LUPIN

OTHER NAME(S):

Altramuz Amarillo, Andean Lupin, Australian Sweet Lupin, Bitter Lupin, Blue Lupin, Hasenklee, Lupin Jaune, Lupine, Lupini Beans, Lupinus Albus, Lupinus Angustifolius, Lupinus Luteus, Lupinus Mutabilis, Narrow Leaf Lupin, Narrow Leaved Lupin, Pearl Lupin, Sweet Lupin, Sweet Tarwi, White Lupin, Yellow Lupin.

Overview

Overview Information

Altramuz Amarillo, Andean Lupin, Australian Sweet Lupin, Bitter Lupin, Blue Lupin, Hasenklee, Lupin Jaune, Lupine, Lupini Beans, Lupinus Albus, Lupinus Angustifolius, Lupinus Luteus, Lupinus Mutabilis, Narrow Leaf Lupin, Narrow Leaved Lupin, Pearl Lupin, Sweet Lupin, Sweet Tarwi, White Lupin, Yellow Lupin.

How does it work?

Lupin is a legume rich in fiber and protein. Specific ingredients in lupin might lower cholesterol and blood sugar.
Uses

Uses & Effectiveness?

Insufficient Evidence for

  • Diabetes. It is too early to know if lupin can lower blood sugar levels in people with diabetes. Some research shows that it helps, but other research does not.
  • High cholesterol. Early research shows that lupin protein and lupin fiber help to lower cholesterol. But lupin seems to be no better than milk proteins for lowering cholesterol.
  • Muscle breakdown. Early research shows that eating lupin in addition to getting electrical stimulation of the muscles and nerves can slow down the breakdown of muscle when compared with wearing a brace for 60 days. It is unclear if this effect is from the lupin or the electrical stimulation.
  • Obesity. Early research shows that replacing part of the usual diet with lupin products does not help overweight or obese patients to lose weight.
  • Bed sores (pressure ulcers).
  • Colon cancer, rectal cancer.
  • High blood pressure.
  • Infection of the intestines by parasites.
  • Infections of the kidney, bladder, or urethra (urinary tract infections or UTIs).
  • Prediabetes.
  • Other conditions.
More evidence is needed to rate lupin for these uses.

Side Effects

Side Effects & Safety

When taken by mouth: Lupin is LIKELY SAFE when used in food amounts. Processed foods containing lupin, including flour, bread, pasta, and breakfast foods, must contain less than 0.02% of toxic chemicals called quinolizidine alkaloids. When used in larger amounts as a medicine, lupin is POSSIBLY SAFE as long as the toxic alkaloid content is less than 0.02%. The most common adverse effects are gas, bloating, and stomach pain.

Lupin is LIKELY UNSAFE when products with toxic levels of alkaloids (sometimes called bitter lupin) are used. They can cause many adverse effects which can lead to breathing problems and death.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Lupin is LIKELY SAFE when used in food amounts. Processed foods containing lupin, including flour, bread, pasta, and breakfast foods, must contain less than 0.02% of toxic chemicals called quinolizidine alkaloids.

Lupin is LIKELY UNSAFE when products with toxic levels of alkaloids (sometimes called bitter lupin) are used. They can cause many adverse effects which can lead to breathing problems and death.

Children: Using lupin by mouth is LIKELY SAFE in food amounts. Processed foods containing lupin, including flour, bread, pasta, and breakfast foods, must contain less than 0.02% of toxic chemicals called quinolizidine alkaloids.

Using lupin by mouth is LIKELY UNSAFE when products with toxic levels of alkaloids (sometimes called bitter lupin) are used. They can cause many side effects which can lead to breathing problems and death. Children are more sensitive to these side effects than adults.

Allergy to peanuts or other legumes: Lupin may cause an allergic reaction in people who are sensitive to peanuts or other legumes such as soy or pea. If you have allergies to peanuts or other legumes, be sure to check with your healthcare provider before using lupin.

Interactions

Interactions?

We currently have no information for LUPIN Interactions.

Dosing

Dosing

The appropriate dose of lupin depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for lupin. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

  • Reis AM, Fernandes NP, Marques SL, et al. Lupine sensitisation in a population of 1,160 subjects. Allergol Immunopathol (Madr). 2007;35(4):162-3. View abstract.
  • Resta D, Boschin G, D'Agostina A, Arnoldi A. Evaluation of total quinolizidine alkaloids content in lupin flours, lupin-based ingredients, and foods. Mol Nutr Food Res. 2008;52(4):490-5. View abstract.
  • Shaw J, Roberts G, Grimshaw K, White S, Hourihane J. Lupin allergy in peanut-allergic children and teenagers. Allergy. 2008;63(3):370-3. View abstract.
  • Sirtori CR, Triolo M, Bosisio R, et al. Hypocholesterolaemic effects of lupin protein and pea protein/fibre combinations in moderately hypercholesterolaemic individuals. Br J Nutr 2012;107:1176-83. View abstract.
  • Skalkos S, Moschonis G, Thomas CJ, McMillan J, Kouris-Blazos A. Effect of lupin-enriched biscuits as substitute mid-meal snacks on post-prandial interstitial glucose excursions in post-surgical hospital patients with type 2 diabetes. Nutrients. 2020;12(5):1239. doi: 10.3390/nu12051239. View abstract.
  • Smith SC, Choy R, Johnson SK, Hall RS, Wildeboer-Veloo AC, Welling GW. Lupin kernel fiber consumption modifies fecal microbiota in healthy men as determined by rRNA gene fluorescent in situ hybridization. Eur J Nutr. 2006;45(6):335-41. View abstract.
  • Thambiraj SR, Phillips M, Koyyalamudi SR, Reddy N. Yellow lupin (Lupinus luteus L.) polysaccharides: Antioxidant, immunomodulatory and prebiotic activities and their structural characterisation. Food Chem. 2018;267:319-28. View abstract.
  • US Food and Drug Administration Consumer Updates. Allergies to a legume called lupin: what you need to know. 08/14/2015. https://www.fda.gov/consumers/consumer-updates/allergies-legume-called-lupin-what-you-need-know (Accessed 10/09/2020).
  • Ward NC, Mori TA, Beilin LJ, et al. The effect of regular consumption of lupin-containing foods on glycaemic control and blood pressure in people with type 2 diabetes mellitus. Food Funct. 2020;11(1):741-7. View abstract.
  • Weisse K, Brandsch C, Zernsdorf B, et al. Lupin protein compared to casein lowers the LDL cholesterol:HDL cholesterol-ratio of hypercholesterolemic adults. Eur J Nutr. 2010;49(2):65-71. View abstract.
  • Zange J, Schopen K, Albracht K, et al. Using the Hephaistos orthotic device to study countermeasure effectiveness of neuromuscular electrical stimulation and dietary lupin protein supplementation, a randomised controlled trial. PLoS One. 2017;12(2):e0171562. View abstract.
  • Bähr M, Fechner A, Kiehntopf M, Jahreis G. Consuming a mixed diet enriched with lupin protein beneficially affects plasma lipids in hypercholesterolemic subjects: a randomized controlled trial. Clin Nutr. 2015 Feb;34(1):7-14. View abstract.
  • Bähr M, Fechner A, Krämer J, Kiehntopf M, Jahreis G. Lupin protein positively affects plasma LDL cholesterol and LDL:HDL cholesterol ratio in hypercholesterolemic adults after four weeks of supplementation: a randomized, controlled crossover study. Nutr J. 2013;12:107. View abstract.
  • Ballabio C, Peñas E, Uberti F, et al. Characterization of the sensitization profile to lupin in peanut-allergic children and assessment of cross-reactivity risk. Pediatr Allergy Immunol. 2013;24(3):270-5. View abstract.
  • Belski R, Mori TA, Puddey IB, et al. Effects of lupin-enriched foods on body composition and cardiovascular disease risk factors: a 12-month randomized controlled weight loss trial. Int J Obes (Lond). 2011;35(6):810-9. View abstract.
  • Bertoglio JC, Calvo MA, Hancke JL, et al. Hypoglycemic effect of lupin seed ?-conglutin in experimental animals and healthy human subjects. Fitoterapia. 2011;82(7):933-8. View abstract.
  • Campbell CP, Jackson AS, Johnson AR, Thomas PS, Yates DH. Occupational sensitization to lupin in the workplace: occupational asthma, rhinitis, and work-aggravated asthma. J Allergy Clin Immunol. 2007;119(5):1133-9. View abstract.
  • Capraro J, Magni C, Scarafoni A, et al. Pasta supplemented with isolated lupin protein fractions reduces body weight gain and food intake of rats and decreases plasma glucose concentration upon glucose overload trial. Food Funct. 2014;5(2):375-80. View abstract.
  • Carvajal-Larenas FE, Linnemann AR, Nout MJ, Koziol M, van Boekel MA. Lupinus mutabilis: Composition, Uses, Toxicology, and Debittering. Crit Rev Food Sci Nutr. 2016;56(9):1454-87. View abstract.
  • Daverio M, Cavicchiolo ME, Grotto P, Lonati D, Cananzi M, Da Dalt L. Bitter lupine beans ingestion in a child: a disregarded cause of acute anticholinergic toxicity. Eur J Pediatr. 2014;173(12):1549-51. View abstract.
  • Di Grande A, Paradiso R, Amico S, Fulco G, Fantauzza B, Noto P. Anticholinergic toxicity associated with lupin seed ingestion: case report. Eur J Emerg Med. 2004;11(2):119-20. View abstract.
  • Dove ER, Mori TA, Chew GT, et al. Lupin and soya reduce glycaemia acutely in type 2 diabetes. Br J Nutr. 2011;106(7):1045-51. View abstract.
  • EFSA Panel on Contaminants in the Food Chain (CONTAM), Schrenk D, Bodin L, Chipman JK, et al. Scientific opinion on the risks for animal and human health related to the presence of quinolizidine alkaloids in feed and food, in particular in lupins and lupin-derived products. EFSA J. 2019;17(11):e05860. doi: 10.2903/j.efsa.2019.5860. View abstract.
  • Eguíluz Gracia I, Martínez González de Lema B, Rubio-Pérez M, et al. Allergic reaction to undeclared lupin in a chocolate. J Investig Allergol Clin Immunol. 2015;25(2):140-2. View abstract.
  • Fechner A, Fenske K, Jahreis G. Effects of legume kernel fibres and citrus fibre on putative risk factors for colorectal cancer: a randomised, double-blind, crossover human intervention trial. Nutr J. 2013;12:101. View abstract.
  • Fechner A, Kiehntopf M, Jahreis G. The formation of short-chain fatty acids is positively associated with the blood lipid-lowering effect of lupin kernel fiber in moderately hypercholesterolemic adults. J Nutr. 2014;144(5):599-607. View abstract.
  • Fornasini M, Castro J, Villacrés E, Narváez L, Villamar MP, Baldeón ME. Hypoglycemic effect of Lupinus mutabilis in healthy volunteers and subjects with dysglycemia. Nutr Hosp. 2012;27(2):425-33. View abstract.
  • Fornasini Salvador MV, Abril-Ulloa SV, Beltrán Carreño P, et al. Efficacy of a Lupinus mutabilis sweet snack as complement to conventional type 2 diabetes mellitus treatment. Nutr Hosp. 2019;36(4):905-11. doi: 10.20960/nh.02590. View abstract.
  • Frick KM, Kamphuis LG, Siddique KHM, Singh KB, Foley RC. Quinolizidine alkaloid biosynthesis in lupins and prospects for grain quality improvement. Front Plant Sci. 2017;8:87. doi: 10.3389/fpls.2017.00087. View abstract.
  • Gayraud J, Mairesse M, Fontaine JF, et al. The prevalence of sensitization to lupin flour in France and Belgium: a prospective study in 5,366 patients, by the Allergy Vigilance Network. Eur Ann Allergy Clin Immunol. 2009;41(1):17-22. View abstract.
  • Hieta N, Hasan T, Mäkinen-Kiljunen S, Lammintausta K. Lupin allergy and lupin sensitization among patients with suspected food allergy. Ann Allergy Asthma Immunol. 2009;103(3):233-7. View abstract.
  • Hodgson JM, Lee YP, Puddey IB, et al. Effects of increasing dietary protein and fibre intake with lupin on body weight and composition and blood lipids in overweight men and women. Int J Obes (Lond). 2010;34(6):1086-94. View abstract.
  • Johnson SK, Chua V, Hall RS, Baxter AL. Lupin kernel fibre foods improve bowel function and beneficially modify some putative faecal risk factors for colon cancer in men. Br J Nutr. 2006;95(2):372-8. View abstract.
  • Lee YP, Mori TA, Sipsas S, et al. Lupin-enriched bread increases satiety and reduces energy intake acutely. Am J Clin Nutr. 2006;84(5):975-80. View abstract.
  • Lima AI, Mota J, Monteiro SA, Ferreira RM. Legume seeds and colorectal cancer revisited: Protease inhibitors reduce MMP-9 activity and colon cancer cell migration. Food Chem. 2016;197(Pt A):30-8. View abstract.
  • Lindvik H, Holden L, Løvik M, Cvancarova M, Halvorsen R. Lupin sensitization and clinical allergy in food allergic children in Norway. Acta Paediatr. 2008;97(1):91-5. View abstract.
  • Litkey J, Dailey MW. Anticholinergic toxicity associated with the ingestion of lupini beans. Am J Emerg Med. 2007;25(2):215-7. View abstract.
  • Moreno-Ancillo A, Gil-Adrados AC, Domínguez-Noche C, Cosmes PM. Lupine inhalation induced asthma in a child. Pediatr Allergy Immunol. 2005;16(6):542-4. View abstract.
  • Peeters KA, Koppelman SJ, Penninks AH, et al. Clinical relevance of sensitization to lupine in peanut-sensitized adults. Allergy. 2009;64(4):549-55. View abstract.
  • Pingault NM, Gibbs RA, Barclay AM, Monaghan M. Two cases of anticholinergic syndrome associated with consumption of bitter lupin flour. Med J Aust. 2009;191(3):173-4. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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