MANGANESE

OTHER NAME(S):

Aminoate de Manganèse, Ascorbate de Manganèse, Chlorure de Manganèse, Citrate de Manganèse, Complexe Aspartate de Manganèse, Dioxyde de Manganèse, Gluconate de Manganèse, Glycérophosphate de Manganèse, Manganèse, Manganese Amino Acid Chelate, Manganese Aminoate, Manganese Ascorbate, Manganese Aspartate Complex, Manganese Chloride, Manganese Chloridetetrahydrate, Manganese Citrate, Manganese Dioxide, Manganese Gluconate, Manganese Glycerophosphate, Manganese Sulfate, Manganese Sulfate Monohydrate, Manganese Sulfate Tetrahydrate, Manganeso, Manganum, Mn, Monohydrate de Sulfate de Manganèse, Sulfate de Manganèse.<br/><br/>

Overview

Overview Information

Manganese is a mineral that is found in several foods including nuts, legumes, seeds, tea, whole grains, and leafy green vegetables. It is considered an essential nutrient, because the body requires it to function properly. People use manganese as medicine.

Manganese is taken by mouth for prevention and treatment of manganese deficiency, a condition in which the body doesn’t have enough manganese. It is also used for weak bones (osteoporosis), painful joints (osteoarthritis), a type of “tired blood” (anemia), weight loss, and symptoms of premenstrual syndrome (PMS).

Manganese is used by IV for manganese deficiency, chronic obstructive pulmonary disease (COPD), and as a trace element in total parenteral nutrition (TPN) preparations.

Manganese is applied to the skin for wound healing.

Look out for manganese that is “hidden” in some supplements. Certain supplements, including those commonly used for osteoarthritis (e.g., Cosamin DS), contain manganese. When using these products, it’s important to follow label directions carefully. At doses slightly higher than the recommended dose, these products provide more than the Tolerable Upper Limit (UL) for adults, 11 mg of manganese per day. Consuming more than 11 mg per day of manganese could cause serious and harmful side effects.

How does it work?

Manganese is an essential nutrient involved in many chemical processes in the body, including processing of cholesterol, carbohydrates, and protein. It might also be involved in bone formation.

Uses

Uses & Effectiveness?

Effective for

  • Low manganese levels in the body (manganese deficiency). Taking manganese by mouth or giving manganese intravenously (by IV) helps to treat or prevent low manganese levels in the body. Also, taking manganese by mouth along with other vitamins and minerals can promote growth in children who have low levels of manganese.

Insufficient Evidence for

  • Complications of lung disease (chronic obstructive pulmonary disease, COPD). Early research suggests that giving manganese, selenium, and zinc intravenously (by IV) may help people with worsened COPD to breathe on their own without help from a machine sooner.
  • Osteoarthritis. Taking a specific product containing manganese, glucosamine hydrochloride, and chondroitin sulfate by mouth for 4 months improves pain and the ability to do normal activities in people with osteoarthritis of the knee and the lower back. However, many studies show that taking glucosamine plus chondroitin without manganese can help treat osteoarthritis. Therefore, the effects of manganese are unclear.
  • Weak bones (osteoporosis). Taking manganese by mouth in combination with calcium, zinc, and copper seems to help reduce spinal bone loss in older women. Also, taking a specific product containing manganese, calcium, vitamin D, magnesium, zinc, copper, and boron for one year seems to improve bone mass in women with weak bones. However, many studies show that taking calcium plus vitamin D without manganese can help treat osteoporosis. Therefore, the effects of manganese are unclear.
  • Premenstrual syndrome (PMS). Early research shows that taking manganese along with calcium helps improve symptoms of PMS, including pain, crying, loneliness, anxiety, restlessness, irritability, mood swings, depression, and tension. Researchers aren’t sure whether the improvement is due to the calcium, manganese, or the combination.
  • Weight loss. Early research shows that taking a specific product containing manganese, 7-oxo-DHEA, L-tyrosine, asparagus root extract, choline bitartrate, inositol, copper gluconate, and potassium iodide by mouth for 8 weeks can slightly reduce weight in overweight people.
  • Wound healing. Early research shows that applying a dressing containing manganese, calcium, and zinc to chronic wounds for 12 weeks may improve wound healing.
  • Anemia.
  • Other conditions.
More evidence is needed to rate the effectiveness of manganese for these uses.

Side Effects

Side Effects & Safety

Manganese is LIKELY SAFE for most adults when taken by mouth in amounts up to 11 mg per day. However, people who have trouble getting rid of manganese from the body, such as people with liver disease, may experience side effects when taking less than 11 mg per day.

Taking more than 11 mg per day by mouth is POSSIBLY UNSAFE for most adults.

Manganese is LIKELY UNSAFE when inhaled by adults for long periods of time. Excess manganese in the body can cause serious side effects, including symptoms resembling Parkinson's disease, such as shaking (tremors).

Special Precautions & Warnings:

Children: Taking manganese by mouth is LIKELY SAFE for children 1 to 3 years in amounts less than 2 mg per day; for children 4 to 8 years in amounts less than 3 mg per day; in children 9 to 13 years, less than 6 mg per day; and in children 14 to 18 years, less than 9 mg per day. Manganese in higher doses than described is POSSIBLY UNSAFE. Talk with your healthcare professional before giving manganese to children. High doses of manganese might cause serious side effects. Manganese is LIKELY UNSAFE when inhaled by children.

Pregnancy and breast-feeding: Manganese is LIKELY SAFE in pregnant or breast-feeding adult women aged 19 or older when taken by mouth in doses of less than 11 mg per day. However, pregnant and lactating women under age 19 should limit doses to less than 9 mg per day. Manganese is POSSIBLY UNSAFE when taken by mouth in higher doses. Doses over 11 mg per day are more likely to cause serious side effects. Manganese is LIKELY UNSAFE when inhaled for long periods of time.

Long-term liver disease: People with long-term liver disease have trouble getting rid of manganese. Manganese can build up in these people and cause shaking, mental problems such as psychosis, and other side effects. If you have liver disease, be careful not to get too much manganese.

Iron-deficiency anemia: People with iron-deficiency anemia seem to absorb more manganese than other people. If you have this condition, be careful not to get too much manganese.

Nutrition that is given intravenously (by IV). People who receive nutrition intravenously (by IV) are at an increased risk of side effects due to manganese.

Interactions

Interactions?

Moderate Interaction

Be cautious with this combination

!

  • Antibiotics (Quinolone antibiotics) interacts with MANGANESE

    Manganese might decrease how much antibiotic the body absorbs. Taking manganese along with some antibiotics might decrease the effectiveness of some antibiotics. To avoid this interaction take manganese supplements at least one hour after antibiotics.<br /><br /> Some of these antibiotics that might interact with manganese include ciprofloxacin (Cipro), enoxacin (Penetrex), norfloxacin (Chibroxin, Noroxin), sparfloxacin (Zagam), trovafloxacin (Trovan), and grepafloxacin (Raxar).

  • Antibiotics (Tetracycline antibiotics) interacts with MANGANESE

    Manganese can attach to tetracyclines in the stomach. This decreases the amount of tetracyclines that can be absorbed. Taking manganese with tetracyclines might decrease the effectiveness of tetracyclines. To avoid this interaction take manganese two hours before or four hours after taking tetracyclines.<br /><br /> Some tetracyclines include demeclocycline (Declomycin), minocycline (Minocin), and tetracycline (Achromycin).

Dosing

Dosing

The following doses have been studied in scientific research:

ADULTS
BY MOUTH:

  • General: No recommended dietary allowances (RDA) for manganese have been established. When there are no RDAs for a nutrient, the Adequate Intake (AI) is used as a guide. The AI is the estimated amount of the nutrient that is used by a group of healthy people and assumed to be adequate. The daily Adequate Intake (AI) levels for manganese are: infants birth to 6 months, 3 mcg; 7 to 12 months, 600 mcg; children 1 to 3 years, 1.2 mg; 4 to 8 years 1.5 mg; boys 9 to 13 years, 1.9 mg; boys 14 to 18 years, 2.2 mg; girls 9 to 18 years, 1.6 mg; men age 19 and older, 2.3 mg; women 19 and older, 1.8 mg; pregnant women age 14 to 50, 2 mg; breastfeeding women, 2.6 mg.
  • Tolerable Upper Intake Levels (UL), the highest level of intake at which unwanted side effects are not expected, for manganese have been established. The daily ULs for manganese are: children 1 to 3 years, 2 mg; 4 to 8 years, 3 mg; 9 to 13 years, 6 mg; 14 to 18 years (including pregnant and breastfeeding women), 9 mg; for adults 19 years and older (including pregnant and breast-feeding women), 11 mg.
BY IV:
  • For low manganese levels in the body (manganese deficiency): For preventing manganese deficiency in adults, total parenteral nutrition containing 200 mcg of elemental manganese per day has been used.
CHILDREN
BY MOUTH:
  • General: No recommended dietary allowances (RDA) for manganese have been established. When there are no RDAs for a nutrient, the Adequate Intake (AI) is used as a guide. The AI is the estimated amount of the nutrient that is used by a group of healthy people and assumed to be adequate. In infants and children, the daily Adequate Intake (AI) levels for manganese are: infants birth to 6 months, 3 mcg; 7 to 12 months, 600 mcg; children 1 to 3 years, 1.2 mg; 4 to 8 years 1.5 mg; boys 9 to 13 years, 1.9 mg; boys 14 to 18 years, 2.2 mg; and girls 9 to 18 years, 1.6 mg. Tolerable Upper Intake Levels (UL), the highest level of intake at which unwanted side effects are not expected, for manganese have been established. The daily ULs for manganese for children are: children 1 to 3 years, 2 mg; 4 to 8 years, 3 mg; 9 to 13 years, 6 mg; and 14 to 18 years (including pregnant and breastfeeding women), 9 mg.
BY IV:
  • For low manganese levels in the body (manganese deficiency): For preventing manganese deficiency in children, total parenteral nutrition containing 2-10 mcg of elemental manganese per day has been used.

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View References

REFERENCES:

  • Freeland-Graves JH, Lin PH. Plasma uptake of manganese as affected by oral loads of manganese, calcium, milk, phosphorus, copper, and zinc. J Am Coll Nutr 1991;10:38-43. View abstract.
  • Freeland-Graves JH, Turnlund JR. Deliberations and evaluations of the approaches, endpoints and paradigms for manganese and molybdenum dietary recommendations. J Nutr 1996;126:2435S-40S. View abstract.
  • Freeland-Graves JH. Manganese: an essential nutrient for humans. Nutr Today 1988;23:13-9.
  • Greger JL. Dietary standards for manganese: overlap between nutritional and toxicological studies. J Nutr 1998;128:368S-71S. View abstract.
  • Hansten PD, Horn JR. Hansten and Horn's Drug Interactions Analysis and Management. Vancouver, CAN:Appl Therapeut, 1999.
  • Benevolenskaia, L. I., Toroptsova, N. V., Nikitinskaia, O. A., Sharapova, E. P., Korotkova, T. A., Rozhinskaia, L. I., Marova, E. I., Dzeranova, L. K., Molitvoslovova, N. N., Men'shikova, L. V., Grudinina, O. V., Lesniak, O. M., Evstigneeva, L. P., Smetnik, V. P., Shestakova, I. G., and Kuznetsov, S. I. [Vitrum osteomag in prevention of osteoporosis in postmenopausal women: results of the comparative open multicenter trial]. Ter.Arkh. 2004;76(11):88-93. View abstract.
  • Davidsson, L., Cederblad, A., Lonnerdal, B., and Sandstrom, B. The effect of individual dietary components on manganese absorption in humans. Am J Clin Nutr 1991;54(6):1065-1070. View abstract.
  • El-Attar, M., Said, M., El-Assal, G., Sabry, N. A., Omar, E., and Ashour, L. Serum trace element levels in COPD patient: the relation between trace element supplementation and period of mechanical ventilation in a randomized controlled trial. Respirology. 2009;14(8):1180-1187. View abstract.
  • Finley, J. W. Manganese absorption and retention by young women is associated with serum ferritin concentration. Am J Clin Nutr 1999;70(1):37-43. View abstract.
  • Gerber, G. B., Leonard, A., and Hantson, P. Carcinogenicity, mutagenicity and teratogenicity of manganese compounds. Crit Rev Oncol Hematol. 2002;42(1):25-34. View abstract.
  • Jiang, Y. and Zheng, W. Cardiovascular toxicities upon manganese exposure. Cardiovasc.Toxicol 2005;5(4):345-354. View abstract.
  • Kies, C. V. Mineral utilization of vegetarians: impact of variation in fat intake. Am J Clin Nutr 1988;48(3 Suppl):884-887. View abstract.
  • Kim, E. A., Cheong, H. K., Joo, K. D., Shin, J. H., Lee, J. S., Choi, S. B., Kim, M. O., Lee, IuJ, and Kang, D. M. Effect of manganese exposure on the neuroendocrine system in welders. Neurotoxicology 2007;28(2):263-269. View abstract.
  • McMillan, D. E. A brief history of the neurobehavioral toxicity of manganese: some unanswered questions. Neurotoxicology 1999;20(2-3):499-507. View abstract.
  • Mehta, R. and Reilly, J. J. Manganese levels in a jaundiced long-term total parenteral nutrition patient: potentiation of haloperidol toxicity? Case report and literature review. JPEN J Parenter.Enteral Nutr 1990;14(4):428-430. View abstract.
  • Nemery, B. Metal toxicity and the respiratory tract. Eur Respir.J 1990;3(2):202-219. View abstract.
  • Salducci, J. and Planche, D. [A therapeutic trial in patients with spasmophilia]. Sem.Hop. 10-7-1982;58(36):2097-2100. View abstract.
  • Zenk, J. L., Helmer, T. R., Kassen, L. J., and Kuskowski, M. A. The effect of 7-KETO NATURALEAN on weight loss: a randomized, double-blind, placebo-controlled trial. Current Therapeutic Research (CURR THER RES) 2002;63(4):263-272.
  • Ziegler, U. E., Schmidt, K., Keller, H. P., and Thiede, A. [Treatment of chronic wounds with an alginate dressing containing calcium zinc and manganese]. Fortschr.Med Orig. 2003;121(1):19-26. View abstract.
  • Barrington WW, Angle CR, Willcockson NK, et al. Autonomic function in manganese alloy workers. Environ Res 1998;78:50-8. View abstract.
  • Chalmin E, Vignaud C, Salomon H, et al. Minerals discovered in Paleolithic black pigments by transmission electron microscopy and micro-X-ray absorption near-edge structure. Applied Physics A 2006;83(2):213-8.
  • Dobson AW, Erikson KM, Aschner M. Manganese neurotoxicity. Ann N Y Acad Sci 2004;1012:115-28. View abstract.
  • Drug Facts and Comparisons. Olin BR, ed. St. Louis, MO: Facts and Comparisons. (updated monthly).
  • Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002. Available at: www.nap.edu/books/0309072794/html/.
  • Hauser RA, Zesiewicz TA, Martinez C, et al. Blood manganese correlates with brain magnetic resonance imaging changes in patients with liver disease. Can J Neurol Sci 1996;23:95-8. View abstract.
  • Krieger D, Krieger S, Jansen O, et al. Manganese and chronic hepatic encephalopathy. Lancet 1995;346:270-4. View abstract.
  • Lee JW. Manganese intoxication. Arch Neurol 2000;57:597-9.. View abstract.
  • Manganese. Clinical Pharmacology Web site. Available at: http://www.clinicalpharmacology-ip.com/ [subscription required]. Updated April 14, 2003.
  • Moghissi KS. Risks and benefits of nutritional supplements during pregnancy. Obstet Gynecol 1981;58:68S-78S. View abstract.
  • O'Dell BL. Mineral interactions relevant to nutrient requirements. J Nutr 1989;119:1832-8. View abstract.
  • Penland JG, Johnson PE. Dietary calcium and manganese effects on menstrual cycle symptoms. Am J Obstet Gynecol 1993;168:1417-23. View abstract.
  • Powers KM, Smith-Weller T, Franklin GM, et al. Parkinson's disease risks associated with dietary iron, manganese, and other nutrient intakes. Neurology 2003;60:1761-6.. View abstract.
  • Randhawa, R. K. and Kawatra, B. L. Effect of dietary protein on the absorption and retention of Zn, Fe, Cu and Mn in pre-adolescent girls. Nahrung 1993;37(4):399-407. View abstract.
  • Rivera JA, González-Cossío T, Flores M, et al. Multiple micronutrient supplementation increases the growth of Mexican infants. Am J Clin Nutr. 2001 Nov;74:657-63. View abstract.
  • Sayre EV, Smith RW. Compositional categories of ancient glass. Science 1961;133(3467):1824-6. View abstract.
  • Strause L, Saltman P, Smith KT, et al. Spinal bone loss in postmenopausal women supplemented with calcium and trace minerals. J Nutr 1994;124:1060-4. View abstract.
  • Young DS. Effects of Drugs on Clinical Laboratory Tests 4th ed. Washington: AACC Press, 1995.
  • Zhou JR, Erdman JW Jr. Phytic acid in health and disease. Crit Rev Food Sci Nutr 1995;35:495-508. View abstract.

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