3,5 diiodothyronine; 3,5-diiodo-L-thyronine; 3,5-L-diiodothyronine; 3,5-T2; Diyodotironina; T2; T-2.


Overview Information

Diiodothyronine is a hormone. It is used as medicine.

People take diiodothyronine for obesity, to treat high levels of cholesterol or other fats (lipids) in the blood (hyperlipidemia), and to increase muscle strength.

How does it work?

Some animal and test tube research suggests that diiodothyronine might speed up metabolism and reduce fat storage. But there is no reliable research in people, so no one knows if diiodothyronine has these effects in people.


Uses & Effectiveness?

Insufficient Evidence for

  • Obesity.
  • High levels of cholesterol or other fats (lipids) in the blood (hyperlipidemia).
  • Improving muscle strength.
  • Other conditions.
More evidence is needed to rate the effectiveness of diiodothyronine for these uses.

Side Effects

Side Effects & Safety

There isn't enough information to know if diiodothyronine is safe.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Not enough is known about the use of diiodothyronine during pregnancy and breast-feeding. Stay on the safe side and avoid use.



We currently have no information for DIIODOTHYRONINE Interactions.



The appropriate dose of diiodothyronine depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for diiodothyronine. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References


  • Ball SG, Sokolov J, Chin WW. 3,5-Diiodo-L-thyronine (T2) has selective thyromimetic effects in vivo and in vitro. J Mol Endocrinol 1997;19:137-47. View abstract.
  • da Silva Teixeira S, Filgueira C, Sieglaff DH, et al. 3,5-diiodothyronine (3,5-T2) reduces blood glucose independently of insulin sensitization in obese mice. Acta Physiol (Oxf) 2017;220(2):238-50. doi: 10.1111/apha.12821. View abstract.
  • Giudetti AM, Leo M, Geelen MJ, Gnoni GV. Short-term stimulation of lipogenesis by 3,5-L-diiodothyronine in cultured rat hepatocytes. Endocrinology 2005;146:3959-66. View abstract.
  • Goglia F. Biological effects of 3,5-diiodothyronine (T(2)). Biochemistry (Mosc) 2005;70:164-72. View abstract.
  • Lanni A, Moreno M, Lombardi A, et al. 3,5-diiodo-L-thyronine powerfully reduces adiposity in rats by increasing the burning of fats. FASEB J 2005;19:1552-4. View abstract.
  • Moreno M, Lombardi A, Lombardi P, et al. Effect of 3,5-diiodo-L-thyronine on thyroid stimulating hormone and growth hormone serum levels in hypothyroid rats. Life Sci 1998;62:2369-77. View abstract.
  • Silvestri E, Schiavo L, Lombardi A, Goglia F. Thyroid hormones as molecular determinants of thermogenesis. Acta Physiol Scand 2005;184:265-83. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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