Morera Negra, Morus nigra, Mulberry, Mûrier Noir, Purple Mulberry.


Overview Information

Black mulberry is a plant. The ripe berry, twigs, and root bark are used to make medicine.

Black mulberry is used for constipation, symptoms of menopause, and runny nose (rhinitis). A molasses made from black mulberry is used for inflamed mouth sores during cancer treatment. But there is no good scientific evidence to support any of these uses.

How does it work?

Black mulberry fruit contains pectin, which might act as a laxative to help stool pass through the bowels.

Chemicals in black mulberry twigs might lower blood sugar by attaching to certain proteins (receptors) in the body. These receptors then tell the body to break down more sugar in the blood. Also, chemicals in black mulberry fruit might lower the amount of sugar in the blood by slowing the breakdown of sugar from food.


Uses & Effectiveness?

Insufficient Evidence for

  • Symptoms of menopause. Early research shows that taking black mulberry leaf extract improves symptoms of menopause and quality of life in women going through menopause.
  • Swelling (inflammation) and sores inside the mouth (oral mucositis). Rinsing the mouth and then swallowing a molasses made from black mulberry seems to reduce mouth sores during cancer treatment.
  • Constipation.
  • Runny nose not caused by allergies or infection (perennial rhinitis).
  • Other conditions.
More evidence is needed to rate the effectiveness of black mulberry for these uses.

Side Effects

Side Effects & Safety

When taken by mouth: Black mulberry fruit and the molasses made from the fruit is POSSIBLY SAFE when eaten as a food. Black mulberry leaf is POSSIBLY SAFE when taken as a medicine for a short amount of time. There isn't enough reliable information to know what the side effects might be when used as a medicine.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if black mulberry is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Allergies: People who are allergic to black mulberry might also be allergic to fig.

Diabetes: Black mulberry might lower blood sugar. If you have diabetes, monitor your blood sugar levels closely. The dose of your diabetes medication might need to be changed.

Surgery: Black mulberry seems to lower blood sugar levels. It might interfere with blood sugar control during and after surgery. Stop using black mulberry at least 2 weeks before a scheduled surgery.



Moderate Interaction

Be cautious with this combination

  • Medications for diabetes (Antidiabetes drugs) interacts with BLACK MULBERRY

    Black mulberry leaves might decrease blood sugar. Diabetes medications are also used to lower blood sugar. Taking black mulberry leaves along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.
    Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.



The appropriate dose of black mulberry for use as treatment depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for black mulberry. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References


  • Caiaffa, M. F., Cataldo, V. M., Tursi, A., and Macchia, L. Fig and mulberry cross-allergy. Ann.Allergy Asthma Immunol. 2003;91(5):493-495. View abstract.
  • de Souza, M. M., Bittar, M., Cechinel-Filho, V., Yunes, R. A., Messana, I., Delle, Monache F., and Ferrari, F. Antinociceptive properties of morusin, a prenylflavonoid isolated from Morus nigra root bark. Z Naturforsch.[C.] 2000;55(3-4):256-260. View abstract.
  • Kim, H., Yoon, Y. J., Shon, J. H., Cha, I. J., Shin, J. G., and Liu, K. H. Inhibitory effects of fruit juices on CYP3A activity. Drug Metab Dispos. 2006;34(4):521-523. View abstract.
  • Muntean, D., Imre, S., Avrigeanu, V., and Csedo, C. Physico-chemical study of the isolated flavonoids from leaves and bark of Morus alba L. and Morus nigra L. species. Farmacia 2002;50:97-103.
  • Costa JPL, Brito HO, Galvão-Moreira LV, Brito LGO, Costa-Paiva L, Brito LMO. Randomized double-blind placebo-controlled trial of the effect of Morus nigra L. (black mulberry) leaf powder on symptoms and quality of life among climacteric women. Int J Gynaecol Obstet 2020;148(2):243-52. View abstract.
  • Demir Dogan M, Can G, Meral R. Effectiveness of black mulberry molasses in prevention of radiotherapy-induced oral mucositis: A randomized controlled study in head and neck cancer patients. J Altern Complement Med. 2017;23(12):971-979. View abstract.
  • Imran M, Khan H, Shah M, Khan R, Khan F. Chemical composition and antioxidant activity of certain Morus species. J Zhejiang Univ Sci B. 2010;11(12):973-80. View abstract.
  • Xu LJ, Yu MH, Huang CY, et al. Isoprenylated flavonoids from Morus nigra and their PPAR ? agonistic activities. Fitoterapia 2018;127:109-14. View abstract.
  • Yazdankhah S, Hojjati M, Azizi MH. The antidiabetic potential of black mulberry extract-enriched pasta through inhibition of enzymes and glycemic index. Plant Foods Hum Nutr 2019;74(1):149-55. View abstract.

Vitamins Survey

Have you ever purchased BLACK MULBERRY?

Did you or will you purchase this product in-store or online?

Where did you or where do you plan to purchase this product?

Where did you or where do you plan to purchase this product?

What factors influenced or will influence your purchase? (check all that apply)

Vitamins Survey

Where did you or where do you plan to purchase this product?

Do you buy vitamins online or instore?

What factors are most important to you? (check all that apply)

This survey is being conducted by the WebMD marketing sciences department.Read More

More Resources for BLACK MULBERRY

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty .