INDIAN LONG PEPPER: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Indian long pepper is a plant. The fruit and root of the plant are used to make medicine. Indian long pepper is commonly used in combination with other herbs in Ayurvedic medicine and other types of traditional medicine.

Indian long pepper is used for gastrointestinal problems, lung problems, arthritis, problems during menstruation, and many other conditions, but there is no scientific evidence to support these uses.

Indian long pepper is also used to enhance how well the body absorbs other drugs.

How does it work ?

Indian long pepper contains certain chemicals. These chemicals may be able to fight certain parasites that can infect people. They might also help to reduce inflammation (swelling) and kill cancer cells. One of these chemicals called piperine also seems to change the lining of the intestines. This change allows some drugs and other substances taken by mouth to be better absorbed by the body.

View References

REFERENCES:

Panossian, A., Nikoyan, N., Ohanyan, N., Hovhannisyan, A., Abrahamyan, H., Gabrielyan, E., and Wikman, G. Comparative study of Rhodiola preparations on behavioral despair of rats. Phytomedicine. 2008;15(1-2):84-91. View abstract.

Agarwal AK, Singh M, Gupta N, et al. Management of giardiasis by an immuno-modulatory herbal drug Pippali rasayana. J Ethnopharmacol 1994;44:143-6. View abstract.

Agarwal AK, Tripathi DM, Sahai R, et al. Management of giardiasis by a herbal drug Pippali Rasayana: a clinical study. J Ethnopharmacol 1997;56:233-6. View abstract.

Bano G, Amla V, Raina RK, et al. The effect of piperine on pharmacokinetics of phenytoin in healthy volunteers. Planta Med 1987;53:568-9.

Bano G, et al. Effect of piperine on bioavailability and pharmacokinetics of propranolol and theophylline in healthy volunteers. Eur J Clin Pharmacol 1991;41;615-7. View abstract.

Bhardwaj RK, Glaeser H, Becquemont L, et al. Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4. J Pharmacol Exp Ther 2002;302:645-50. View abstract.

Ghoshal S, Prasad BN, Lakshmi V. Antiamoebic activity of Piper longum fruits against Entamoeba histolytica in vitro and in vivo. J Ethnopharmacol 1996;50:167-70. View abstract.

Go J, Park TS, Han GH, et al. Piperlongumine decreases cognitive impairment and improves hippocampal function in aged mice. Int J Mol Med. 2018;42(4):1875-1884. View abstract.

Guo Z, Xu J, Xia J, Wu Z, Lei J, Yu J. Anti-inflammatory and antitumour activity of various extracts and compounds from the fruits of Piper longum L. J Pharm Pharmacol. 2019;71(7):1162-1171. View abstract.

Han, Y., Chin Tan, T. M., and Lim, L. Y. In vitro and in vivo evaluation of the effects of piperine on P-gp function and expression. Toxicol.Appl.Pharmacol. 8-1-2008;230(3):283-289. View abstract.

Hiwale, A. R., Dhuley, J. N., and Naik, S. R. Effect of co-administration of piperine on pharmacokinetics of beta-lactam antibiotics in rats. Indian J Exp.Biol. 2002;40(3):277-281. View abstract.

Kasibhatta, R. and Naidu, M. U. Influence of piperine on the pharmacokinetics of nevirapine under fasting conditions: a randomised, crossover, placebo-controlled study. Drugs R.D. 2007;8(6):383-391. View abstract.

Khajuria A, Zutshi U, Bedi KL. Permeability characteristics of piperine on oral absorption-an active alkaloid from peppers and a bioavailability enhancer. Indian J Exp Biol 1998;36:46-50. View abstract.

Lu C, Zhang B, Xu T, et al. Piperlongumine reduces ovalbumin induced asthma and airway inflammation by regulating nuclear factor ?B activation. Int J Mol Med. 2019;44(5):1855-1865. View abstract.

Mujumdar, A. M., Dhuley, J. N., Deshmukh, V. K., Raman, P. H., Thorat, S. L., and Naik, S. R. Effect of piperine on pentobarbitone induced hypnosis in rats. Indian J Exp.Biol. 1990;28(5):486-487. View Abstract.

Panda, S. and Kar, A. Piperine lowers the serum concentrations of thyroid hormones, glucose and hepatic 5'D activity in adult male mice. Horm.Metab Res. 2003;35(9):523-526. View abstract.

Pattanaik S, Hota D, Prabhakar S, et al. Pharmacokinetic interaction of a single dose of piperine with steady-state carbamazepine in epilepsy patients. Phytother Res 2009;23:1281-6. View abstract.

Reen, R. K., Roesch, S. F., Kiefer, F., Wiebel, F. J., and Singh, J. Piperine impairs cytochrome P4501A1 activity by direct interaction with the enzyme and not by down regulation of CYP1A1 gene expression in the rat hepatoma 5L cell line. Biochem.Biophys.Res.Commun. 1-17-1996;218(2):562-569. View abstract.

Reen, R. K., Wiebel, F. J., and Singh, J. Piperine inhibits aflatoxin B1-induced cytotoxicity and genotoxicity in V79 Chinese hamster cells genetically engineered to express rat cytochrome P4502B1. J Ethnopharmacol. 1997;58(3):165-173. View abstract.

Shah AH, Al-Shareef AH, Ageel AM, Qureshi S. Toxicity studies in mice of common spices, Cinnamomum zeylanicum bark and Piper longum fruits. Plant Foods Hum Nutr 1998;52:231-9. View abstract.

Sharma, P., Varma, M. V., Chawla, H. P., and Panchagnula, R. In situ and in vivo efficacy of peroral absorption enhancers in rats and correlation to in vitro mechanistic studies. Farmaco 2005;60(11-12):874-883. View abstract.

Yadav V, Krishnan A, Vohora D. A systematic review on Piper longum L.: Bridging traditional knowledge and pharmacological evidence for future translational research. J Ethnopharmacol. 2020;247:112255. View abstract.

Zutshi, R. K., Singh, R., Zutshi, U., Johri, R. K., and Atal, C. K. Influence of piperine on rifampicin blood levels in patients of pulmonary tuberculosis. J Assoc.Physicians India 1985;33(3):223-224. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.

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INDIAN LONG PEPPER

Overview

How does it work ?

Uses & Effectiveness ?

Insufficient Evidence for

Side Effects

Special Precautions and Warnings

Interactions ?

Moderate Interaction

Phenytoin (Dilantin) interacts with INDIAN LONG PEPPER

Propranolol (Inderal) interacts with INDIAN LONG PEPPER

Theophylline interacts with INDIAN LONG PEPPER

Dosing

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