CHYMOTRYPSIN

OTHER NAME(S):

A-Chymotrypsin, A-Chymotrypsine, Alpha-Chymotrypsin, Alpha-Chymotrypsine, Chymotrypsin A, Chymotrypsine A, Chymotrypsin B, Chymotrypsine B, Chymotrypsine, Chymotrypsinum, L-Chymotrypsin, L-Chymotrypsine, Quimotripsina.<br/><br/>

Overview

Overview Information

Chymotrypsin is an enzyme. An enzyme is a substance that speeds up certain chemical reactions in the body. People use chymotrypsin to make medicine.

People take chymotrypsin by mouth or as a shot to reduce redness and swelling associated with pockets of infection (abscesses), ulcers, surgery, or traumatic injuries; and to help loosen phlegm in asthma, bronchitis, lung diseases, and sinus infections.

It is also taken by mouth to reduce liver damage in burn patients; and to assist in wound repair.

Chymotrypsin is sometimes breathed in (inhaled) or applied to the skin (used topically) for conditions that involve pain and swelling (inflammation) and for infections.

During cataract surgery, chymotrypsin is sometimes used to reduce damage to the eye.

How does it work?

Chymotrypsin has ingredients that reduce swelling (inflammation) and tissue destruction.

Uses

Uses & Effectiveness?

Effective for

  • Cataract surgery, when used by a healthcare professional.

Possibly Effective for

  • Burns. There is some evidence that chymotrypsin might decrease tissue destruction in burn patients.
  • Hand Fractures. Taking chymotrypsin by mouth seems to be effective for reducing redness and swelling associated with hand fractures.

Insufficient Evidence for

More evidence is needed to rate the effectiveness of chymotrypsin for these uses.

Side Effects

Side Effects & Safety

Chymotrypsin is safe when used in the eye by a healthcare professional. Chymotrypsin can cause side effects when used in the eye, including an increase in pressure in the eye and other eye conditions such as uveitis, paralysis of the iris, and keratitis.

It also seems to be safe for most people when taken by mouth to reduce redness and swelling following surgery or injury, and when applied directly to the skin for burns.

Not enough is known about the safety of chymotrypsin for its other uses.

Rarely, chymotrypsin might cause an allergic reaction when taken by mouth. Symptoms include itching, shortness of breath, swelling of the lips or throat, shock, loss of consciousness, and death.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Not enough is known about the use of chymotrypsin during pregnancy and breast-feeding. Stay on the safe side and avoid use.

Interactions

Interactions?

We currently have no information for CHYMOTRYPSIN Interactions.

Dosing

Dosing

The following doses have been studied in scientific research:

BY MOUTH:

  • To reduce tissue damage in burn patients: a 6:1 ratio (trypsin:chymotrypsin), in a combined amount of 200,000 units USP four times daily for ten days.
BY INJECTION:
  • Healthcare providers inject a solution of chymotrypsin into the eyes as part of cataract surgery.

View References

REFERENCES:

  • Dukes, MNG. Meyler's Side Effects of Drugs. 13th ed. Elsevier: Amsterdam, 1997.
  • Latha B, Ramakrishnan M, Jayaraman V, Babu M. Serum enzymatic changes modulated using trypsin: chymotrypsin preparation during burn wounds in humans. Burns 1997;23:560-4. View abstract.
  • Latha B, Ramakrishnan M, Jayaraman V, Babu M. The efficacy of trypsin: chymotrypsin preparation in the reduction of oxidative damage during burn injury. Burns 1998;24:532-8. View abstract.
  • McCue FC, Webster TM, Gieck J. Clinical effects of proteolytic enzymes after reconstructive hand surgery. Int Surg 1972;57:479-82.
  • Shaw PC. The use of a trypsin-chymotrypsin formulation in fractures of the hand. Br J Clin Pract 1969;23:25-6.

More Resources for CHYMOTRYPSIN

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2018.