FOXGLOVE

OTHER NAME(S):

Dé de Berg&egrave;re, Dead Man's Bells, Digitale, Digitale Laineuse, Digitale Pourpre, Digitale Pourprée, Digitalis lanata, Digitalis purpurea, Doigtier, Fairy Cap, Fairy Finger, Foxglove, Gant-de-Berg&egrave;re, Gant-de-Notre-Dame, Gantelée, Ganti&egrave;re, Grande Digitale, Lady's Thimble, Lion's Mouth, Purple Foxglove, Scotch Mercury, Throatwort, Witch's Bells, Woolly Foxglove.<br/><br/>

Overview

Overview Information

Foxglove is a plant. Although the parts of the plant that grow above the ground can be used for medicine, foxglove is unsafe for self-medication. All parts of the plant are poisonous.

Chemicals taken from foxglove are used to make a prescription drug called digoxin. Digitalis lanata is the major source of digoxin in the US.

Foxglove is used for congestive heart failure (CHF) and relieving associated fluid retention (edema); irregular heartbeat, including atrial fibrillation and “flutter;” asthma; epilepsy; tuberculosis; constipation; headache; and spasm. It is also used to cause vomiting and for healing wounds and burns.

How does it work?

Foxglove contains chemicals from which the prescription medication digoxin (Lanoxin) is made. These chemicals can increase the strength of heart muscle contractions, change heart rate, and increase heart blood output.

Uses

Uses & Effectiveness?

Likely Effective for

Insufficient Evidence for

More evidence is needed to rate the effectiveness of foxglove for these uses.

Side Effects

Side Effects & Safety

Foxglove is UNSAFE for anyone to take by mouth without the advice and care of a healthcare professional. Some people are especially sensitive to the toxic side effects of foxglove and should be extra careful to avoid use.

Foxglove can cause irregular heart function and death. Signs of foxglove poisoning include stomach upset, small eye pupils, blurred vision, strong slow pulse, nausea, vomiting, dizziness, excessive urination, fatigue, muscle weakness and tremors, stupor, confusion, convulsions, abnormal heartbeats, and death. Long-term use of foxglove can lead to symptoms of toxicity, including visual halos, yellow-green vision, and stomach upset.

Deaths have occurred when foxglove was mistaken for comfrey.

Special Precautions & Warnings:

Children: Taking foxglove by mouth is LIKELY UNSAFE for children.

Pregnancy and breast-feeding: Foxglove is UNSAFE when taken by mouth for self-medication. Do not use.

Heart disease: Although foxglove is effective for some heart conditions, it is too dangerous for people to use on their own. Heart disease needs to be diagnosed, treated, and monitored by a healthcare professional.

Kidney disease: People with kidney problems may not clear foxglove from their system very well. This can increase the chance of foxglove build-up and poisoning.

Interactions

Interactions?

Major Interaction

Do not take this combination

!

  • Digoxin (Lanoxin) interacts with FOXGLOVE

    Digoxin (Lanoxin) helps the heart beat more strongly. Digitalis also seems to affect the heart. Taking digitalis along with digoxin can increase the effects of digoxin and increase the risk of side effects. Do not take digitalis if you are taking digoxin (Lanoxin) without talking to your healthcare professional.

  • Quinine interacts with FOXGLOVE

    Digitalis can affect the heart. Quinine can also affect the heart. Taking quinine along with digitalis might cause serious heart problems.

Moderate Interaction

Be cautious with this combination

!

  • Antibiotics (Macrolide antibiotics) interacts with FOXGLOVE

    Digitalis can affect the heart. Some antibiotics might increase how much digitalis the body absorbs. Increasing how much digitalis the body absorbs might increase the effects and side effects of digitalis.<br /> Some antibiotics called macrolide antibiotics include erythromycin, azithromycin, and clarithromycin.

  • Antibiotics (Tetracycline antibiotics) interacts with FOXGLOVE

    Taking some antibiotics called tetracyclines with digitalis might increase the chance of side effects from digitalis.<br /> Some tetracyclines include demeclocycline (Declomycin), minocycline (Minocin), and tetracycline (Achromycin).

  • Stimulant laxatives interacts with FOXGLOVE

    Digitalis can affect the heart. The heart uses potassium. Laxatives called stimulant laxatives can decrease potassium levels in the body. Low potassium levels can increase the chance of side effects from digitalis.<br /> Some stimulant laxatives include bisacodyl (Correctol, Dulcolax), cascara, castor oil (Purge), senna (Senokot), and others.

  • Water pills (Diuretic drugs) interacts with FOXGLOVE

    Digitalis might affect the heart. "Water pills" can decrease potassium in the body. Low potassium levels can also affect the heart and increase the risk of side effects from digitalis.<br /> Some "water pills" that can deplete potassium include chlorothiazide (Diuril), chlorthalidone (Thalitone), furosemide (Lasix), hydrochlorothiazide (HCTZ, HydroDiuril, Microzide), and others.

Dosing

Dosing

The appropriate dose of foxglove depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for foxglove. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

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View References

REFERENCES:

  • Agarwal, C., Tyagi, A., and Agarwal, R. Gallic acid causes inactivating phosphorylation of cdc25A/cdc25C-cdc2 via ATM-Chk2 activation, leading to cell cycle arrest, and induces apoptosis in human prostate carcinoma DU145 cells. Mol.Cancer Ther 2006;5(12):3294-3302. View abstract.
  • ALDRICH, B. J., FRITH, M. L., and WRIGHT, S. E. Paper chromatographic detection of new constituents of Digitalis lanata. J Pharm.Pharmacol. 1956;8(12):1042-1049. View abstract.
  • Bassoli, B. K., Cassolla, P., Borba-Murad, G. R., Constantin, J., Salgueiro-Pagadigorria, C. L., Bazotte, R. B., da Silva, R. S., and de Souza, H. M. Chlorogenic acid reduces the plasma glucose peak in the oral glucose tolerance test: effects on hepatic glucose release and glycaemia. Cell Biochem.Funct. 2008;26(3):320-328. View abstract.
  • Bessen, H. A. Therapeutic and toxic effects of digitalis: William Withering, 1785. J.Emerg.Med. 1986;4(3):243-248. View abstract.
  • Brewer, L. A., III. The failing myocardium. Historical notes. Am.J Surg. 1984;147(6):712-718. View abstract.
  • BRINDLE, H., RIGBY, G., and SHARMA, S. N. The assay of tincture of digitalis and the determination of the constituents of Digitalis species. J Pharm.Pharmacol. 1955;7(11):942-953. View abstract.
  • Brunton, T. L. and Tunnicliffe, F. W. On the Cause of the Rise of Blood-pressure produced by Digitalis. J Physiol 10-19-1896;20(4-5):354-363. View abstract.
  • Brustbauer, R. and Wenisch, C. [Bradycardiac atrial fibrillation after consuming herbal tea]. Dtsch.Med Wochenschr. 7-25-1997;122(30):930-932. View abstract.
  • Chen, C. Y., Peng, W. H., Tsai, K. D., and Hsu, S. L. Luteolin suppresses inflammation-associated gene expression by blocking NF-kappaB and AP-1 activation pathway in mouse alveolar macrophages. Life Sci 11-30-2007;81(23-24):1602-1614. View abstract.
  • Chen, T. G., Lee, J. J., Lin, K. H., Shen, C. H., Chou, D. S., and Sheu, J. R. Antiplatelet activity of caffeic acid phenethyl ester is mediated through a cyclic GMP-dependent pathway in human platelets. Chin J Physiol 6-30-2007;50(3):121-126. View abstract.
  • Chiang, C. T., Way, T. D., and Lin, J. K. Sensitizing HER2-overexpressing cancer cells to luteolin-induced apoptosis through suppressing p21(WAF1/CIP1) expression with rapamycin. Mol.Cancer Ther 2007;6(7):2127-2138. View abstract.
  • Chlopcikova, S., Psotova, J., Miketova, P., Sousek, J., Lichnovsky, V., and Simanek, V. Chemoprotective effect of plant phenolics against anthracycline-induced toxicity on rat cardiomyocytes. Part II. caffeic, chlorogenic and rosmarinic acids. Phytother.Res. 2004;18(5):408-413. View abstract.
  • Choi, E. M. Modulatory effects of luteolin on osteoblastic function and inflammatory mediators in osteoblastic MC3T3-E1 cells. Cell Biol.Int 2007;31(9):870-877. View abstract.
  • Critchfield, J. W., Butera, S. T., and Folks, T. M. Inhibition of HIV activation in latently infected cells by flavonoid compounds. AIDS Res.Hum.Retroviruses 1-1-1996;12(1):39-46. View abstract.
  • de Man, E. and Peeke, H. V. Dietary ferulic acid, biochanin A, and the inhibition of reproductive behavior in Japanese quail (Coturnix coturnix). Pharmacol.Biochem.Behav. 1982;17(3):405-411. View abstract.
  • Dickstein, E. S. and Kunkel, F. W. Foxglove tea poisoning. Am.J Med 1980;69(1):167-169. View abstract.
  • Erdogan, A., Most, A. K., Wienecke, B., Fehsecke, A., Leckband, C., Voss, R., Grebe, M. T., Tillmanns, H., Schaefer, C. A., and Kuhlmann, C. R. Apigenin-induced nitric oxide production involves calcium-activated potassium channels and is responsible for antiangiogenic effects. J Thromb.Haemost. 2007;5(8):1774-1781. View abstract.
  • Erlenkamp, S., Gretzer, B., Zillikens, S., Glitsch, H. G., Pusch, H., Staroske, T., and Welzel, P. Na+/K+ pump inhibition and positive inotropic effect of digitoxigenin and some C-22-substituted derivatives in sheep cardiac preparations. Naunyn Schmiedebergs Arch.Pharmacol. 1998;357(1):54-62. View abstract.
  • Faried, A., Kurnia, D., Faried, L. S., Usman, N., Miyazaki, T., Kato, H., and Kuwano, H. Anticancer effects of gallic acid isolated from Indonesian herbal medicine, Phaleria macrocarpa (Scheff.) Boerl, on human cancer cell lines. Int J Oncol. 2007;30(3):605-613. View abstract.
  • Fernandez-Martinez, E., Bobadilla, R. A., Morales-Rios, M. S., Muriel, P., and Perez-Alvarez, V. M. Trans-3-phenyl-2-propenoic acid (cinnamic acid) derivatives: structure-activity relationship as hepatoprotective agents. Med Chem. 2007;3(5):475-479. View abstract.
  • Friedman, P. L. and Smith, T. W. Foxglove and Fab: immunological approaches to digitalis intoxication. Int.J.Cardiol. 1983;3(2):237-240. View abstract.
  • Fujii, Y., Ikeda, Y., and Yamazaki, M. High-performance liquid chromatographic determination of secondary cardiac glycosides in Digitalis purpurea leaves. J Chromatogr. 10-6-1989;479(2):319-325. View abstract.
  • Fujikawa, T., Yamaguchi, A., Morita, I., Takeda, H., and Nishibe, S. Protective effects of Acanthopanax senticosus Harms from Hokkaido and its components on gastric ulcer in restrained cold water stressed rats. Biol.Pharm.Bull. 1996;19(9):1227-1230. View abstract.
  • Gering-Ward, B. and Junior, P. [New constituents of Penstemon digitalis]. Planta Med 1989;55(1):75-78. View abstract.
  • Gerova, M., Kristek, F., Cacanyiova, S., and Cebova, M. Acetylcholine and bradykinin enhance hypotension and affect the function of remodeled conduit arteries in SHR and SHR treated with nitric oxide donors. Braz.J Med Biol.Res. 2005;38(6):959-966. View abstract.
  • Goldman, P. Herbal medicines today and the roots of modern pharmacology. Ann.Intern.Med 10-16-2001;135(8 Pt 1):594-600. View abstract.
  • Granado-Serrano, A. B., Martin, M. A., Izquierdo-Pulido, M., Goya, L., Bravo, L., and Ramos, S. Molecular mechanisms of (-)-epicatechin and chlorogenic acid on the regulation of the apoptotic and survival/proliferation pathways in a human hepatoma cell line. J Agric.Food Chem. 3-7-2007;55(5):2020-2027. View abstract.
  • Guerrero, J. A., Navarro-Nunez, L., Lozano, M. L., Martinez, C., Vicente, V., Gibbins, J. M., and Rivera, J. Flavonoids inhibit the platelet TxA(2) signalling pathway and antagonize TxA(2) receptors (TP) in platelets and smooth muscle cells. Br.J Clin.Pharmacol. 2007;64(2):133-144. View abstract.
  • HARKISS, K. J. and RIGBY, G. J. An investigation of the constituents of Digitalis purpurea. J Pharm.Pharmacol. 1958;10(4):228-236. View abstract.
  • HARKISS, K. J. and RIGBY, G. J. Counter-current separation of constituents of Digitalis purpurea. J Pharm.Pharmacol. 1958;10(4):237-241. View abstract.
  • Hauptman, P. J. and Kelly, R. A. Digitalis. Circulation 3-9-1999;99(9):1265-1270. View abstract.
  • Hazan, R., Levine, A., and Abeliovich, H. Benzoic acid, a weak organic acid food preservative, exerts specific effects on intracellular membrane trafficking pathways in Saccharomyces cerevisiae. Appl.Environ.Microbiol. 2004;70(8):4449-4457. View abstract.
  • Hollman, A. Drugs for atrial fibrillation. Digoxin comes from Digitalis lanata. BMJ 4-6-1996;312(7035):912. View abstract.
  • Howdieshell, T. R., Gay, M., DiPiro, J. T., Mooney, S., Duvall, R., Eckles, S., and Baisden, R. Heparin versus citrate regional anticoagulation during autotransfusion in a porcine intra-abdominal hemorrhage model. Am.Surg. 1997;63(11):1014-1018. View abstract.
  • Hsu, C. L. and Yen, G. C. Effect of gallic acid on high fat diet-induced dyslipidaemia, hepatosteatosis and oxidative stress in rats. Br.J Nutr 2007;98(4):727-735. View abstract.
  • Hung, C. C., Tsai, W. J., Kuo, L. M., and Kuo, Y. H. Evaluation of caffeic acid amide analogues as anti-platelet aggregation and anti-oxidative agents. Bioorg.Med Chem. 3-1-2005;13(5):1791-1797. View abstract.
  • Iwai, K., Kim, M. Y., Onodera, A., and Matsue, H. Physiological effects and active ingredients of Viburnum dilatatum Thunb fruits on oxidative stress. Biofactors 2004;21(1-4):273-275. View abstract.
  • Jiang, H., Xia, Q., Wang, X., Song, J., and Bruce, I. C. Luteolin induces vasorelaxion in rat thoracic aorta via calcium and potassium channels. Pharmazie 2005;60(6):444-447. View abstract.
  • Jowett, N. I. Foxglove poisoning. Hosp.Med 2002;63(12):758-759. View abstract.
  • Jung, J. E., Kim, H. S., Lee, C. S., Park, D. H., Kim, Y. N., Lee, M. J., Lee, J. W., Park, J. W., Kim, M. S., Ye, S. K., and Chung, M. H. Caffeic acid and its synthetic derivative CADPE suppress tumor angiogenesis by blocking STAT3-mediated VEGF expression in human renal carcinoma cells. Carcinogenesis 2007;28(8):1780-1787. View abstract.
  • Kerr, D. J., Elliott, H. L., and Hillis, W. S. Epileptiform seizures and electroencephalographic abnormalities as manifestations of digoxin toxicity. Br.Med J (Clin.Res.Ed) 1-16-1982;284(6310):162-163. View abstract.
  • Kim, M. J., Choi, S. J., Lim, S. T., Kim, H. K., Heo, H. J., Kim, E. K., Jun, W. J., Cho, H. Y., Kim, Y. J., and Shin, D. H. Ferulic acid supplementation prevents trimethyltin-induced cognitive deficits in mice. Biosci.Biotechnol.Biochem. 2007;71(4):1063-1068. View abstract.
  • Kim, S. H., Jun, C. D., Suk, K., Choi, B. J., Lim, H., Park, S., Lee, S. H., Shin, H. Y., Kim, D. K., and Shin, T. Y. Gallic acid inhibits histamine release and pro-inflammatory cytokine production in mast cells. Toxicol.Sci 2006;91(1):123-131. View abstract.
  • Krikler, D. M. The foxglove, "The old woman from Shropshire" and William Withering. J Am.Coll.Cardiol. 1985;5(5 Suppl A):3A-9A. View abstract.
  • Kroes, B. H., van den Berg, A. J., Quarles van Ufford, H. C., van Dijk, H., and Labadie, R. P. Anti-inflammatory activity of gallic acid. Planta Med 1992;58(6):499-504. View abstract.
  • Lacassie, E., Marquet, P., Martin-Dupont, S., Gaulier, J. M., and Lachatre, G. A non-fatal case of intoxication with foxglove, documented by means of liquid chromatography-electrospray-mass spectrometry. J Forensic Sci 2000;45(5):1154-1158. View abstract.
  • Lee, T. C. Van Gogh's vision. Digitalis intoxication? JAMA 2-20-1981;245(7):727-729. View abstract.
  • Lee, W. J., Chen, W. K., Wang, C. J., Lin, W. L., and Tseng, T. H. Apigenin inhibits HGF-promoted invasive growth and metastasis involving blocking PI3K/Akt pathway and beta 4 integrin function in MDA-MB-231 breast cancer cells. Toxicol.Appl.Pharmacol. 1-15-2008;226(2):178-191. View abstract.
  • Liu, A. L., Liu, B., Qin, H. L., Lee, S. M., Wang, Y. T., and Du, G. H. Anti-influenza virus activities of flavonoids from the medicinal plant Elsholtzia rugulosa. Planta Med 2008;74(8):847-851. View abstract.
  • Losi, G., Puia, G., Garzon, G., de Vuono, M. C., and Baraldi, M. Apigenin modulates GABAergic and glutamatergic transmission in cultured cortical neurons. Eur.J Pharmacol. 10-11-2004;502(1-2):41-46. View abstract.
  • Lovkova, M. I., Buzuk, G. N., Sokolova, S. M., Kliment'eva, N. I., Ponomareva, S. M., Shelepova, O. V., and Vorotnitskaia, I. E. [Medicinal plants--concentrators of chromium. The role of chromium in alkaloid metabolism]. Izv.Akad.Nauk Ser.Biol. 1996;(5):552-564. View abstract.
  • Lugt, C. B. and Noordhoek-Ananias, L. Quantitative fluorimetric determination of the main cardiac glycosides in Digitalis purpurea leaves. Planta Med 1974;25(3):267-273. View abstract.
  • Maixent, J. M., Fenard, S., and Kawamoto, R. M. Tissue localization of active Na,K-ATPase isoenzymes by determination of their profile of inhibition with ouabain, digoxin, digitoxigenin and LND 796, a new aminosteroid cardiotonic. J Recept.Res. 1991;11(1-4):687-698. View abstract.
  • Mamiya, T., Kise, M., and Morikawa, K. Ferulic acid attenuated cognitive deficits and increase in carbonyl proteins induced by buthionine-sulfoximine in mice. Neurosci.Lett. 1-10-2008;430(2):115-118. View abstract.
  • Markaverich, B. M. and Gregory, R. R. Preliminary assessment of luteolin as an affinity ligand for type II estrogen--binding sites in rat uterine nuclear extracts. Steroids 1993;58(6):268-274. View abstract.
  • Mitchell, G. Foxed by the foxglove. Aust.Fam.Physician 1993;22(6):997-999. View abstract.
  • MIYATAKE, K., OKANO, A., HOJI, K., and MIKI, T. Studies on the constituents of Digitalis purpurea L. II. Paper partition chromatography of cardioglycosides from digitalis seeds. Pharm.Bull. 1957;5(2):157-163. View abstract.
  • MIYATAKE, K., OKANO, A., HOJI, K., and MIKI, T. Studies on the constituents of Digitalis purpurea L. III. Gitostin, a new cardiotonic glycoside from digitalis seeds. Pharm.Bull. 1957;5(2):163-167. View abstract.
  • Navarro-Nunez, L., Lozano, M. L., Palomo, M., Martinez, C., Vicente, V., Castillo, J., Benavente-Garcia, O., Diaz-Ricart, M., Escolar, G., and Rivera, J. Apigenin inhibits platelet adhesion and thrombus formation and synergizes with aspirin in the suppression of the arachidonic acid pathway. J Agric.Food Chem. 5-14-2008;56(9):2970-2976. View abstract.
  • Odontuya, G., Hoult, J. R., and Houghton, P. J. Structure-activity relationship for antiinflammatory effect of luteolin and its derived glycosides. Phytother.Res. 2005;19(9):782-786. View abstract.
  • Oh, J. W., Lee, J. Y., Han, S. H., Moon, Y. H., Kim, Y. G., Woo, E. R., and Kang, K. W. Effects of phenylethanoid glycosides from Digitalis purpurea L. on the expression of inducible nitric oxide synthase. J Pharm.Pharmacol. 2005;57(7):903-910. View abstract.
  • Oishi, A., Miyamoto, K., Kashii, S., and Yoshimura, N. Photopsia as a manifestation of digitalis toxicity. Can.J Ophthalmol. 2006;41(5):603-604. View abstract.
  • OKANO, A. Studies on the constituents of Digitalis purpurea L. VI. Glucodigifucoside, a new cardiotonic glycoside. Pharm.Bull. 1957;5(3):272-276. View abstract.
  • OKANO, A. Studies on the constituents of Digitalis purpurea L. VII. Enzymatic decomposition of glucodigifucoside. Pharm.Bull. 1957;5(3):279-282. View abstract.
  • OKANO, A. Studies on the constituents of Digitalis purpurea L. VIII. The isolation of neogitostin, a new cardiotonic glycoside. Chem.Pharm.Bull.(Tokyo) 1958;6(2):173-177. View abstract.
  • OKANO, A., HOJI, K., MIKI, T., and MIYATAKE, K. Studies on the constituents of Digitalis purpurea L. IV. Enzymatic decomposition of gitostin. Pharm.Bull. 1957;5(2):167-171. View abstract.
  • OKANO, A., HOJI, K., MIKI, T., and MIYATAKE, K. Studies on the constituents of Digitalis purpurea L. V. On the acetates of some cardiotonic glycosides. Pharm.Bull. 1957;5(2):171-176. View abstract.
  • Omvik, P. [Foxglove poisoning]. Tidsskr.Nor Laegeforen. 5-30-1981;101(15):949-950. View abstract.
  • Ozaki, Y. Antiinflammatory effect of tetramethylpyrazine and ferulic acid. Chem.Pharm.Bull.(Tokyo) 1992;40(4):954-956. View abstract.
  • Pakrashi, A. and Pakrasi, P. Antifertility efficacy of the plant Aristolochia indica linn on mouse. Contraception 1979;20(1):49-54. View abstract.
  • Pakrashi, A., Kabir, S. N., and Ray, H. 3-(4-hydroxy phenyl)-2-propenoic acid - a reproductive inhibitor in male rat. Contraception 1981;23(6):677-686. View abstract.
  • Panda, S. and Kar, A. Apigenin (4',5,7-trihydroxyflavone) regulates hyperglycaemia, thyroid dysfunction and lipid peroxidation in alloxan-induced diabetic mice. J Pharm Pharmacol 2007;59(11):1543-1548. View abstract.
  • Qiusheng, Z., Xiling, S., Xubo, Meng, S., and Changhai, W. Protective effects of luteolin-7-glucoside against liver injury caused by carbon tetrachloride in rats. Pharmazie 2004;59(4):286-289. View abstract.
  • Ramlakhan, S. L. and Fletcher, A. K. It could have happened to Van Gogh: a case of fatal purple foxglove poisoning and review of the literature. Eur.J Emerg.Med 2007;14(6):356-359. View abstract.
  • Rathore, S. S., Wang, Y., and Krumholz, H. M. Sex-based differences in the effect of digoxin for the treatment of heart failure. N.Engl.J Med 10-31-2002;347(18):1403-1411. View abstract.
  • Rich, S. A., Libera, J. M., and Locke, R. J. Treatment of foxglove extract poisoning with digoxin-specific Fab fragments. Ann.Emerg.Med 1993;22(12):1904-1907. View abstract.
  • Riehle, M., Bereiter-Hahn, J., and Boller, B. Effects of ouabain and digitoxin on the respiration of chick embryo cardiomyocytes in culture. Arzneimittelforschung. 1991;41(4):378-384. View abstract.
  • Sim, G. S., Lee, B. C., Cho, H. S., Lee, J. W., Kim, J. H., Lee, D. H., Kim, J. H., Pyo, H. B., Moon, D. C., Oh, K. W., Yun, Y. P., and Hong, J. T. Structure activity relationship of antioxidative property of flavonoids and inhibitory effect on matrix metalloproteinase activity in UVA-irradiated human dermal fibroblast. Arch.Pharm.Res. 2007;30(3):290-298. View abstract.
  • Simpkiss, M. and Holt, D. Digitalis poisoning due to the accidental ingestion of foxglove leaves. Ther.Drug Monit. 1983;5(2):217. View abstract.
  • Slifman, N. R., Obermeyer, W. R., Aloi, B. K., Musser, S. M., Correll, W. A., Jr., Cichowicz, S. M., Betz, J. M., and Love, L. A. Contamination of botanical dietary supplements by Digitalis lanata. N.Engl.J.Med. 9-17-1998;339(12):806-811. View abstract.
  • Smith, T. W., Antman, E. M., Friedman, P. L., Blatt, C. M., and Marsh, J. D. Digitalis glycosides: mechanisms and manifestations of toxicity. Part III. Prog.Cardiovasc.Dis. 1984;27(1):21-56. View abstract.
  • Sri, Balasubashini M., Rukkumani, R., and Menon, V. P. Protective effects of ferulic acid on hyperlipidemic diabetic rats. Acta Diabetol. 2003;40(3):118-122. View abstract.
  • Srinivasan, M., Rukkumani, R., Ram, Sudheer A., and Menon, V. P. Ferulic acid, a natural protector against carbon tetrachloride-induced toxicity. Fundam.Clin.Pharmacol. 2005;19(4):491-496. View abstract.
  • Srinivasan, M., Sudheer, A. R., and Menon, V. P. Ferulic Acid: therapeutic potential through its antioxidant property. J Clin.Biochem.Nutr 2007;40(2):92-100. View abstract.
  • Stenkvist, B. Is digitalis a therapy for breast carcinoma? Oncol.Rep. 1999;6(3):493-496. View abstract.
  • Szkolnicka, B., Satora, L., Morawska, J., and Szpak, D. [Cardiotoxic plants]. Przegl.Lek. 2005;62(6):621-623. View abstract.
  • Takeda, H., Tsuji, M., Inazu, M., Egashira, T., and Matsumiya, T. Rosmarinic acid and caffeic acid produce antidepressive-like effect in the forced swimming test in mice. Eur.J Pharmacol. 8-9-2002;449(3):261-267. View abstract.
  • Takeda, H., Tsuji, M., Miyamoto, J., Masuya, J., Iimori, M., and Matsumiya, T. Caffeic acid produces antidepressive- and/or anxiolytic-like effects through indirect modulation of the alpha 1A-adrenoceptor system in mice. Neuroreport 5-23-2003;14(7):1067-1070. View abstract.
  • Thierry, S., Blot, F., Lacherade, J. C., Lefort, Y., Franzon, P., and Brun-Buisson, C. Poisoning with foxglove extract: favorable evolution without Fab fragments. Intensive Care Med 2000;26(10):1586. View abstract.
  • Tormakangas, L., Vuorela, P., Saario, E., Leinonen, M., Saikku, P., and Vuorela, H. In vivo treatment of acute Chlamydia pneumoniae infection with the flavonoids quercetin and luteolin and an alkyl gallate, octyl gallate, in a mouse model. Biochem.Pharmacol. 10-15-2005;70(8):1222-1230. View abstract.
  • Uozaki, M., Yamasaki, H., Katsuyama, Y., Higuchi, M., Higuti, T., and Koyama, A. H. Antiviral effect of octyl gallate against DNA and RNA viruses. Antiviral Res. 2007;73(2):85-91. View abstract.
  • Wade, O. L. Digoxin 1785-1985. I. Two hundred years of digitalis. J.Clin.Hosp.Pharm. 1986;11(1):3-9. View abstract.
  • Warth, A. D. Mechanism of action of benzoic acid on Zygosaccharomyces bailii: effects on glycolytic metabolite levels, energy production, and intracellular pH. Appl.Environ.Microbiol. 1991;57(12):3410-3414. View abstract.
  • Wiegrebe, H. and Wichtl, M. High-performance liquid chromatographic determination of cardenolides in Digitalis leaves after solid-phase extraction. J Chromatogr. 2-5-1993;630(1-2):402-407. View abstract.
  • Xu, L. N., Xu, D. C., Zhang, B. J., and Wang, R. L. [Studies on mechanism of the antiplatelet effect of sodium ferulate--effect on TXA2/PGI2 balance]. Zhongguo Yi.Xue.Ke.Xue.Yuan Xue.Bao. 1984;6(6):414-417. View abstract.
  • Yaginuma, M., Orimo, S., Kurosawa, T., Arai, M., and Hiyamuta, E. [Muscle weakness of the upper arms in the last trimester of administering digitalis]. Rinsho Shinkeigaku 1988;28(3):338-341. View abstract.
  • Yamasaki, H., Uozaki, M., Katsuyama, Y., Utsunomiya, H., Arakawa, T., Higuchi, M., Higuti, T., and Koyama, A. H. Antiviral effect of octyl gallate against influenza and other RNA viruses. Int J Mol.Med 2007;19(4):685-688. View abstract.
  • Yasuda, T., Takasawa, A., Nakazawa, T., Ueda, J., and Ohsawa, K. Inhibitory effects of urinary metabolites on platelet aggregation after orally administering Shimotsu-To, a traditional Chinese medicine, to rats. J Pharm.Pharmacol. 2003;55(2):239-244. View abstract.
  • Yin, Z. Z., Zhang, L. Y., and Xu, L. N. [The effect of Dang-Gui (Angelica sinensis) and its ingredient ferulic acid on rat platelet aggregation and release of 5-HT (author's transl)]. Yao Xue.Xue.Bao. 1980;15(6):321-326. View abstract.
  • Zhang, Y. H., Park, Y. S., Kim, T. J., Fang, L. H., Ahn, H. Y., Hong, J. T., Kim, Y., Lee, C. K., and Yun, Y. P. Endothelium-dependent vasorelaxant and antiproliferative effects of apigenin. Gen.Pharmacol. 2000;35(6):341-347. View abstract.
  • Zuo, G. Y., Li, Z. Q., Chen, L. R., and Xu, X. J. In vitro anti-HCV activities of Saxifraga melanocentra and its related polyphenolic compounds. Antivir.Chem.Chemother. 2005;16(6):393-398. View abstract.
  • Burnham TH, ed. Drug Facts and Comparisons, Updated Monthly. Facts and Comparisons, St. Louis, MO.
  • Chang CJ, Chiu JH, Tseng LM, et al. Modulation of HER2 expression by ferulic acid on human breast cancer MCF7 cells. Eur J Clin Invest 2006;36:588-96. View abstract.
  • Chung TW, Moon SK, Chang YC, et al. Novel and therapeutic effect of caffeic acid and caffeic acid phenyl ester on hepatocarcinoma cells: complete regression of hepatoma growth and metastasis by dual mechanism. FASEB J 2004;18:1670-81. View abstract.
  • De Smet PAGM, Keller K, Hansel R, Chandler RF, Eds. Adverse Effects of Herbal Drugs 1. Verlag, Berlin: Springer, 1992.
  • Dorsch, W., Bittinger, M., Kaas, A., Muller, A., Kreher, B., and Wagner, H. Antiasthmatic effects of Galphimia glauca, gallic acid, and related compounds prevent allergen- and platelet-activating factor-induced bronchial obstruction as well as bronchial hyperreactivity in guinea pigs. Int Arch Allergy Immunol. 1992;97(1):1-7. View abstract.
  • Foster S, Tyler VE. Tyler's Honest Herbal, 4th ed., Binghamton, NY: Haworth Herbal Press, 1999.
  • Gossel TA, Bricker JD. Principles of Clinical Toxicology. New York, NY:Raven Press, 1994.
  • Guerrero JA, Lozano ML, Castillo J, et al. Flavonoids inhibit platelet function through binding to the thromboxane A2 receptor. J Thromb Haemost 2005;3(2):369-376. View abstract.
  • Johnson JA, Lalonde RL. Congestive Heart Failure. Eds. DiPiro JT, et al. Pharmacotherapy, third ed. Stamford: Appleton and Lange, 1997.

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