Aceite de Soja, Dolichos soja, Glycine gracilis, Glycine hispida, Glycine max, Glycine soja, Huile de Germes de Soja, Huile de Germes de Soya, Huile de Soja, Huile de Soya, Intralipid, Intralipide, Legume, Légumineuse, Phaseolus max, Soja hispida, Soja max, Soy Bean Oil, Soy Oil, Soya Oil, Soyca, Travmulsion.


Overview Information

Soybean oil is oil produced from the seeds of the soybean plant.

Chemicals from soybean oil, called plant sterols, are used for high cholesterol. Soybean oil is also used as a mosquito repellant and as a nutritional supplement in intravenous feedings.

Be careful not to confuse soybean oil with other soy products or avocado soy unsaponifiables.

How does it work?

Soybean oil works to lower cholesterol levels by decreasing cholesterol absorption in the gut.


Uses & Effectiveness?

Likely Effective for

  • Mosquito repellant.. Soybean oil is an ingredient in some commercial mosquito repellents. It seems to work about as well as some other mosquito repellents, including some products that contain about 4.7% DEET. But it doesn't last as long as products that contain 10% to 35% DEET.

Possibly Effective for

  • High cholesterol. Soybean oil plant sterols used in margarine seem to help lower total cholesterol and LDL (or "bad") cholesterol, without affecting HDL (or "good") cholesterol. Soybean oil-based mayonnaise also seems to help lower both total and "bad" cholesterol levels, but it might also lower "good" cholesterol levels.

Insufficient Evidence for

  • Heart disease. Eating 1.5 tablespoons of soybean oil per day as part of a low-fat, low-cholesterol diet may help prevent heart disease. But research is limited.
  • Other conditions.
More evidence is needed to rate the effectiveness of soybean oil for these uses.
Side Effects

Side Effects & Safety

When taken by mouth: Soybean oil is LIKELY SAFE for most adults when taken by mouth in amounts normally found in food. There isn't enough reliable information to know if soybean oil is safe when used in the amounts found in medicine.

When applied to the skin: Soybean oil is LIKELY SAFE when applied to the skin as an insect repellent in recommended amounts.

When given by IV: Pharmaceutical quality soybean oil is LIKELY SAFE when used as a nutritional supplement in intravenous (IV) feedings.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Soybean oil is LIKELY SAFE for pregnant and breast-feeding women when used as part of the diet. But there isn't enough reliable information to know if soybean oil is safe to use in the amounts found in medicine when pregnant or breast-feeding. Stay on the safe side and stick to food amounts.

Peanut or soybean allergy: People who are allergic to peanuts, and other plants that are members of the Fabaceae/Leguminosea family might also be allergic to soybean oil.



We currently have no information for SOYBEAN OIL Interactions.



The following doses have been studied in scientific research:


  • For high cholesterol: Margarines and mayonnaise enriched with soybean oil have been used.
  • For mosquito repellant: Applying a 2% soybean oil product, such as Bite Blocker (HOMS LLC), to the skin every 2 hours has been used.

View References


  • Appelboom, T., Schuermans, J., Verbruggen, G., Henrotin, Y., and Reginster, J. Y. Symptoms modifying effect of avocado/soybean unsaponifiables (ASU) in knee osteoarthritis. A double blind, prospective, placebo-controlled study. Scand J Rheumatol 2001;30(4):242-247. View abstract.
  • Blotman, F., Maheu, E., Wulwik, A., Caspard, H., and Lopez, A. Efficacy and safety of avocado/soybean unsaponifiables in the treatment of symptomatic osteoarthritis of the knee and hip. A prospective, multicenter, three-month, randomized, double-blind, placebo-controlled trial. Rev Rhum Engl Ed 1997;64(12):825-834. View abstract.
  • Aguila MB, Sa Silva SP, Pinheiro AR, Mandarim-de-Lacerda CA. Effects of long-term intake of edible oils on hypertension and myocardial and aortic remodelling in spontaneously hypertensive rats. J Hypertens 2004;22:921-9. View abstract.
  • Bardare M, Magnolfi C, Zani G. Soy sensitivity: personal observation on 71 children with food intolerance. Allerg Immunol (Paris) 1988;20:63-6.
  • Drugs in Pregnancy and Lactation. 4th ed. Baltimore, MD: Williams & Wilkins, 1994.
  • Duenas-Laita A, Pineda F, Armentia A. Hypersensitivity to generic drugs with soybean oil. N Engl J Med 2009;361(13):1317-8. View abstract.
  • Eigenmann PA, Burks AW, Bannon GA, et al. Identification of unique peanut and soy allergens in sera adsorbed with cross-reacting antibodies. J Allergy Clin Immunol 1996;98:969-78. View abstract.
  • Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at:
  • FDA. RE: Qualified Health Claim Petition - Soybean Oil and Reduced Risk of Coronary Heart Disease (Docket No. FDA-2016-Q-0995). July 2017. Available at: Accessed on March 16, 2020.
  • Fradin MS, Day JF. Comparative efficacy of insect repellents against mosquito bites. N Engl J Med 2002;347:13-8. View abstract.
  • Ganji V, Kies CV. Psyllium husk fibre supplementation to soybean and coconut oil diets of humans: effect on fat digestibility and faecal fatty acid excretion. Eur J Clin Nutr 1994;48:595-7. View abstract.
  • Henrotin YE, Sanchez C, Deberg MA, et al. Avocado/soybean unsaponifiables increase aggrecan synthesis and reduce catabolic and proinflammatory mediator production by human osteoarthritic chondrocytes. J Rheumatol 2003;30:1825-34. View abstract.
  • Karupaiah T, Chuah KA, Chinna K, et al. Comparing effects of soybean oil- and palm olein-based mayonnaise consumption on the plasma lipid and lipoprotein profiles in human subjects: a double-blind randomized controlled trial with cross-over design. Lipids Health Dis 2016;15(1):131. View abstract.
  • Lequesne M, Maheu E, Cadet C, Dreiser RL. Structural effect of avocado/soybean unsaponifiables on joint space loss in osteoarthritis of the hip. Arthritis Rheum 2002;47:50-8.. View abstract.
  • Lichtenstein AH, Ausman LM, Jalbert SM, et al. Effects of different forms of dietary hydrogenated fats on serum lipoprotein cholesterol levels. N Engl J Med 1999;340:1933-40. View abstract.
  • Maheu E, Cadet C, Marty M, et al. Randomised, controlled trial of avocado-soybean unsaponifiable (Piascledine) effect on structure modification in hip osteoarthritis: the ERADIAS study. Ann Rheum Dis 2014;73(2):376-84. View abstract.
  • Maheu E, Mazieres B, Valat JP, et al. Symptomatic efficacy of avocado/soybean unsaponifiables in the treatment of osteoarthritis of the knee and hip: a prospective, randomized, double-blind, placebo-controlled, multicenter clinical trial with a six-month treatment period and a two-month followup demonstrating a persistent effect. Arthritis Rheum 1998;41:81-91. View abstract.
  • Martinez-Abundis E, Gonzalez-Ortiz M, Mercado-Sesma AR, Reynoso-von-Dratein C, Moreno-Andrade A. Effect of avocado soybean unsaponifiables on insulin secretion and insulin sensitivity in patients with obesity. Obes Facts 2013;6(5):443-8.View abstract.
  • Public Health Agency of Canada. Canadian Recommendations for the Prevention and Treatment of Malaria Among International Travelers - 2009. Volume 35S1. Available at: Accessed: May 26, 2017.
  • Public Health Agency of Canada. Canadian Recommendations for the Prevention and Treatment of Malaria Among International Travellers. Available at: (Accessed 24 May 2005).
  • Stuchlik M, Zak S. Lipid-based vehicle for oral drug delivery. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2001;145:17-26. View abstract.
  • Weststrate JA, Meijer GW. Plant sterol-enriched margarines and reduction of plasma total- and LDL-cholesterol concentrations in normocholesterolaemic and mildly hypercholesterolaemic subjects. Eur J Clin Nutr 1998;52:334-43. View abstract.

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