INDIAN LONG PEPPER

OTHER NAME(S):

Bi Ba, Bi Bo, Jaborandi Pepper, Kana, Langer Pfeffer, Lindipipper, Long Pepper, Magadhi, Magdhi, Pimienta Larga, Pimenta-Longa, Piper longum, Pippali, Pippli, Poivre Long, Poivre Long d'Inde, Poivrier Long, Poivrier Long d'Inde, Poivre Long Indien, Ushana.

Overview

Overview Information

Indian long pepper is a plant. The fruit and root of the plant are used to make medicine. Indian long pepper is commonly used in combination with other herbs in Ayurvedic medicine and other types of traditional medicine.

Indian long pepper is used for gastrointestinal problems, lung problems, arthritis, problems during menstruation, and many other conditions, but there is no scientific evidence to support these uses.

Indian long pepper is also used to enhance how well the body absorbs other drugs.

How does it work?

Indian long pepper contains certain chemicals. These chemicals may be able to fight certain parasites that can infect people. They might also help to reduce inflammation (swelling) and kill cancer cells. One of these chemicals called piperine also seems to change the lining of the intestines. This change allows some drugs and other substances taken by mouth to be better absorbed by the body.

Uses

Uses & Effectiveness?

Insufficient Evidence for

  • Headache.
  • Toothache.
  • Asthma.
  • Arthritis.
  • Bronchitis.
  • Cholera.
  • Memory and thinking skills (cognitive function).
  • Coma.
  • Cough.
  • Diarrhea.
  • Epilepsy.
  • Fever.
  • Heart disease.
  • Stomach pain.
  • Stroke.
  • Indigestion (dyspepsia).
  • Menstrual disorders.
  • Other conditions.
More evidence is needed to rate the effectiveness of Indian long pepper for these uses.

Side Effects

Side Effects & Safety

When taken by mouth: Indian long pepper fruit is LIKELY SAFE when used in food. There isn't enough reliable information to know if Indian long pepper is safe or what the side effects might be when used as a medicine.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if Indian long pepper is safe to use as medicine when pregnant or breast-feeding. Stay on the safe side and avoid use.

Bleeding conditions: Indian long pepper might slow blood clotting. In theory, taking Indian long pepper in amounts greater than those in food might increase the risk of bleeding in people with bleeding disorders.

Diabetes: Indian long pepper might affect blood sugar levels. In theory, taking Indian long pepper in amounts greater than those in food might affect blood sugar control in people with diabetes. Dosing adjustments for diabetes medications might be needed.

Surgery: Indian long pepper might slow blood clotting and affect blood sugar levels. In theory, taking Indian long pepper in amounts treater than those found in food might cause bleeding complications or affect blood sugar levels during surgery. You should stop taking Indian long pepper in amounts greater than those in food at least 2 weeks before surgery.

Interactions

Interactions?

Moderate Interaction

Be cautious with this combination

!
  • Phenytoin (Dilantin) interacts with INDIAN LONG PEPPER

    Indian long pepper might increase how much phenytoin (Dilantin) the body absorbs. Taking Indian long pepper along with phenytoin (Dilantin) might increase the effects and side effects of phenytoin (Dilantin).

  • Propranolol (Inderal) interacts with INDIAN LONG PEPPER

    Indian long pepper might increase how much propranolol (Inderal) the body absorbs. Taking Indian long pepper along with propranolol (Inderal) might increase the effects and side effects of propranolol (Inderal).

  • Theophylline interacts with INDIAN LONG PEPPER

    Indian long pepper can increase how much theophylline the body absorbs. Taking theophylline along with Indian long pepper might increase the effects and side effects of theophylline.

Dosing

Dosing

The appropriate dose of Indian long pepper depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for Indian long pepper. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

  • Panossian, A., Nikoyan, N., Ohanyan, N., Hovhannisyan, A., Abrahamyan, H., Gabrielyan, E., and Wikman, G. Comparative study of Rhodiola preparations on behavioral despair of rats. Phytomedicine. 2008;15(1-2):84-91. View abstract.
  • Agarwal AK, Singh M, Gupta N, et al. Management of giardiasis by an immuno-modulatory herbal drug Pippali rasayana. J Ethnopharmacol 1994;44:143-6. View abstract.
  • Agarwal AK, Tripathi DM, Sahai R, et al. Management of giardiasis by a herbal drug Pippali Rasayana: a clinical study. J Ethnopharmacol 1997;56:233-6. View abstract.
  • Bano G, Amla V, Raina RK, et al. The effect of piperine on pharmacokinetics of phenytoin in healthy volunteers. Planta Med 1987;53:568-9.
  • Bano G, et al. Effect of piperine on bioavailability and pharmacokinetics of propranolol and theophylline in healthy volunteers. Eur J Clin Pharmacol 1991;41;615-7. View abstract.
  • Bhardwaj RK, Glaeser H, Becquemont L, et al. Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4. J Pharmacol Exp Ther 2002;302:645-50. View abstract.
  • Ghoshal S, Prasad BN, Lakshmi V. Antiamoebic activity of Piper longum fruits against Entamoeba histolytica in vitro and in vivo. J Ethnopharmacol 1996;50:167-70. View abstract.
  • Go J, Park TS, Han GH, et al. Piperlongumine decreases cognitive impairment and improves hippocampal function in aged mice. Int J Mol Med. 2018;42(4):1875-1884. View abstract.
  • Guo Z, Xu J, Xia J, Wu Z, Lei J, Yu J. Anti-inflammatory and antitumour activity of various extracts and compounds from the fruits of Piper longum L. J Pharm Pharmacol. 2019;71(7):1162-1171. View abstract.
  • Han, Y., Chin Tan, T. M., and Lim, L. Y. In vitro and in vivo evaluation of the effects of piperine on P-gp function and expression. Toxicol.Appl.Pharmacol. 8-1-2008;230(3):283-289. View abstract.
  • Hiwale, A. R., Dhuley, J. N., and Naik, S. R. Effect of co-administration of piperine on pharmacokinetics of beta-lactam antibiotics in rats. Indian J Exp.Biol. 2002;40(3):277-281. View abstract.
  • Kasibhatta, R. and Naidu, M. U. Influence of piperine on the pharmacokinetics of nevirapine under fasting conditions: a randomised, crossover, placebo-controlled study. Drugs R.D. 2007;8(6):383-391. View abstract.
  • Khajuria A, Zutshi U, Bedi KL. Permeability characteristics of piperine on oral absorption-an active alkaloid from peppers and a bioavailability enhancer. Indian J Exp Biol 1998;36:46-50. View abstract.
  • Lu C, Zhang B, Xu T, et al. Piperlongumine reduces ovalbumin induced asthma and airway inflammation by regulating nuclear factor ?B activation. Int J Mol Med. 2019;44(5):1855-1865. View abstract.
  • Mujumdar, A. M., Dhuley, J. N., Deshmukh, V. K., Raman, P. H., Thorat, S. L., and Naik, S. R. Effect of piperine on pentobarbitone induced hypnosis in rats. Indian J Exp.Biol. 1990;28(5):486-487. View Abstract.
  • Panda, S. and Kar, A. Piperine lowers the serum concentrations of thyroid hormones, glucose and hepatic 5'D activity in adult male mice. Horm.Metab Res. 2003;35(9):523-526. View abstract.
  • Pattanaik S, Hota D, Prabhakar S, et al. Pharmacokinetic interaction of a single dose of piperine with steady-state carbamazepine in epilepsy patients. Phytother Res 2009;23:1281-6. View abstract.
  • Reen, R. K., Roesch, S. F., Kiefer, F., Wiebel, F. J., and Singh, J. Piperine impairs cytochrome P4501A1 activity by direct interaction with the enzyme and not by down regulation of CYP1A1 gene expression in the rat hepatoma 5L cell line. Biochem.Biophys.Res.Commun. 1-17-1996;218(2):562-569. View abstract.
  • Reen, R. K., Wiebel, F. J., and Singh, J. Piperine inhibits aflatoxin B1-induced cytotoxicity and genotoxicity in V79 Chinese hamster cells genetically engineered to express rat cytochrome P4502B1. J Ethnopharmacol. 1997;58(3):165-173. View abstract.
  • Shah AH, Al-Shareef AH, Ageel AM, Qureshi S. Toxicity studies in mice of common spices, Cinnamomum zeylanicum bark and Piper longum fruits. Plant Foods Hum Nutr 1998;52:231-9. View abstract.
  • Sharma, P., Varma, M. V., Chawla, H. P., and Panchagnula, R. In situ and in vivo efficacy of peroral absorption enhancers in rats and correlation to in vitro mechanistic studies. Farmaco 2005;60(11-12):874-883. View abstract.
  • Yadav V, Krishnan A, Vohora D. A systematic review on Piper longum L.: Bridging traditional knowledge and pharmacological evidence for future translational research. J Ethnopharmacol. 2020;247:112255. View abstract.
  • Zutshi, R. K., Singh, R., Zutshi, U., Johri, R. K., and Atal, C. K. Influence of piperine on rifampicin blood levels in patients of pulmonary tuberculosis. J Assoc.Physicians India 1985;33(3):223-224. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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