WHITE MULBERRY

OTHER NAME(S):

Chinese White Mulberry, Chi Sang, Chin Sang, Common Mulberry, Egyptian Mulberry, Mon Tea, Mora, Moral Blanco, Morera Blanca, Morin, Morus alba, Morus indica, Morus multicaulis, Mûrier Blanc, Mûrier Blanc de Chine, Mûrier Commun, Mûrier du Ver à Soie, Russian Mulberry, Silkworm Mulberry.

Overview

Overview Information

White mulberry is an herb. The powdered leaves are most commonly used for medicine. The fruit can be used for food, either raw or cooked.

White mulberry is used for diabetes, high cholesterol levels, high blood pressure, the common cold, and many other conditions, but there is no good scientific evidence to support these uses.

White mulberry is native to China and is the food of silkworms. It was introduced into the United States in colonial times, during an attempt to establish a silk industry. The wood is very flexible and durable and has been used to make tennis rackets, hockey sticks, furniture, and boats.

How does it work?

There are some chemicals in white mulberry that work in a similar way to some medicines used for type 2 diabetes. They slow the breakdown of sugars in the gut so that they are absorbed more slowly into the blood. This helps the body keep blood sugar levels in the desirable range.

Uses

Uses & Effectiveness?

Possibly Effective for

  • Diabetes. The powdered leaves of white mulberry seem to lower blood sugar in people who have type 2 diabetes. Taking the powdered leaf three times a day for 4 weeks seems to decrease fasting blood sugar levels better than the antidiabetes medication glyburide.

Insufficient Evidence for

  • High levels of cholesterol or other fats (lipids) in the blood (hyperlipidemia). In a small study of people with type 2 diabetes, taking white mulberry leaf for 4 weeks seems to reduce total cholesterol and low-density lipoprotein (LDL, or "bad") cholesterol levels.
  • Asthma.
  • Common cold.
  • Constipation.
  • Cough.
  • Dizziness (vertigo).
  • Hair loss and premature greying.
  • High blood pressure.
  • Joint pain.
  • Obesity.
  • Weak and brittle bones (osteoporosis).
  • Sore throat.
  • Ringing in the ears (tinnitus).
  • Other conditions.
More evidence is needed to rate the effectiveness of white mulberry for these uses.

Side Effects

Side Effects & Safety

When taken by mouth: White mulberry is POSSIBLY SAFE for most people when the powdered leaf is taken for up to 5-12 weeks. There isn't enough reliable information to know if white mulberry berries are safe when taken as a medicine or what the side effects might be.

Special Precautions & Warnings:

Pregnancy and breast-feeding:There isn't enough reliable information to know if white mulberry is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Diabetes: White mulberry might lower blood sugar levels in people with diabetes. Watch for signs of low blood sugar (hypoglycemia) and monitor your blood sugar carefully if you have diabetes and use white mulberry.

Interactions

Interactions?

We currently have no information for WHITE MULBERRY Interactions.

Dosing

Dosing

The following doses have been studied in scientific research:

BY MOUTH:

  • For diabetes:1 gram of the powdered leaf taken three times daily.

View References

REFERENCES:

  • Andallu B, Suryakantham V, Lakshmi Srikanthi B, Reddy GK. Effect of mulberry (Morus indica L.) therapy on plasma and erythrocyte membrane lipids in patients with type 2 diabetes. Clin Chim Acta 2001;314:47-53. View abstract.
  • Andallu B, Varadacharyulu NC. Antioxidant role of mulberry (Morus indica L. cv. Anantha) leaves in streptozotocin-diabetic rats. Clin Chim Acta 2003;338:3-10. View abstract.
  • Andallu B, Varadacharyulu NC. Gluconeogenic substrates and hepatic gluconeogenic enzymes in streptozotocin-diabetic rats: effect of mulberry (Morus indica L.) leaves. J Med Food 2007;10:41-8. View abstract.
  • Asano N, Oseki K, Tomioka E, et al. N-containing sugars from Morus alba and their glycosidase inhibitory activities. Carbohydr Res 1994;259:243-55. View abstract.
  • Asano N, Yamashita T, Yasuda K, et al. Polyhydroxylated alkaloids isolated from mulberry trees (Morus alba L.) and silkworms (Bombyx mori L.). J Agric Food Chem 2001;49:4208-13. View abstract.
  • Chen J, Li X. Hypolipidemic effect of flavonoids from mulberry leaves in triton WR-1339 induced hyperlipidemic mice. Asia Pac J Clin Nutr 2007;16(Suppl 1):290-4. View abstract.
  • Doi K, Kojima T, Makino M, et al. Studies on the constituents of the leaves of Morus alba L. Chem Pharm Bull 2001;49:151-3. View abstract.
  • Du J, He ZD, Jiang RW, et al. Antiviral flavonoids from the root bark of Morus alba L. Phytochemistry 2003;62:1235-8. View abstract.
  • El-Beshbishy HA, Singab AN, Sinkkonen J, Pihlaja K. Hypolipidemic and antioxidant effects of Morus alba L. (Egyptian mulberry) root bark fractions supplementation in cholesterol-fed rats. Life Sci 2006;78:2724-33. View abstract.
  • Enkhmaa B, Shiwaku K, Katsube T, et al. Mulberry (Morus alba L) leaves and their major flavonol quercetin 3-(6-malonylglucoside) attenuate atherosclerotic lesion development in LDL receptor-deficient mice. J Nutr 2005;135:729-34. View abstract.
  • Hansawasdi C, Kawabata J. Alpha-glucosidase inhibitory effect of mulberry (Morus alba) leaves on Caco-2. Fitoterapia 2006;77:568-73. View abstract.
  • Hwang KH, Kim YK. Promoting effect and recovery activity from physical stress of the fruit of Morus alba. Biofactors 2004;21:267-71. View abstract.
  • Kimura T, Nakagawa K, Kubota H, et al. Food-grade mulberry powder enriched with 1-deoxynojirimycin suppresses the elevation of postprandial blood glucose in humans. J Agric Food Chem 2007;55:5869-74. View abstract.
  • Lee J, Chae K, Ha J, et al. Regulation of obesity and lipid disorders by herbal extracts from Morus alba, Melissa officinalis, and Artemisia capillaris in high-fat diet-induced obese mice. J Ethnopharmacol 2008;115:263-70. View abstract.
  • Lee SH, Choi SY, Kim H, et al. Mulberroside F isolated from the leaves of Morus alba inhibits melanin biosynthesis. Biol Pharm Bull 2002;25:1045-8. View abstract.
  • Moore LM. Plant Guide: White Mulberry. United States Department of Agriculture, Natural Resources Conservation Service. Available at: https://plants.usda.gov/plantguide/pdf/pg_moal.pdf. (Accessed 3 September 2009).
  • Mudra M, Ercan-Fang N, Zhong L, et al. Influence of mulberry leaf extract on the blood glucose and breath hydrogen response to ingestion of 75 g sucrose by type 2 diabetic and control subjects. Diabetes Care 2007;30:1272-4. View abstract.
  • Oku T, Yamada M, Nakamura M, et al. Inhibitory effects of extractives from leaves of Morus alba on human and rat small intestinal disaccharidase activity. Br J Nutr 2006;95:933-8. View abstract.
  • Park KM, You JS, Lee HY, et al. Kuwanon G: an antibacterial agent from the root bark of Morus alba against oral pathogens. J Ethnopharmacol 2003;84:181-5. View abstract.
  • Skupien K, Kostrzewa-Nowak D, Oszmianski J, Tarasiuk J. In vitro antileukaemic activity of extracts from chokeberry (Aronia melanocarpa [Michx] Elliott) and mulberry (Morus alba L.) leaves against sensitive and multidrug resistant HL60 cells. Phytother Res 2008;22:689-94. View abstract.
  • Yu Z, Fong WP, Cheng CH. The dual actions of morin (3,5,7,2',4'-pentahydroxyflavone) as a hypouricemic agent: uricosuric effect and xanthine oxidase inhibitory activity. J Pharmacol Exp Ther 2006;316:169-75. View abstract.
  • Andallu B, Suryakantham V, Lakshmi Srikanthi B, Reddy GK. Effect of mulberry (Morus indica L.) therapy on plasma and erythrocyte membrane lipids in patients with type 2 diabetes. Clin Chim Acta 2001;314:47-53. View abstract.
  • Andallu B, Varadacharyulu NC. Antioxidant role of mulberry (Morus indica L. cv. Anantha) leaves in streptozotocin-diabetic rats. Clin Chim Acta 2003;338:3-10. View abstract.
  • Andallu B, Varadacharyulu NC. Gluconeogenic substrates and hepatic gluconeogenic enzymes in streptozotocin-diabetic rats: effect of mulberry (Morus indica L.) leaves. J Med Food 2007;10:41-8. View abstract.
  • Asano N, Oseki K, Tomioka E, et al. N-containing sugars from Morus alba and their glycosidase inhibitory activities. Carbohydr Res 1994;259:243-55. View abstract.
  • Asano N, Yamashita T, Yasuda K, et al. Polyhydroxylated alkaloids isolated from mulberry trees (Morus alba L.) and silkworms (Bombyx mori L.). J Agric Food Chem 2001;49:4208-13. View abstract.
  • Chen J, Li X. Hypolipidemic effect of flavonoids from mulberry leaves in triton WR-1339 induced hyperlipidemic mice. Asia Pac J Clin Nutr 2007;16(Suppl 1):290-4. View abstract.
  • Da Villa G, Ianiro G, Mangiola F, et al. White mulberry supplementation as adjuvant treatment of obesity. J Biol Regul Homeost Agents 2014;28(1):141-5. View abstract.
  • Doi K, Kojima T, Makino M, et al. Studies on the constituents of the leaves of Morus alba L. Chem Pharm Bull 2001;49:151-3. View abstract.
  • Du J, He ZD, Jiang RW, et al. Antiviral flavonoids from the root bark of Morus alba L. Phytochemistry 2003;62:1235-8. View abstract.
  • El-Beshbishy HA, Singab AN, Sinkkonen J, Pihlaja K. Hypolipidemic and antioxidant effects of Morus alba L. (Egyptian mulberry) root bark fractions supplementation in cholesterol-fed rats. Life Sci 2006;78:2724-33. View abstract.
  • Enkhmaa B, Shiwaku K, Katsube T, et al. Mulberry (Morus alba L) leaves and their major flavonol quercetin 3-(6-malonylglucoside) attenuate atherosclerotic lesion development in LDL receptor-deficient mice. J Nutr 2005;135:729-34. View abstract.
  • Gurukar MSA, Chilkunda ND. Morus alba leaf bioactives modulate peroxisome proliferator activated receptor ? in the kidney of diabetic rat and impart beneficial effect. J Agric Food Chem 2018;66(30):7923-34. doi: 10.1021/acs.jafc.8b01357. View abstract.
  • Hansawasdi C, Kawabata J. Alpha-glucosidase inhibitory effect of mulberry (Morus alba) leaves on Caco-2. Fitoterapia 2006;77:568-73. View abstract.
  • Hwang KH, Kim YK. Promoting effect and recovery activity from physical stress of the fruit of Morus alba. Biofactors 2004;21:267-71. View abstract.
  • Jung S, Lee MS, Choi AJ, Kim CT, Kim Y. Anti-Inflammatory effects of high hydrostatic pressure extract of mulberry (Morus alba) fruit on LPS-stimulated RAW264.7 cells. Molecules 2019;24(7):0. pii: E1425. doi: 10.3390/molecules24071425. View abstract.
  • Kimura T, Nakagawa K, Kubota H, et al. Food-grade mulberry powder enriched with 1-deoxynojirimycin suppresses the elevation of postprandial blood glucose in humans. J Agric Food Chem 2007;55:5869-74. View abstract.
  • Lee J, Chae K, Ha J, et al. Regulation of obesity and lipid disorders by herbal extracts from Morus alba, Melissa officinalis, and Artemisia capillaris in high-fat diet-induced obese mice. J Ethnopharmacol 2008;115:263-70. View abstract.
  • Lee SH, Choi SY, Kim H, et al. Mulberroside F isolated from the leaves of Morus alba inhibits melanin biosynthesis. Biol Pharm Bull 2002;25:1045-8. View abstract.
  • Moore LM. Plant Guide: White Mulberry. United States Department of Agriculture, Natural Resources Conservation Service. Available at: https://plants.usda.gov/plantguide/pdf/pg_moal.pdf. (Accessed 3 September 2009).
  • Mudra M, Ercan-Fang N, Zhong L, et al. Influence of mulberry leaf extract on the blood glucose and breath hydrogen response to ingestion of 75 g sucrose by type 2 diabetic and control subjects. Diabetes Care 2007;30:1272-4. View abstract.
  • Oku T, Yamada M, Nakamura M, et al. Inhibitory effects of extractives from leaves of Morus alba on human and rat small intestinal disaccharidase activity. Br J Nutr 2006;95:933-8. View abstract.
  • Park KM, You JS, Lee HY, et al. Kuwanon G: an antibacterial agent from the root bark of Morus alba against oral pathogens. J Ethnopharmacol 2003;84:181-5. View abstract.
  • Skupien K, Kostrzewa-Nowak D, Oszmianski J, Tarasiuk J. In vitro antileukaemic activity of extracts from chokeberry (Aronia melanocarpa [Michx] Elliott) and mulberry (Morus alba L.) leaves against sensitive and multidrug resistant HL60 cells. Phytother Res 2008;22:689-94. View abstract.
  • Trimarco V, Izzo R, Stabile E, et al. Effects of a new combination of nutraceuticals with Morus alba on lipid profile, insulin sensitivity and endothelial function in dyslipidemic subjects. A cross-over, randomized, double-blind trial. High Blood Press Cardiovasc Prev 2015;22(2):149-54. doi: 10.1007/s40292-015-0087-2. View abstract.
  • Wattanathorn J, Somboonporn W, Sungkamanee S, Thukummee W, Muchimapura S. A double-blind placebo-controlled randomized trial evaluating the effect of polyphenol-rich herbal congee on bone turnover markers of the perimenopausal and menopausal women. Oxid Med Cell Longev 2018; 21:2018:2091872. doi: 10.1155/2018/2091872. View abstract.
  • Yu Z, Fong WP, Cheng CH. The dual actions of morin (3,5,7,2',4'-pentahydroxyflavone) as a hypouricemic agent: uricosuric effect and xanthine oxidase inhibitory activity. J Pharmacol Exp Ther 2006;316:169-75. View abstract.

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