RASPBERRY KETONE

OTHER NAME(S):

4-(4-Hydroxyphenyl) butan-2-one, Cetona de Frambuesa, C├ętone de Framboise, Raspberry Ketones, Red Raspberry Ketone, RK.<br/><br/>

Overview

Overview Information

Raspberry ketone is a chemical from red raspberries, as well as kiwifruit, peaches, grapes, apples, other berries, vegetables such as rhubarb, and the bark of yew, maple, and pine trees.

People take raspberry ketone by mouth for weight loss. It became popular for weight loss after it was mentioned on the Dr. Oz television show during the segment called "Raspberry ketone: Miracle fat-burner in a bottle" in February 2012.

People apply raspberry ketone to the skin for hair loss.

Raspberry ketone is also used in foods, cosmetics, and other manufacturing as a fragrance or flavoring agent.

How does it work?

Raspberry ketone is a chemical from red raspberries that is thought to help for weight loss. Some research in animals or in test tubes shows that raspberry ketone might increase some measures of metabolism. It might also affect a hormone in the body called adiponectin. Adiponectin can increase the rate at which the body burns fat and reduce appetite. However, it is important to keep in mind that there is no reliable scientific evidence that raspberry ketone improves weight loss when taken by people.

Uses

Uses & Effectiveness?

Insufficient Evidence for

  • Hair loss (alopecia areata). Early research shows that applying a raspberry ketone solution to the scalp might increase hair growth in people with hair loss.
  • Male pattern baldness (androgenic alopecia). Early research shows that applying a raspberry ketone solution to the scalp might increase hair growth in people with male pattern baldness
  • Obesity. Early research suggests that taking raspberry ketone plus vitamin C might decrease weight and body fat in healthy people. Other research suggests that taking a specific product (Prograde Metabolism) containing raspberry ketone (Razberi K, Integrity Nutraceuticals) and other ingredients including caffeine twice daily for 8 weeks reduces body weight by 2%, fat mass by 7.8%, waist circumference by 2%, and hip circumference by 1.7%. The effects of taking raspberry ketone alone are not clear.
  • Other conditions.
More evidence is needed to rate raspberry ketone for these uses.

Side Effects

Side Effects & Safety

Raspberry ketone is POSSIBLY SAFE when taken by mouth appropriately as part of a product containing other ingredients in the short-term. Doses of 1000 mg of a specific formulation (Prograde Metabolism), which contains raspberry ketone (Razberi K, Integrity Nutraceuticals) and other ingredients, including caffeine, has been used safely twice daily for 8 weeks.

There isn't enough reliable information available to know if taking raspberry ketone alone is safe. There are some concerns about the safety of raspberry ketone because it is chemically related to a stimulant called synephrine. Therefore, it is possible that raspberry ketone might cause feelings of jitteriness, increase blood pressure, or rapid heartbeat. In one report, someone who took raspberry ketone described feelings of being shaky and a pounding heart beat (palpitations).

Special Precautions & Warnings:

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking raspberry ketone if you are pregnant or breast feeding. Stay on the safe side and avoid use.

Diabetes: Raspberry ketone might lower blood sugar levels. In theory, raspberry ketone might make blood sugar drop too low in people already taking medications for diabetes.

Interactions

Interactions?

We currently have no information for RASPBERRY KETONE Interactions.

Dosing

Dosing

The appropriate dose of raspberry ketone depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for raspberry ketone. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

  • Feron, G., Mauvais, G., Martin, F., Semon, E., and Blin-Perrin, C. Microbial production of 4-hydroxybenzylidene acetone, the direct precursor of raspberry ketone. Lett.Appl.Microbiol. 2007;45(1):29-35. View abstract.
  • Jeong, J. B. and Jeong, H. J. Rheosmin, a naturally occurring phenolic compound inhibits LPS-induced iNOS and COX-2 expression in RAW264.7 cells by blocking NF-kappaB activation pathway. Food Chem.Toxicol. 2010;48(8-9):2148-2153. View abstract.
  • Koeduka, T., Watanabe, B., Suzuki, S., Hiratake, J., Mano, J., and Yazaki, K. Characterization of raspberry ketone/zingerone synthase, catalyzing the alpha, beta-hydrogenation of phenylbutenones in raspberry fruits. Biochem.Biophys.Res Commun. 8-19-2011;412(1):104-108. View abstract.
  • Lin, C. H., Ding, H. Y., Kuo, S. Y., Chin, L. W., Wu, J. Y., and Chang, T. S. Evaluation of in Vitro and in Vivo Depigmenting Activity of Raspberry Ketone from Rheum officinale. Int.J Mol.Sci. 2011;12(8):4819-4835. View abstract.
  • Sporstol, S. and Scheline, R. R. The metabolism of 4-(4-hydroxyphenyl)butan-2-one (raspberry ketone) in rats, guinea-pigs and rabbits. Xenobiotica 1982;12(4):249-257. View abstract.
  • Ushiki, M., Ikemoto, T., and Sato, Y. Anti-obese activities of raspberry ketone. Aroma Research 2002;3(4):361.
  • Park KS. Raspberry ketone increases both lipolysis and fatty acid oxidation in 3T3-L1 adipocytes. Planta Med 2010;76:1654-8. View abstract.
  • Adverse Event Report. Raspberry Ketone. Natural MedWatch, April 27, 2012.
  • Adverse Event Report. Raspberry Ketone. Natural MedWatch, September 18, 2011.
  • Beekwilder J, van der Meer IM, Sibbesen O, et al. Microbial production of natural raspberry ketone. Biotechnol J 2007;2:1270-9. View abstract.
  • Harada N, Okajima K, Narimatsu N, et al. Effect of topical application of raspberry ketone on dermal production of insulin-like growth factor-I in mice and on hair growth and skin elasticity in humans. Growth Horm IGF Res 2008;18:335-44. View abstract.
  • Lopez, H. L., Ziegenfuss, T. N., Hofheins, J. E., Habowski, S. M., Arent, S. M., Weir, J. P., and Ferrando, A. A. Eight weeks of supplementation with a multi-ingredient weight loss product enhances body composition, reduces hip and waist girth, and increases energy levels in overweight men and women. J Int Soc Sports Nutr 2013;10(1):22. View abstract.
  • Morimoto C, Satoh Y, Hara M, et al. Anti-obese action of raspberry ketone. Life Sci 2005;77:194-204. . View abstract.
  • Ogawa Y, Akamatsu M, Hotta Y, et al. Effect of essential oils, such as raspberry ketone and its derivatives, on antiandrogenic activity based on in vitro reporter gene assay. Bioorg Med Chem Lett 2010;20:2111-4. View abstract.
  • Ushiki M, Ikemoto T, Sato Y. Anti-obese activities of raspberry ketone. Aroma Research 2002;3:361.
  • Wang L, Meng X, Zhang F. Raspberry ketone protects rats fed high-fat diets against nonalcoholic steatohepatitis. J Med Food 2012;15:495-503. View abstract.
  • Feron, G., Mauvais, G., Martin, F., Semon, E., and Blin-Perrin, C. Microbial production of 4-hydroxybenzylidene acetone, the direct precursor of raspberry ketone. Lett.Appl.Microbiol. 2007;45(1):29-35. View abstract.
  • Jeong, J. B. and Jeong, H. J. Rheosmin, a naturally occurring phenolic compound inhibits LPS-induced iNOS and COX-2 expression in RAW264.7 cells by blocking NF-kappaB activation pathway. Food Chem.Toxicol. 2010;48(8-9):2148-2153. View abstract.
  • Koeduka, T., Watanabe, B., Suzuki, S., Hiratake, J., Mano, J., and Yazaki, K. Characterization of raspberry ketone/zingerone synthase, catalyzing the alpha, beta-hydrogenation of phenylbutenones in raspberry fruits. Biochem.Biophys.Res Commun. 8-19-2011;412(1):104-108. View abstract.
  • Lin, C. H., Ding, H. Y., Kuo, S. Y., Chin, L. W., Wu, J. Y., and Chang, T. S. Evaluation of in Vitro and in Vivo Depigmenting Activity of Raspberry Ketone from Rheum officinale. Int.J Mol.Sci. 2011;12(8):4819-4835. View abstract.
  • Sporstol, S. and Scheline, R. R. The metabolism of 4-(4-hydroxyphenyl)butan-2-one (raspberry ketone) in rats, guinea-pigs and rabbits. Xenobiotica 1982;12(4):249-257. View abstract.
  • Ushiki, M., Ikemoto, T., and Sato, Y. Anti-obese activities of raspberry ketone. Aroma Research 2002;3(4):361.
  • Park KS. Raspberry ketone increases both lipolysis and fatty acid oxidation in 3T3-L1 adipocytes. Planta Med 2010;76:1654-8. View abstract.
  • Adverse Event Report. Raspberry Ketone. Natural MedWatch, April 27, 2012.
  • Adverse Event Report. Raspberry Ketone. Natural MedWatch, September 18, 2011.
  • Beekwilder J, van der Meer IM, Sibbesen O, et al. Microbial production of natural raspberry ketone. Biotechnol J 2007;2:1270-9. View abstract.
  • Harada N, Okajima K, Narimatsu N, et al. Effect of topical application of raspberry ketone on dermal production of insulin-like growth factor-I in mice and on hair growth and skin elasticity in humans. Growth Horm IGF Res 2008;18:335-44. View abstract.
  • Lopez, H. L., Ziegenfuss, T. N., Hofheins, J. E., Habowski, S. M., Arent, S. M., Weir, J. P., and Ferrando, A. A. Eight weeks of supplementation with a multi-ingredient weight loss product enhances body composition, reduces hip and waist girth, and increases energy levels in overweight men and women. J Int Soc Sports Nutr 2013;10(1):22. View abstract.
  • Morimoto C, Satoh Y, Hara M, et al. Anti-obese action of raspberry ketone. Life Sci 2005;77:194-204. . View abstract.
  • Ogawa Y, Akamatsu M, Hotta Y, et al. Effect of essential oils, such as raspberry ketone and its derivatives, on antiandrogenic activity based on in vitro reporter gene assay. Bioorg Med Chem Lett 2010;20:2111-4. View abstract.
  • Ushiki M, Ikemoto T, Sato Y. Anti-obese activities of raspberry ketone. Aroma Research 2002;3:361.
  • Wang L, Meng X, Zhang F. Raspberry ketone protects rats fed high-fat diets against nonalcoholic steatohepatitis. J Med Food 2012;15:495-503. View abstract.

More Resources for RASPBERRY KETONE

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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