1,4-Butanediol is converted to GHB in the body. GHB slows down the brain, which can cause loss of consciousness along with dangerous slowing of breathing and other vital functions.
People use 1,4-Butanediol for muscle strength, obesity, insomnia, and other purposes, but there is no good scientific evidence to support any use. It is also unsafe.
Don't confuse 1,4-butanediol with GHB or Gamma Butyrolactone (GBL). These are not the same.
Uses & Effectiveness
We currently have no information for 1,4-BUTANEDIOL overview.
Special Precautions and Warnings
Slow heart rate (bradycardia): Gamma-hydroxybutyrate (GHB) is a chemical that is formed when the body breaks down 1,4-butanediol. GHB can slow the heart and may make bradycardia worse in people who have this condition.
Epilepsy: GHB is a chemical that is formed when the body breaks down 1,4-butanediol. GHB can cause seizures and might make epilepsy worse.
Surgery: 1,4-Butanediol can slow down the central nervous system (CNS). Anesthesia and some other medications used during surgery have the same effect. Using 1,4-butanediol along with these other medications might slow down the CNS too much. Stop using 1,4-butanediol at least 2 weeks before a scheduled surgery.
A rare disorder called succinic semialdehyde dehydrogenase deficiency: People with this condition are at a greater risk for serious adverse reactions from 1,4-butanediol. Do not use 1,4-butanediol if you have this condition.
Alcohol (Ethanol) interacts with 1,4-BUTANEDIOL
Alcohol can cause sleepiness and drowsiness. Taking 1,4-butanediol along with alcohol increases the sleepiness and drowsiness caused by alcohol. Do not take 1,4-butanediol if you have been drinking.
Medications for pain (Narcotic drugs) interacts with 1,4-BUTANEDIOL
Some medications for pain can cause sleepiness and drowsiness. Taking 1,4-butanediol along with some medications for pain increases the sleepiness and drowsiness caused by these medicationss. Do not take 1,4-butanediol if you are taking medications for pain.
Sedative medications (CNS depressants) interacts with 1,4-BUTANEDIOL
1,4-Butanediol might cause sleepiness and slowed breathing. Some medications, called sedatives, can also cause sleepiness and slowed breathing. Taking 1,4-Butanediol with sedative medications can cause breathing problems and/or too much sleepiness.
Do not take this combination
Amphetamines interacts with 1,4-BUTANEDIOL
Amphetamines are drugs that can speed up your nervous system. 1,4-Butanediol is changed in the body to gamma-hydroxybutyrate (GHB). GHB can slow down your nervous system. Taking 1,4-butanediol along with amphetamines can lead to serious side effects.
Medications used to prevent seizures (Anticonvulsants) interacts with 1,4-BUTANEDIOL
1,4-Butanediol may increase the risk of seizures. Taking 1,4-Butanediol may decrease the effects of medications used to prevent seizures and increase the risk of seizures.
Naloxone (Narcan) interacts with 1,4-BUTANEDIOL
1,4-Butanediol is changed by the body to another chemical called GHB. GHB can affect the brain. Taking naloxone along with 1,4-butanediol might decrease the effects of 1,4-butanediol and GHB on the brain.
Ritonavir (Norvir) interacts with 1,4-BUTANEDIOL
Ritonavir might decrease how quickly the body gets rid of 1,4-butanediol. This could cause serious side effects.
Saquinavir (Fortovase, Invirase) interacts with 1,4-BUTANEDIOL
Saquinavir might decrease how fast the body gets rid of 1,4-butanediol. This could cause serious side effects.
Divalproex sodium (Depakote) interacts with 1,4-BUTANEDIOL
1,4-Butanediol is changed in the body to GHB. Taking divalproex sodium at the same time as 1,4-butanediol might decrease how quickly the body gets rid of GHB. This could cause serious side effects.
Topiramate (Topamax) interacts with 1,4-BUTANEDIOL
1,4-Butanediol is changed in the body to GHB. Taking topiramate at the same time as 1,4-butanediol might decrease how quickly the body gets rid of GHB. This could cause serious side effects.
Be cautious with this combination
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