RASPBERRY KETONE

OTHER NAME(S):

4-(4-Hydroxyphenyl) butan-2-one, Cetona de Frambuesa, Cétone de Framboise, Frambinone, Raspberry Ketones, Red Raspberry Ketone, RK.<br/><br/>

Overview

Overview Information

Raspberry ketone is a chemical from red raspberries, as well as kiwifruit, peaches, grapes, apples, other berries, vegetables such as rhubarb, and the bark of yew, maple, and pine trees.

People take raspberry ketone by mouth for obesity. It became popular for this after it was mentioned on the Dr. Oz television show during a segment called "Raspberry ketone: Miracle fat-burner in a bottle" in February 2012. But there is no good scientific evidence to support its use for this or any other purpose.

People apply raspberry ketone to the skin for hair loss.

Raspberry ketone is also used in foods, cosmetics, and other manufacturing as a fragrance or flavoring agent.

How does it work?

Raspberry ketone is a chemical from red raspberries that is thought to help with obesity. Some research in animals or in test tubes shows that raspberry ketone might increase metabolism, increase the rate at which the body burns fat, and reduce appetite. But there is no reliable scientific evidence that raspberry ketone improves weight loss in humans.

Uses

Uses & Effectiveness?

Insufficient Evidence for

  • Patchy hair loss (alopecia areata). Early research shows that applying a raspberry ketone solution to the scalp might increase hair growth in people with patchy hair loss.
  • Male pattern baldness (androgenic alopecia). Early research shows that applying a raspberry ketone solution to the scalp might increase hair growth in people with male pattern baldness
  • Obesity. Early research suggests that taking raspberry ketone plus vitamin C might decrease weight and body fat in healthy people. Other research suggests that taking a specific product (Prograde Metabolism, Ultimate Wellness Systems) containing raspberry ketone (Razberi K, Integrity Nutraceuticals) and other ingredients twice daily for 8 weeks reduces body weight, body fat, and waist and hip measurements when used with dieting, compared to dieting alone in overweight people. The effects of taking raspberry ketone alone are not clear.
  • Other conditions.
More evidence is needed to rate raspberry ketone for these uses.

Side Effects

Side Effects & Safety

When taken by mouth: There isn't enough reliable information to know if raspberry ketone is safe. There are some concerns about its safety because it is chemically related to a stimulant called synephrine. Therefore, it is possible that raspberry ketone might cause feelings of jitteriness, and might increase blood pressure and heart rate. In one report, someone who took raspberry ketone described feelings of being shaky and having a pounding heart (palpitations).

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if raspberry ketone is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Diabetes: Raspberry ketone might affect blood sugar levels. In theory, raspberry ketone might make it more difficult to control blood sugar in people taking medicines for diabetes.

Interactions

Interactions?

We currently have no information for RASPBERRY KETONE Interactions.

Dosing

Dosing

The appropriate dose of raspberry ketone depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for raspberry ketone. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

  • Feron, G., Mauvais, G., Martin, F., Semon, E., and Blin-Perrin, C. Microbial production of 4-hydroxybenzylidene acetone, the direct precursor of raspberry ketone. Lett.Appl.Microbiol. 2007;45(1):29-35. View abstract.
  • Jeong, J. B. and Jeong, H. J. Rheosmin, a naturally occurring phenolic compound inhibits LPS-induced iNOS and COX-2 expression in RAW264.7 cells by blocking NF-kappaB activation pathway. Food Chem.Toxicol. 2010;48(8-9):2148-2153. View abstract.
  • Koeduka, T., Watanabe, B., Suzuki, S., Hiratake, J., Mano, J., and Yazaki, K. Characterization of raspberry ketone/zingerone synthase, catalyzing the alpha, beta-hydrogenation of phenylbutenones in raspberry fruits. Biochem.Biophys.Res Commun. 8-19-2011;412(1):104-108. View abstract.
  • Lin, C. H., Ding, H. Y., Kuo, S. Y., Chin, L. W., Wu, J. Y., and Chang, T. S. Evaluation of in Vitro and in Vivo Depigmenting Activity of Raspberry Ketone from Rheum officinale. Int.J Mol.Sci. 2011;12(8):4819-4835. View abstract.
  • Sporstol, S. and Scheline, R. R. The metabolism of 4-(4-hydroxyphenyl)butan-2-one (raspberry ketone) in rats, guinea-pigs and rabbits. Xenobiotica 1982;12(4):249-257. View abstract.
  • Ushiki, M., Ikemoto, T., and Sato, Y. Anti-obese activities of raspberry ketone. Aroma Research 2002;3(4):361.
  • Park KS. Raspberry ketone increases both lipolysis and fatty acid oxidation in 3T3-L1 adipocytes. Planta Med 2010;76:1654-8. View abstract.
  • Adverse Event Report. Raspberry Ketone. Natural MedWatch, April 27, 2012.
  • Adverse Event Report. Raspberry Ketone. Natural MedWatch, September 18, 2011.
  • Beekwilder J, van der Meer IM, Sibbesen O, et al. Microbial production of natural raspberry ketone. Biotechnol J 2007;2:1270-9. View abstract.
  • Harada N, Okajima K, Narimatsu N, et al. Effect of topical application of raspberry ketone on dermal production of insulin-like growth factor-I in mice and on hair growth and skin elasticity in humans. Growth Horm IGF Res 2008;18:335-44. View abstract.
  • Lopez, H. L., Ziegenfuss, T. N., Hofheins, J. E., Habowski, S. M., Arent, S. M., Weir, J. P., and Ferrando, A. A. Eight weeks of supplementation with a multi-ingredient weight loss product enhances body composition, reduces hip and waist girth, and increases energy levels in overweight men and women. J Int Soc Sports Nutr 2013;10(1):22. View abstract.
  • Morimoto C, Satoh Y, Hara M, et al. Anti-obese action of raspberry ketone. Life Sci 2005;77:194-204. . View abstract.
  • Ogawa Y, Akamatsu M, Hotta Y, et al. Effect of essential oils, such as raspberry ketone and its derivatives, on antiandrogenic activity based on in vitro reporter gene assay. Bioorg Med Chem Lett 2010;20:2111-4. View abstract.
  • Ushiki M, Ikemoto T, Sato Y. Anti-obese activities of raspberry ketone. Aroma Research 2002;3:361.
  • Wang L, Meng X, Zhang F. Raspberry ketone protects rats fed high-fat diets against nonalcoholic steatohepatitis. J Med Food 2012;15:495-503. View abstract.
  • Feron, G., Mauvais, G., Martin, F., Semon, E., and Blin-Perrin, C. Microbial production of 4-hydroxybenzylidene acetone, the direct precursor of raspberry ketone. Lett.Appl.Microbiol. 2007;45(1):29-35. View abstract.
  • Garcia, C. V., Quek, S. Y., Stevenson, R. J., and Winz, R. A. Characterization of the bound volatile extract from baby kiwi (Actinidia arguta). J Agric.Food Chem. 8-10-2011;59(15):8358-8365. View abstract.
  • Jeong, J. B. and Jeong, H. J. Rheosmin, a naturally occurring phenolic compound inhibits LPS-induced iNOS and COX-2 expression in RAW264.7 cells by blocking NF-kappaB activation pathway. Food Chem.Toxicol. 2010;48(8-9):2148-2153. View abstract.
  • Koeduka, T., Watanabe, B., Suzuki, S., Hiratake, J., Mano, J., and Yazaki, K. Characterization of raspberry ketone/zingerone synthase, catalyzing the alpha, beta-hydrogenation of phenylbutenones in raspberry fruits. Biochem.Biophys.Res Commun. 8-19-2011;412(1):104-108. View abstract.
  • Lin, C. H., Ding, H. Y., Kuo, S. Y., Chin, L. W., Wu, J. Y., and Chang, T. S. Evaluation of in Vitro and in Vivo Depigmenting Activity of Raspberry Ketone from Rheum officinale. Int.J Mol.Sci. 2011;12(8):4819-4835. View abstract.
  • Sporstol, S. and Scheline, R. R. The metabolism of 4-(4-hydroxyphenyl)butan-2-one (raspberry ketone) in rats, guinea-pigs and rabbits. Xenobiotica 1982;12(4):249-257. View abstract.
  • Ushiki, M., Ikemoto, T., and Sato, Y. Anti-obese activities of raspberry ketone. Aroma Research 2002;3(4):361.
  • Park KS. Raspberry ketone increases both lipolysis and fatty acid oxidation in 3T3-L1 adipocytes. Planta Med 2010;76:1654-8. View abstract.
  • Adverse Event Report. Raspberry Ketone. Natural MedWatch, April 27, 2012.
  • Adverse Event Report. Raspberry Ketone. Natural MedWatch, September 18, 2011.
  • Beekwilder J, van der Meer IM, Sibbesen O, et al. Microbial production of natural raspberry ketone. Biotechnol J 2007;2:1270-9. View abstract.
  • Electronic Code of Federal Regulations. Title 21, Chapter 1, Subchapter B, Part 172: food additives permitted for direct addition to food for human consumption. Available at: https://www.ecfr.gov/cgi-bin/text-idx?SID=59189f37d05de4dda57b07856d8d56f8&mc=true&node=pt21.3.172&rgn=div5#se21.3.172_1515
  • Harada N, Okajima K, Narimatsu N, et al. Effect of topical application of raspberry ketone on dermal production of insulin-like growth factor-I in mice and on hair growth and skin elasticity in humans. Growth Horm IGF Res 2008;18:335-44. View abstract.
  • Kshatriya D, Li X, Giunta GM, et al. Phenolic-enriched raspberry fruit extract (Rubus idaeus) resulted in lower weight gain, increased ambulatory activity, and elevated hepatic lipoprotein lipase and heme oxygenase-1 expression in male mice fed a high-fat diet. Nutr Res 2019;68:19-33. doi: 10.1016/j.nutres.2019.05.005. View abstract.
  • Lopez, H. L., Ziegenfuss, T. N., Hofheins, J. E., Habowski, S. M., Arent, S. M., Weir, J. P., and Ferrando, A. A. Eight weeks of supplementation with a multi-ingredient weight loss product enhances body composition, reduces hip and waist girth, and increases energy levels in overweight men and women. J Int Soc Sports Nutr 2013;10(1):22. View abstract.
  • Mir TM, Ma G, Ali Z, Khan IA, Ashfaq MK. Effect of Raspberry Ketone on Normal, Obese and Health-Compromised Obese Mice: A Preliminary Study. J Diet Suppl 2019 Oct 11:1-16. doi: 10.1080/19390211.2019.1674996. [Epub ahead of print]. View abstract.
  • Morimoto C, Satoh Y, Hara M, et al. Anti-obese action of raspberry ketone. Life Sci 2005;77:194-204. . View abstract.
  • Ogawa Y, Akamatsu M, Hotta Y, et al. Effect of essential oils, such as raspberry ketone and its derivatives, on antiandrogenic activity based on in vitro reporter gene assay. Bioorg Med Chem Lett 2010;20:2111-4. View abstract.
  • Ushiki M, Ikemoto T, Sato Y. Anti-obese activities of raspberry ketone. Aroma Research 2002;3:361.
  • Wang L, Meng X, Zhang F. Raspberry ketone protects rats fed high-fat diets against nonalcoholic steatohepatitis. J Med Food 2012;15:495-503. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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