., and Zakiah, I. Effect of Eurycoma longifolia extract on the Glutathione level in Plasmodium falciparum infected erythrocytes in vitro. Trop.Biomed. 2005;22(2):155-163. View abstract.
  • Mohd Ridzuan, M. A., Sow, A., Noor, Rain A., Mohd, Ilham A., and Zakiah, I. Eurycoma longifolia extract-artemisinin combination: parasitemia suppression of Plasmodium yoelii-infected mice. Trop.Biomed. 2007;24(1):111-118. View abstract.
  • Mohd, Ilam. Opportunities on the planting of medicinal and herbal plants in Malaysia. Planter 1998;74(867):339-342.
  • Mohd-Fuat, A. R., Kofi, E. A., and Allan, G. G. Mutagenic and cytotoxic properties of three herbal plants from Southeast Asia. Trop.Biomed. 2007;24(2):49-59. View abstract.
  • Morita H, Kishi E, Takeya K, and et al. Highly oxygenated quassinoids from Eurycoma longifolia. Phytochemistry 1993;33(3):691-696.
  • Morita H, Kishi E, Takeya K, and et al. New quassinoids from the roots of Eurycoma longifolia. Planta Medica 1990;56(6)
  • Morita H, Kishi E, Takeya K, and Itokawa H. Biphenylneolignans from wood of Eurycoma longifolia. Phytochemistry 1992;31(11):3993-3995.
  • Muhamad AS, Chen CK, Ooi FK, and et al. Effects of Eurycoma longifolia Jack Supplementation on Recreational Athletes' Endurance Running Capacity and Physiological Responses in the Heat. International Journal of Applied Sports Sciences 2010;22(1):119.
  • Muhamad AS, Chen CK, Ooi FK, and et al. EURYCOMA LONGIFOLIA JACK: MEDICINAL PROPERTIES AND ITS EFFECT ON ENDURANCE EXERCISE PERFORMANCE. Asian Journal of Exercise & Sports Science 2009;6(1)
  • Nowroji K, Rahmah N, Chan KL, and et al. Cytotoxicity activity of root extract/fractions of Eurycoma longifolia Jack root against vero and Hs27cells. Journal of Medicinal Plants Research 2012;4(22):2383-2387.
  • Nurhanan MY, Azimahtol HLP, and Azizol AK. Cytotoxicity studies of Eurycoma longifolia extracts against a panel of human cancer cell lines. Proceedings of the Seminar on Medicinal and Aromatic Plants 2002;124-127.
  • Nurhanan, M. Y., Azimahtol Hawariah, L. P., Mohd, Ilham A., and Mohd Shukri, M. A. Cytotoxic effects of the root extracts of Eurycoma longifolia Jack. Phytother Res 2005;19(11):994-996. View abstract.
  • Oei-Koch A and L Kraus. Constituents of Eurycoma longifolia Jack. Part 3. Bitter principles (eurycomalacton). Scientia Pharmaceutica (Austria) 1980;48:110-117.
  • Oei-Koch A and L Kraus. Substances in Eurycoma longifolia. I. Sterols, saponins. / Inhaltsstoffe von Eurycoma longifolia Jack. I. Sterols, Saponine. Planta Medica 1978;34(3):339-340.
  • Reddy KRN, Nurdijati SB, and Salleh B. Efficacy of aqueous medicinal plant extracts on growth and citrinin production by Penicillium citrinum isolated from rice grains. African Journal of Microbiology Research 2010;4(23):2562-2565.
  • Rosli N, Maziah M, Chan KL, and et al. Factors affecting the accumulation of 9-methoxycanthin-6-one in callus cultures of Eurycoma longifolia. Journal of Forestry Research 2009;20(1):54-58.
  • Said MM, Gibbons S, and Zloh M. Chemometrics analysis of solid herbal products and development of spectral databases. Journal of Pharmacy and Pharmacology 2010;62:1203-1204.
  • Sareena HH and Ashril Y. 2002; 12th Commonwealth International Sport Conference.
  • Sholikhah, E. N., Wijayanti, M. A., Nurani, L. H., and Mustofa. Stage specificity of pasak bumi root (Eurycoma longifolia Jack) isolate on Plasmodium falciparum cycles. Med J Malaysia. 2008;63 Suppl A:98-99. View abstract.
  • Shuid, A. N., Abu Bakar, M. F., Abdul Shukor, T. A., Muhammad, N., Mohamed, N., and Soelaiman, I. N. The anti-osteoporotic effect of Eurycoma Longifolia in aged orchidectomised rat model. Aging.Male. 2011;14(3):150-154. View abstract.
  • Sriwilaijaroen N, Kondo S, and et al. Antiplasmodial effects of Brucea javanica (L.) Merr. and Eurycoma longifolia Jack extracts and their combination with chloroquine and quinine on Plasmodium falciparum in culture. Tropical Medicine and Health 2010;38(2):61-68.
  • Suppakan N and Suriyapananont S. Thai crude drugs: preparations and specifications. Part 16. Eurycoma longifolia Jack. Mahidol University Journal of Pharmaceutical Sciences 1983;10:43-48.
  • Tan, S., Yuen, K. H., and Chan, K. L. HPLC analysis of plasma 9-methoxycanthin-6-one from Eurycoma longifolia and its application in a bioavailability/pharmacokinetic study. Planta.Med 2002;68(4):355-358. View abstract.
  • Tee, T. T. and Azimahtol, H. L. Induction of apoptosis by Eurycoma longifolia jack extracts. Anticancer.Res 2005;25(3B):2205-2213. View abstract.
  • Tee, T. T., Cheah, Y. H., and Hawariah, L. P. F16, a fraction from Eurycoma longifolia jack extract, induces apoptosis via a caspase-9-independent manner in MCF-7 cells. Anticancer.Res 2007;27(5A):3425-3430. View abstract.
  • Teh, C. H., Abdulghani, M., Morita, H., Shiro, M., Hussin, A. H., and Chan, K. L. Comparative X-ray and conformational analysis of a new crystal of 13alpha,21-dihydroeurycomanone with eurycomanone from Eurycoma longifolia and their anti-estrogenic activity using the uterotrophic assay. Planta.Med 2011;77(2):128-132. View abstract.
  • Teh, C. H., Teoh, S. C., Yeap, C. S., Chan, K. L., and Fun, H. K. 4,5,7,8,17-Penta-hydr-oxy-14,18-dimethyl-6-methyl-ene-3,10-dioxapenta-cyclo-[9.8. 0.0.0.0]nona-dec-14-ene-9,16-dione methanol solvate dihydrate. Acta Crystallogr.Sect.E.Struct.Rep.Online. 2009;65(Pt 4):o898-o899. View abstract.
  • Tzar M, Hamidah Y, Hartini M, and etal. The Antibacterial or Antifungal Effects of Eurycoma longifolia Root Extract. The Internet Journal of Herbal and Plant Medicine 2011;1(1)
  • Ueda, J. Y., Tezuka, Y., Banskota, A. H., Le, Tran Q., Tran, Q. K., Harimaya, Y., Saiki, I., and Kadota, S. Antiproliferative activity of Vietnamese medicinal plants. Biol.Pharm.Bull. 2002;25(6):753-760. View abstract.
  • Vittachi, Nury. Flower power. Far Eastern Economic Review 1994;157(18)
  • Ang HH, Cheang HS, Yusof AP. Effects of Eurycoma longifolia Jack (Tongkat Ali) on the initiation of sexual performance of inexperienced castrated male rats. Exp Anim 2000;49:35-8. View abstract.
  • Ang HH, Cheang HS. Effects of Eurycoma longifolia jack on laevator ani muscle in both uncastrated and testosterone-stimulated castrated intact male rats. Arch Pharm Res 2001;24:437-40. View abstract.
  • Ang HH, Cheang HS. Studies on the anxiolytic activity of Eurycoma longifolia Jack roots in mice. Jpn J Pharmacol 1999;79:497-500. View abstract.
  • Ang HH, Ikeda S, Gan EK. Evaluation of the potency activity of aphrodisiac in Eurycoma longifolia Jack. Phytother Res 2001;15:435-6. View abstract.
  • Ang HH, Lee EL, Cheang HS. Determination of mercury by cold vapor atomic absorption spectrophotometer in Tongkat Ali preparations obtained in Malaysia. Int J Toxicol 2004;23:65-71. View abstract.
  • Ang HH, Lee KL. Analysis of lead in Tongkat Ali hitam herbal preparations in Malaysia. Toxicol Environ Chem 2005;87:521-8.
  • Ang HH, Lee KL. Contamination of mercury in Tongkat Ali hitam herbal preparations. Food Chem Toxicol 2006;44:1245-50. View abstract.
  • Ang HH, Lee KL. Effect of Eurycoma longifolia Jack on orientation activities in middle-aged male rats. Fundam Clin Pharmacol 2002;16:479-83. View abstract.
  • Ang HH, Ngai TH. Aphrodisiac evaluation in non-copulator male rats after chronic administration of Eurycoma longifolia Jack. Fundam Clin Pharmacol 2001;15:265-8. View abstract.
  • Ang HH, Sim MK. Eurycoma longifolia Jack enhances libido in sexually experienced male rats. Exp Anim 1997;46:287-90. View abstract.
  • Bedir E, Abou-Gazar H, Ngwendson JN, Khan IA. Eurycomaoside: a new quassinoid-type glycoside from the roots of Eurycoma longifolia. Chem Pharm Bull (Tokyo) 2003;51:1301-3. View abstract.
  • Bhat R, Karmin AA. Tongkat ali (Eurycoma longifolia jack): a review on its ethnobotany and pharmacological importance. Fitoterapia 2010;81:669-79. View abstract.
  • Chan KL, Choo CY, Abdullah NR, Ismail Z. Antiplasmodial studies of Eurycoma longifolia Jack using the lactate dehydrogenase assay of Plasmodium falciparum. J Ethnopharmacol 2004;92:223-7. View abstract.
  • Chan KL, Choo CY. The toxicity of some quassinoids from Eurycoma longifolia. Planta Med 2002;68:662-4. View abstract.
  • Jiwajinda S, Santisopasri V, Murakami A, et al. In vitro anti-tumor promoting and anti-parasitic activities of the quassinoids from Eurycoma longifolia, a medicinal plant in Southeast Asia. J Ethnopharmacol 2002;82:55-8. View abstract.
  • Low BS, Ng BH, Choy WP, et al. Bioavailability and pharmacokinetic studies of eurycomanone from Eurycoma longifolia. Planta Med 2005;71:803-7. View abstract.
  • Miller LG. Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions. Arch Int Med 1998;158:2200-11.. View abstract.
  • Miyake K, tezuka Y, Awale S, et al. Quassinoids for Eurycoma longifolia. J Nat Prod 2009;72:2135-40. View abstract.
  • Qinna N, Taha H, Matalka KZ, Badwan AA. A new herbal combination, Etana, for enhancing erectile function: an efficacy and safety study in animals. International Journal of Impotence Research 2009;21:315-20. View abstract.
  • Salman SA, Amrah S, Wahab MS, et al. Modification of propranolol's bioavailability by Eurycoma longifolia water-based extract. J Clin Pharm Ther 2010;35:691-6. View abstract.
  • Tambi MI, Imran MK, Henkel RR. Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism? Andrologia 2011 Jun 15. doi: 10.1111/j.1439-0272.2011.01168.x. [Epub ahead of print] . View abstract.
  • Tambi MI, Imran MK. Eurycoma longifolia jack in managing idiopathic male infertility. J Androl 2010;12:376-80. View abstract.
  • Wahab NA, Mokhtar NM, Halim WN, Das S. The effect of Eurycoma longifolia jack on spermatogenesis in estrogen-treated rats. Clinics 2010;65:93-8. View abstract.
  • Wernsdorfer WH, Ismail S, Chan KL, et al. Activity of Eurycoma longifolia root extract against Plasmodium falciparum in vitro. Wien Klin Wochenschr 2009;121(Suppl 3):23-26. View abstract.
  • Zanoli P, Zavatti M, Montanari C, Baraldi M. Influcence of Eurycoma longifolia on the copulatory activity of sexually sluggish and impotenet male rats. J Ethnopharmacol 2009;126:308-13. View abstract.

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