Acide Pangamique, Ácido Pangámico, Calcium Pangamate, Calgam, Di-isopropylamine Dichloroacetate, Vitamin B15, Vitamine B15.


Overview Information

There is no standard chemical identity for pangamic acid. Formulations can include one or more of the following: sodium gluconate, calcium gluconate, glycine, diisopropylamine dichloroacetate, dimethylglycine, calciumchloride, dicalcium phosphate, stearic acid, cellulose, or other chemical compounds.

Pangamic acid is the name given to a product originally claimed to contain D-gluconodimethyl aminoacetic acid, which was obtained from apricot kernels and later from rice bran. It is also referred to as vitamin B15, but pangamic acid is not generally recognized as a vitamin.

Research by Russian sports scientists focused attention on pangamic acid, but little, if any, research has been conducted in the US.

Natural sources for D-gluconodimethyl aminoacetic acid include brewer's yeast, whole brown rice, sesame seeds, and pumpkin seeds.

Despite serious safety concerns, pangamic acid is used for improving exercise endurance; treating asthma and related diseases, skin conditions including eczema, lung problems, painful nerve and joint conditions, cancer, and arthritis; improving the oxygenation of the heart, brain, and other vital organs; and “detoxifying” the body. It is also used for treating alcoholism, hangovers, and fatigue; protecting against urban air pollutants; extending cell life; strengthening the immune system; lowering bloodcholesterol levels; and assisting in hormone regulation.

How does it work?

Since there is no standard identity for the chemicals in pangamic acid, how it might work is unknown. Although pangamic acid is also called vitamin B15, there is no research that shows it is required by the body, as the term “vitamin” would suggest.


Uses & Effectiveness?

Possibly Ineffective for

Insufficient Evidence for

More evidence is needed to rate the effectiveness of pangamic acid for these uses.

Side Effects

Side Effects & Safety

Pangamic acid is considered UNSAFE. Chemicals found in some formulations of pangamic acid may cause cancer.

Special Precautions & Warnings:

Pregnancy and breast-feeding: It’s UNSAFE to use pangamic acid if you are pregnant or breast-feeding. It’s difficult to know exactly what chemicals are in the product you are using. Some chemicals found in some formulations can cause birth defects and/or cancer.

Kidney conditions: Pangamic acid can cause kidney stones and other kidney problems, making existing kidney disease worse. Don’t use it.



Moderate Interaction

Be cautious with this combination

  • Digoxin (Lanoxin) interacts with PANGAMIC ACID

    Digoxin (Lanoxin) helps the heart beat more strongly. Some types of pangamic acid contain calcium. Calcium might also affect the heart. Taking pangamic acid along with digoxin (Lanoxin) might increase the effects and side effects of digoxin (Lanoxin).

  • Medications for high blood pressure (Calcium channel blockers) interacts with PANGAMIC ACID

    Some medications for high blood pressure affect calcium in the body. These medications are called calcium channel blockers. Taking pangamic acid that contains calcium might decrease the effectiveness of these medications for high blood pressure.
    Some medications for high blood pressure include nifedipine (Adalat, Procardia), verapamil (Calan, Isoptin, Verelan), diltiazem (Cardizem), isradipine (DynaCirc), felodipine (Plendil), amlodipine (Norvasc), and others.

  • Water pills (Thiazide diuretics) interacts with PANGAMIC ACID

    Some pangamic acid can contain calcium. Some "water pills" increase the amount of calcium in the body. Taking large amounts of calcium with some "water pills" might cause there to be too much calcium in the body. This could cause serious side effects including kidney problems.
    Some of these "water pills" include chlorothiazide (Diuril), hydrochlorothiazide (HydroDIURIL, Esidrix), indapamide (Lozol), metolazone (Zaroxolyn), and chlorthalidone (Hygroton).



The appropriate dose of pangamic acid depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for pangamic acid. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References


  • Burnham TH, ed. Drug Facts and Comparisons, Updated Monthly. Facts and Comparisons, St. Louis, MO.
  • FDA Office of Regulatory Affairs. Sec. 457.100 Pangamic Acid and Pangamic Acid Products Unsafe for Food and Drug Use. (CPG 7121.01). 1995. Available at: (Accessed 16 July 1999).
  • Gray ME, Titlow LW. The effect of pangamic acid on maximal treadmill performance. Med Sci Sports Exerc 1982;14:424-7. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
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