Bergamot oil has several active chemicals and is commonly used as aromatherapy. When applied to the skin, the chemicals in bergamot oil can make the skin sensitive to sunlight.
Bergamot is used for high levels of cholesterol or other fats in the blood. It is also used for anxiety, mental alertness, joint pain, and many other conditions, but there is no good scientific evidence to support these other uses.
Don't confuse bergamot with other citrus fruits such as bitter orange and sweet orange.
Uses & Effectiveness ?
Possibly Effective for
- High levels of cholesterol or other fats (lipids) in the blood (hyperlipidemia). Taking bergamot extract by mouth seems to lower low-density lipoprotein (LDL or "bad") cholesterol levels in people with high cholesterol. It's not clear if it helps high-density lipoprotein (HDL or "good") cholesterol or triglyceride levels.
Possibly Ineffective for
- Anxiety. Inhaling bergamot oil as aromatherapy doesn't seem to reduce anxiety in people undergoing radiation therapy.
- Mental alertness. Inhaling bergamot oil as aromatherapy doesn't seem to improve mental alertness. In fact, it might decrease mental alertness in healthy adults due to its relaxing effects.
When applied to the skin: Bergamot oil is possibly unsafe. It might harm the skin.
When inhaled: Bergamot oil is possibly safe when inhaled, short-term.
Special Precautions and Warnings
When applied to the skin: Bergamot oil is possibly unsafe. It might harm the skin.
When inhaled: Bergamot oil is possibly safe when inhaled, short-term. Pregnancy and breast-feeding: It is possibly unsafe to use bergamot oil on the skin when pregnant or breast-feeding. There isn't enough reliable information to know if bergamot is safe to take by mouth when pregnant or breastfeeding. Stay on the safe side and stick with amounts commonly found in foods.
Children: Bergamot OIL is commonly consumed in foods. But taking large amounts of bergamot oil is possibly unsafe. There have been serious side effects, including convulsion and death, in children who have taken large amounts of bergamot oil. There isn't enough reliable information to know if bergamot extract is safe to use in children.
Surgery: Bergamot might lower blood sugar and interfere with blood sugar control during surgery. Stop using bergamot at least 2 weeks before a scheduled surgery.
Medications that increase sensitivity to sunlight (Photosensitizing drugs) interacts with BERGAMOT
Some medications might make the skin more sensitive to sunlight. Bergamot might also make the skin more sensitive to sunlight. Using these products together might increase the risk of sunburn, blistering, or rashes when the skin is exposed to sunlight. Be sure to wear sunblock and protective clothing when spending time in the sun.
Medications for diabetes (Antidiabetes drugs) interacts with BERGAMOT
Bergamot might lower blood sugar levels. Taking bergamot along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.
Be cautious with this combination
Bergamot extract has most often been used by adults in doses of up to 1000 mg by mouth daily for 4-12 weeks. Speak with a healthcare provider to find out what dose might be best for a specific condition.
Chang, S. Y. [Effects of aroma hand massage on pain, state anxiety and depression in hospice patients with terminal cancer]. Taehan Kanho.Hakhoe.Chi 2008;38(4):493-502. View abstract.
Finsterer, J. Earl Grey tea intoxication. Lancet 4-27-2002;359(9316):1484. View abstract.
Girard, J., Unkovic, J., Delahayes, J., and Lafille, C. [Phototoxicity of Bergamot oil. Comparison between humans and guinea pigs]. Dermatologica 1979;158(4):229-243. View abstract.
Bode, C. W., Zager, A., and Hansel, W. Photodynamic and photo-cross-linking potential of bergamottin. Pharmazie 2005;60(1):78-79. View abstract.
Gould, A. and Martin, G. N. A good odour to breathe? The effect of pleasant ambient odour on human visual vigilance. Applied Cognitive Psychology 2001;15(2):225-232.
Gruson, L. M. and Chang, M. W. Berloque dermatitis mimicking child abuse. Arch.Pediatr.Adolesc.Med. 2002;156(11):1091-1093. View abstract.
Hansen, T. M. and Hansen, B. The effect of aromatherapy on health complaints. A randomised, controlled trial. International Journal of Essential Oil Therapeutics 2007;1(2):67-71.
Hongratanaworakit, T. Aroma-therapeutic effects of massage blended essential oils on humans. Nat.Prod.Commun. 2011;6(8):1199-1204. View abstract.
Hwang, J. H. [The effects of the inhalation method using essential oils on blood pressure and stress responses of clients with essential hypertension]. Taehan Kanho.Hakhoe.Chi 2006;36(7):1123-1134. View abstract.
Kaddu, S., Kerl, H., and Wolf, P. Accidental bullous phototoxic reactions to bergamot aromatherapy oil. J.Am.Acad.Dermatol. 2001;45(3):458-461. View abstract.
Kimura, M., Mori, T., Suzuki, H., Endo, S., and Kawano, K. EEG Changes in Odor Effects after the Stress of Long Monotonous Work. Journal of International Society of Life Information Science 2001;19(2):271-274.
Mandalari, G., Bennett, R. N., Bisignano, G., Saija, A., Dugo, G., Lo Curto, R. B., Faulds, C. B., and Waldron, K. W. Characterization of flavonoids and pectins from bergamot (Citrus bergamia Risso) peel, a major byproduct of essential oil extraction. J.Agric.Food Chem. 1-11-2006;54(1):197-203. View abstract.
Mollace, V., Sacco, I., Janda, E., Malara, C., Ventrice, D., Colica, C., Visalli, V., Muscoli, S., Ragusa, S., Muscoli, C., Rotiroti, D., and Romeo, F. Hypolipemic and hypoglycaemic activity of bergamot polyphenols: from animal models to human studies. Fitoterapia 2011;82(3):309-316. View abstract.
Morliere, P., Huppe, G., Averbeck, D., Young, A. R., Santus, R., and Dubertret, L. In vitro photostability and photosensitizing properties of bergamot oil. Effects of a cinnamate sunscreen. J.Photochem.Photobiol.B 1990;7(2-4):199-208. View abstract.
Placzek, M., Fromel, W., Eberlein, B., Gilbertz, K. P., and Przybilla, B. Evaluation of phototoxic properties of fragrances. Acta Derm.Venereol. 2007;87(4):312-316. View abstract.
Seo, J. Y. [The effects of aromatherapy on stress and stress responses in adolescents]. J Korean Acad.Nurs. 2009;39(3):357-365. View abstract.
Statti, G. A., Conforti, F., Sacchetti, G., Muzzoli, M., Agrimonti, C., and Menichini, F. Chemical and biological diversity of Bergamot (Citrus bergamia) in relation to environmental factors. Fitoterapia 2004;75(2):212-216. View abstract.
Valkova, S. UVB phototherapeutic modalities. Comparison of two treatments for chronic plaque psoriasis. Acta Dermatovenerol.Alp Panonica.Adriat. 2007;16(1):26-30. View abstract.
Walsh, D. Using aromatherapy in the management of psoriasis. Nurs.Stand. 12-18-1996;11(13-15):53-56. View abstract.
Weisenseel, P. and Woitalla, S. [Toxic mustard plaster dematitis and phototoxic dematitis after application of bergamot oil]. MMW.Fortschr.Med. 12-15-2005;147(51-52):53, 55. View abstract.
Yasui, Y. and Hirone, T. Action spectrum for bergamot-oil phototoxicity measured by sunburn cell counting. J.Dermatol. 1994;21(5):319-322. View abstract.
Young, A. R., Walker, S. L., Kinley, J. S., Plastow, S. R., Averbeck, D., Morliere, P., and Dubertret, L. Phototumorigenesis studies of 5-methoxypsoralen in bergamot oil: evaluation and modification of risk of human use in an albino mouse skin model. J.Photochem.Photobiol.B 1990;7(2-4):231-250. View abstract.
Zacher, K. D. and Ippen, H. [Contact dermatitis caused by bergamot oil]. Derm.Beruf.Umwelt. 1984;32(3):95-97. View abstract.
Zaynoun, S. T., Johnson, B. E., and Frain-Bell, W. A study of oil of bergamot and its importance as a phototoxic agent. I. Characterization and quantification of the photoactive component. Br.J.Dermatol. 1977;96(5):475-482. View abstract.
Zaynoun, S. T., Johnson, B. E., and Frain-Bell, W. A study of oil of bergamot and its importance as a phototoxic agent. II. Factors which affect the phototoxic reaction induced by bergamot oil and psoralen derivatives. Contact Dermatitis 1977;3(5):225-239. View abstract.
Bruno A, Pandolfo G, Crucitti M, Cedro C, Zoccali RA, Muscatello MRA. Bergamot Polyphenolic Fraction Supplementation Improves Cognitive Functioning in Schizophrenia: Data From an 8-Week, Open-Label Pilot Study. J Clin Psychopharmacol 2017;37(4):468-71. View abstract.
Bruno A, Pandolfo G, Crucitti M, et al. Low-Dose of Bergamot-Derived Polyphenolic Fraction (BPF) Did Not Improve Metabolic Parameters in Second Generation Antipsychotics-Treated Patients: Results from a 60-days Open-Label Study. Front Pharmacol 2017;8:197 View abstract.
Cai Y, Xing G, Shen T, Zhang S, Rao J, Shi R. Effects of 12-week supplementation of Citrus bergamia extracts-based formulation CitriCholess on cholesterol and body weight in older adults with dyslipidemia: a randomized, double-blind, placebo-controlled trial. Lipids Health Dis 2017;16(1):251. View abstract.
Cicero AFG, Fogacci F, Bove M, Giovannini M, Borghi C. Three-arm, placebo-controlled, randomized clinical trial evaluating the metabolic effect of a combined nutraceutical containing a bergamot standardized flavonoid extract in dyslipidemic overweight subjects. Phytother Res. 2019;33(8):2094-2101. View abstract.
Da Pozzo E, De Leo M, Faraone I, et al. Antioxidant and antisenescence effects of bergamot juice. Oxid Med Cell Longev. 2018;2018:9395804. View abstract.
De Leo M, Piragine E, Pirone A, et al. Protective effects of bergamot (Citrus bergamia Risso & Poiteau) juice in rats fed with high-fat diet. Planta Med. 2020;86(3):180-189. View abstract.
Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
Ferlazzo N, Cirmi S, Calapai G, Ventura-Spagnolo E, Gangemi S, Navarra M. Anti-Inflammatory Activity of Citrus bergamia Derivatives: Where Do We Stand? Molecules 2016;21(10). View abstract.
Ferro Y, Montalcini T, Mazza E, et al. Randomized clinical trial: Bergamot citrus and wild cardoon reduce liver steatosis and body weight in non-diabetic individuals aged over 50 years. Front Endocrinol (Lausanne). 2020;11:494. View abstract.
Florentin M, Liberopoulos E, Elisaf MS, Tsimihodimos V. No effect of fenugreek, bergamot and olive leaf extract on glucose homeostasis in patients with prediabetes: a randomized double-blind placebo-controlled study. Arch Med Sci Atheroscler Dis. 2019;4:e162-e166. View abstract.
Gliozzi M, Carresi C, Musolino V, et al. The effect of bergamot-derived polyphenolic fraction on LDL small dense particles and non alcoholic fatty liver disease in patients with metabolic syndrome. Advances in Biological Chemistry. 2014;4(02):129.
Gliozzi M, Walker R, Muscoli S, et al. Bergamot polyphenolic fraction enhances rosuvastatin-induced effect on LDL-cholesterol, LOX-1 expression and protein kinase B phosphorylation in patients with hyperlipidemia. Int J Cardiol 2013;170(2):140-5. View abstract.
Graham PH, Browne L, Cox H, Graham J. Inhalation aromatherapy during radiotherapy: results of a placebo-controlled double-blind randomized trial. J Clin Oncol 2003;21:2372-6. View abstract.
Hawkins JR, Weatherby N, Wrye B, Ujcich Ward KU. Bergamot aromatherapy for medical office-induced anxiety among children with an autism spectrum disorder: A randomized, controlled, blinded clinical trial. Holist Nurs Pract. 2019;33(5):285-294. View abstract.
Izzo A, D'Arienzo M, Sergiacomi P, Marrese C, Bonucci M, Riccioni C. Prospective Observational Study: The Role of a Bergamot Based Nutraceutical in Dyslipidaemia and Arthralgia for Subjects Undergoing Aromatase Inhibitors Based Therapy. Ann Med Health Sci Res 2017;7:4-9.
Mannucci C, Navarra M, Calapai F, Squeri R, Gangemi S, Calapai G. Clinical Pharmacology of Citrus bergamia: A Systematic Review. Phytother Res 2017;31(1):27-39. View abstract.
McDonnell B, Newcomb P. Trial of essential oils to improve sleep for patients in cardiac rehabilitation. J Altern Complement Med. 2019;25(12):1193-1199. View abstract.
Musolino V, Gliozzi M, Bombardelli E, et al. The synergistic effect of Citrus bergamia and Cynara cardunculus extracts on vascular inflammation and oxidative stress in non-alcoholic fatty liver disease. J Tradit Complement Med. 2020;10(3):268-274. View abstract.
Naganuma M, Hirose S, Nakayama Y, et al. A study of the phototoxicity of lemon oil. Arch Dermatol Res 1985;278:31-6. . View abstract.
Navarra M, Mannucci C, Delbò M, Calapai G. Citrus bergamia essential oil: from basic research to clinical application. Front Pharmacol 2015;6:36. View abstract.
Navarro-Triviño FJ, Jadczak P, Ruiz-Villaverde R. Allergic contact dermatitis caused by Lavandula angustifolia and cross-reaction with Citrus bergamia essential oils in an aromatherapist. Int J Dermatol. 2021;60(2):241-243. View abstract.
Ndao DH, Ladas EJ, Cheng B, Sands SA, Snyder KT, Garvin JH Jr, Kelly KM. Inhalation aromatherapy in children and adolescents undergoing stem cell infusion: results of a placebo-controlled double-blind trial. Psychooncology. 2012 Mar;21(3):247-54. doi: 10.1002/pon.1898. Epub 2010 Dec 27. View abstract.
Pasyar N, Rambod M, Araghi F. The effect of bergamot orange essence on anxiety, salivary cortisol, and alpha amylase in patients prior to laparoscopic cholecystectomy: A controlled trial study. Complement Ther Clin Pract. 2020;39:101153. View abstract.
Rombolà L, Scuteri D, Adornetto A, et al. Anxiolytic-like effects of bergamot essential oil are insensitive to flumazenil in rats. Evid Based Complement Alternat Med. 2019;2019:2156873. View abstract.
Rondanelli M, Peroni G, Riva A, et al. Bergamot phytosome improved visceral fat and plasma lipid profiles in overweight and obese class I subject with mild hypercholesterolemia: A randomized placebo controlled trial. Phytother Res. 2021;35(4):2045-2056. View abstract.
Toth PP, Patti AM, Nikolic D, et al. Bergamot reduces plasma lipids, atherogenic small dense LDL, and subclinical atherosclerosis in subjects with moderate hypercholesterolemia: A 6 months prospective study. Front Pharmacol. 2016;6:299. View abstract.
Wiebe E. A randomized trial of aromatherapy to reduce anxiety before abortion. Eff Clin Pract 2000;3(4):166-9. View abstract.
Xiong M, Li Y, Tang P, Zhang Y, Cao M, Ni J, Xing M. Effectiveness of aromatherapy massage and inhalation on symptoms of depression in Chinese community-dwelling older adults. J Altern Complement Med. 2018;24(7):717-724. View abstract.
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