SOYBEAN OIL

OTHER NAME(S):

Aceite de Soja, Dolichos soja, Glycine gracilis, Glycine hispida, Glycine max, Glycine soja, Huile de Germes de Soja, Huile de Germes de Soya, Huile de Soja, Huile de Soya, Intralipid, Intralipide, Legume, Légumineuse, Phaseolus max, Soja hispida, Soja max, Soy Bean Oil, Soy Oil, Soya Oil, Soyca, Travmulsion.<br/><br/>

Overview

Overview Information

Soybean oil is produced from the seeds of the soybean plant.

Plant sterols, chemicals derived from soybean oil, are used to lower total cholesterol and "bad" low-density lipoprotein (LDL) cholesterol. Specially processed soybean oil is used to treat osteoarthritis.

Some people apply soybean oil directly to the skin to repel mosquitoes and other insects.

Soybean oil is also used as a nutritional supplement in intravenous feedings.

How does it work?

Soybean oil works to lower cholesterol levels by decreasing cholesterol absorption in the gut. Specific processed parts of soybean oil called unsaponifiables may have a beneficial effect on joints.

Uses

Uses & Effectiveness?

Likely Effective for

  • Preventing mosquito bites. Soybean oil is an ingredient in some commercial mosquito repellents. It seems to work about as well as some other mosquito repellents, including some products that contain about 4.7% DEET. However, it does not last as long as products that contain 10% to 35% DEET.

Possibly Effective for

  • Lowering cholesterol levels in people with high cholesterol. Soybean oil plant sterols used in margarine seem to help lower total cholesterol and LDL (or "bad") cholesterol, without affecting HDL (or "good") cholesterol. Soybean oil-based mayonnaise also seems to help lower both total and "bad" cholesterol levels, but it might also lower "good" cholesterol levels.
  • Osteoarthritis. Certain extracts made from avocado and soybean oils are called avocado soybean unsaponifiables (ASU). Taking ASU by mouth for several months seems to reduce pain and overall disability in people with hip or knee osteoarthritis. However, the long-term effects of ASU are unclear. Some evidence shows that taking ASU for 2-3 years does not reduce symptoms of osteoarthritis in most people. However, it might prevent osteoarthritis from becoming worse in people who have severe hip osteoarthritis.

Insufficient Evidence for

  • Weight loss. Early research in people who are overweight or obese shows that taking certain extracts made from avocado and soybean oils, called avocado soybean unsaponifiables, daily for 3 months does not improve the body's response to insulin.
  • Other conditions.
More evidence is needed to rate the effectiveness of soybean oil for these uses.
Side Effects

Side Effects & Safety

Soybean oil is LIKELY SAFE for most adults when taken by mouth in amounts normally found in food and when applied to the skin as an insect repellent in recommended amounts. Pharmaceutical quality soybean oil is also safe when used as a nutritional supplement in intravenous (IV) feedings.

One specific form of soybean oil, called the unsaponifiable fractions of soybean oil, is POSSIBLY SAFE when taken by mouth daily for up to 3 years.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Soybean oil is LIKELY SAFE for pregnant and breast-feeding women when used as part of the diet. But the safety of taking soybean oil in amounts greater than those found in foods during pregnancy and breast-feeding is not known. Stay on the safe side and avoid use of higher doses of soybean oil.

Peanut or soybean allergy: People who are allergic to peanuts, and other plants that are members of the Fabaceae/Leguminosea family might also be allergic to soybean oil.

Interactions

Interactions?

We currently have no information for SOYBEAN OIL Interactions.

Dosing

Dosing

The following doses have been studied in scientific research:

BY MOUTH:

  • For lowering high cholesterol: Margarines and mayonnaise enriched with soybean oil have been used.
  • For osteoarthritis: 300-600 mg of a specific avocado and soybean unsaponifiables (ASU) product (Piascledine 300, Laboratoires Expanscience) daily for 3-6 months has been used.
APPLIED TO THE SKIN:
  • For preventing mosquito bites: Applying a 2% soybean oil product, such as Bite Blocker (HOMS LLC), to the skin every 2 hours has been used.

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View References

REFERENCES:

  • Blotman, F., Maheu, E., Wulwik, A., Caspard, H., and Lopez, A. Efficacy and safety of avocado/soybean unsaponifiables in the treatment of symptomatic osteoarthritis of the knee and hip. A prospective, multicenter, three-month, randomized, double-blind, placebo-controlled trial. Rev Rhum Engl Ed 1997;64(12):825-834. View abstract.
  • Boumediene, K., Felisaz, N., Bogdanowicz, P., Galera, P., Guillou, G. B., and Pujol, J. P. Avocado/soya unsaponifiables enhance the expression of transforming growth factor beta1 and beta2 in cultured articular chondrocytes. Arthritis Rheum. 1999;42(1):148-156. View abstract.
  • Khayyal, M. T. and el Ghazaly, M. A. The possible "chondroprotective" effect of the unsaponifiable constituents of avocado and soya in vivo. Drugs Exp.Clin.Res. 1998;24(1):41-50. View abstract.
  • Aguila MB, Sa Silva SP, Pinheiro AR, Mandarim-de-Lacerda CA. Effects of long-term intake of edible oils on hypertension and myocardial and aortic remodelling in spontaneously hypertensive rats. J Hypertens 2004;22:921-9. View abstract.
  • Bardare M, Magnolfi C, Zani G. Soy sensitivity: personal observation on 71 children with food intolerance. Allerg Immunol (Paris) 1988;20:63-6.
  • Christensen R, Bartels EM, Astrup A, Bliddal H. Symptomatic efficacy of avocado-soybean unsaponifiables (ASU) in osteoarthritis (OA) patients: a meta-analysis of randomized controlled trials. Osteoarthritis Cartilage 2008;16(4):399-408. View abstract.
  • Drugs in Pregnancy and Lactation. 4th ed. Baltimore, MD: Williams & Wilkins, 1994.
  • Duenas-Laita A, Pineda F, Armentia A. Hypersensitivity to generic drugs with soybean oil. N Engl J Med 2009;361(13):1317-8. View abstract.
  • Eigenmann PA, Burks AW, Bannon GA, et al. Identification of unique peanut and soy allergens in sera adsorbed with cross-reacting antibodies. J Allergy Clin Immunol 1996;98:969-78. View abstract.
  • Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  • FDA. Center for Science in the Public Interest. A Food Labeling Guide. Available at: http://www.cfsan.fda.gov/~dms/flg-6c.html
  • Fradin MS, Day JF. Comparative efficacy of insect repellents against mosquito bites. N Engl J Med 2002;347:13-8. View abstract.
  • Ganji V, Kies CV. Psyllium husk fibre supplementation to soybean and coconut oil diets of humans: effect on fat digestibility and faecal fatty acid excretion. Eur J Clin Nutr 1994;48:595-7. View abstract.
  • Henrotin YE, Sanchez C, Deberg MA, et al. Avocado/soybean unsaponifiables increase aggrecan synthesis and reduce catabolic and proinflammatory mediator production by human osteoarthritic chondrocytes. J Rheumatol 2003;30:1825-34. View abstract.
  • Karupaiah T, Chuah KA, Chinna K, et al. Comparing effects of soybean oil- and palm olein-based mayonnaise consumption on the plasma lipid and lipoprotein profiles in human subjects: a double-blind randomized controlled trial with cross-over design. Lipids Health Dis 2016;15(1):131. View abstract.
  • Lequesne M, Maheu E, Cadet C, Dreiser RL. Structural effect of avocado/soybean unsaponifiables on joint space loss in osteoarthritis of the hip. Arthritis Rheum 2002;47:50-8.. View abstract.
  • Lichtenstein AH, Ausman LM, Jalbert SM, et al. Effects of different forms of dietary hydrogenated fats on serum lipoprotein cholesterol levels. N Engl J Med 1999;340:1933-40. View abstract.
  • Lippiello L, Nardo JV, Harlan R, Chiou T. Metabolic effects of avocado/soy unsaponifiables on articular chondrocytes. Evid Based Complement Alternat Med 2008;5(2):191-7. View abstract.
  • Maheu E, Cadet C, Marty M, et al. Randomised, controlled trial of avocado-soybean unsaponifiable (Piascledine) effect on structure modification in hip osteoarthritis: the ERADIAS study. Ann Rheum Dis 2014;73(2):376-84. View abstract.
  • Maheu E, Mazieres B, Valat JP, et al. Symptomatic efficacy of avocado/soybean unsaponifiables in the treatment of osteoarthritis of the knee and hip: a prospective, randomized, double-blind, placebo-controlled, multicenter clinical trial with a six-month treatment period and a two-month followup demonstrating a persistent effect. Arthritis Rheum 1998;41:81-91. View abstract.
  • Martinez-Abundis E, Gonzalez-Ortiz M, Mercado-Sesma AR, Reynoso-von-Dratein C, Moreno-Andrade A. Effect of avocado soybean unsaponifiables on insulin secretion and insulin sensitivity in patients with obesity. Obes Facts 2013;6(5):443-8.View abstract.
  • Public Health Agency of Canada. Canadian Recommendations for the Prevention and Treatment of Malaria Among International Travelers - 2009. Volume 35S1. Available at: http://www.phac-aspc.gc.ca/publicat/ccdr-rmtc/09vol35/35s1/index-eng.php. Accessed: May 26, 2017.
  • Public Health Agency of Canada. Canadian Recommendations for the Prevention and Treatment of Malaria Among International Travellers. Available at: http://www.phac-aspc.gc.ca/publicat/ccdr-rmtc/04vol30/30s1/page2_e.html (Accessed 24 May 2005).
  • Stuchlik M, Zak S. Lipid-based vehicle for oral drug delivery. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2001;145:17-26. View abstract.
  • Weststrate JA, Meijer GW. Plant sterol-enriched margarines and reduction of plasma total- and LDL-cholesterol concentrations in normocholesterolaemic and mildly hypercholesterolaemic subjects. Eur J Clin Nutr 1998;52:334-43. View abstract.
  • Appelboom, T., Schuermans, J., Verbruggen, G., Henrotin, Y., and Reginster, J. Y. Symptoms modifying effect of avocado/soybean unsaponifiables (ASU) in knee osteoarthritis. A double blind, prospective, placebo-controlled study. Scand J Rheumatol 2001;30(4):242-247. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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© Therapeutic Research Faculty 2018.