Black Catechu: Acacia à Cachou, Acacia catechu, Acacia Catechu Heartwood Extract, Black Cutch, Cachou de Pegu, Cachou Noir, Cachou, Cashou, Catechu nigrum, Catecu, Cutch, Dark Catechu, Er Cha, Khair, Khadira, Mimosa catechu, Pegu Catechu.<br/> Pale Catechu: Cachou Pâle, Cube Gambir, Extrait de Brindille/Feuille d’Uncaria Gambier, Gambier, Gambir, Gambir Catechu, Nauclea gambir, Ourouparia gambir, Terra Japonica, Uncaria gambier, Uncaria Gambier Leaf/Twig Extract.<br/><br/>
Overview InformationCatechu is an herb. The leaves, shoots, and wood are used to make medicine. The two types of catechu, black catechu and pale catechu, contain slightly different chemicals, but they are used for the same purposes and at the same dose.
Catechu is used for diarrhea, swelling of the nose and throat, dysentery, swelling of the colon (colitis), bleeding, indigestion, osteoarthritis, and cancer.
People apply catechu directly to the skin for skin diseases, hemorrhoids, and traumatic injuries; to stop bleeding; and for dressing wounds.
Catechu is included in mouthwashes and gargles used for gum disease (gingivitis), pain and swelling inside the mouth (stomatitis), sore throat, and mouth ulcers.
In foods and beverages, catechu is used as a flavoring agent.
How does it work?It is thought that catechu may contain chemicals that can decrease inflammation and kill bacteria.
Uses & Effectiveness
Insufficient Evidence for
- Osteoarthritis. Developing research suggests that taking 500 mg of a specific catechu extract in combination with a specific Baikal skullcap flavonoid extract known as flavocoxid (Limbrel, Primus Pharmaceuticals) twice daily significantly reduces symptoms of osteoarthritis of the knee.
- Swelling of the nose and throat.
- Swelling in the colon.
- Skin diseases.
- Other conditions.
Side Effects & SafetyCatechu is safe in amounts found in food. But there's not enough information to know if it's safe in the larger amounts that are used as medicine. A specific combination product called flavocoxid (Limbrel, Primus Pharmaceuticals) that contains catechu was safely used in research studies lasting up to 12 weeks. However, there are concerns that this combination product might cause liver problems in some people. This side effect does not appear to be common and might only occur in people who have a type of allergic reaction to it.
It’s also not known whether it’s safe to apply catechu directly to the skin.
Special Precautions & Warnings:Pregnancy and breast-feeding: Catechu is safe for pregnant and breast-feeding women in food amounts. But larger medicinal amounts should be avoided until more is known.
Low blood pressure (hypotension): Catechu might lower blood pressure. There is a concern that it might lower blood pressure too much, causing fainting and other symptoms, in people who already have low blood pressure.
Surgery: Because catechu might lower blood pressure, there is a concern that it might interfere with blood pressure control during and after surgery. Stop using catechu at least 2 weeks before a scheduled surgery.
Be cautious with this combination
Medications for high blood pressure (Antihypertensive drugs) interacts with CATECHU
Catechu might decrease blood pressure. Taking catechu along with medications used for high blood pressure might cause your blood pressure to go too low.<br/><br/> Some medications for high blood pressure include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), Amlodipine (Norvasc), hydrochlorothiazide (HydroDIURIL), furosemide (Lasix), and many others.
The appropriate dose of catechu depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for catechu. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
- Altavilla D, Squadrito F, Bitto A, et al. Flavocoxid, a dual inhibitor of cyclooxygenase and 5-lipoxygenase, blunts pro-inflammatory phenotype activation in endotoxin-stimulated macrophages. Br J Pharmacol 2009;157:1410-18. View abstract.
- Burnett BP, Jia Q, Zhao Y, Levy RM. A medicinal extract of Scutellaria baicalensis and Acacia catechu acts as a dual inhibitor of cyclooxygenase and 5-lipoxygenase to reduce inflammation. J Med Food 2007;10:442-51. View abstract.
- Chalasani N, Vuppalanchi R, Navarro V, et al. Acute liver injury due to flavocoxid (Limbrel), a medical food for osteoarthritis: a case series. Ann Intern Med 2012;156:857-60. View abstract.
- Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
- Koga T, Meydani M. Effect of plasma metabolites of (+)-catechin and quercetin on monocyte adhesion to human aortic endothelial cells. Am J Clin Nutr 2001;73:941-8.. View abstract.
- Levy RM, Khokhlov A, Kopenkin S, et al. Efficacy and safety of flavocoxid, a novel therapeutic, compared with naproxen: a randomized multicenter controlled trial in subjects with osteoarthritis of the knee. Adv Ther 2010;27:731-42. View abstract.
- Levy RM, Saikovsky R, Shmidt E, et al. Flavocoxid is as effective as naproxen for managing the signs and symptoms of osteoarthritis of the knee in humans: a short-term randomized, double-blind pilot study. Nutr Res 2009;29:298-304. View abstract.
- Li RW, Myers SP, Leach DN, et al. A cross-cultural study: anti-inflammatory activity of Australian and Chinese plants. J Ethnopharmacol 2003;85:25-32. View abstract.
- Morgan SL, Baggott JE, Moreland L, et al. The safety of flavocoxid, a medical food, in the dietary management of knee osteoarthritis. J Med Food 2009;12:1143-8. View abstract.
- PL-Detail Document, Liver Toxicity and Limbrel. Pharmacist's Letter/Prescriber's Letter. September 2012.
- Reichenbach S, Juni P. Medical food and food supplements: not always as safe as generally assumed. Ann Intern Med 2012;156:894-5. View abstract.
- Sham JS, Chiu KW, Pang PK. Hypotensive action of Acacia catechu. Planta Med 1984;50:177-80. View abstract.