OCTACOSANOL

OTHER NAME(S):

1-Octacosanol, Hexacosanol (26-C), N-octacosanol, Octacosyl Alcohol, Tetracosanol (24-C), Tétracosanol (24-C), Triacontanol (30-C).<br/><br/>

Overview

Overview Information

Octacosanol is a chemical found in a variety of plants, including sugar cane and wheat germ oil. It is chemically similar to vitamin E.

Octacosanol is used to improve exercise performance including strength, stamina, and reaction time. It is also used for herpes infections, skin diseases, Parkinson's disease, amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), high cholesterol, and “hardening of the arteries” (atherosclerosis).

Be careful not to confuse octacosanol with policosanol.

How does it work?

Octacosanol might help improve the way our body uses oxygen.

Uses

Uses & Effectiveness?

Insufficient Evidence for

  • Amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease). Early research suggests that octacosanol does not improve symptoms of ALS.
  • Parkinson's disease. Developing research suggests that octacosanol might improve symptoms in some people with Parkinson’s disease.
  • Improving athletic performance including strength, stamina, and reaction time.
  • Herpes infections.
  • Skin diseases.
  • High cholesterol.
  • “Hardening of the arteries” (atherosclerosis).
  • Other conditions.
More evidence is needed to rate the effectiveness of octacosanol for these uses.

Side Effects

Side Effects & Safety

There is not enough information to know if octacosanol is safe.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Not enough is known about the use of octacosanol during pregnancy and breast-feeding. Stay on the safe side and avoid use.

Parkinson’s disease: Octacosanol might make some symptoms of Parkinson’s disease worse if it is used with the Parkinson’s disease medication levodopa/carbidopa. Don’t use this combination.

Interactions

Interactions?

Moderate Interaction

Be cautious with this combination

!
  • Levodopa/Carbidopa (Sinemet) interacts with OCTACOSANOL

    Levodopa/carbidopa (Sinemet) is used for Parkinson's disease. Taking octacosanol along with levodopa/carbidopa (Sinemet) might make Parkinson's disease symptoms worse. Do not take octacosanol if you are taking levodopa/carbidopa (Sinemet).

Dosing

Dosing

The appropriate dose of octacosanol depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for octacosanol. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

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  • Lin Y, Rudrum M, van der Wielen RP, et al. Wheat germ policosanol failed to lower plasma cholesterol in subjects with normal to mildly elevated cholesterol concentrations. Metabolism 2004;53:1309-14. View abstract.
  • Alcocer, L., Fernandez, L., Campos, E., and Mas, R. A comparative study of policosanol Versus acipimox in patients with type II hypercholesterolemia. Int.J.Tissue React. 1999;21(3):85-92. View abstract.
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  • Cabrera, L., Uribarri, E., Laguna, A., Sierra, R., Mederos, D., Gonzalez, M., and Gonzalez, V. Study of the interaction between policosanol and excipients. Boll.Chim.Farm. 2002;141(2):138-142. View abstract.
  • Carbajal, D., Arruzazabala, M. L., Mas, R., Molina, V., and Valdes, S. Effect of policosanol on experimental thrombosis models. Prostaglandins Leukot.Essent.Fatty Acids 1994;50(5):249-251. View abstract.
  • Castano, G., Mas, Ferreiro R., Fernandez, L., Gamez, R., Illnait, J., and Fernandez, C. A long-term study of policosanol in the treatment of intermittent claudication. Angiology 2001;52(2):115-125. View abstract.
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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2018.