GLYCONUTRIENTS

OTHER NAME(S):

Ambrotose, Gluconutrientes, Glyconutriments, Manapol.<br/><br/>

Overview

Overview Information

Glyconutrients are plant sugars linked in chains. The body breaks down these sugar chains into simple sugars. The most commonly used glyconutrients contain plant sugars from aloe and larch arabinogalactan. People use these sugars to make medicine.

Glyconutrients are used for alcoholism, allergy, asthma, and many other conditions, but there is no good scientific evidence to support these uses.

How does it work?

Glyconutrients might stimulate the immune system or promote the growth of certain bacteria in the colon that are thought to be beneficial.

Uses

Uses & Effectiveness?

Insufficient Evidence for

  • Attention deficit-hyperactivity disorder (ADHD). Early research shows that taking a glyconutrient supplement for 3 weeks reduces the number and severity of ADHD symptoms and improves conduct in children with ADHD. However, taking the glyconutrient supplement for 3 more weeks in combination with a plant-based supplement plus fruits and vegetables does not improve symptoms any more.
  • Memory and thinking skills (cognitive function). Some early research shows that taking a glyconutrient supplement (Ambrotose Complex, Mannatech Inc.) for 12 weeks improves some parts of memory in middle-aged people. But taking a single glyconutrient supplement does not seem to improve memory in these people. However, taking a single dose of a glyconutrient supplement (Ambrotose Complex, Mannatech Inc.) might improve mental function in some college students.
  • A condition caused by a poor diet or the body's inability to absorb nutrients. Early research shows that taking glyconutrients (Ambrotose Complex, Mannatech Inc.) for one month improves height and weight in young children whose weight is low for their age.
  • Feelings of well-being. Early research shows that taking a glyconutrient supplement (Ambrotose Complex, Mannatech Inc.) for 12 weeks improves parts of mental well-being, such as energy, calmness, sleep quality, and concentration, in middle-aged people.
  • Allergy.
  • Alzheimer disease.
  • Lou Gehrig's disease (amyotrophic lateral sclerosis or ALS).
  • Asthma.
  • Hardening of the arteries (atherosclerosis).
  • Athletic performance.
  • Autism.
  • Cancer.
  • Cerebral palsy.
  • Chronic fatigue syndrome.
  • Common cold.
  • A type of inflammatory bowel disease (Crohn disease).
  • Cystic fibrosis.
  • Depression.
  • Down syndrome.
  • Dyslexia.
  • Fibromyalgia.
  • Hepatitis.
  • HIV/AIDS.
  • An inherited brain disorder that affects movements, emotions, and thinking (Huntington disease).
  • Fertility problems.
  • Flu.
  • Lupus.
  • An eye disease that leads to vision loss in older adults (age-related macular degeneration or AMD).
  • Multiple sclerosis (MS).
  • A group of inherited disorders that cause muscle weakness and muscle loss (muscular dystrophy).
  • An autoimmune disorder that causes muscle weakness and muscle fatigue (myasthenia gravis).
  • Parkinson disease.
  • Arthritis.
  • Stroke.
  • An inherited condition that causes destructinon of nerve cells (Tay-Sachs disease).
  • Tourette's syndrome.
  • Canker sores.
  • Dental diseases.
  • Other conditions.
More evidence is needed to rate the effectiveness of glyconutrients for these uses.

Side Effects

Side Effects & Safety

When taken by mouth: Glyconutrients are POSSIBLY SAFE when taken in doses of about 9 grams daily for 7 weeks. They can cause intestinal gas (flatulence), bloating, and thirst.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking glyconutrients if you are pregnant or breast-feeding. Stay on the safe side and avoid use.

"Auto-immune diseases" such as multiple sclerosis (MS), lupus (systemic lupus erythematosus, SLE), rheumatoid arthritis (RA), or other conditions: Glyconutrients might cause the immune system to become more active. This might increase the symptoms of auto-immune diseases. If you have an auto-immune condition, it's best to avoid using glyconutrients as medicine until more is known.

Interactions

Interactions?

We currently have no information for GLYCONUTRIENTS Interactions.

Dosing

Dosing

The appropriate dose of glyconutrients depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for glyconutrients. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

  • Haji, Faraji M. and Haji, Tarkhani A. The effect of sour tea (Hibiscus sabdariffa) on essential hypertension. J.Ethnopharmacol. 1999;65(3):231-236. View abstract.
  • Alavi A, Fraser O, Tarelli E, Bland M, Axford J. An open-label dosing study to evaluate the safety and effects of a dietary plant-derived polysaccharide supplement on the N-glycosylation status of serum glycoproteins in healthy subjects. Eur J Clin Nutr 2011;65(5):648-656. View abstract.
  • Alton G, Hasilik M, Niehues R, et al. Direct utilization of mannose for mammalian glycoprotein biosynthesis. Glycobiology 1998;8:285-95. View abstract.
  • Best T, Bryan J, Burns N. An investigation of the effects of saccharides on the memory performance of middle-aged adults. J Nutr Health Aging 2008;12(9):657-662. View abstract.
  • Best T, Kemps E, Bryan J. Perceived changes in well-being following polysaccharide intake in middle-aged adults. Applied Res Qual Life 2012;7(2):183-192.
  • Best T, Kemps E, Bryan J. Saccharide effects on cognition and well-being in middle-aged adults: a randomized controlled trial. Dev Neuropsychol 2010;35(1):66-80. View abstract.
  • Brydon WG, Merrick MV, Hannan J. Absorbed dose from 14C xylose and 14C mannose. Br J Radiol 1987;60(714):563-566. View abstract.
  • Cook GC. Rates and mechanisms of glucose, galactose, and xylose absorption in man in vivo. Scand J Gastroenterol 1977;12(6):733-737. View abstract.
  • Dawson DJ, Burrows PC, Lobley RW, Holmes R. The kinetics of monosaccharide absorption by human jejunal biopsies: evidence for active and passive processes. Digestion 1987;38(2):124-132. View abstract.
  • Dykman K, Ford CR, Gardiner T. The effect of glyconutritional supplementation on toddlers with failure to thrive. Glycoscience Nutr 2000;1(36):1-7.
  • Dykman KD, Dykman RA. Effect of nutritional supplements on attentional-deficit hyperactivity disorder. Integr Physiol Behav Sci 1998;33(1):49-60. View abstract.
  • Gauntt C, Busness D, Wood HJ, et al. A glyconutritional mixture (Ambrotose&reg;) provides some amelioration to mice with coxsackievirus-induced pancreatitis. Age (Omaha) 1999;22:149-158. View abstract.
  • Goux WJ, Boyd S, Tone CM, Ford CR, McAnalley BH. Effect of glyconutritionals on oxidative stress in human subjects: A pilot study. Glycoscience Nutr 2001;2(12):1-11.
  • Johnson SL, Mayersohn M, Conrad KA. Gastrointestinal absorption as a function of age: xylose absorption in healthy adults. Clin Pharmacol Ther 1985;38(3):331-335. View abstract.
  • Koetzner, L., Grover, G., Boulet, J., and Jacoby, H. I. Plant-derived polysaccharide supplements inhibit dextran sulfate sodium-induced colitis in the rat. Dig Dis Sci 2010;55(5):1278-1285. View abstract.
  • Lefkowitz DL, Stuart R, Gnade BT, Roberts E, Lefkowitz SS. Effects of a glyconutrient on macrophage functions. Int J Immunopharmacol 2000;22(4):299-308. View abstract.
  • Marzorati M, Verhelst A, Luta G, et al. In vitro modulation of the human gastrointestinal microbial community by plant-derived polysaccharide-rich dietary supplements. Int J Food Microbiol 2010;139(3):168-176. View abstract.
  • McAnalley B, Dykman RA, Dykman KD, Hall JE. An interpretation of the effects of a single dose of a glyconutritional supplement on the brain function of healthy college students, including a review of brainwave function. Glycoscience Nutr 2002;3(4).
  • Myers, S. P., Stevenson, L., Cheras, P. A., O'Connor, J., Brooks, L., Rolfe, M., Conellan, P., and Morris, C. A forced titration study of the antioxidant and immunomodulatory effects of Ambrotose AO supplement. BMC Complement Altern Med 2010;10:16. View abstract.
  • National Council Against Health Fraud. "Mannatech investors file class-action suits." Consumer Health Digest (Sept. 2005) Web. 1 October 2015.
  • Rolston DD, Mathan VI. Xylose transport in the human jejunum. Dig Dis Sci 1989;34(4):553-558. View abstract.
  • Schnaar RL, Freeze HH. A "glyconutrient sham". Glycobiology 2008;18(9):652-7; discussion 658-63. View abstract.
  • See DM, Cimoch P, Chou S, Chang J, Tilles J. The in vitro immunomodulatory effects of glyconutrients on peripheral blood mononuclear cells of patients with chronic fatigue syndrome. Integr Physiol Behav Sci 1998;33(3):280-287. View abstract.
  • Sierpina VS, Murray RK. Glyconutrients: the state of the science and the impact of glycomics. Explore 2006;2(6):488-494.
  • Sinnott RA, Ramberg J, Krichner JM, et al. Utilization of arabinogalactan, aloe vera gel polysaccharides, and a mixed daccharide dietary supplement by human colonic bacteria in vitro. Int J Probiotics Prebiotics 2007;2:97-104.
  • Stancil AN, Hicks LH. Glyconutrients and perception, cognition, and memory. Percept Mot Skills 2009;108(1):259-270. View abstract.
  • Talent JM, Gracy RW. Pilot study of oral polymeric N-acetyl-D-glucosamine as a potential treatment for patients with osteoarthritis. Clin Ther 1996;18(6):1184-1190. View abstract.
  • Wang C, Szabo JS, Dykman RA. Effects of a carbohydrate supplement upon resting brain activity. Integr Physiol Behav Sci 2004;39(2):126-138. View abstract.
  • Haji, Faraji M. and Haji, Tarkhani A. The effect of sour tea (Hibiscus sabdariffa) on essential hypertension. J.Ethnopharmacol. 1999;65(3):231-236. View abstract.
  • Alavi A, Fraser O, Tarelli E, Bland M, Axford J. An open-label dosing study to evaluate the safety and effects of a dietary plant-derived polysaccharide supplement on the N-glycosylation status of serum glycoproteins in healthy subjects. Eur J Clin Nutr 2011;65(5):648-656. View abstract.
  • Alton G, Hasilik M, Niehues R, et al. Direct utilization of mannose for mammalian glycoprotein biosynthesis. Glycobiology 1998;8:285-95. View abstract.
  • Best T, Bryan J, Burns N. An investigation of the effects of saccharides on the memory performance of middle-aged adults. J Nutr Health Aging 2008;12(9):657-662. View abstract.
  • Best T, Kemps E, Bryan J. Perceived changes in well-being following polysaccharide intake in middle-aged adults. Applied Res Qual Life 2012;7(2):183-192.
  • Best T, Kemps E, Bryan J. Saccharide effects on cognition and well-being in middle-aged adults: a randomized controlled trial. Dev Neuropsychol 2010;35(1):66-80. View abstract.
  • Brydon WG, Merrick MV, Hannan J. Absorbed dose from 14C xylose and 14C mannose. Br J Radiol 1987;60(714):563-566. View abstract.
  • Cook GC. Rates and mechanisms of glucose, galactose, and xylose absorption in man in vivo. Scand J Gastroenterol 1977;12(6):733-737. View abstract.
  • Dawson DJ, Burrows PC, Lobley RW, Holmes R. The kinetics of monosaccharide absorption by human jejunal biopsies: evidence for active and passive processes. Digestion 1987;38(2):124-132. View abstract.
  • Dykman K, Ford CR, Gardiner T. The effect of glyconutritional supplementation on toddlers with failure to thrive. Glycoscience Nutr 2000;1(36):1-7.
  • Dykman KD, Dykman RA. Effect of nutritional supplements on attentional-deficit hyperactivity disorder. Integr Physiol Behav Sci 1998;33(1):49-60. View abstract.
  • Gauntt C, Busness D, Wood HJ, et al. A glyconutritional mixture (Ambrotose&reg;) provides some amelioration to mice with coxsackievirus-induced pancreatitis. Age (Omaha) 1999;22:149-158. View abstract.
  • Goux WJ, Boyd S, Tone CM, Ford CR, McAnalley BH. Effect of glyconutritionals on oxidative stress in human subjects: A pilot study. Glycoscience Nutr 2001;2(12):1-11.
  • Johnson SL, Mayersohn M, Conrad KA. Gastrointestinal absorption as a function of age: xylose absorption in healthy adults. Clin Pharmacol Ther 1985;38(3):331-335. View abstract.
  • Koetzner, L., Grover, G., Boulet, J., and Jacoby, H. I. Plant-derived polysaccharide supplements inhibit dextran sulfate sodium-induced colitis in the rat. Dig Dis Sci 2010;55(5):1278-1285. View abstract.
  • Lefkowitz DL, Stuart R, Gnade BT, Roberts E, Lefkowitz SS. Effects of a glyconutrient on macrophage functions. Int J Immunopharmacol 2000;22(4):299-308. View abstract.
  • Marzorati M, Verhelst A, Luta G, et al. In vitro modulation of the human gastrointestinal microbial community by plant-derived polysaccharide-rich dietary supplements. Int J Food Microbiol 2010;139(3):168-176. View abstract.
  • McAnalley B, Dykman RA, Dykman KD, Hall JE. An interpretation of the effects of a single dose of a glyconutritional supplement on the brain function of healthy college students, including a review of brainwave function. Glycoscience Nutr 2002;3(4).
  • Myers, S. P., Stevenson, L., Cheras, P. A., O'Connor, J., Brooks, L., Rolfe, M., Conellan, P., and Morris, C. A forced titration study of the antioxidant and immunomodulatory effects of Ambrotose AO supplement. BMC Complement Altern Med 2010;10:16. View abstract.
  • National Council Against Health Fraud. "Mannatech investors file class-action suits." Consumer Health Digest (Sept. 2005) Web. 1 October 2015.
  • Roca E, Cantó E, Nescolarde L, et al. Effects of a polysaccharide-based multi-ingredient supplement on salivary immunity in non-elite marathon runners. J Int Soc Sports Nutr. 2019;16(1):14. View abstract.
  • Rolston DD, Mathan VI. Xylose transport in the human jejunum. Dig Dis Sci 1989;34(4):553-558. View abstract.
  • Schnaar RL, Freeze HH. A "glyconutrient sham" and the Jenner glycobiology and medicine symposium. Glycobiology. 2017;27(5):383-384. View abstract.
  • Schnaar RL, Freeze HH. A "glyconutrient sham". Glycobiology 2008;18(9):652-7; discussion 658-63. View abstract.
  • See DM, Cimoch P, Chou S, Chang J, Tilles J. The in vitro immunomodulatory effects of glyconutrients on peripheral blood mononuclear cells of patients with chronic fatigue syndrome. Integr Physiol Behav Sci 1998;33(3):280-287. View abstract.
  • Sierpina VS, Murray RK. Glyconutrients: the state of the science and the impact of glycomics. Explore 2006;2(6):488-494.
  • Sinnott RA, Ramberg J, Krichner JM, et al. Utilization of arabinogalactan, aloe vera gel polysaccharides, and a mixed daccharide dietary supplement by human colonic bacteria in vitro. Int J Probiotics Prebiotics 2007;2:97-104.
  • Stancil AN, Hicks LH. Glyconutrients and perception, cognition, and memory. Percept Mot Skills 2009;108(1):259-270. View abstract.
  • Talent JM, Gracy RW. Pilot study of oral polymeric N-acetyl-D-glucosamine as a potential treatment for patients with osteoarthritis. Clin Ther 1996;18(6):1184-1190. View abstract.
  • Wang C, Szabo JS, Dykman RA. Effects of a carbohydrate supplement upon resting brain activity. Integr Physiol Behav Sci 2004;39(2):126-138. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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