MAGNOLIA

OTHER NAME(S):

Beaver Tree, Bourgeon Floral de Magnolia, Buergeria salicifolia, Chuan houpu, Cortex Magnoliae Officinalis, Flos Magnoliae, Ho-No-Ki, Holly Bay, Hou Po, Hou Po Hua, Houpohua, Houpo, Houpu, Indian Bark, Japanese whitebark, Koboku, Magnolia, Magnolia Bark, Magnolia biondii, Magnolia conspicua, Magnolia denudata, Magnolia emargenata, Magnolia fargesii, Magnolia Flower Bud, Magnolia glauca, Magnolia heptaperta, Magnolia hypoleuca, Magnolia nicholsoniana, Magnolia obovate, Magnolia officinalis, Magnolia proctoriana, Magnolia Rouge, Magnolia salicifolia, Magnolia sargentiana, Magnolia sprengeri, Magnolia taliensis, Magnolia virginiana, Magnolia wilsonii, Magnolia yulan, Red Bay, Red Magnolia, Swamp Laurel, Swamp Sassafras, Sweet Bay, Tuhoupu, White Bay, White Laurel, Xin Ye Hua, Xin Yi Hua, Xinyi, Xinyihua.<br/><br/>

Overview

Overview Information

Magnolia is a plant. People use the bark and flower buds to make medicine.

People use magnolia for conditions including weight loss, stress, gingivitis, plaque, and other conditions, but there is no good scientific evidence to support most of these uses.

How does it work?

Magnolia seems to have anxiety-reducing activity. It might also increase steroid production by the body to treat asthma. Chemicals in magnolia might kill bacteria in the mouth. This might help to prevent cavities or reduce the swelling of gums. Most research on magnolia has been in laboratories.

Uses

Uses & Effectiveness?

Possibly Effective for

  • Gum inflammation (gingivitis). Chewing gum or using a toothpaste containing magnolia extract seems to reduce the swelling and bleeding of gums.

Insufficient Evidence for

  • Anxiety. Research shows that taking a specific product containing extracts of magnolia plus phellodendron reduces some negative feelings of anxiety caused by stress, such as tension or nervousness. But taking this product doesn't seem to improve long-standing feelings of anxiety due to stress.
  • Dental plaque. Using a toothpaste containing magnolia extract and xylitol might reduce the severity of dental plaque by a small amount.
  • Menopausal symptoms. Early research shows that taking a specific product containing magnolia, soy, and other natural products decreases hot flashes and improves sleep quality compared to taking soy alone.
  • Stress. Early research shows that taking a specific product containing extracts of magnolia plus phellodendron improves mood and decreases stress in people with mental stress.
  • Weight loss. So far, there isn't much evidence that magnolia causes weight loss. There is some research showing that overweight women who take a specific product containing a combination of extracts of magnolia plus phellodendron don't gain as much weight as other women. They seem to eat fewer calories, possibly because the magnolia reduces their stress-related eating. But there is no reliable evidence that taking this product actually causes weight loss.
  • Common cold.
  • Depression.
  • Diabetes.
  • Digestion problems.
  • Facial dark spots.
  • Headache.
  • High cholesterol levels in the blood.
  • Nasal congestion.
  • Runny nose.
  • Toothaches.
  • Other conditions.
More evidence is needed to rate the effectiveness of magnolia for these uses.

Side Effects

Side Effects & Safety

Magnolia is POSSIBLY SAFE for most people when taken by mouth or applied as a toothpaste, short-term. Magnolia has been taken by mouth for up to one year and used in a toothpaste for up to 6 months. Some people may develop skin rashes when magnolia is applied to the skin.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Taking magnolia flower bud by mouth is UNSAFE during pregnancy. There are reports that magnolia can cause the uterus to contract and that might cause a miscarriage. Not enough is known about the safety of using magnolia bark during pregnancy. Stay on the safe side and avoid use.

Not enough is known about the safety of using magnolia during breast-feeding. Stay on the safe side and avoid use.

Surgery: Magnolia can slow down the central nervous system. There is a concern that it might slow down the nervous system too much when combined with anesthesia and other medications used during and after surgery. Magnolia might also slow blood clotting and cause bleeding during and after surgery. Stop using magnolia at least 2 weeks before a scheduled surgery.

Interactions

Interactions?

Moderate Interaction

Be cautious with this combination

!
  • Alcohol interacts with MAGNOLIA

    Alcohol can cause sleepiness and drowsiness. Magnolia bark might also cause sleepiness and drowsiness. Taking large amounts of magnolia bark along with alcohol might cause too much sleepiness.

  • Sedative medications (Barbiturates) interacts with MAGNOLIA

    Magnolia bark might cause sleepiness and drowsiness. Medications that cause sleepiness are called sedatives. Taking magnolia bark along with sedative medications might cause too much sleepiness.<br/><br/> Some sedative medications include amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), pentobarbital (Nembutal), phenobarbital (Luminal), secobarbital (Seconal), and others.

  • Sedative medications (Benzodiazepines) interacts with MAGNOLIA

    Magnolia bark might cause sleepiness and drowsiness. Drugs that cause sleepiness and drowsiness are called sedative medications. Taking magnolia bark along with sedative medications might cause too much sleepiness. Do not take magnolia bark if you are taking sedative medications.<br/><br/> Some of these sedative medications include clonazepam (Klonopin), diazepam (Valium), lorazepam (Ativan), and others.

  • Sedative medications (CNS depressants) interacts with MAGNOLIA

    Magnolia bark might cause sleepiness and drowsiness. Medications that cause sleepiness are called sedatives. Taking magnolia bark along with sedative medications might cause too much sleepiness.<br/><br/> Some sedative medications include clonazepam (Klonopin), lorazepam (Ativan), phenobarbital (Donnatal), zolpidem (Ambien), and others.

Dosing

Dosing

The following doses have been studied in scientific research:

ADULTS

APPLIED TO THE SKIN:

  • For gingivitis: A toothpaste containing 0.3% magnolia has been used twice daily. Improvements are seen by 3 months. Chewing gum containing magnolia bark extract 0.17% and xylitol 30% has been chewed for 5 minutes three times daily for 30 days.

View References

REFERENCES:

  • Kalman, D. S., Feldman, S., Feldman, R., Schwartz, H. I., Krieger, D. R., and Garrison, R. Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial. Nutr J 2008;7:11. View abstract.
  • Campus G, Cagetti MG, Cocco F, Sale S, Sacco G, Strohmenger L, Lingström P. Effect of a sugar-free chewing gum containing magnolia bark extract on different variables related to caries and gingivitis: a randomized controlled intervention trial. Caries Res. 2011;45(4):393-9. View abstract.
  • De Franciscis P, Grauso F, Luisi A, Schettino MT, Torella M, Colacurci N. Adding Agnus Castus and Magnolia to Soy Isoflavones Relieves Sleep Disturbances Besides Postmenopausal Vasomotor Symptoms-Long Term Safety and Effectiveness. Nutrients. 2017;9(2):129. View abstract.
  • Feng WS, He YH, Zheng XK, Wang JC, Cao YG, Zhang YL, Song K. Four New Monoterpenoid Glycosides from the Flower Buds of Magnolia biondii. Molecules. 2016 Jun 3;21(6). pii: E728. View abstract.
  • Garrison R, Chambliss WG. Effect of a proprietary Magnolia and Phellodendron extract on weight management: a pilot, double-blind, placebo-controlled clinical trial. Altern Ther Health Med 2006;12:50-4. View abstract.
  • Ghys K, De Palma A, Vandevenne A, Werbrouck J, Goossens A. Magnolia officinalis bark extract, a recently identified contact allergen in 'anti-ageing' cosmetics. Contact Dermatitis. 2015 Aug;73(2):130-2. View abstract.
  • Hellström MK, Ramberg P. The effect of a dentifrice containing Magnolia extract on established plaque and gingivitis in man: a six-month clinical study. Int J Dent Hyg. 2014 May;12(2):96-102. View abstract.
  • Hou YC, Chao PD, Chen SY. Honokiol and magnolol increased hippocampal acetylcholine release in freely-moving rats. Am J Chin Med 2000;28:379-84. View abstract.
  • Jung KY, Kim DS, Oh SR, et al. Magnone A and B, novel anti-PAF tetrahydrofuran lignans from the flower buds of Magnolia fargesii. J Nat Prod 1998;61:808-11. View abstract.
  • Kuribara H, Kishi E, Hattori N, et al. The anxiolytic effect of two oriental herbal drugs in Japan attributed to honokiol from magnolia bark. J Pharm Pharmacol 2000;52:1425-9. View abstract.
  • Kuribara H, Kishi E, Maruyama Y. Does dihydrohonokiol, a potent anxiolytic compound, result in the development of benzodiazepine-like side effects? J Pharm Pharmacol 2000;52:1017-22. View abstract.
  • Maruyama Y, Kuribara H, Kishi E, et al. Confirmation of the anxiolytic-like effect of dihydrohonokiol following behavioural and biochemical assessments. J Pharm Pharmacol 2001;53:721-5. View abstract.
  • Nakazawa T, Yasuda T, Ohsawa K. Metabolites of orally administered Magnolia officinalis extract in rats and man and its antidepressant-like effects in mice. J Pharm Pharmacol 2003;55:1583-91. View abstract.
  • Nilausen TD, Johansen JD, Thyssen JP. Allergic contact dermatitis of the face caused by Magnolia officinalis bark extract. Contact Dermatitis. 2016;75(6):385-87. View abstract.
  • Poivre M, Duez P. Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & E. Wilson (Houpo) and its constituents. J Zhejiang Univ Sci B. 2017;18(3):194-214. View abstract.
  • Porciani PF, Grandini S, Chazine M. The effect of zinc lactate and magnolia bark extract added tablets on volatile sulfur-containing compounds in the oral cavity. J Clin Dent. 2014;25(3):53-6. View abstract.
  • Porciani PF, Grandini S. The effect of zinc acetate and magnolia bark extract added to chewing gum on volatile sulfur-containing compounds in the oral cavity. J Clin Dent. 2012;23(3):76-9. View abstract.
  • Raison-Peyron N, Césaire A, Du-Thanh A, Dereure O. Allergic contact dermatitis caused by Magnolia officinalis bark extract in a facial anti-ageing cream. Contact Dermatitis. 2015 Jun;72(6):416-7. View abstract.
  • Schifano F, Guarino V, Papanti DG, Baccarin J, Orsolini L, Corkery JM. Is there a potential of misuse for Magnolia officinalis compounds/metabolites? Hum Psychopharmacol Clin Exp. 2017;32:e2595. View abstract.
  • Shahbazi F, Sadighi S, Dashti-Khavidaki S, et al. Effect of Silymarin Administration on Cisplatin Nephrotoxicity: Report from A Pilot, Randomized, Double-Blinded, Placebo-Controlled Clinical Trial. Phytother Res. 2015;29(7):1046-53. View abstract.
  • Tachikawa E, Takahashi M, Kashimoto T. Effects of extract and ingredients isolated from Magnolia obovata thunberg on catecholamine secretion from bovine adrenal chromaffin cells. Biochem Pharmacol 2000;60:433-40. View abstract.
  • Talbott SM, Talbott JA, Pugh M. Effect of Magnolia officinalis and Phellodendron amurense (Relora®) on cortisol and psychological mood state in moderately stressed subjects. J Int Soc Sports Nutr. 2013;10(1):37. View abstract.
  • Teng CM, Chen CC, Ko FN, et al. Two antiplatelet agents from Magnolia officinalis. Thromb Res 1988;50:757-65. View abstract.
  • Wang SM, Lee LJ, Huang YT, et al. Magnolol stimulates steroidogenesis in rat adrenal cells. Br J Pharmacol 2000;131:1172-8. View abstract.
  • Yimam M, Jiao P, Hong M, et al. UP601, a standardized botanical composition composed of Morus alba, Yerba mate and Magnolia officinalis for weight loss. BMC Complement Altern Med. 2017;17(1):114. View abstract.
  • Zhong WB, Wang CY, Ho KJ, et al. Magnolol induces apoptosis in human leukemia cells via cytochrome c release and caspase activation. Anticancer Drugs 2003;14:211-7. View abstract.

More Resources for MAGNOLIA

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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