CARBON 60 (C60)


Carbon 60, Carbon Cage, Buckminsterfullerene, Buckyball, Fullerine C60.


Overview Information

Carbon 60 is a molecule made up of 60 carbon atoms. The layout of the atoms forms a molecule shaped like a soccer ball. Carbon 60 was first used in nanotechnology and electronics. Recently there is interest in using carbon 60 in medicine.

Carbon 60 has been used for acne, aging skin, and other conditions, but there is no good scientific evidence to support any use.

Coronavirus disease 2019 (COVID-19): There is no good evidence to support using carbon 60 for COVID-19. Follow healthy lifestyle choices and proven prevention methods instead

How does it work?

Carbon 60 is an antioxidant. Antioxidants may help protect cells from free radicals.


Uses & Effectiveness?

Insufficient Evidence for

  • Acne. Early research suggests that applying a carbon 60 gel on the skin for 8 weeks seems to improve acne.
  • Aging skin. Early research suggests that applying a carbon 60 gel on the skin for 8 weeks doesn't improve wrinkled skin in middle aged women.
More evidence is needed to rate carbon 60 for these uses.

Side Effects

Side Effects & Safety

When taken by mouth: There is not enough reliable information about the safety of taking carbon 60 by mouth. Stay on the safe side and avoid use.

When applied to the skin: Carbon 60 is POSSIBLY SAFE when applied to the skin for up to 8 weeks.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking carbon 60 if you are pregnant or breast-feeding. Stay on the safe side and avoid use.


We currently have no information for CARBON 60 (C60) Interactions.



The appropriate dose of carbon 60 depends on several factors such as the user's age, health, and several other conditions. At this time, there is not enough scientific information to determine an appropriate range of doses for carbon 60. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References


  • Torres VM, Srdjenovic B, Jacevic V, Simic VD, Djordjevic A, Simplício AL. Fullerenol C60(OH)24 prevents doxorubicin-induced acute cardiotoxicity in rats. Pharmacol Rep. 2010;62(4):707-18. View abstract.
  • Yudoh K, Karasawa R, Masuko K, Kato T. Water-soluble fullerene (C60) inhibits the development of arthritis in the rat model of arthritis. Int J Nanomedicine. 2009;4:217-25. View abstract.
  • Zhu X, Sollogoub M, Zhang Y. Biological applications of hydrophilic C60 derivatives (hC60s)- a structural perspective. Eur J Med Chem. 2016;115:438-52. View abstract.
  • Ema M, Tanaka J, Kobayashi N, et al. Genotoxicity evaluation of fullerene C60 nanoparticles in a comet assay using lung cells of intratracheally instilled rats. Regul Toxicol Pharmacol. 2012;62(3):419-24. View abstract.
  • Grebinyk A, Grebinyk S, Prylutska S, et al. C60 fullerene accumulation in human leukemic cells and perspectives of LED-mediated photodynamic therapy. Free Radic Biol Med. 2018;124:319-327. View abstract.
  • Inui S, Aoshima H, Nishiyama A, Itami S. Improvement of acne vulgaris by topical fullerene application: unique impact on skin care. Nanomedicine. 2011;7(2):238-41. View abstract.
  • Kato S, Taira H, Aoshima H, Saitoh Y, Miwa N. Clinical evaluation of fullerene-C60 dissolved in squalane for anti-wrinkle cosmetics.J Nanosci Nanotechnol. 2010 Oct;10(10):6769-74. Clinical Trial. View abstract.
  • Kolosnjaj J, Szwarc H, Moussa F. Toxicity studies of fullerenes and derivatives Adv Exp Med Biol. 2007;620:168-80. View abstract.
  • Nielsen GD, Roursgaard M, Jensen KA, Poulsen SS, Larsen ST. In vivo biology and toxicology of fullerenes and their derivatives. Basic Clin Pharmacol Toxicol. 2008;103(3):197-208. View abstract.
  • Shinohara N, Gamo M, Nakanishi J. Fullerene c60: inhalation hazard assessment and derivation of a period-limited acceptable exposure level. Toxicol Sci. 2011;123(2):576-89. View abstract.
  • Song M, Liu S, Yin J, Wang H. Interaction of human serum album and C60 aggregates in solution. Int J Mol Sci. 2011;12(8):4964-74. View abstract.
  • Song M, Yuan S, Yin J, et al. Size-dependent toxicity of nano-C60 aggregates: more sensitive indication by apoptosis-related Bax translocation in cultured human cells. Environ Sci Technol. 2012;46(6):3457-64. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
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