Oregon grape is used for scaly, itchy skin (psoriasis), eczema (atopic dermatitis), stomach problems, and other conditions, but there is no good scientific evidence to support these uses.
How does it work ?
Uses & Effectiveness ?
Possibly Effective for
- Scaly, itchy skin (psoriasis). Some evidence suggests that applying a specific 10% Oregon grape extract cream (Relieva by Apollo Pharmaceutical) can reduce the severity of psoriasis and improve quality of life for people who have psoriasis. It might be as effective as the medicationcalcipotriene (Dovonex) cream for some people.
Insufficient Evidence for
- Eczema (atopic dermatitis). Early research suggests that applying a specific Oregon grape extract cream (Relieva by Apolla Pharmaceutical) for 12 weeks might improve the severity and area of itchy and inflamed skin in people with a skin condition called eczema.
- Stomach ulcers.
- Stomach upset.
- Other conditions.
When applied to the skin: Oregon grape cream is POSSIBLY SAFE for most people when applied directly to the skin. It can cause some side effects such as itching, burning, irritation, and allergic reactions.
Special Precautions and Warnings
Children: It's LIKELY UNSAFE to give Oregon grape to infants. The berberine in Oregon grape can cause brain damage (kernicterus) in newborns, particularly premature newborns who have jaundice. Jaundice is a condition in which there is yellowing of the eyes and skin caused by bile pigments in the blood. There isn't enough reliable information to know if Oregon grape is safe to give to older children. Stay on the safe side and avoid use.
Diabetes: Oregon grape can lower blood sugar. Oregon grape may cause blood sugar to become too low in people who are also taking antidiabetes medications. Use with caution.
Low blood pressure: Oregon grape can lower blood pressure. Oregon grape might increase the risk of blood pressure becoming too low in people who already have low blood pressure. Use with caution.
Cyclosporine (Neoral, Sandimmune) interacts with OREGON GRAPE
The body breaks down cyclosporine (Neoral, Sandimmune) to get rid of it. Oregon grape might decrease how fast the body breaks down cyclosporine (Neoral, Sandimmune). This might cause there to be too much cyclosporine (Neoral, Sandimmune) in the body and potentially cause side effects.
Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with OREGON GRAPE
Some medications are changed and broken down by the liver.
Oregon grape might decrease how quickly the liver breaks down some medications. Taking Oregon grape along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking Oregon grape, talk to your healthcare provider if you are taking any medications that are changed by the liver. Some medications changed by the liver include cyclosporine (Neoral, Sandimmune), lovastatin (Mevacor), clarithromycin (Biaxin), indinavir (Crixivan), sildenafil (Viagra), triazolam (Halcion), and many others.
Be cautious with this combination
APPLIED TO THE SKIN:
- For scaly, itchy skin (psoriasis): A specific 10% Oregon grape bark extract cream (Relieva, Apolla Pharmaceutical) is applied to affected areas 2-3 times daily.
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