THEAFLAVIN

OTHER NAME(S):

Teaflavina, Théaflavin, Théaflavine, Theaflavin-3-gallate, Theaflavin-3'-gallate, Theaflavin-3-3'-digallate, Theaflavins.

Overview

Overview Information

Theaflavin is a chemical in black tea that is formed from fermentation of green tea. It is used as medicine.

People take theaflavin for high levels of cholesterol or other fats (lipids) in the blood (hyperlipidemia), heart disease, obesity, and cancer, but there is no good scientific evidence to support these uses.

How does it work?

Theaflavin has antioxidant, antiviral, and anti-cancer effects in test tube experiments and in animals. The effects of theaflavin in humans are not well studied.

Uses

Uses & Effectiveness?

Insufficient Evidence for

  • High levels of cholesterol or other fats (lipids) in the blood (hyperlipidemia).Early research shows that taking a green tea extract with extra theaflavin seems to help reduce cholesterol.
  • Heart disease.
  • Cancer.
  • Other conditions.
More evidence is needed to rate the effectiveness of theaflavin for these uses.

Side Effects

Side Effects & Safety

When taken by mouth: Theaflavin is LIKELY SAFE in the amounts found in brewed black tea. Theaflavin is POSSIBLY SAFE in the amounts found in medicine when used for up to 12 weeks.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information available to know if theaflavin is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Interactions

Interactions?

We currently have no information for THEAFLAVIN Interactions.

Dosing

Dosing

The appropriate dose of theaflavin depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for theaflavin. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

  • Aizawa T, Yamamoto A, Ueno T. Effect of oral theaflavin administration on body weight, fat, and muscle in healthy subjects: a randomized pilot study. Biosci Biotechnol Biochem 2017;81(2):311-5. doi: 10.1080/09168451.2016.1246170. View abstract.
  • Cai F, Li CR, Wu JL, et al. Theaflavin ameliorates cerebral ischemia-reperfusion injury in rats through its anti-inflammatory effect and modulation of STAT-1. Mediators Inflamm 2006;2006:30490. View abstract.
  • Chen CN, Lin CP, Huang KK, et al. Inhibition of SARS-CoV 3C-like Protease Activity by Theaflavin-3,3'-digallate (TF3). Evid Based Complement Alternat Med 2005;2:209-15. View abstract.
  • Fuchs D, de Graaf Y, van Kerckhoven R, Draijer R. Effect of tea theaflavins and catechins on microvascular function. Nutrients 2014;6(12):5772-85. doi: 10.3390/nu6125772. View abstract.
  • Fukuda I, Sakane I, Yabushita Y, et al. Black tea theaflavins suppress dioxin-induced transformation of the aryl hydrocarbon receptor. Biosci Biotechnol Biochem 2005;69:883-90. View abstract.
  • Henning SM, Aronson W, Niu Y, et al. Tea polyphenols and theaflavins are present in prostate tissue of humans and mice after green and black tea consumption. J Nutr 2006;136(7):1839-43. View abstract.
  • Jhoo JW, Lo CY, Li S, et al. Stability of black tea polyphenol, theaflavin, and identification of theanaphthoquinone as its major radical reaction product. Agric Food Chem 2005;53:6146-50. View abstract.
  • Kundu T, Dey S, Roy M, et al. Induction of apoptosis in human leukemia cells by black tea and its polyphenol theaflavin. Cancer Lett 2005;230:111-21. View abstract.
  • Lee MJ, Lambert JD, Prabhu S, et al. Delivery of tea polyphenols to the oral cavity by green tea leaves and black tea extract. Cancer Epidemiol Biomarkers Prev 2004;13(1):132-7. View abstract.
  • Liu S, Lu H, Zhao Q, et al. Theaflavin derivatives in black tea and catechin derivatives in green tea inhibit HIV-1 entry by targeting gp41. Biochim Biophys Acta 2005;1723:270-81. View abstract.
  • Maron DJ, Lu GP, Cai NS, et al. Cholesterol-lowering effect of a theaflavin-enriched green tea extract: a randomized controlled trial. Arch Intern Med 2003;163:1448-53.. View abstract.
  • Matsui T, Tanaka T, Tamura S, et al. alpha-Glucosidase inhibitory profile of catechins and theaflavins. J Agric Food Chem 2007;55:99-105. View abstract.
  • Mizuno H, Cho YY, Zhu F, et al. Theaflavin-3, 3'-digallate induces epidermal growth factor receptor downregulation. Mol Carcinog 2006;45:204-12. View abstract.
  • Takemoto M, Takemoto H, Kouno H, Soeda T, Moriya T. A simple, enzymatic biotransformation method using fresh green tea leaves efficiently generates theaflavin-containing fermentation water that has potent physiological functions in mice and humans. Biol Pharm Bull 2017;40(6):860-6. doi: 10.1248/bpb.b17-00062. View abstract.
  • Tu YY, Tang AB, Watanabe N. The theaflavin monomers inhibit the cancer cells growth in vitro. Acta Biochim Biophys Sin (Shanghai) 2004;36:508-12. View abstract.
  • Way TD, Lee HH, Kao MC, Lin JK. Black tea polyphenol theaflavins inhibit aromatase activity and attenuate tamoxifen resistance in HER2/neu-transfected human breast cancer cells through tyrosine kinase suppression. Eur J Cancer 2004;40:2165-74. View abstract.
  • Yanagida A, Shoji A, Shibusawa Y, et al. Analytical separation of tea catechins and food-related polyphenols by high-speed counter-current chromatography. J Chromatogr A 2006;1112:195-201. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2018.