PERILLA

OTHER NAME(S):

Basilic Japonais, Beefsteak Plant, Dentidia nankinensis, Huile de Graines de Pérille, Huile de Graines de Shiso, Huile de Pérille, Huile de Shiso, Ja-So-Yeop, Japanese Basil, Japanese Melissea, Menthe Pourpre, Ocimum frutescens, Perilla arguta, Perilla frutescens, Perilla nankinensis, Perilla ocymoides, Perilla Oil, Perilla Seed Oil, Pérille, Pérille de Nankin, Pérille de Nankin Pourpre, Pérille de Nankin Vert, Purple Mint, Purple Perilla, Shiso, Shiso Japonais, Silam, Wild Coleus, Zi Su.<br/><br/>

Overview

Overview Information

Perilla is an herb. The leaf, stem, and seed are used to make medicine.

Perilla is commonly used by mouth for asthma and allergies, among many other conditions. But there is limited scientific evidence to support any of these uses.

In foods, perilla is used as a flavoring, in tea, and to prevent fish and crab poisoning.

In manufacturing, perilla seed oil is used commercially in the production of varnishes, dyes, and inks.

How does it work?

Perilla contains chemicals that might decrease swelling and affect other chemicals that cause asthma and allergy symptoms. Some chemicals in perilla might kill cancer cells.

Uses

Uses & Effectiveness?

Insufficient Evidence for

  • Seasonal allergies (hayfever). Perilla extract seems to decrease symptoms of seasonal allergies in some people. But more research is needed.
  • Asthma. Using perilla seed oil might improve lung function in some people with asthma. But more research is needed.
  • Canker sores. Cooking with perilla seed oil for 8 months might decrease the average monthly occurrence of canker sores in people with recurrent canker sores.
  • Upset stomach (dyspepsia). Perilla extract does not seem to improve bloating, stomach discomfort, gas, or other symptoms in people who complain of stomach problems.
  • Cancer.
  • Causing sweating.
  • Depression.
  • Nausea.
  • Relieving spasms.
  • Sunstroke.
  • Other conditions.
More evidence is needed to rate the effectiveness of perilla for these uses.

Side Effects

Side Effects & Safety

Perilla is POSSIBLY SAFE for most people when taken by mouth for up to 8 months. When put on the skin, perilla can cause an allergic skin reaction and rash. Some people are allergic to perilla and the symptoms may be severe.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking perilla if you are pregnant or breast-feeding. Stay on the safe side and avoid use.

Interactions

Interactions?

We currently have no information for PERILLA Interactions.

Dosing

Dosing

The appropriate dose of perilla depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for perilla. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

  • Baba, S., Osakabe, N., Natsume, M., Yasuda, A., Muto, Y., Hiyoshi, K., Takano, H., Yoshikawa, T., and Terao, J. Absorption, metabolism, degradation and urinary excretion of rosmarinic acid after intake of Perilla frutescens extract in humans. Eur J Nutr 2005;44(1):1-9. View abstract.
  • Gatchalian-Yee, M., Imamura, M., Nonaka, M., Gu, J. Y., and Sugano, M. Effect of dietary fats on cholesterol metabolism and eicosanoid production in hamsters fed undigested fraction of soybean protein. J Nutr Sci Vitaminol.(Tokyo) 1994;40(5):499-504. View abstract.
  • Gu, J. Y., Wakizono, Y., Dohi, A., Nonaka, M., Sugano, M., and Yamada, K. Effect of dietary fats and sesamin on the lipid metabolism and immune function of Sprague-Dawley rats. Biosci.Biotechnol.Biochem. 1998;62(10):1917-1924. View abstract.
  • Hamazaki, K., Itomura, M., Hamazaki, T., and Sawazaki, S. Effects of cooking plant oils on recurrent aphthous stomatitis: a randomized, placebo-controlled, double-blind trial. Nutrition 2006;22(5):534-538. View abstract.
  • Hirose, M., Masuda, A., Ito, N., Kamano, K., and Okuyama, H. Effects of dietary perilla oil, soybean oil and safflower oil on 7,12-dimethylbenz[a]anthracene (DMBA) and 1,2-dimethyl-hydrazine (DMH)-induced mammary gland and colon carcinogenesis in female SD rats. Carcinogenesis 1990;11(5):731-735. View abstract.
  • Ihara, M., Umekawa, H., Takahashi, T., and Furuichi, Y. Comparative effects of short- and long-term feeding of safflower oil and perilla oil on lipid metabolism in rats. Comp Biochem Physiol B Biochem Mol.Biol 1998;121(2):223-231. View abstract.
  • Inouye, S., Uchida, K., and Yamaguchi, H. In-vitro and in-vivo anti-Trichophyton activity of essential oils by vapour contact. Mycoses 2001;44(3-4):99-107. View abstract.
  • Inouye, S., Yamaguchi, H., and Takizawa, T. Screening of the antibacterial effects of a variety of essential oils on respiratory tract pathogens, using a modified dilution assay method. J Infect.Chemother. 2001;7(4):251-254. View abstract.
  • Kanzaki, T. and Kimura, S. Occupational allergic contact dermatitis from Perilla frutescens (shiso). Contact Dermatitis 1992;26(1):55-56. View abstract.
  • Kim, H. K. and Choi, H. Stimulation of acyl-CoA oxidase by alpha-linolenic acid-rich perilla oil lowers plasma triacylglycerol level in rats. Life Sci 8-5-2005;77(12):1293-1306. View abstract.
  • Ko, W. C., Shih, C. M., Leu, I. J., Chen, T. T., and Chang, J. P. Mechanisms of relaxant action of luteolin in isolated guinea pig trachea. Planta Med 2005;71(5):406-411. View abstract.
  • Kurowska, E. M., Dresser, G. K., Deutsch, L., Vachon, D., and Khalil, W. Bioavailability of omega-3 essential fatty acids from perilla seed oil. Prostaglandins Leukot.Essent.Fatty Acids 2003;68(3):207-212. View abstract.
  • Linnabary, R. D., Warren, J., Wilson, B. J., and Byerly, C. S. Acute bovine pulmonary emphysema produced by Perilla frutescens. Mod.Vet.Pract. 1978;59(9):684-686. View abstract.
  • Makino, T., Ito, M., Kiuchiu, F., Ono, T., Muso, E., and Honda, G. Inhibitory effect of decoction of Perilla frutescens on cultured murine mesangial cell proliferation and quantitative analysis of its active constituents. Planta Med 2001;67(1):24-28. View abstract.
  • Makino, T., Ono, T., Liu, N., Nakamura, T., Muso, E., and Honda, G. Suppressive effects of rosmarinic acid on mesangioproliferative glomerulonephritis in rats. Nephron 2002;92(4):898-904. View abstract.
  • Makino, T., Ono, T., Matsuyama, K., Nogaki, F., Miyawaki, S., Honda, G., and Muso, E. Suppressive effects of Perilla frutescens on IgA nephropathy in HIGA mice. Nephrol.Dial.Transplant. 2003;18(3):484-490. View abstract.
  • Makino, T., Ono, T., Muso, E., Honda, G., and Sasayama, S. Suppressive effects of Perilla frutescens on spontaneous IgA nephropathy in ddY mice. Nephron 1999;83(1):40-46. View abstract.
  • Nakazawa, T. and Ohsawa, K. Metabolites of orally administered Perilla frutescens extract in rats and humans. Biol.Pharm.Bull. 2000;23(1):122-127. View abstract.
  • Narisawa, T., Takahashi, M., Kotanagi, H., Kusaka, H., Yamazaki, Y., Koyama, H., Fukaura, Y., Nishizawa, Y., Kotsugai, M., Isoda, Y., and . Inhibitory effect of dietary perilla oil rich in the n-3 polyunsaturated fatty acid alpha-linolenic acid on colon carcinogenesis in rats. Jpn.J Cancer Res 1991;82(10):1089-1096. View abstract.
  • Okamoto, M., Mitsunobu, F., Ashida, K., Mifune, T., Hosaki, Y., Tsugeno, H., Harada, S., and Tanizaki, Y. Effects of dietary supplementation with n-3 fatty acids compared with n-6 fatty acids on bronchial asthma. Intern Med 2000;39(2):107-111. View abstract.
  • Osakabe, N., Takano, H., Sanbongi, C., Yasuda, A., Yanagisawa, R., Inoue, K., and Yoshikawa, T. Anti-inflammatory and anti-allergic effect of rosmarinic acid (RA); inhibition of seasonal allergic rhinoconjunctivitis (SAR) and its mechanism. Biofactors 2004;21(1-4):127-131. View abstract.
  • Sanbongi, C., Takano, H., Osakabe, N., Sasa, N., Natsume, M., Yanagisawa, R., Inoue, K. I., Sadakane, K., Ichinose, T., and Yoshikawa, T. Rosmarinic acid in perilla extract inhibits allergic inflammation induced by mite allergen, in a mouse model. Clin Exp Allergy 2004;34(6):971-977. View abstract.
  • Shin, T. Y., Kim, S. H., Kim, S. H., Kim, Y. K., Park, H. J., Chae, B. S., Jung, H. J., and Kim, H. M. Inhibitory effect of mast cell-mediated immediate-type allergic reactions in rats by Perilla frutescens. Immunopharmacol.Immunotoxicol. 2000;22(3):489-500. View abstract.
  • Takano, H., Osakabe, N., Sanbongi, C., Yanagisawa, R., Inoue, K., Yasuda, A., Natsume, M., Baba, S., Ichiishi, E., and Yoshikawa, T. Extract of Perilla frutescens enriched for rosmarinic acid, a polyphenolic phytochemical, inhibits seasonal allergic rhinoconjunctivitis in humans. Exp.Biol.Med.(Maywood.) 2004;229(3):247-254. View abstract.
  • Ueda, H. and Yamazaki, M. Inhibition of tumor necrosis factor-alpha production by orally administering a perilla leaf extract. Biosci.Biotechnol.Biochem 1997;61(8):1292-1295. View abstract.
  • Ueda, H., Yamazaki, C., and Yamazaki, M. Inhibitory effect of Perilla leaf extract and luteolin on mouse skin tumor promotion. Biol Pharm Bull. 2003;26(4):560-563. View abstract.
  • Yamamoto, H. and Ogawa, T. Antimicrobial activity of perilla seed polyphenols against oral pathogenic bacteria. Biosci.Biotechnol.Biochem. 2002;66(4):921-924. View abstract.
  • Yun, L., Onodera, H., Takagi, H., Koujitani, T., Yasuhara, K., Mitsumori, K., and Hirose, M. [A 13-week subchronic oral toxicity study of Perilla extracts in F344 rats]. Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku 1999;(117):104-107. View abstract.
  • Benegut Spreadsheet. RFI Ingredients. Available at: https://rfiingredients.com/wp-content/uploads/2013/12/Benegut_07122016.pdf. Accessed: November 18, 2018.
  • Buchwald-Werner S, Fujii H, Reule C, Schoen C. Perilla extract improves gastrointestinal discomfort in a randomized placebo controlled double blind human pilot study. BMC Complement Altern Med 2014;14:173. View abstract.
  • Golik A, Zaidenstein R, Dishi V, et al. Effects of captopril and enalapril on zinc metabolism in hypertensive patients. J Am Coll Nutr 1998;17:75-8. View abstract.
  • Makino T, Ono T, Muso E, Honda G. Inhibitory effect of Perilla frutescens and its phenolic constituents on cultured murine mesangial cell proliferation. Planta Med 1998;64:541-45. View abstract.
  • Okamoto M, Mitsunobu F, Ashida K, et al. Effects of perilla seed oil supplementation on leukotriene generation by leucocytes in patients with asthma associated with lipometabolism. Int Arch Allergy Immunol 2000;122:137-42. View abstract.
  • Thomas SS, Kim M, Lee SJ, Cha YS. Antiobesity effects of purple perilla (Perilla frutescens var. acuta) on adipocyte differentiation and mice fed a high-fat diet. J Food Sci. 2018;83(9):2384-2393. View abstract.
  • Uemura T, Yashiro T, Oda R, et al. Intestinal anti-inflammatory activity of perillaldehyde. J Agric Food Chem. 2018;66(13):3443-3448. View abstract.
  • Yu H, Qiu JF, Ma LJ, Hu YJ, Li P, Wan JB. Phytochemical and phytopharmacological review of Perilla frutescens L. (Labiatae), a traditional edible-medicinal herb in China. Food Chem Toxicol 2017;108(Pt B):375-91. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2018.