CALENDULA

OTHER NAME(S):

Caléndula, Calendula officinalis, Calendule, English Garden Marigold, Fleur de Calendule, Fleur de Tous les Mois, Garden Marigold, Gold-Bloom, Holligold, Marigold, Marybud, Pot Marigold, Souci des Champs, Souci des Jardins, Souci des Vignes, Souci Officinal, Zergul.<br/><br/>

Overview

Overview Information

Calendula is a plant. The flower is used to make medicine.

Calendula flower is used to prevent muscle spasms, start menstrual periods, and reduce fever. It is also used for treating sore throat and mouth, menstrual cramps, cancer, and stomach and duodenal ulcers. Calendula has also been used for measles, smallpox, and jaundice.

Calendula is applied to the skin to reduce pain and swelling (inflammation) and to treat poorly healing wounds and leg ulcers. It is also applied to the skin (used topically) for nosebleeds, varicose veins, hemorrhoids, inflammation of the rectum (proctitis), ear infection, gum disease, peeling lips (exfoliative cheilitis), diaper rash, vaginal yeast infection, and inflammation of the lining of the eyelid (conjunctivitis). Essential oil of calendula has been used as an insect repellant.

Don’t confuse calendula with ornamental marigolds of the Tagets genus, which are commonly grown in vegetable gardens.

How does it work?

It is thought that the chemicals in calendula help new tissue grow in wounds and decrease swelling in the mouth and throat.

Uses

Uses & Effectiveness?

Insufficient Evidence for

  • Anal tears (anal fissures). Early research suggests that that applying calendula to the affected area may reduce pain in people with anal tears who do not respond to treatment with sitz baths and the medication nifedipine.
  • Diabetic foot ulcers. Early research shows that using a calendula spray in addition to standard care and hygiene might prevent infection and decrease odor in people with long-term foot ulcer from diabetes.
  • Diaper rash. Some early research suggests that applying a calendula ointment to the skin for 10 days improves diaper rash compared to aloe gel. But other early research shows that applying calendula cream does not improve diaper rash as effectively as bentonite solution.
  • Peeling lips (exfoliative cheilitis). Early research shows that using calendula ointment for 15 days might help stop peeling lips.
  • Gum inflammation. Early research shows that rinsing the mouth with a specific calendula tincture for 6 months might decrease plaque, gum inflammation, and bleeding by 10% to 18% compared to using water to rinse. Other early research shows that rinsing the mouth with a combination mouthwash containing calendula, rosemary, and ginger for 2 weeks decreases plaque, gum inflammation, and bleeding compared to placebo mouthwash. In fact, it the combination mouthwash seems to work as effectively as chlorhexidine mouthwash.
  • Insect repellant. Applying calendula essential oil to the skin does not seem to repel mosquitoes as effectively as applying DEET.
  • Ear infections (otitis media). Early research shows that applying a specific product that contains mullein, garlic, calendula, and St. John’s wort to the ear for 3 days reduces ear pain in children and teenagers with ear infections.
  • Pressure ulcers. Early research shows that using a specific calendula product might improve the healing of long-term pressure ulcers.
  • Skin inflammation due to radiation therapy (radiation dermatitis). Early research suggests that applying calendula ointment on the skin might reduce radiation dermatitis in people receiving radiation therapy for breast cancer. However, other early research shows that using a calendula cream is no different than petroleum jelly for reducing radiation dermatitis.
  • Thinning of the wall of the vagina (vaginal atrophy). Early research suggests that applying a gel containing calendula, Lactobacillus sporogenes, isoflavones, and lactic acid to the vagina for 4 weeks reduces symptoms of vaginal atrophy such as vaginal itching, burning, dryness, and pain during intercourse.
  • Vaginal yeast infection. Early research shows that applying calendula cream inside the vagina for 7 days does not treat yeast infections as effectively as using clotrimazole cream.
  • Leg ulcers. Early research shows that applying a calendula ointment to the skin speeds up the healing of leg ulcers caused by poor blood circulation.
  • Wound healing. Early research shows that applying calendula ointment along with routine care does not improve the healing of surgical cut of the vagina made during childbirth.
  • Cancer.
  • Fever.
  • Hemorrhoids.
  • Muscle spasms.
  • Nosebleeds.
  • Promoting menstruation.
  • Treating mouth and throat soreness.
  • Varicose veins.
  • Other conditions.
More evidence is needed to rate the effectiveness of calendula for these uses.

Side Effects

Side Effects & Safety

Preparations of calendula flower are LIKELY SAFE for most people when taken by mouth or applied to the skin.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Don’t take calendula by mouth if you are pregnant. It is LIKELY UNSAFE. There is a concern that it might cause a miscarriage. It’s best to avoid topical use as well until more is known.

There is not enough reliable information about the safety of using calendula if you are breast-feeding. Stay on the safe side and avoid use.

Allergy to ragweed and related plants: Calendula may cause an allergic reaction in people who are sensitive to the Asteraceae/Compositae family. Members of this family include ragweed, chrysanthemums, marigolds, daisies, and many others. If you have allergies, be sure to check with your healthcare provider before taking calendula.

Surgery: Calendula might cause too much drowsiness if combined with medications used during and after surgery. Stop taking calendula at least 2 weeks before a scheduled surgery.

Interactions

Interactions?

Moderate Interaction

Be cautious with this combination

!
  • Sedative medications (CNS depressants) interacts with CALENDULA

    Calendula might cause sleepiness and drowsiness. Medications that cause sleepiness are called sedatives. Taking calendula along with sedative medications might cause too much sleepiness.<br /><br /> Some sedative medications include clonazepam (Klonopin), lorazepam (Ativan), phenobarbital (Donnatal), zolpidem (Ambien), and others.

Dosing

Dosing

The appropriate dose of calendula depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for calendula. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

  • Akhtar, N., Zaman, S. U., Khan, B. A., Amir, M. N., and Ebrahimzadeh, M. A. Calendula extract: effects on mechanical parameters of human skin. Acta Pol.Pharm. 2011;68(5):693-701. View abstract.
  • Andersen, F. A., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., Marks, J. G., Jr., Shank, R. C., Slaga, T. J., and Snyder, P. W. Final report of the Cosmetic Ingredient Review Expert Panel amended safety assessment of Calendula officinalis-derived cosmetic ingredients. Int.J.Toxicol. 2010;29(6 Suppl):221S-2243. View abstract.
  • Anonymous. Final report on the safety assessment of Calendula officinalis extract and Calendula officinalis. Int J Toxicol 2001;20 Suppl 2:13-20. View abstract.
  • Bashir, S., Janbaz, K. H., Jabeen, Q., and Gilani, A. H. Studies on spasmogenic and spasmolytic activities of Calendula officinalis flowers. Phytother Res 2006;20(10):906-910. View abstract.
  • Benomar, S., Boutayeb, S., Lalya, I., Errihani, H., Hassam, B., and El Gueddari, B. K. [Treatment and prevention of acute radiation dermatitis]. Cancer Radiother. 2010;14(3):213-216. View abstract.
  • Bojadjiev C. On the sedative and hypotensive effect of preparations from the plant Calendula officinalis. Nauch Trud Visshi Med Inst Sof 1964;43:15-20.
  • Chargari, C., Fromantin, I., and Kirova, Y. M. [Importance of local skin treatments during radiotherapy for prevention and treatment of radio-induced epithelitis]. Cancer Radiother. 2009;13(4):259-266. View abstract.
  • Cravotto, G., Boffa, L., Genzini, L., and Garella, D. Phytotherapeutics: an evaluation of the potential of 1000 plants. J Clin Pharm Ther 2010;35(1):11-48. View abstract.
  • de, Andrade M., Clapis, M. J., do Nascimento, T. G., Gozzo, Tde O., and de Almeida, A. M. Prevention of skin reactions due to teletherapy in women with breast cancer: a comprehensive review. Rev.Lat.Am.Enfermagem. 2012;20(3):604-611. View abstract.
  • Della Loggia R. and et al. Topical anti-inflammatory activity of Calendula officinalis extracts. Planta Med 1990;56:658.
  • Della, Loggia R., Tubaro, A., Sosa, S., Becker, H., Saar, S., and Isaac, O. The role of triterpenoids in the topical anti-inflammatory activity of Calendula officinalis flowers. Planta Med 1994;60(6):516-520. View abstract.
  • Duran, V., Matic, M., Jovanovc, M., Mimica, N., Gajinov, Z., Poljacki, M., and Boza, P. Results of the clinical examination of an ointment with marigold (Calendula officinalis) extract in the treatment of venous leg ulcers. Int.J.Tissue React. 2005;27(3):101-106. View abstract.
  • Kassab, S., Cummings, M., Berkovitz, S., van, Haselen R., and Fisher, P. Homeopathic medicines for adverse effects of cancer treatments. Cochrane.Database.Syst.Rev. 2009;(2):CD004845. View abstract.
  • Khalif, I. L., Quigley, E. M., Makarchuk, P. A., Golovenko, O. V., Podmarenkova, L. F., and Dzhanayev, Y. A. Interactions between symptoms and motor and visceral sensory responses of irritable bowel syndrome patients to spasmolytics (antispasmodics). J.Gastrointestin.Liver Dis. 2009;18(1):17-22. View abstract.
  • Klouchek-Popova, E., Popov, A., Pavlova, N., and Krusteva, S. Influence of the physiological regeneration and epithelialization using fractions isolated from Calendula officinalis. Acta Physiol Pharmacol Bulg. 1982;8(4):63-67. View abstract.
  • Kumar, S., Juresic, E., Barton, M., and Shafiq, J. Management of skin toxicity during radiation therapy: a review of the evidence. J.Med.Imaging Radiat.Oncol. 2010;54(3):264-279. View abstract.
  • Kundakovic, T., Milenkovic, M., Zlatkovic, S., Nikolic, V., Nikolic, G., and Binic, I. Treatment of venous ulcers with the herbal-based ointment Herbadermal(R): a prospective non-randomized pilot study. Forsch.Komplementmed. 2012;19(1):26-30. View abstract.
  • Lievre M, Marichy J, Baux S, and et al. Controlled study of three ointments for the local management of 2nd and 3rd degree burns. Clin Trials Meta-analysis 1992;28:9-12.
  • Machado, M. A., Contar, C. M., Brustolim, J. A., Candido, L., Azevedo-Alanis, L. R., Gregio, A. M., Trevilatto, P. C., and Soares de Lima, A. A. Management of two cases of desquamative gingivitis with clobetasol and Calendula officinalis gel. Biomed.Pap.Med.Fac.Univ Palacky.Olomouc.Czech.Repub. 2010;154(4):335-338. View abstract.
  • Marukami, T., Kishi, A., and Yoshikawa, M. Medicinal flowers. IV. Marigold. (2): Structures of new ionone and sesquiterpene glycosides from Egyptian Calendula officinalis. Chem Pharm Bull (Tokyo) 2001;49(8):974-978. View abstract.
  • McQuestion, M. Evidence-based skin care management in radiation therapy. Semin.Oncol Nurs 2006;22(3):163-173. View abstract.
  • McQuestion, M. Evidence-based skin care management in radiation therapy: clinical update. Semin.Oncol.Nurs. 2011;27(2):e1-17. View abstract.
  • Naseer, S. and Lorenzo-Rivero, S. Role of Calendula extract in treatment of anal fissures. Am.Surg. 2012;78(8):E377-E378. View abstract.
  • Neto, J. J., Fracasso, J. F., Neves, M. D. C. L. C., and et al. Treatment of varicose ulcer and skin lesions with calendula. Revista de Ciencias Farm Sao Paulo 1996;17:181-186.
  • Neukirch, H., D'Ambrosio, M., Dalla, Via J., and Guerriero, A. Simultaneous quantitative determination of eight triterpenoid monoesters from flowers of 10 varieties of Calendula officinalis L. and characterisation of a new triterpenoid monoester. Phytochem.Anal. 2004;15(1):30-35. View abstract.
  • Pommier, P., Gomez, F., Sunyach, M. P., D'Hombres, A., Carrie, C., and Montbarbon, X. Phase III randomized trial of Calendula officinalis compared with trolamine for the prevention of acute dermatitis during irradiation for breast cancer. J Clin.Oncol. 4-15-2004;22(8):1447-1453. View abstract.
  • Rao, SG, Udupa, AL, Udupa SL, and et al. Calendula and Hypericum: Two homeopathic drugs promoting wound healing in rats. Fitoterapia 1991;62(6):508-510.
  • Reddy, K. K., Grossman, L., and Rogers, G. S. Common complementary and alternative therapies with potential use in dermatologic surgery: risks and benefits. J Am Acad Dermatol 2013;68(4):e127-e135. View abstract.
  • Samochowiec L. Pharmacological study of saponosides from Aralia mandshurica Rupr. et Maxim and Calendula officinalis L. Herba Pol. 1983;29:151-155.
  • Sarrell EM, Mandelberg A, and Cohen HA. Efficacy of naturopathic extracts in the management of ear pain associated with acute otitis media. Arch Pediatr Adolesc Med 2001;155(7):796-799.
  • Sarrell, E. M., Cohen, H. A., and Kahan, E. Naturopathic treatment for ear pain in children. Pediatrics 2003;111(5 Pt 1):e574-e579. View abstract.
  • Shaparenko BA, Slivko AB, Bazarova OV, and et al. On use of medicinal plants for treatment of patients with chronic suppurative otitis. Zh Ushn Gorl Bolezn 1979;39:48-51.
  • Silva, E. J., Goncalves, E. S., Aguiar, F., Evencio, L. B., Lyra, M. M., Coelho, M. C., Fraga, Mdo C., and Wanderley, A. G. Toxicological studies on hydroalcohol extract of Calendula officinalis L. Phytother Res 2007;21(4):332-336. View abstract.
  • Tedeschi, C. and Benvenuti, C. Comparison of vaginal gel isoflavones versus no topical treatment in vaginal dystrophy: results of a preliminary prospective study. Gynecol.Endocrinol. 2012;28(8):652-654. View abstract.
  • Tjeerdsma, F., Jonkman, M. F., and Spoo, J. R. Temporary arrest of basal cell carcinoma formation in a patient with basal cell naevus syndrome (BCNS) since treatment with a gel containing various plant extracts. J.Eur.Acad.Dermatol.Venereol. 2011;25(2):244-245. View abstract.
  • Ukiya, M., Akihisa, T., Yasukawa, K., Tokuda, H., Suzuki, T., and Kimura, Y. Anti-inflammatory, anti-tumor-promoting, and cytotoxic activities of constituents of marigold (Calendula officinalis) flowers. J Nat Prod 2006;69(12):1692-1696. View abstract.
  • Yoshikawa, M., Murakami, T., Kishi, A., Kageura, T., and Matsuda, H. Medicinal flowers. III. Marigold. (1): hypoglycemic, gastric emptying inhibitory, and gastroprotective principles and new oleanane-type triterpene oligoglycosides, calendasaponins A, B, C, and D, from Egyptian Calendula officinalis. Chem Pharm Bull (Tokyo) 2001;49(7):863-870. View abstract.
  • Zitterl-Eglseer, K., Sosa, S., Jurenitsch, J., Schubert-Zsilavecz, M., Della, Loggia R., Tubaro, A., Bertoldi, M., and Franz, C. Anti-oedematous activities of the main triterpendiol esters of marigold (Calendula officinalis L.). J Ethnopharmacol. 1997;57(2):139-144. View abstract.
  • Adib-Hajbaghery M, Mahmoudi M, Mashaiekhi M. The effects of Bentonite and Calendula on the improvement of infantile diaper dermatitis. J Res Med Sci. 2014;19(4):314-8. View abstract.
  • Arora D, Rani A, Sharma A. A review on phytochemistry and ethnopharmacological aspects of genus Calendula. Pharmacogn Rev. 2013;7(14):179-87. View abstract.
  • Buzzi M, de Freitas F, Winter M. A Prospective, Descriptive Study to Assess the Clinical Benefits of Using Calendula officinalis Hydroglycolic Extract for the Topical Treatment of Diabetic Foot Ulcers. Ostomy Wound Manage. 2016;62(3):8-24. View abstract.
  • Buzzi M, Freitas Fd, Winter Mde B. Pressure ulcer healing with Plenusdermax Calendula officinalis L. extract. Rev Bras Enferm. 2016;69(2):250-7. View abstract.
  • Eghdampour F, Jahdie F, Kheyrkhah M, et al. The Impact of Aloe vera and Calendula on Perineal Healing after Episiotomy in Primiparous Women: A Randomized Clinical Trial. J Caring Sci. 2013;2(4):279-86. View abstract.
  • Foster S, Tyler VE. Tyler's Honest Herbal, 4th ed., Binghamton, NY: Haworth Herbal Press, 1999.
  • Gol'dman II. [Anaphylactic shock after gargling with an infusion of Calendula]. Klin Med (Mosk) 1974;52:142-3. View abstract.
  • Kalvatchev Z, Walder R, Garzaro D. Anti-HIV activity of extracts from Calendula officinalis flowers. Biomed Pharmacother 1997;51:176-80. View abstract.
  • Khairnar MS, Pawar B, Marawar PP, et al. Evaluation of Calendula officinalis as an anti-plaque and anti-gingivitis agent. J Indian Soc Periodontol. 2013;17(6):741-7. View abstract.
  • Mahmoudi M, Adib-Hajbaghery M, Mashaiekhi M. Comparing the effects of Bentonite &amp; Calendula on the improvement of infantile diaper dermatitis: A randomized controlled trial. Indian J Med Res. 2015;142(6):742-6. View abstract.
  • Mahyari S, Mahyari B, Emami SA, et al. Evaluation of the efficacy of a polyherbal mouthwash containing Zingiber officinale, Rosmarinus officinalis and Calendula officinalis extracts in patients with gingivitis: A randomized double-blind placebo-controlled trial. Complement Ther Clin Pract 2016;22:93-8. View abstract.
  • Panahi Y, Sharif MR, Sharif A, et al. A randomized comparative trial on the therapeutic efficacy of topical aloe vera and Calendula officinalis on diaper dermatitis in children. ScientificWorldJournal. 2012;2012:810234. View abstract.
  • Paulsen E. Contact sensitization from Compositae-containing herbal remedies and cosmetics. Contact Dermatitis 2002;47:189-98. View abstract.
  • Reider N, Komericki P, Hausen BM, et al. The seamy side of natural medicines: contact sensitization to arnica (Arnica montana L.) and marigold (Calendula officinalis L.). Contact Dermatitis 2001;45:269-72.. View abstract.
  • Roveroni-Favaretto LH, Lodi KB, Almeida JD. Topical Calendula officinalis L. successfully treated exfoliative cheilitis: a case report. Cases J. 2009;2:9077. View abstract.
  • Saffari E, Mohammad-Alizadeh-Charandabi S, Adibpour M, et al. Comparing the Effects of Calendula Officinalis and Clotrimazole on Vaginal Candidiasis: A Randomized Controlled Trial. Women Health. 2016. View abstract.
  • Sharp L, Finnilä K, Johansson H, et al. No differences between Calendula cream and aqueous cream in the prevention of acute radiation skin reactions--results from a randomised blinded trial. Eur J Oncol Nurs. 2013;17(4):429-35. View abstract.
  • Tavassoli M, Shayeghi M, Abai M, et al. Repellency Effects of Essential Oils of Myrtle (Myrtus communis), Marigold (Calendula officinalis) Compared with DEET against Anopheles stephensi on Human Volunteers. Iran J Arthropod Borne Dis. 2011;5(2):10-22. View abstract.

More Resources for CALENDULA

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. © Therapeutic Research Faculty 2009.