XANTHAN GUM

OTHER NAME(S):

Bacterial Polysaccharide, Corn Sugar Gum, Goma Xantana, Gomme de Sucre de Maïs, Gomme de Xanthane, Gomme Xanthane, Polysaccharide Bactérien, Polysaccharide de Type Xanthane, Polysaccharide Xanthane, Xanthan, Xanthomonas campestris.

Overview

Overview Information

Xanthan gum is a chain of sugar building blocks made by fermenting simple sugars with a specific kind of bacteria. It is sometimes used to make medicine.

Xanthan gum is used for diabetes, constipation, dry eye, and many other conditions, but there is no good scientific evidence to support most of these uses.

In manufacturing, xanthan gum is used as a thickening and stabilizing agent in foods, toothpastes, and medicines.

How does it work?

Xanthan gum swells in the intestine, which stimulates the intestine to push stool through. It also seems to slow the absorption of sugar from the digestive tract.

Uses

Uses & Effectiveness?

Possibly Effective for

  • Constipation.
  • Trouble swallowing.

Insufficient Evidence for

  • Diabetes.
  • Dry eye.
  • High cholesterol.
  • An autoimmune disorder in which the glands that produce tears and saliva are damaged (Sjogren syndrome).
Side Effects

Side Effects & Safety

When taken by mouth: Xanthan gum is LIKELY SAFE in the amounts found in foods. It is also LIKELY SAFE when taken as a medicine in doses up to 15 grams per day. It can cause some side effects such as intestinal gas and bloating.

When applied to the skin: Xanthan gum is LIKELY SAFE when used appropriately.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if xanthan gum is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid using amounts larger than those normally found in foods.

Nausea, vomiting, appendicitis, hard stools that are difficult to expel (fecal impaction), narrowing or blockage of the intestine, or undiagnosed stomach pain: Do not use xanthan gum if you have any of these conditions. It is a bulk-forming laxative that could be harmful in these situations.

Surgery: Xanthan gum might lower blood sugar levels. There is a concern that it might interfere with blood sugar control during and after surgery. Stop using xanthan gum at least 2 weeks before a scheduled surgery.

Interactions

Interactions?

Moderate Interaction

Be cautious with this combination

!
  • Medications for diabetes (Antidiabetes drugs) interacts with XANTHAN GUM

    Xanthan gum might decrease blood sugar by decreasing the absorption of sugars from food. Diabetes medications are also used to lower blood sugar. Taking xanthan gum with diabetes medications might cause your blood sugar to be too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.
    Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.

Dosing

Dosing

The following doses have been studied in scientific research:

BY MOUTH:

  • For constipation: Up to 15 grams per day has been used.

View References

REFERENCES:

  • Aerts O, Clinck B, Schramme M, Lambert J. Contact allergy caused by Tinosorb M: let us not forget about xanthan gum. Contact Dermatitis 2015;72(2):121-3. doi: 10.1111/cod.12324. View abstract.
  • Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
  • Daly J, Tomlin J, Read NW. The effect of feeding xanthan gum on colonic function in man: correlation with in vitro determinants of bacterial breakdown. Br J Nutr 1993;69: 897-902. View abstract.
  • Eastwood MA, Brydon WG, Anderson DM. The dietary effects of xanthan gum in man. Food Addit Contam 1987;4:17-26. View abstract.
  • Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  • Llamas-Moreno JF, Baiza-Durán LM, Saucedo-Rodríguez LR, Alaníz-De la O JF. Efficacy and safety of chondroitin sulfate/xanthan gum versus polyethylene glycol/propylene glycol/hydroxypropyl guar in patients with dry eye. Clin Ophthalmol 2013;7:995-9. View abstract.
  • Osilesi O, Trout DL, Glover EE, et al. Use of xanthan gum in dietary management of diabetes mellitus. Am J Clin Nutr 1985;42: 597-603. View abstract.
  • Pérez-Balbuena AL, Ochoa-Tabares JC, Belalcazar-Rey S, et al. Efficacy of a fixed combination of 0.09 % xanthan gum/0.1 % chondroitin sulfate preservative free vs polyethylene glycol/propylene glycol in subjects with dry eye disease: a multicenter randomized controlled trial. BMC Ophthalmol. 2016 Sep;16(1):164. View abstract.
  • Rofes L, Arreola V, Mukherjee R, Swanson J, Clav é P. The effects of a xanthan gum-based thickener on the swallowing function of patients with dysphagia. Aliment Pharmacol Ther 2014;39(10):1169-79. doi: 10.1111/apt.12696. View abstract.
  • Sargent EV, Adolph J, Clemmons MK, et al. Evaluation of flu-like symptoms in workers handling xanthan gum powder. Occup Med 1990;32:625-30. View abstract.
  • Tanaka H, Nishikawa Y, Kure K, Tsuda K, Hosokawa M. The addition of xanthan gum to enteral nutrition suppresses postprandial glycemia in humans. J Nutr Sci Vitaminol (Tokyo) 2018;64(4):284-6. doi: 10.3177/jnsv.64.284. View abstract.
  • van der Reijden WA, Buijs MJ, Damen JJ, et al. Influence of polymers for use in saliva substitutes on de- and remineralization of enamel in vitro. Caries Res 1997;31:216-23. View abstract.
  • van der Reijden WA, van der Kwaak, Vissink A, et al. Treatment of xerostomia with polymer-based saliva substitutes in patients with Sjogren's syndrome. Arthritis Rheum 1996;39:57-63. View abstract.
  • Vilardell N, Rofes L, Arreola V, Speyer R, Clavé P. A comparative study between modified starch and xanthan gum thickeners in post-stroke oropharyngeal dysphagia. Dysphagia 2016;31(2):169-79. doi: 10.1007/s00455-015-9672-8. View abstract.
  • Wade A, Weller PJ, eds. Handbook of Pharmaceutical Excipients. 2nd ed. Washington, DC: Am Pharmaceutical Assn, 1994.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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