Calendula flower is commonly used for wounds, rashes, infection, inflammation, and many other conditions. However, there is no strong evidence to support calendula for any use.
Don't confuse calendula with ornamental marigolds of the Tagetes genus, which are commonly grown in vegetable gardens.
How does it work ?
Uses & Effectiveness ?
Insufficient Evidence for
- Overgrowth of bacteria in the vagina. Early research suggests that applying vaginal cream containing calendula might improve burning, odor, and pain in women with bacterial vaginosis.
- Foot sores in people with diabetes. Early research shows that using a calendula spray in addition to standard care and hygiene might prevent infection and decrease odor in people with a long-term foot ulcer from diabetes.
- Diaper rash. Some early research suggests that applying a calendula ointment to the skin for 10 days improves diaper rash compared to aloe gel. But other early research shows that applying calendula cream does not improve diaper rash as effectively as bentonite solution.
- A mild form of gum disease (gingivitis). Early research shows that rinsing the mouth with a specific calendula tincture for 6 months might decrease plaque, gum inflammation, and bleeding more than rinsing with water.
- Mosquito repellent. Applying calendula essential oil to the skin does not seem to repel mosquitoes as effectively as applying DEET.
- White patches inside the mouth that are usually caused by smoking (oral leukoplakia). Using tobacco can cause white patches to develop inside the mouth. Early research suggests that applying calendula gel inside the mouth might reduce the size of these white patches.
- Bed sores (pressure ulcers). Early research shows that using a specific calendula product might improve the healing of long-term pressure ulcers.
- Skin damage caused by radiation therapy (radiation dermatitis). Early research suggests that applying calendula ointment on the skin might reduce skin damage in people receiving radiation therapy for breast cancer. But other early research shows that using a calendula cream is no better than petroleum jelly.
- Vaginal yeast infections. Early research shows that applying calendula cream inside the vagina for 7 days does not treat yeast infections as effectively as using clotrimazole cream.
- Leg sores caused by weak blood circulation (venous leg ulcer). Early research shows that applying a calendula ointment to the skin speeds up the healing of leg ulcers caused by poor blood circulation.
- Wound healing. Early research shows that applying calendula ointment to an episiotomy wound for 5 days after childbirth reduces redness, bruising, swelling, and discharge. The calendula ointment might improve these symptoms better than betadine solution.
- A lung disease that makes it harder to breathe (chronic obstructive pulmonary disease or COPD).
- A condition that causes persistent pelvic pain, urinary problems, and sexual problems (Chronic prostatitis and chronic pelvic pain syndrome).
- Ear infections (otitis media).
- Muscle spasms.
- Promoting menstruation.
- Swelling (inflammation) and sores inside the mouth (oral mucositis).
- Thinning of vaginal tissue (vaginal atrophy).
- Treating mouth and throat soreness.
- Varicose veins.
- Other conditions.
When applied to the skin: Preparations of calendula flower are LIKELY SAFE for most people when applied to the skin.
Special Precautions and Warnings
There isn't enough reliable information to know if calendula is safe to use when breast-feeding. Stay on the safe side and avoid use.
Allergy to ragweed and related plants: Calendula may cause an allergic reaction in people who are sensitive to the Asteraceae/Compositae family. Members of this family include ragweed, chrysanthemums, marigolds, daisies, and many others. If you have allergies, be sure to check with your healthcare provider before taking calendula.
Surgery: Calendula might cause too much drowsiness if combined with medications used during and after surgery. Stop taking calendula at least 2 weeks before a scheduled surgery.
Sedative medications (CNS depressants) interacts with CALENDULA
Calendula might cause sleepiness and drowsiness. Medications that cause sleepiness are called sedatives. Taking calendula along with sedative medications might cause too much sleepiness.
Some sedative medications include clonazepam (Klonopin), lorazepam (Ativan), phenobarbital (Donnatal), zolpidem (Ambien), and others.
Be cautious with this combination
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Anonymous. Final report on the safety assessment of Calendula officinalis extract and Calendula officinalis. Int J Toxicol 2001;20 Suppl 2:13-20. View abstract.
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Pommier, P., Gomez, F., Sunyach, M. P., D'Hombres, A., Carrie, C., and Montbarbon, X. Phase III randomized trial of Calendula officinalis compared with trolamine for the prevention of acute dermatitis during irradiation for breast cancer. J Clin.Oncol. 4-15-2004;22(8):1447-1453. View abstract.
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Tedeschi, C. and Benvenuti, C. Comparison of vaginal gel isoflavones versus no topical treatment in vaginal dystrophy: results of a preliminary prospective study. Gynecol.Endocrinol. 2012;28(8):652-654. View abstract.
Tjeerdsma, F., Jonkman, M. F., and Spoo, J. R. Temporary arrest of basal cell carcinoma formation in a patient with basal cell naevus syndrome (BCNS) since treatment with a gel containing various plant extracts. J.Eur.Acad.Dermatol.Venereol. 2011;25(2):244-245. View abstract.
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Yoshikawa, M., Murakami, T., Kishi, A., Kageura, T., and Matsuda, H. Medicinal flowers. III. Marigold. (1): hypoglycemic, gastric emptying inhibitory, and gastroprotective principles and new oleanane-type triterpene oligoglycosides, calendasaponins A, B, C, and D, from Egyptian Calendula officinalis. Chem Pharm Bull (Tokyo) 2001;49(7):863-870. View abstract.
Zitterl-Eglseer, K., Sosa, S., Jurenitsch, J., Schubert-Zsilavecz, M., Della, Loggia R., Tubaro, A., Bertoldi, M., and Franz, C. Anti-oedematous activities of the main triterpendiol esters of marigold (Calendula officinalis L.). J Ethnopharmacol. 1997;57(2):139-144. View abstract.
Adib-Hajbaghery M, Mahmoudi M, Mashaiekhi M. The effects of Bentonite and Calendula on the improvement of infantile diaper dermatitis. J Res Med Sci. 2014;19(4):314-8. View abstract.
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Buzzi M, de Freitas F, Winter M. A Prospective, Descriptive Study to Assess the Clinical Benefits of Using Calendula officinalis Hydroglycolic Extract for the Topical Treatment of Diabetic Foot Ulcers. Ostomy Wound Manage. 2016;62(3):8-24. View abstract.
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Eghdampour F, Jahdie F, Kheyrkhah M, et al. The Impact of Aloe vera and Calendula on Perineal Healing after Episiotomy in Primiparous Women: A Randomized Clinical Trial. J Caring Sci. 2013;2(4):279-86. View abstract.
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Khairnar MS, Pawar B, Marawar PP, et al. Evaluation of Calendula officinalis as an anti-plaque and anti-gingivitis agent. J Indian Soc Periodontol. 2013;17(6):741-7. View abstract.
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Kodiyan J, Amber KT. A Review of the Use of Topical Calendula in the Prevention and Treatment of Radiotherapy-Induced Skin Reactions. Antioxidants (Basel). 2015;4(2):293-303. View abstract.
Madisetti M, Kelechi TJ, Mueller M, Amella EJ, Prentice MA. Feasibility, acceptability, and tolerability of RGN107 in the palliative wound care management of chronic wound symptoms. J Wound Care. 2017;26(Sup1):S25-S34. View abstract.
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Morgia G, Russo GI, Urzì D, et al. A phase II, randomized, single-blinded, placebo-controlled clinical trial on the efficacy of Curcumina and Calendula suppositories for the treatment of patients with chronic prostatitis/chronic pelvic pain syndrome type III. Arch Ital Urol Androl. 2017;89(2):110-113. View abstract.
Panahi Y, Sharif MR, Sharif A, et al. A randomized comparative trial on the therapeutic efficacy of topical aloe vera and Calendula officinalis on diaper dermatitis in children. ScientificWorldJournal. 2012;2012:810234. View abstract.
Paulsen E. Contact sensitization from Compositae-containing herbal remedies and cosmetics. Contact Dermatitis 2002;47:189-98. View abstract.
Pazhohideh Z, Mohammadi S, Bahrami N, Mojab F, Abedi P, Maraghi E. The effect of <i>Calendula officinalis</i> versus metronidazole on bacterial vaginosis in women: A double-blind randomized controlled trial. J Adv Pharm Technol Res. 2018;9(1):15-19. View abstract.
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Reider N, Komericki P, Hausen BM, et al. The seamy side of natural medicines: contact sensitization to arnica (Arnica montana L.) and marigold (Calendula officinalis L.). Contact Dermatitis 2001;45:269-72.. View abstract.
Roveroni-Favaretto LH, Lodi KB, Almeida JD. Topical Calendula officinalis L. successfully treated exfoliative cheilitis: a case report. Cases J. 2009;2:9077. View abstract.
Saffari E, Mohammad-Alizadeh-Charandabi S, Adibpour M, et al. Comparing the Effects of Calendula Officinalis and Clotrimazole on Vaginal Candidiasis: A Randomized Controlled Trial. Women Health. 2016. View abstract.
Sharp L, Finnilä K, Johansson H, et al. No differences between Calendula cream and aqueous cream in the prevention of acute radiation skin reactions--results from a randomised blinded trial. Eur J Oncol Nurs. 2013;17(4):429-35. View abstract.
Singh M, Bagewadi A. Comparison of effectiveness of <i>Calendula officinalis</i> extract gel with lycopene gel for treatment of tobacco-induced homogeneous leukoplakia: A randomized clinical trial. Int J Pharm Investig. 2017;7(2):88-93. View abstract.
Tavassoli M, Shayeghi M, Abai M, et al. Repellency Effects of Essential Oils of Myrtle (Myrtus communis), Marigold (Calendula officinalis) Compared with DEET against Anopheles stephensi on Human Volunteers. Iran J Arthropod Borne Dis. 2011;5(2):10-22. View abstract.
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