Overview

Hordenine is a chemical naturally found in barley (Hordeum vulgare). It can also be found in algae, cacti, and some grass species. It is similar in chemical structure to stimulants found in bitter orange. Hordenine is included in many dietary supplements used for athletic performance and weight loss.

People take hordenine by mouth for obesity and improving athletic performance, but there is no good scientific evidence to support these uses.

How does it work ?

Hordenine is similar in chemical structure to stimulants found in bitter orange. Some research shows that it might stimulate the central nervous system, and increase heart rate, blood pressure, and breathing rate. These effects seem to be short-lived and require high doses.

Uses & Effectiveness ?

Insufficient Evidence for

  • Athletic performance.
  • Obesity.
  • Other conditions.
More evidence is needed to rate hordenine for these uses.

Side Effects

When taken by mouth: Hordenine is POSSIBLY UNSAFE. Hordenine is similar in structure to stimulants found in bitter orange. In theory, hordenine might have similar stimulant effects and side effects such as rapid heart rate and high blood pressure.

Special Precautions and Warnings

When taken by mouth: Hordenine is POSSIBLY UNSAFE. Hordenine is similar in structure to stimulants found in bitter orange. In theory, hordenine might have similar stimulant effects and side effects such as rapid heart rate and high blood pressure. Pregnancy and breast-feeding: There isn't enough reliable information to know if hordenine is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

High blood pressure: Hordenine is similar to stimulants found in bitter orange. In theory, taking hordenine might make high blood pressure worse.

Kidney stones: Taking hordenine might increase the risk for kidney stones.

Surgery: Hordenine might interfere with surgery by increasing blood pressure and heart rate. Stop taking hordenine at least 2 weeks before surgery.

Interactions ?

    Moderate Interaction

    Be cautious with this combination

  • Medications for depression (MAOIs) interacts with HORDENINE

    Hordenine might stimulate the body. Some medications used for depression can increase chemicals that also have stimulant effects. Taking hordenine with these medications used for depression might cause serious side effects including fast heartbeat, high blood pressure, seizures, nervousness, and others.

    Some of these medications used for depression include isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate).

  • Stimulant drugs interacts with HORDENINE

    Stimulant drugs speed up the nervous system. By speeding up the nervous system, stimulant medications can make you feel jittery and speed up your heartbeat. Hordenine might also speed up the nervous system. In theory, taking hordenine along with stimulant drugs might cause serious problems including increased heart rate and high blood pressure. Avoid taking stimulant drugs along with hordenine.

    Some stimulant drugs include amphetamine, caffeine, methylphenidate, pseudoephedrine, and many others.

Dosing

The appropriate dose of hordenine depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for hordenine (in children/in adults). Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.