CAFFEIC ACID: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Caffeic acid is a type of phenolic acid found in many plants and foods, such as apples and red wine. Coffee is the main source of caffeic acid in the diet.

Caffeic acid might have antioxidant and anti-inflammatory effects. It might also have effects on the immune system.

People use caffeic acid for athletic performance, obesity, and other purposes, but there is no good scientific evidence to support these uses.

Uses & Effectiveness ?

We currently have no information for CAFFEIC ACID overview.

Side Effects

When taken by mouth: Caffeic acid is commonly consumed in foods. But there isn't enough reliable information to know if caffeic acid is safe to use as medicine or what the side effects might be.

Special Precautions and Warnings

When taken by mouth: Caffeic acid is commonly consumed in foods. But there isn't enough reliable information to know if caffeic acid is safe to use as medicine or what the side effects might be.

Pregnancy and breast-feeding: Caffeic acid is commonly consumed in foods. But there isn't enough reliable information to know if caffeic acid is safe to use as medicine when pregnant or breast-feeding. Stay on the safe side and avoid use.

Insomnia. Caffeic acid might have a mild stimulating effect that could make insomnia worse. But this effect is much less than with caffeine.

Interactions ?

Moderate Interaction

Be cautious with this combination

Medications moved by pumps in cells (Organic Anion Transporter 1 (OAT1) Substrates) interacts with CAFFEIC ACID
Some medications are moved in and out of cells by pumps. Caffeic acid might change how these pumps work and change how much medication stays in the body. In some cases, this might change the effects and side effects of a medication.
Medications moved by pumps in cells (Organic Anion Transporter 3 (OAT3) Substrates) interacts with CAFFEIC ACID
Some medications are moved in and out of cells by pumps. Caffeic acid might change how these pumps work and change how much medication stays in the body. In some cases, this might change the effects and side effects of a medication.

Minor Interaction

Be watchful with this combination

Levodopa interacts with CAFFEIC ACID
Caffeic acid might change the way the body breaks down and gets rid of levodopa. But it's not clear if this is a big concern.

Dosing

Caffeic acid is found in many plants and foods. Coffee is the biggest source of caffeic acid in the diet, but it's also found in red wine, berries, apples, olives, artichokes, and pears. As medicine, there isn't enough reliable information to know what an appropriate dose of caffeic acid might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.

View References

REFERENCES:

Chang WC, Hsieh CH, Hsiao MW, et al. Caffeic acid induces apoptosis in human cervical cancer cells through the mitochondrial pathway. Taiwan J Obstet Gynecol 2010;49:419-24. View abstract.

Chung TW, Moon SK, Chang YC, et al. Novel and therapeutic effect of caffeic acid and caffeic acid phenyl ester on hepatocarcinoma cells: complete regression of hepatoma growth and metastasis by dual mechanism. FASEB J 2004;18:1670-81. View abstract.

Dayman J, Jepson JB. The metabolism of caffeic acid in humans: the dehydroxylating action of intestinal bacteria. Biochem J 1969;113(2):11P. View abstract.

Farah A, Donangelo CM. Phenolic compounds in coffee. Braz J Plant Physiol 2006;18:23-36.

Ferreira PG, Lima MA, Bernedo-Navarro RA, et al. Stimulation of acidic reduction of nitrite to nitric oxide by soybean phenolics: possible relevance to gastrointestinal host defense. J Agric Food Chem 2011;59:5609-19. View abstract.

Ikeda K, Tsujimoto K, Uozaki M, et al. Inhibition of multiplication of herpes simplex virus by caffeic acid. Int J Mol Med 2011;28:595-8. View abstract.

Kim JH, Lee BJ, Kim JH, et al. Antiangiogenic effect of caffeic acid on retinal neovascularization. Vascul Pharmacol 2009;51:262-7. View abstract.

Nardini M, D'Aquino M, Tomassi G, et al. Inhibition of human low-density lipoprotein oxidation by caffeic acid and other hydroxycinnamic acid derivatives. Free Radic Biol Med 1995;19:541-52. View abstract.

Novaes RD, Gonçalves RV, Peluzio Mdo C, et al. 3,4-Dihydroxycinnamic acid attenuates the fatigue and improves exercise tolerance in rats. Biosci Biotechnol Biochem 2012;76:1025-7. View abstract.

Ohnishi R, Ito H, Iguchi A, et al. Effects of chlorogenic acid and its metabolites on spontaneous locomotor activity in mice. Biosci Biotechnol Biochem 2006;70:2560-3. View abstract.

Olthol MR, Hollman PCH, Katan MB. Chlorogenic acid and caffeic acid are absorbed in humans. J Nutr 2001;131:66-71. View abstract.

Renouf M, Guy PA, Marmet C, et al. Measurement of caffeic and ferulic acid equivalents in plasma after coffee consumption: small intestine and colon are key sites for coffee metabolism. Mol Nutr Food Res 2010;54:760-6. View abstract.

Shinomiya K, Omichi J, Ohnishi R, et al. Effects of chlorogenic acid and its metabolites on the sleep-wakefulness cycle in rats. Eur J Pharmacol 2004;504:185-9. View abstract.

Simonetti P, Gardana C, Pietta P. Plasma levels of caffeic acid and antioxidant status after red wine intake. J Agric Food Chem 2001;49:5964-8. View abstract.

Uwai Y, Ozeki Y, Isaka T, et al. Inhibitory effect of caffeic acid on human organic anion transporters hOAT1 and hOAT3: a novel candidate for food-drug interaction. Drug Metab Pharmacokinet 2011;26:486-93. View abstract.

Wallerath T, Li H, Godtel-Ambrust U, et al. A blend of polyphenolic compounds explains the stimulatory effect of red wine on human endothelial NO synthase. Nitric Oxide 2005;12:97-104. View abstract.

Wang LH, Hsu KY, Uang YS, et al. Caffeic acid improves the bioavailability of L-dopa in rabbit plasma. Phytother Res 2010;24:852-8. View abstract.

Chang WC, Hsieh CH, Hsiao MW, et al. Caffeic acid induces apoptosis in human cervical cancer cells through the mitochondrial pathway. Taiwan J Obstet Gynecol 2010;49:419-24. View abstract.

Dayman J, Jepson JB. The metabolism of caffeic acid in humans: the dehydroxylating action of intestinal bacteria. Biochem J 1969;113(2):11P. View abstract.

Farah A, Donangelo CM. Phenolic compounds in coffee. Braz J Plant Physiol 2006;18:23-36.

Grabska-Kobylecka I, Kaczmarek-Bak J, Figlus M, et al. The presence of caffeic acid in cerebrospinal fluid: Evidence that dietary polyphenols can cross the blood-brain barrier in humans. Nutrients. 2020;12(5):1531. View abstract.

Ikeda K, Tsujimoto K, Uozaki M, et al. Inhibition of multiplication of herpes simplex virus by caffeic acid. Int J Mol Med 2011;28:595-8. View abstract.

Kim JH, Lee BJ, Kim JH, et al. Antiangiogenic effect of caffeic acid on retinal neovascularization. Vascul Pharmacol 2009;51:262-7. View abstract.

Novaes RD, Gonçalves RV, Peluzio Mdo C, et al. 3,4-Dihydroxycinnamic acid attenuates the fatigue and improves exercise tolerance in rats. Biosci Biotechnol Biochem 2012;76:1025-7. View abstract.

Ohnishi R, Ito H, Iguchi A, et al. Effects of chlorogenic acid and its metabolites on spontaneous locomotor activity in mice. Biosci Biotechnol Biochem 2006;70:2560-3. View abstract.

Olthol MR, Hollman PCH, Katan MB. Chlorogenic acid and caffeic acid are absorbed in humans. J Nutr 2001;131:66-71. View abstract.

Paciello F, Di Pino A, Rolesi R, et al. Anti-oxidant and anti-inflammatory effects of caffeic acid: in vivo evidences in a model of noise-induced hearing loss. Food Chem Toxicol. 2020;143:111555. View abstract.

Shinomiya K, Omichi J, Ohnishi R, et al. Effects of chlorogenic acid and its metabolites on the sleep-wakefulness cycle in rats. Eur J Pharmacol 2004;504:185-9. View abstract.

Simonetti P, Gardana C, Pietta P. Plasma levels of caffeic acid and antioxidant status after red wine intake. J Agric Food Chem 2001;49:5964-8. View abstract.

Wallerath T, Li H, Godtel-Ambrust U, et al. A blend of polyphenolic compounds explains the stimulatory effect of red wine on human endothelial NO synthase. Nitric Oxide 2005;12:97-104. View abstract.

Wang LH, Hsu KY, Uang YS, et al. Caffeic acid improves the bioavailability of L-dopa in rabbit plasma. Phytother Res 2010;24:852-8. View abstract.

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.

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CAFFEIC ACID - Uses, Side Effects, and More