Overview
Breadfruit is used for arthritis, asthma, back pain, wound healing, ear infections, and other conditions, but there is no good scientific evidence to support these uses.
How does it work ?
Uses & Effectiveness ?
Insufficient Evidence for
- Arthritis.
- Asthma.
- Back pain.
- Diabetes.
- Diarrhea.
- Fever.
- Gout.
- High blood pressure.
- Leg weakness and pain (sciatica).
- Liver disease.
- Sprains.
- Stomach pain.
- Toothache.
- Wound healing.
- Other conditions.
Side Effects
There isn't enough information available to know if breadfruit is safe as a medicine or what the side effects might be.
Special Precautions and Warnings
There isn't enough information available to know if breadfruit is safe as a medicine or what the side effects might be. Pregnancy and breast-feeding: Not enough is known about the use of breadfruit as a medicine during pregnancy and breast-feeding. Stay on the safe side and avoid use.
Bleeding disorders: There is concern that breadfruit might increase the risk of bleeding. Don't use breadfruit as a medicine if you have a bleeding disorder.
Allergies: Breadfruit might cause allergic reactions in people sensitive to bananas or Benjamin fig.
Hypotension: Breadfruit might lower blood pressure. This might cause blood pressure to drop too low in people who already have low blood pressure.
Interactions ?
Medications for high blood pressure (Antihypertensive drugs) interacts with BREADFRUIT
Breadfruit might lower blood pressure. Taking breadfruit along with medications for high blood pressure might cause your blood pressure to go too low.
Some medications for high blood pressure include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), Amlodipine (Norvasc), hydrochlorothiazide (HydroDiuril), furosemide (Lasix), and many others.Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with BREADFRUIT
Breadfruit might slow blood clotting. Taking breadfruit along with medications that also slow clotting might increase the chances of bruising and bleeding.
Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.Medications changed by the liver (Cytochrome P450 2C8 (CYP2C8) substrates) interacts with BREADFRUIT
Some medications are changed and broken down by the liver. Breadfruit might decrease how quickly the liver breaks down some medications. Taking breadfruit along with some medications that are broken down by the liver may increase the effects and side effects of some medications. Before taking breadfruit, talk to your healthcare provider if you take any medications that are changed by the liver.
Some medications that are changed by the liver include amiodarone (Cardarone), paclitaxel (Taxol), nonsteroidal anti-inflammatory drugs (NSAIDs) such as diclofenac (Voltaren) and ibuprofen (Motrin), rosiglitazone (Avandia), and others.Medications changed by the liver (Glucuronidated drugs) interacts with BREADFRUIT
Some medications are changed and broken down by the liver. Breadfruit might decrease how quickly the liver breaks down some medications. Taking breadfruit along with some medications that are broken down by the liver might increase the effects and side effects of these medications.
Some of these medications changed by the liver include acetaminophen (Tylenol, others) and oxazepam (Serax), haloperidol (Haldol), lamotrigine (Lamictal), morphine (MS Contin, Roxanol), zidovudine (AZT, Retrovir), and others.
Moderate Interaction
Be cautious with this combination
Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with BREADFRUIT
Some medications are changed and broken down by the liver. Breadfruit might decrease how quickly the liver breaks down some medications. Taking breadfruit along with some medications that are broken down by the liver might increase the effects and side effects of some medications.
Some medications that are changed by the liver include amitriptyline (Elavil), amiodarone (Cordarone), citalopram (Celexa), felodipine (Plendil), lansoprazole (Prevacid), ondansetron (Zofran), prednisone (Deltasone, Orasone), sertraline (Zoloft), sibutramine (Meridia), and many others.
Minor Interaction
Be watchful with this combination
Dosing
Adewusi SR, Orisadare BO, Oke OL. Studies on weaning diets in Nigeria: 2 protein sources. Plant Foods Hum Nutr 1992;42(2):183-192. View abstract.
Altman LJ, Zito S. W. Sterols and triterpenes from the fruit of Artocarpus altilis. Phytochemistry 1976;5:829-830.
Bahado-Singh PS, Wheatley AO, Ahmad MH, Morrison EY, Asemota HN. Food processing methods influence the glycaemic indices of some commonly eaten West Indian carbohydrate-rich foods. Br J Nutr 2006;96(3):476-481. View abstract.
Baum, H. E. The name of the breadfruit. Science 1903;18(457):439. View abstract.
Bennett FD, Nozzolillo C. How many seeds in a seeded breadfruit, Artocarpus altilis (Moraceae)? Economic Bot 1987;41(3):370-374.
Chan SC, Ko HH, Lin CN. New prenylflavonoids from Artocarpus communis. J Nat Prod 2003;66(3):427-430. View abstract.
De Greef JM, Lieutier-Colas F, Bessot JC, et al. Urticaria and rhinitis to shrubs of Ficus benjamina and breadfruit in a banana-allergic road worker: evidence for a cross-sensitization between Moracea, banana and latex. Int Arch Allergy Immunol 2001;125(2):182-184. View abstract.
Deivanai S, Subhash JB. Breadfruit (Artocarpus altilis Fosb.) - an underutilized and neglected fruit plant species. Middle East J Sci Res 2010;6(5):418-428.
Donsing P, Limpeanchob N, Viyoch J. Evaluation of the effect of Thai breadfruit's heartwood extract on melanogenesis-inhibitory and antioxidation activities. J Cosmet Sci 2008;59(1):41-58. View abstract.
Englberger L, Marks GC, Fitzgerald MH. Factors to consider in Micronesian food-based interventions: a case study of preventing vitamin A deficiency. Public Health Nutr 2004;7(3):423-431. View abstract.
Esuoso KO, Bamiro FO. Studies on the baking properties of non-wheat flours--I. Breadfruit (Artocarpus artilis). Int J Food Sci Nutr 1995;46(3):267-273. View abstract.
Fang SC, Hsu CL, Yu YS, Yen GC. Cytotoxic effects of new geranyl chalcone derivatives isolated from the leaves of Artocarpus communis in SW 872 human liposarcoma cells. J Agric Food Chem 2008;56(19):8859-8868. View abstract.
Floch H. [Nutrition in French Guiana; breeding of swine and raising of breadfruit.]. Publ Inst Pasteur Guyane Fr Inini 1955;16(383):1-6. View abstract.
Golden KD, Williams OJ. Amino acid, fatty acid, and carbohydrate content of Artocarpus altilis (breadfruit). J Chromatogr Sci 2001;39(6):243-250. View abstract.
Graham HD, Negron de Bravo E. Composition of the breadfruit. J Food Sci 1981;46(2):535.
Huang AS, Titchenal CA, Meilleur BA. Nutrient Composition of Taro Corms and Breadfruit. J Food Compost Anal 2000;13(5):859-864.
Lu Y, Sun C, Wang Y, Pan Y. Two-dimensional counter-current chromatography for the preparative separation of prenylflavonoids from Artocarpus altilis. J Chromatogr A 2007;1151(1-2):31-36. View abstract.
Oliveira C, Felix W, Moreira RA, Teixeira JA, Domingues L. Expression of frutalin, an alpha-D-galactose-binding jacalin-related lectin, in the yeast Pichia pastoris. Protein Expr Purif 2008;60(2):188-193. View abstract.
Patil AD, Freyer AJ, Killmer L, et al. A new dimeric dihydrochalcone and a new prenylated flavone from the bud covers of Artocarpus altilis: potent inhibitors of cathepsin K. J Nat Prod 2002;65(4):624-627. View abstract.
Pineau N, Pousset JL, Preud'Homme JL, Aucouturier P. Structural and functional similarities of breadfruit seed lectin and jacalin. Mol Immunol 1990;27(3):237-240. View abstract.
Ramdath DD, Isaacs RL, Teelucksingh S, Wolever TM. Glycaemic index of selected staples commonly eaten in the Caribbean and the effects of boiling v. crushing. Br J Nutr 2004;91(6):971-977. View abstract.
Rincon AM, Bou Rached L, Aragoza LE, Padilla F. [Effect of acetylation and oxidation on some properties of breadfruit (Artocarpus altilis) seed starch]. Arch Latinoam Nutr 2007;57(3):287-294. View abstract.
Rincon AM, Padilla FC. Physicochemical properties of Venezuelan breadfruit (Artocarpus altilis) starch. Arch Latinoam Nutr 2004;54(4):449-456. View abstract.
Shimizu K, Fukuda M, Kondo R, Sakai K. The 5 alpha-reductase inhibitory components from heartwood of Artocarpus incisus: structure-activity investigations. Planta Med 2000;66(1):16-19. View abstract.
Shimizu K, Kondo R, Sakai K, Lee SH, Sato H. The inhibitory components from Artocarpus incisus on melanin biosynthesis. Planta Med 1998;64(5):408-412. View abstract.
Spary E, White P. Food of paradise: Tahitian breadfruit and the autocritique of European consumption. Endeavour 2004;28(2):75-80. View abstract.
Trindade MB, Lopes JL, Soares-Costa A, et al. Structural characterization of novel chitin-binding lectins from the genus Artocarpus and their antifungal activity. Biochim Biophys Acta 2006;1764(1):146-152. View abstract.
Wang Y, Deng T, Lin L, Pan Y, Zheng X. Bioassay-guided isolation of antiatherosclerotic phytochemicals from Artocarpus altilis. Phytother Res 2006;20(12):1052-1055. View abstract.
Wang Y, Xu K, Lin L, Pan Y, Zheng X. Geranyl flavonoids from the leaves of Artocarpus altilis. Phytochemistry 2007;68(9):1300-1306. View abstract.
Washburn FL. Breadfruit in the Marquesas. Science 1924;59(1529):359-360. View abstract.
Weng JR, Chan SC, Lu YH, et al. Antiplatelet prenylflavonoids from Artocarpus communis. Phytochemistry 2006;67(8):824-829. View abstract.
Wootton M, Tumaalii F. Composition of Flours from Samoan Breadfruit. J Food Sci 2006;49(5):1396-1397.
Worrell DB, Carrington CMS, Huber DJ. Growth, maturation and ripening of breadfruit, Artocarpus altilis (Park.) Fosb. Scientia Horticult 1998;76:17-28.
Young RE, Williams LAD, Gardner MT, Fletcher CK. An extract of the leaves of the breadfruit Artocarpus altilis (parkinson) fosberg exerts a negative inotropic effect on rat myocardium. Phytother Res 2006;7(2):190-193.
Zerega NJ, Ragone D, Motley TJ. Complex origins of breadfruit (Artocarpus altilis, Moraceae): implications for human migrations in Oceania. Am J Bot 2004;91(5):760-6. View abstract.
Adewusi SR, Orisadare BO, Oke OL. Studies on weaning diets in Nigeria: 2 protein sources. Plant Foods Hum Nutr 1992;42(2):183-192. View abstract.
Altman LJ, Zito S. W. Sterols and triterpenes from the fruit of Artocarpus altilis. Phytochemistry 1976;5:829-830.
Bahado-Singh PS, Wheatley AO, Ahmad MH, Morrison EY, Asemota HN. Food processing methods influence the glycaemic indices of some commonly eaten West Indian carbohydrate-rich foods. Br J Nutr 2006;96(3):476-481. View abstract.
Baum, H. E. The name of the breadfruit. Science 1903;18(457):439. View abstract.
Bennett FD, Nozzolillo C. How many seeds in a seeded breadfruit, Artocarpus altilis (Moraceae)? Economic Bot 1987;41(3):370-374.
Chan SC, Ko HH, Lin CN. New prenylflavonoids from Artocarpus communis. J Nat Prod 2003;66(3):427-430. View abstract.
De Greef JM, Lieutier-Colas F, Bessot JC, et al. Urticaria and rhinitis to shrubs of Ficus benjamina and breadfruit in a banana-allergic road worker: evidence for a cross-sensitization between Moracea, banana and latex. Int Arch Allergy Immunol 2001;125(2):182-184. View abstract.
Deivanai S, Subhash JB. Breadfruit (Artocarpus altilis Fosb.) - an underutilized and neglected fruit plant species. Middle East J Sci Res 2010;6(5):418-428.
Donsing P, Limpeanchob N, Viyoch J. Evaluation of the effect of Thai breadfruit's heartwood extract on melanogenesis-inhibitory and antioxidation activities. J Cosmet Sci 2008;59(1):41-58. View abstract.
Englberger L, Marks GC, Fitzgerald MH. Factors to consider in Micronesian food-based interventions: a case study of preventing vitamin A deficiency. Public Health Nutr 2004;7(3):423-431. View abstract.
Esuoso KO, Bamiro FO. Studies on the baking properties of non-wheat flours--I. Breadfruit (Artocarpus artilis). Int J Food Sci Nutr 1995;46(3):267-273. View abstract.
Fang SC, Hsu CL, Yu YS, Yen GC. Cytotoxic effects of new geranyl chalcone derivatives isolated from the leaves of Artocarpus communis in SW 872 human liposarcoma cells. J Agric Food Chem 2008;56(19):8859-8868. View abstract.
Floch H. [Nutrition in French Guiana; breeding of swine and raising of breadfruit.]. Publ Inst Pasteur Guyane Fr Inini 1955;16(383):1-6. View abstract.
Golden KD, Williams OJ. Amino acid, fatty acid, and carbohydrate content of Artocarpus altilis (breadfruit). J Chromatogr Sci 2001;39(6):243-250. View abstract.
Graham HD, Negron de Bravo E. Composition of the breadfruit. J Food Sci 1981;46(2):535.
Huang AS, Titchenal CA, Meilleur BA. Nutrient Composition of Taro Corms and Breadfruit. J Food Compost Anal 2000;13(5):859-864.
Liu Y, Ragone D, Murch SJ. Breadfruit (Artocarpus altilis): a source of high-quality protein for food security and novel food products. Amino Acids. 2015;47(4):847-56. View abstract.
Lu Y, Sun C, Wang Y, Pan Y. Two-dimensional counter-current chromatography for the preparative separation of prenylflavonoids from Artocarpus altilis. J Chromatogr A 2007;1151(1-2):31-36. View abstract.
Nwokocha CR, Owu DU, McLaren M, et al. Possible mechanisms of action of the aqueous extract of Artocarpus altilis (breadfruit) leaves in producing hypotension in normotensive Sprague-Dawley rats. Pharm Biol. 2012;50(9):1096-102. View abstract.
Oliveira C, Felix W, Moreira RA, Teixeira JA, Domingues L. Expression of frutalin, an alpha-D-galactose-binding jacalin-related lectin, in the yeast Pichia pastoris. Protein Expr Purif 2008;60(2):188-193. View abstract.
Patil AD, Freyer AJ, Killmer L, et al. A new dimeric dihydrochalcone and a new prenylated flavone from the bud covers of Artocarpus altilis: potent inhibitors of cathepsin K. J Nat Prod 2002;65(4):624-627. View abstract.
Pineau N, Pousset JL, Preud'Homme JL, Aucouturier P. Structural and functional similarities of breadfruit seed lectin and jacalin. Mol Immunol 1990;27(3):237-240. View abstract.
Qu W, Liu X. Identification of cytochrome P450 isoforms involved in the metabolism of artocarpin and assessment of its drug-drug interaction. Biomed Chromatogr. 2018;32(4). View abstract.
Ramdath DD, Isaacs RL, Teelucksingh S, Wolever TM. Glycaemic index of selected staples commonly eaten in the Caribbean and the effects of boiling v. crushing. Br J Nutr 2004;91(6):971-977. View abstract.
Rincon AM, Bou Rached L, Aragoza LE, Padilla F. [Effect of acetylation and oxidation on some properties of breadfruit (Artocarpus altilis) seed starch]. Arch Latinoam Nutr 2007;57(3):287-294. View abstract.
Rincon AM, Padilla FC. Physicochemical properties of Venezuelan breadfruit (Artocarpus altilis) starch. Arch Latinoam Nutr 2004;54(4):449-456. View abstract.
Shimizu K, Fukuda M, Kondo R, Sakai K. The 5 alpha-reductase inhibitory components from heartwood of Artocarpus incisus: structure-activity investigations. Planta Med 2000;66(1):16-19. View abstract.
Shimizu K, Kondo R, Sakai K, Lee SH, Sato H. The inhibitory components from Artocarpus incisus on melanin biosynthesis. Planta Med 1998;64(5):408-412. View abstract.
Siddesha JM, Angaswamy N, Vishwanath BS. Phytochemical screening and evaluation of in vitro angiotensin-converting enzyme inhibitory activity of Artocarpus altilis leaf. Nat Prod Res. 2011;25(20):1931-40. View abstract.
Spary E, White P. Food of paradise: Tahitian breadfruit and the autocritique of European consumption. Endeavour 2004;28(2):75-80. View abstract.
Tiraravesit N, Yakaew S, Rukchay R, et al. Artocarpus altilis heartwood extract protects skin against UVB in vitro and in vivo. J Ethnopharmacol. 2015;175:153-62. View abstract.
Trindade MB, Lopes JL, Soares-Costa A, et al. Structural characterization of novel chitin-binding lectins from the genus Artocarpus and their antifungal activity. Biochim Biophys Acta 2006;1764(1):146-152. View abstract.
Wang Y, Deng T, Lin L, Pan Y, Zheng X. Bioassay-guided isolation of antiatherosclerotic phytochemicals from Artocarpus altilis. Phytother Res 2006;20(12):1052-1055. View abstract.
Wang Y, Xu K, Lin L, Pan Y, Zheng X. Geranyl flavonoids from the leaves of Artocarpus altilis. Phytochemistry 2007;68(9):1300-1306. View abstract.
Washburn FL. Breadfruit in the Marquesas. Science 1924;59(1529):359-360. View abstract.
Weng JR, Chan SC, Lu YH, et al. Antiplatelet prenylflavonoids from Artocarpus communis. Phytochemistry 2006;67(8):824-829. View abstract.
Wootton M, Tumaalii F. Composition of Flours from Samoan Breadfruit. J Food Sci 2006;49(5):1396-1397.
Worrell DB, Carrington CMS, Huber DJ. Growth, maturation and ripening of breadfruit, Artocarpus altilis (Park.) Fosb. Scientia Horticult 1998;76:17-28.
Young RE, Williams LAD, Gardner MT, Fletcher CK. An extract of the leaves of the breadfruit Artocarpus altilis (parkinson) fosberg exerts a negative inotropic effect on rat myocardium. Phytother Res 2006;7(2):190-193.
Zerega NJ, Ragone D, Motley TJ. Complex origins of breadfruit (Artocarpus altilis, Moraceae): implications for human migrations in Oceania. Am J Bot 2004;91(5):760-6. View abstract.
No related vitamins found
CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.
This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.