Dimethylhexylamine (DMHA) was originally used as a drug for nasal congestion. Today, DMHA is included as an ingredient in dietary supplement products to boost workout performance, "burn fat," or increase weight loss. But there's no good scientific research to support these uses.

Some products claim that DMHA comes naturally from aconite plants, but there is no clear evidence that DMHA can be found in these plants. It is likely that DMHA found in dietary supplements is made in a laboratory rather than produced from natural sources.

DMHA appears to be similar to another stimulant called dimethylamylamine (DMAA). DMAA has been removed from the market in certain countries due to safety concerns.

How does it work ?

DMHA is thought to have stimulant effects similar to decongestants such as pseudoephedrine, ephedrine, and others. Some promoters say that it is a safer alternative to ephedrine and dimethylamylamine (DMAA). However, there is no scientific evidence to back up this claim.

Uses & Effectiveness ?

Insufficient Evidence for

  • Athletic performance.
  • Weight loss.
  • Other conditions.
More evidence is needed to rate DMHA for these uses.

Side Effects

When taken by mouth: DMHA is POSSIBLY UNSAFE when taken by mouth. DMHA might have side effects similar to dimethylamylamine (DMAA), which include heart attack and death.

Special Precautions and Warnings

When taken by mouth: DMHA is POSSIBLY UNSAFE when taken by mouth. DMHA might have side effects similar to dimethylamylamine (DMAA), which include heart attack and death. Pregnancy and breast-feeding: There isn't enough reliable information to know if DMHA is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

High blood pressure: DMHA might have stimulant effects and increase blood pressure. If you have high blood pressure, avoid taking DMHA .

Glaucoma: DMHA might have stimulant effects and cause blood vessels to constrict. This could worsen some types of glaucoma. If you have glaucoma, avoid taking DMHA .

Irregular heartbeat (heart arrhythmia): DMHA might have stimulant effects and cause a rapid heartbeat. This could worsen heartarrhythmias. If you have an irregular heartbeat, avoid taking DMHA .

Surgery: DMHA might have stimulant effects, so it might interfere with surgery by increasing heart rate and blood pressure. Stop taking DMHA at least 2 weeks before a scheduled surgery.

Interactions ?

    Moderate Interaction

    Be cautious with this combination

  • Stimulant drugs interacts with DIMETHYLHEXYLAMINE (DMHA)

    Stimulant drugs speed up the nervous system. By speeding up the nervous system, stimulant medications can make you feel jittery and speed up your heartbeat. DMHA might also speed up the nervous system. Taking DMHA along with stimulant drugs might cause serious problems including increased heart rate and high blood pressure. Avoid taking stimulant drugs along with DMHA .

    Some stimulant drugs include amphetamine, caffeine, diethylpropion (Tenuate), methylphenidate, phentermine (Ionamin), pseudoephedrine (Sudafed, others), and many others.


The appropriate dose of DMHA depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for DMHA . Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.