GOLDTHREAD

OTHER NAME(S):

Anemone groenlandica, Cankerroot, Chinese Coptis, Chinese Goldthread, Coptide, Coptide à Trois Feuilles, Coptide Chinois, Coptide du Groenland, Coptide Savoyane, Coptide Trifoliolée, Coptidis Rhizome, Coptis, Coptis chinensis, Coptis deltoidea, Coptis groenlandica, Coptis Rhizome, Coptis teeta, Coptis teetoides, Coptis trifolia, Golden Thread, Goldenthread, Huang Lian, Huanglian, Mouth Root, Racine Jaune, Rhizoma Coptidis, Savoyane, Tisavoyane Jaune, Yellowroot.<br/><br/>

Overview

Overview Information

Goldthread is a plant. The underground stem (rhizome) is used to make medicine.

Goldthread is used for digestive disorders, parasite infections including leishmaniasis, and trichomoniasis, and a skin condition called psoriasis.

How does it work?

Goldthread might decrease acid in the stomach. It also appears to have antibacterial effects.

Uses

Uses & Effectiveness?

Insufficient Evidence for

  • Digestive problems.
  • Leishmaniasis (a parasite infection that affects the skin).
  • Trichomoniasis (a parasite infection that is transmitted sexually).
  • Psoriasis (a skin condition).
  • Other conditions.
More evidence is needed to rate the effectiveness of goldthread for these uses.

Side Effects

Side Effects & Safety

There is not enough information to know if goldthread is safe in medicinal amounts. Goldthread is UNSAFE in newborn infants.

Special Precautions & Warnings:

Children: Goldthread is UNSAFE in children. It contains a chemical called berberine that can increase the amount of bilirubin in newborns. Bilirubin is a chemical released by the liver. Too much bilirubin can lead to permanent brain damage in newborns, especially in newborns born too early.

Pregnancy and breast-feeding: Goldthread is UNSAFE during pregnancy. It contains a chemical called berberine that is thought to cross the placenta and may cause harm to the developing child. Brain damage due to too much bilirubin has developed in newborn infants exposed to berberine. Beginning research suggests pregnant women who take goldthread during the first three months of pregnancy increase the risk that their newborns will have birth defects affecting the central nervous system.

It’s also UNSAFE for breast-feeding mothers to take goldthread. Berberine and other harmful chemicals in goldthread can be transferred to the infant through breast milk.

Interactions

Interactions?

Moderate Interaction

Be cautious with this combination

!
  • Cyclosporine (Neoral, Sandimmune) interacts with GOLDTHREAD

    The body breaks down cyclosporine (Neoral, Sandimmune) to get rid of it. Goldthread might decrease how fast the body breaks down cyclosporine (Neoral, Sandimmune). This might cause there to be too much cyclosporine (Neoral, Sandimmune) in the body and potentially cause side effects.

  • Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with GOLDTHREAD

    Some medications are changed and broken down by the liver.<nb>Goldthread might decrease how quickly the liver breaks down some medications. Taking goldthread along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking goldthread, talk to your healthcare provider if you are taking any medications that are changed by the liver.<nb>Some medications changed by the liver include cyclosporine (Neoral, Sandimmune), lovastatin (Mevacor), clarithromycin (Biaxin), indinavir (Crixivan), sildenafil (Viagra), triazolam (Halcion), and many others.

Dosing

Dosing

The appropriate dose of goldthread depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for goldthread. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

  • Amin AH, Subbaiah TV, Abbasi KM. Berberine sulfate: antimicrobial activity, bioassay, and mode of action. Can J Microbiol 1969;15:1067-76. View abstract.
  • Ang ES, Lee ST, Gan CS, et al. Evaluating the role of alternative therapy in burn wound management: randomized trial comparing moist exposed burn ointment with conventional methods in the management of patients with second-degree burns. MedGenMed 2001;3:3. View abstract.
  • Anis KV, Rajeshkumar NV, Kuttan R. Inhibition of chemical carcinogenesis by berberine in rats and mice. J Pharm Pharmacol 2001;53:763-8. . View abstract.
  • Chan E. Displacement of bilirubin from albumin by berberine. Biol Neonate 1993;63:201-8. View abstract.
  • Chuang CH, Doyle P, Wang JD, et al. Herbal medicines used during the first trimester and major congenital malformations: an analysis of data from a pregnancy cohort study. Drug Saf 2006;29:537-48. View abstract.
  • Cuellar MJ, Giner RM, Recio MC, et al. Topical anti-inflammatory activity of some Asian medicinal plants used in dermatological disorders. Fitoterapia 2001;72:221-9. View abstract.
  • Gupte S. Use of berberine in treatment of giardiasis. Am J Dis Child 1975;129:866. View abstract.
  • Hsiang CY, Wu SL, Cheng SE, Ho TY. Acetaldehyde-induced interleukin-1beta and tumor necrosis factor-alpha production is inhibited by berberine through nuclear factor-kappaB signaling pathway in HepG2 cells. J Biomed Sci 2005;12:791-801. View abstract.
  • Hsieh MT, Peng WH, Wu CR, Wang WH. The ameliorating effects of the cognitive-enhancing Chinese herbs on scopolamine-induced amnesia in rats. Phytother Res 2000;14:375-7. View abstract.
  • Janbaz KH, Gilani AH. Studies on preventive and curative effects of berberine on chemical-induced hepatotoxicity in rodents. Fitoterapia 2000;71:25-33.. View abstract.
  • Kaneda Y, Torii M, Tanaka T, Aikawa M. In vitro effects of berberine sulphate on the growth and structure of Entamoeba histolytica, Giardia lamblia and Trichomonas vaginalis. Ann Trop Med Parasitol 1991;85:417-25. View abstract.
  • Khosla PG, Neeraj VI, Gupta SK, et al. Berberine, a potential drug for trachoma. Rev Int Trach Pathol Ocul Trop Subtrop Sante Publique 1992;69:147-65. View abstract.
  • Kim SH, Shin DS, Oh MN, et al. Inhibition of the bacterial surface protein anchoring transpeptidase sortase by isoquinoline alkaloids. Biosci Biotechnol Biochem 2004;68:421-4.. View abstract.
  • Kong LD, Cheng CH, Tan RX. Monoamine oxidase inhibitors from rhizoma of Coptis chinensis. Planta Med 2001;67:74-6. View abstract.
  • Li B, Shang JC, Zhou QX. [Study of total alkaloids from rhizoma coptis chinensis on experimental gastric ulcers]. Chin J Integr Med 2005;11:217-21. View abstract.
  • Lin CC, Ng LT, Hsu FF, et al. Cytotoxic effects of Coptis chinensis and Epimedium sagittatum extracts and their major constituents (berberine, coptisine and icariin) on hepatoma and leukaemia cell growth. Clin Exp Pharmacol Physiol 2004;31:65-9. View abstract.
  • Lin LT, Liu LT, Chiang LC, Lin CC. In vitro anti-hepatoma activity of fifteen natural medicines from Canada. Phytother Res 2002;16:440-4. View abstract.
  • Lust J. The herb book. New York, NY: Bantam Books, 1999.
  • Rehman J, Dillow JM, Carter SM, et al. Increased production of antigen-specific immunoglobulins G and M following in vivo treatment with the medicinal plants Echinacea angustifolia and Hydrastis canadensis. Immunol Lett 1999;68:391-5. View abstract.
  • Scazzocchio F, Corneta MF, Tomassini L, Palmery M. Antibacterial activity of Hydrastis canadensis extract and its major isolated alkaloids. Planta Med 2001;67:561-4. View abstract.
  • Schinella GR, Tournier HA, Prieto JM, et al. Inhibition of Trypanosoma cruzi growth by medical plant extracts. Fitoterapia 2002;73:569-75. View abstract.
  • Schinella GR, Tournier HA, Prieto JM, et al. Antioxidant activity of anti-inflammatory plant extracts. Life Sci 2002;70:1023-33. View abstract.
  • Sun D, Courtney HS, Beachey EH. Berberine sulfate blocks adherence of Streptococcus pyogenes to epithelial cells, fibronectin, and hexadecane. Antimicrob Agents Chemother 1988;32:1370-4. View abstract.
  • Tsai PL, Tsai TH. Hepatobiliary excretion of berberine. Drug Metab Dispos 2004;32:405-12. . View abstract.
  • Wang GP, Tang FQ, Zhou JP. [Effect of Coptis Chinensis compound on the gene expression in transplanted tumor tissue in nasopharyngeal carcinoma cell line of CNE1 by cDNA microarray]. Hunan Yi Ke Da Xue Xue Bao. 2003;28:347-52. View abstract.
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  • Wu X, Li Q, Xin H, Yu A, Zhong M. Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study. Eur J Clin Pharmacol 2005;61:567-72. View abstract.
  • Yang LQ, Singh M, Yap EH, et al. In vitro response of Blastocystis hominis against traditional Chinese medicine. J Ethnopharmacol 1996;55:35-42. View abstract.
  • Yokozawa T, Satoh A, Cho EJ, et al. Protective role of Coptidis Rhizoma alkaloids against peroxynitrite-induced damage to renal tubular epithelial cells. J Pharm Pharmacol 2005;57:367-74. View abstract.
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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2018.