Apple polyphenols are used for obesity, hay fever, high levels of cholesterol or other fats (lipids) in the blood (hyperlipidemia), and many other conditions, but there is no good scientific evidence to support these uses.
How does it work ?
Uses & Effectiveness ?
Insufficient Evidence for
- Male-pattern baldness (androgenic alopecia). Early research shows that applying an apple polyphenol product to the scalp can increase hair growth in some men with male-pattern baldness.
- Hay fever. Early research shows that drinking a drink with apple polyphenols reduces runny nose in people with hay fever. Other early research shows that taking apple polyphenol once daily for 12 weeks, starting about 2 weeks before cedar pollen season, can reduce sneezing in patients with a specific form of hay fever called Japanese cedar pollinosis.
- Athletic performance. Early research shows that taking apple and grape polyphenols can allow athletes to exercise for a little bit longer before getting tired.
- High levels of cholesterol or other fats (lipids) in the blood (hyperlipidemia). Early research shows that eating apples with more polyphenols does not affect cholesterol levels compared to eating apples with low polyphenols. But not all research agrees.
- High blood pressure. Early research shows that taking apple polyphenols does not seem to improve blood pressure in people with high blood pressure.
- Obesity. Early research shows that drinking a beverage with apple polyphenols can reduce the amount of body fat in adults who are overweight or obese.
Special Precautions and Warnings
We currently have no information for APPLE POLYPHENOLS overview.
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Enomoto, T., Nagasako-Akazome, Y., Kanda, T., Ikeda, M., and Dake, Y. Clinical effects of apple polyphenols on persistent allergic rhinitis: A randomized double-blind placebo-controlled parallel arm study. J Investig.Allergol.Clin Immunol. 2006;16(5):283-289. View abstract.
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Cicero AFG, Caliceti C, Fogacci F, et al. Effect of apple polyphenols on vascular oxidative stress and endothelium function: a translational study. Mol Nutr Food Res. 2017. View abstract.
Deley G, Guillemet D, Allaert FA, Babault N. An Acute Dose of Specific Grape and Apple Polyphenols Improves Endurance Performance: A Randomized, Crossover, Double-Blind versus Placebo Controlled Study. Nutrients. 2017;9(8). pii: E917. View abstract.
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Kishi K, Saito M, Saito T, et al. Clinical efficacy of apple polyphenol for treating cedar pollinosis. Biosci Biotechnol Biochem. 2005;69(4):829-32. View abstract.
Lee YC, Cheng CW, Lee HJ, Chu HC. Apple polyphenol suppresses indomethacin-induced gastric damage in experimental animals by lowering oxidative stress status and modulating the MAPK signaling pathway. J Med Food. 2017;20(11):1113-20. Erratum in: J Med Food. 2017;20(12):1250. View abstract.
Makarova E, Górnas P, Konrade I, et al. Acute anti-hyperglycaemic effects of an unripe apple preparation containing phlorizin in healthy volunteers: a preliminary study. J Sci Food Agric. 2015;95(3):560-8. View abstract.
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Saarenhovi M, Salo P, Scheinin M, et al. The effect of an apple polyphenol extract rich in epicatechin and flavan-3-ol oligomers on brachial artery flow-mediated vasodilatory function in volunteers with elevated blood pressure. Nutr. J 2017;16(1):73. View abstract.
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Shoji T, Yamada M, Miura T, et al. Chronic administration of apple polyphenols ameliorates hyperglycaemia in high-normal and borderline subjects: A randomised, placebo-controlled trial. Diabetes Res Clin Pract. 2017;129:43-51. View abstract.
Sommella E, Badolati N, Riccio G, et al. A boost in mitochondrial activity underpins the cholesterol-lowering effect of Annurca apple polyphenols on hepatic cells. Nutrients. 2019;11(1). pii: E163. View abstract.
Soriano-Maldonado A, Hidalgo M, Arteaga P, de Pascual-Teresa S, Nova E. Effects of regular consumption of vitamin C-rich or polyphenol-rich apple juice on cardiometabolic markers in healthy adults: a randomized crossover trial. Eur J Nutr. 2014 Dec;53(8):1645-57. View abstract.
Takahashi T, Kamimura A, Kagoura M, et al. Investigation of the topical application of procyanidin oligomers from apples to identify their potential use as a hair-growing agent. J Cosmet Dermatol. 2005;4(4):245-9. View abstract.
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