The name citrulline comes from Citrullus vulgaris, the Latin term for watermelon. Unlike some amino acids, L-citrulline isn't used to make protein, but it might help increase other chemicals the body needs to make protein. It might also help improve blood flow and reduce blood pressure.
People use L-citrulline for athletic performance, sickle cell disease, erectile dysfunction (ED), high blood pressure in the lungs, heart disease, and many other conditions, but there is no good scientific evidence to support most of these uses.
Uses & Effectiveness
Possibly Effective for
Possibly Ineffective for
- Age-related muscle loss (sarcopenia). Taking L-citrulline by mouth does not seem to increase muscle strength in older adults who regularly exercise.
Special Precautions and Warnings
Children: L-citrulline is possibly safe when taken by mouth.
Surgery: L-citrulline might affect blood pressure. It might interfere with blood pressure control during and after surgery. Stop taking L-citrulline at least 2 weeks before a scheduled surgery.
Medications for high blood pressure (Antihypertensive drugs) interacts with L-CITRULLINE
L-citrulline might lower blood pressure. Taking L-citrulline along with medications that lower blood pressure might cause blood pressure to go too low. Monitor your blood pressure closely.
Medications for male sexual dysfunction (Phosphodiesterase-5 Inhibitors) interacts with L-CITRULLINE
L-citrulline might lower blood pressure. Some medications for male sexual dysfunction can also lower blood pressure. Taking L-citrulline along with these medications might cause blood pressure to go too low.
Be cautious with this combination
CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.
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© Therapeutic Research Faculty 2020.