Overview
Manganese is the twelfth most common element on the earth's crust. In the body, it's involved in many chemical processes, including the processing of cholesterol, carbohydrates, and protein. It might also be involved in bone formation.
People use manganese for manganese deficiency. It is also used for hay fever, osteoporosis, osteoarthritis, wound healing, and many other conditions, but there is no good scientific evidence to support these uses.
Uses & Effectiveness ?
Effective for
- Manganese deficiency. Taking manganese by mouth or by IV can treat or prevent low manganese levels in the body. IV products can only be given by a healthcare provider.
Side Effects
When inhaled: Manganese is likely unsafe when used in moderate amounts, long-term. Excess manganese in the body can cause serious side effects, including poor bone health and symptoms similar to Parkinson disease, such as tremors.
Special Precautions and Warnings
When inhaled: Manganese is likely unsafe when used in moderate amounts, long-term. Excess manganese in the body can cause serious side effects, including poor bone health and symptoms similar to Parkinson disease, such as tremors.
Children: Taking manganese by mouth is likely safe for children when consumed in amounts below the daily tolerable upper intake level (UL) by age: less than 2 mg for those 1-3 years; less than 3 mg for those 4-8 years; less than 6 mg for those 9-13 years; and less than 9 mg for those 14-18 years. Taking higher doses is possibly unsafe. Manganese is also likely unsafe when inhaled by children.
Pregnancy and breast-feeding: Manganese is likely safe when taken by mouth while pregnant or breast-feeding in doses below the tolerable upper intake level (UL). This means less than 11 mg daily for those 19 years and older and less than 9 mg daily in those under 19 years-old. Manganese is possibly unsafe when taken by mouth in higher doses. Doses over 11 mg daily are more likely to cause serious side effects. Taking too much manganese might also decrease the birth size of male infants. Manganese is likely unsafe when inhaled while pregnant or breast-feeding.
Liver disease: People with long-term liver disease have trouble getting rid of manganese. Manganese can build up and cause side effects. If you have liver disease, be careful not to get too much manganese.
Iron-deficiency anemia: People with iron-deficiency anemia seem to absorb more manganese than other people. If you have this condition, be careful not to get too much manganese.
Interactions ?
Antibiotics (Quinolone antibiotics) interacts with MANGANESE
Manganese can attach to quinolone antibiotics in the stomach, decreasing the amount of antibiotics that can be absorbed by the body. This might decrease their effects. To avoid this interaction, take manganese supplements at least one hour after quinolone antibiotics.
Antibiotics (Tetracycline antibiotics) interacts with MANGANESE
Manganese can attach to tetracycline antibiotics in the stomach, decreasing the amount of antibiotics that can be absorbed by the body. This might decrease their effects. To avoid this interaction, take manganese two hours before or four hours after taking tetracyclines.
Medications for mental conditions (Antipsychotic drugs) interacts with MANGANESE
Taking certain antipsychotic drugs along with manganese might worsen side effects of manganese in some people.
Moderate Interaction
Be cautious with this combination
Dosing
As medicine, manganese has most often been used by adults in combination with other ingredients, in doses of 0.5-5.6 mg by mouth daily for up to 24 weeks. Speak with a healthcare provider to find out what dose might be best for a specific condition.
Benevolenskaia, L. I., Toroptsova, N. V., Nikitinskaia, O. A., Sharapova, E. P., Korotkova, T. A., Rozhinskaia, L. I., Marova, E. I., Dzeranova, L. K., Molitvoslovova, N. N., Men'shikova, L. V., Grudinina, O. V., Lesniak, O. M., Evstigneeva, L. P., Smetnik, V. P., Shestakova, I. G., and Kuznetsov, S. I. [Vitrum osteomag in prevention of osteoporosis in postmenopausal women: results of the comparative open multicenter trial]. Ter.Arkh. 2004;76(11):88-93. View abstract.
Davidsson, L., Cederblad, A., Lonnerdal, B., and Sandstrom, B. The effect of individual dietary components on manganese absorption in humans. Am J Clin Nutr 1991;54(6):1065-1070. View abstract.
El-Attar, M., Said, M., El-Assal, G., Sabry, N. A., Omar, E., and Ashour, L. Serum trace element levels in COPD patient: the relation between trace element supplementation and period of mechanical ventilation in a randomized controlled trial. Respirology. 2009;14(8):1180-1187. View abstract.
Finley, J. W. Manganese absorption and retention by young women is associated with serum ferritin concentration. Am J Clin Nutr 1999;70(1):37-43. View abstract.
Gerber, G. B., Leonard, A., and Hantson, P. Carcinogenicity, mutagenicity and teratogenicity of manganese compounds. Crit Rev Oncol Hematol. 2002;42(1):25-34. View abstract.
Jiang, Y. and Zheng, W. Cardiovascular toxicities upon manganese exposure. Cardiovasc.Toxicol 2005;5(4):345-354. View abstract.
Kies, C. V. Mineral utilization of vegetarians: impact of variation in fat intake. Am J Clin Nutr 1988;48(3 Suppl):884-887. View abstract.
Kim, E. A., Cheong, H. K., Joo, K. D., Shin, J. H., Lee, J. S., Choi, S. B., Kim, M. O., Lee, IuJ, and Kang, D. M. Effect of manganese exposure on the neuroendocrine system in welders. Neurotoxicology 2007;28(2):263-269. View abstract.
McMillan, D. E. A brief history of the neurobehavioral toxicity of manganese: some unanswered questions. Neurotoxicology 1999;20(2-3):499-507. View abstract.
Mehta, R. and Reilly, J. J. Manganese levels in a jaundiced long-term total parenteral nutrition patient: potentiation of haloperidol toxicity? Case report and literature review. JPEN J Parenter.Enteral Nutr 1990;14(4):428-430. View abstract.
Nemery, B. Metal toxicity and the respiratory tract. Eur Respir.J 1990;3(2):202-219. View abstract.
Salducci, J. and Planche, D. [A therapeutic trial in patients with spasmophilia]. Sem.Hop. 10-7-1982;58(36):2097-2100. View abstract.
Saudin, F., Gelas, P., and Bouletreau, P. [Trace elements in artificial nutrition. Art and practice]. Ann Fr.Anesth.Reanim. 1988;7(4):320-332. View abstract.
Wada, O. and Yanagisawa, H. [Trace elements and their physiological roles]. Nippon Rinsho 1996;54(1):5-11. View abstract.
Zenk, J. L., Helmer, T. R., Kassen, L. J., and Kuskowski, M. A. The effect of 7-KETO NATURALEAN on weight loss: a randomized, double-blind, placebo-controlled trial. Current Therapeutic Research (CURR THER RES) 2002;63(4):263-272.
Ziegler, U. E., Schmidt, K., Keller, H. P., and Thiede, A. [Treatment of chronic wounds with an alginate dressing containing calcium zinc and manganese]. Fortschr.Med Orig. 2003;121(1):19-26. View abstract.
Baker B, Ali A, Isenring L. Recommendations for manganese supplementation to adult patients receiving long-term home parenteral nutrition: an analysis of the supporting evidence. Nutr Clin Pract 2016;31(2):180-5. doi: 10.1177/0884533615591600. View abstract.
Barrington WW, Angle CR, Willcockson NK, et al. Autonomic function in manganese alloy workers. Environ Res 1998;78:50-8. View abstract.
Das A Jr, Hammad TA. Efficacy of a combination of FCHG49 glucosamine hydrochloride, TRH122 low molecular weight sodium chondroitin sulfate and manganese ascorbate in the management of knee osteoarthritis. Osteoarthritis Cartilage 2000;8:343-50. View abstract.
Dobson AW, Erikson KM, Aschner M. Manganese neurotoxicity. Ann N Y Acad Sci 2004;1012:115-28. View abstract.
Drug Facts and Comparisons. Olin BR, ed. St. Louis, MO: Facts and Comparisons. (updated monthly).
Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002. Available at: www.nap.edu/books/0309072794/html/.
Freeland-Graves JH, Lin PH. Plasma uptake of manganese as affected by oral loads of manganese, calcium, milk, phosphorus, copper, and zinc. J Am Coll Nutr 1991;10:38-43. View abstract.
Freeland-Graves JH, Turnlund JR. Deliberations and evaluations of the approaches, endpoints and paradigms for manganese and molybdenum dietary recommendations. J Nutr 1996;126:2435S-40S. View abstract.
Freeland-Graves JH. Manganese: an essential nutrient for humans. Nutr Today 1988;23:13-9.
Grasso M, de Vincentiis M, Agolli G, Cilurzo F, Grasso R. The effectiveness of long-term course of Sterimar Mn nasal spray for treatment of the recurrence rates of acute allergic rhinitis in patients with chronic allergic rhinitis. Drug Des Devel Ther 2018;12:705-9. doi: 10.2147/DDDT.S145173. View abstract.
Hansten PD, Horn JR. Hansten and Horn's Drug Interactions Analysis and Management. Vancouver, CAN:Appl Therapeut, 1999.
Hauser RA, Zesiewicz TA, Martinez C, et al. Blood manganese correlates with brain magnetic resonance imaging changes in patients with liver disease. Can J Neurol Sci 1996;23:95-8. View abstract.
Ho CSH, Ho RCM, Quek AML. Chronic manganese toxicity associated with voltage-gated potassium channel complex antibodies in a relapsing neuropsychiatric disorder. Int J Environ Res Public Health 2018;15(4). pii: E783. doi: 10.3390/ijerph15040783. View abstract.
Kresovich JK, Bulka CM, Joyce BT, et al. The inflammatory potential of dietary manganese in a cohort of elderly men. Biol Trace Elem Res 2018;183(1):49-57. doi: 10.1007/s12011-017-1127-7. View abstract.
Krieger D, Krieger S, Jansen O, et al. Manganese and chronic hepatic encephalopathy. Lancet 1995;346:270-4. View abstract.
Lee JW. Manganese intoxication. Arch Neurol 2000;57:597-9.. View abstract.
Leffler CT, Philippi AF, Leffler SG, et al. Glucosamine, chondroitin, and manganese ascorbate for degenerative joint disease of the knee or low back: a randomized, double-blind, placebo-controlled pilot study. Mil Med 1999;164:85-91. View abstract.
Li D, Ge X, Liu Z, et al. Association between long-term occupational manganese exposure and bone quality among retired workers. Environ Sci Pollut Res Int 2020;27(1):482-9. View abstract.
Martin KV, Sucharew H, Dietrich KN, et al. Co-exposure to manganese and lead and pediatric neurocognition in East Liverpool, Ohio. Environ Res 2021;202:111644. View abstract.
Moghissi KS. Risks and benefits of nutritional supplements during pregnancy. Obstet Gynecol 1981;58:68S-78S. View abstract.
O'Dell BL. Mineral interactions relevant to nutrient requirements. J Nutr 1989;119:1832-8. View abstract.
Penland JG, Johnson PE. Dietary calcium and manganese effects on menstrual cycle symptoms. Am J Obstet Gynecol 1993;168:1417-23. View abstract.
Powers KM, Smith-Weller T, Franklin GM, et al. Parkinson's disease risks associated with dietary iron, manganese, and other nutrient intakes. Neurology 2003;60:1761-6.. View abstract.
Racette BA, Nelson G, Dlamini WW, et al. Depression and anxiety in a manganese-exposed community. Neurotoxicology 2021;85:222-33. View abstract.
Randhawa, R. K. and Kawatra, B. L. Effect of dietary protein on the absorption and retention of Zn, Fe, Cu and Mn in pre-adolescent girls. Nahrung 1993;37(4):399-407. View abstract.
Rivera JA, González-Cossío T, Flores M, et al. Multiple micronutrient supplementation increases the growth of Mexican infants. Am J Clin Nutr. 2001 Nov;74:657-63. View abstract.
Ruiz-Azcona L, Fernández-Olmo I, Expósito A, et al. Impact of environmental airborne manganese exposure on cognitive and motor functions in adults: a systematic review and meta-analysis. Int J Environ Res Public Health 2021;18(8):4075. View abstract.
Schuh MJ. Possible Parkinson's disease induced by chronic manganese supplement ingestion. Consult Pharm. 2016;31(12):698-703. doi: 10.4140/TCP.n.2016.698. View abstract.
Strause L, Saltman P, Smith KT, et al. Spinal bone loss in postmenopausal women supplemented with calcium and trace minerals. J Nutr 1994;124:1060-4. View abstract.
Vanek VW, Borum P, Buchman A, et al. A.S.P.E.N. position paper: recommendations for changes in commercially available parenteral multivitamin and multi-trace element products. Nutr Clin Pract. 2012;27:440-491.doi: 10.1177/0884533612446706 View abstract.
Yamamoto M, Sakurai K, Eguchi A, et al.; Japan Environment and Children's Study Group: Association between blood manganese level during pregnancy and birth size: the Japan environment and children's study (JECS). Environ Res 2019;172:117-26. View abstract.
Young DS. Effects of Drugs on Clinical Laboratory Tests 4th ed. Washington: AACC Press, 1995.
Zhou JR, Erdman JW Jr. Phytic acid in health and disease. Crit Rev Food Sci Nutr 1995;35:495-508. View abstract.
Select a condition to view a list of vitamins
You Might Also Like
CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.
This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.