CETYLATED FATTY ACIDS (CFAs)

OTHER NAME(S):

Acides Gras Cetylated, Acides Gras Cétylés, Acides Gras Estérisés, Acides Gras Mono-Insaturés Cétylés, Ácidos Grasos Cetilados, Cerasomal-cis-9-cetylmyristoleate, Cetyl Decanoate, Cetyl Laurate, Cetyl Laureate, Cetyl Myristate, Cetyl Myristoleate, Cetyl Oleate, Cetyl Palmitate, Cetyl Palmitoleate, Cetyl Stearate, Cetylated Monounsaturated Fatty Acids, Cetylmyristoleate, CFA, Cis-9-cetylmyristoleate, CM, CMO, Esterified Fatty Acid Carbons, Esterified Fatty Acids, Lauréate Cétyl, Myristate Cétyl, Myristoléate Cétyl, Oléate Cétyl, Palmitate Cétyl, Palmitoléate Cétyl.

Overview

Overview Information

Cetylated fatty acids are a group of naturally occurring fats. But cetylated fatty acids used as medicine are often made in a lab. These fats include cetyl myristoleate, cetyl myristate, cetyl palmitoleate, cetyl laurate, cetyl palmitate, and cetyl oleate. Cetyl myristoleate receives the most attention. Many products containing cetyl myristoleate also contain a mixture of these other cetylated fatty acids.

Cetylated fatty acids are commonly used for osteoarthritis. They are also used for other types of arthritis, knee pain, fibromyalgia, and other conditions, but there is no good scientific evidence to support these uses.

How does it work?

Cetylated fatty acids might help lubricate joints and muscles, soften tissues, and increase flexibility. It also might help the immune system and reduce inflammation (swelling).

Uses

Uses & Effectiveness?

Possibly Effective for

  • Osteoarthritis. Taking a specific blend of cetylated fatty acids combined with soy lecithin and fish oil by mouth seems to decrease pain and improve knee motion in people with knee osteoarthritis. But this combination doesn't appear to improve knee stiffness in the morning. Applying specific blends of cetylated fatty acids directly to the skin either alone or in combination with menthol also seems to decrease pain and improve function in people with this condition.

Insufficient Evidence for

  • Knee pain. A small study shows that taking cetylated fatty acids doesn't reduce pain in adults with mild knee pain that is not caused by arthritis.
  • A condition that causes persistent muscle pain (myofascial pain syndrome).
  • Rheumatoid arthritis (RA).
  • Systemic lupus erythematosus (SLE).
  • Multiple sclerosis (MS).
  • A type of arthritis that mainly affects the spine (ankylosing spondylitis).
  • Reactive arthritis.
  • Behcet disease.
  • Sjogren syndrome.
  • Psoriasis.
  • Fibromyalgia.
  • A lung disease that makes it harder to breathe (chronic obstructive pulmonary disease or COPD).
  • Enlarged prostate (benign prostatic hyperplasia or BPH).
  • Breast implant illness.
  • Leukemia.
  • Cancers.
  • Back pain.
  • Other conditions.
There isn't enough evidence to rate the effectiveness of cetylated fatty acids for these uses.

Side Effects

Side Effects & Safety

When taken by mouth: Cetylated fatty acids are POSSIBLY SAFE when taken by mouth, short-term. Side effects have not been reported. But there is not much information available about the safety of long-term use.

When applied to the skin: Cetylated fatty acids are POSSIBLY SAFE when applied to the skin, short-term. Some people might be sensitive to creams containing cetylated fatty acids.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if cetylated fatty acids are safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Interactions

Interactions?

We currently have no information for CETYLATED FATTY ACIDS (CFAs) Interactions.

Dosing

Dosing

The following doses have been studied in scientific research:

BY MOUTH:

  • For osteoarthritis: 1050 mg of a specific blend of cetylated fatty acids plus 150 mg of soy lecithin and 225 mg of fish oil taken 6 times daily.
APPLIED TO THE SKIN:
  • For osteoarthritis: Specific blends of cetylated fatty acids applied twice daily to the affected joint.

View References

REFERENCES:

  • Ameye LG, Chee WS. Osteoarthritis and nutrition. From nutraceuticals to functional foods: a systematic review of the scientific evidence. Arthritis Res Ther 2006;8(4):R127. View abstract.
  • Ariani A, Parisi S, Guidelli GM, Bardelli M, Bertini A, Fusaro E. Short-term effect of topical cetylated fatty acid on early and advanced knee osteoarthritis: A multi-center study. Arch Rheumatol. 2018;33(4):438-442. View abstract.
  • Diehl HW, May EL. Cetyl myristoleate isolated from Swiss albino mice: an apparent protective agent against adjuvant arthritis in rats. J Pharm Sci 1994;83:296-9. View abstract.
  • Golini J, Jones WL. Kre-Celazine® as a viable treatment for juvenile rheumatoid arthritis/juvenile idiopathic arthritis - a pilot study. J Med Food 2014;17(9):1022-6. View abstract.
  • Hesslink R Jr, Armstrong D 3rd, Nagendran MV, et al. Cetylated fatty acids improve knee function in patients with osteoarthritis. J Rheumatol 2002;29:1708-12. View abstract.
  • Hudita A, Galateanu B, Dinescu S, et al. In vitro effects of cetylated fatty acids mixture from celadrin on chondrogenesis and inflammation with impact on osteoarthritis. Cartilage. 2020;11(1):88-97. View abstract.
  • Kraemer WJ, Ratamess NA, Anderson JM, et al. Effect of a cetylated fatty acid topical cream on functional mobility and quality of life of patients with osteoarthritis. J Rheumatol 2004;31:767-74. View abstract.
  • Kraemer WJ, Ratamess NA, Maresh CM, et al. A cetylated fatty acid topical cream with menthol reduces pain and improves functional performance in individuals with arthritis. J Strength Cond Res 2005;19:475-80. View abstract.
  • Kraemer WJ, Ratamess NA, Maresh CM, et al. Effects of treatment with a cetylated fatty acid topical cream on static postural stability and plantar pressure distribution in patients with knee osteoarthritis. J Strength Cond Res 2005;19:115-21. View abstract.
  • Lee SC, Jin HS, Joo Y, Kim YC, Moon JY. The minimal effective dose of cis-9-cetylmyristoleate (CMO) in persons presenting with knee joint pain: a double-blind, randomized, placebo-controlled trial. Medicine (Baltimore). 2017 Mar;96(9):e6149.
  • Sharan D, Jacob BN, Ajeesh PS, Bookout JB, Barathur RR. The effect of cetylated fatty esters and physical therapy on myofascial pain syndrome of the neck. J Bodyw Mov Ther. 2011;15(3):363-74. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2018.