1-Octacosanol, Hexacosanol (26-C), N-octacosanol, Octacosyl Alcohol, Tetracosanol (24-C), Tétracosanol (24-C), Triacontanol (30-C).<br/><br/>


Overview Information

Octacosanol is a chemical found in a variety of plants, including sugar cane and wheat germ oil. It is chemically similar to vitamin E.

Octacosanol is used to improve exercise performance including strength, stamina, and reaction time. It is also used for herpes infections, skin diseases, Parkinson's disease, amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), high cholesterol, and “hardening of the arteries” (atherosclerosis).

Be careful not to confuse octacosanol with policosanol.

How does it work?

Octacosanol might help improve the way our body uses oxygen.


Uses & Effectiveness?

Insufficient Evidence for

  • Amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease). Early research suggests that octacosanol does not improve symptoms of ALS.
  • Parkinson's disease. Developing research suggests that octacosanol might improve symptoms in some people with Parkinson’s disease.
  • Improving athletic performance including strength, stamina, and reaction time.
  • Herpes infections.
  • Skin diseases.
  • High cholesterol.
  • “Hardening of the arteries” (atherosclerosis).
  • Other conditions.
More evidence is needed to rate the effectiveness of octacosanol for these uses.

Side Effects

Side Effects & Safety

There is not enough information to know if octacosanol is safe.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Not enough is known about the use of octacosanol during pregnancy and breast-feeding. Stay on the safe side and avoid use.

Parkinson’s disease: Octacosanol might make some symptoms of Parkinson’s disease worse if it is used with the Parkinson’s disease medication levodopa/carbidopa. Don’t use this combination.



Moderate Interaction

Be cautious with this combination

  • Levodopa/Carbidopa (Sinemet) interacts with OCTACOSANOL

    Levodopa/carbidopa (Sinemet) is used for Parkinson's disease. Taking octacosanol along with levodopa/carbidopa (Sinemet) might make Parkinson's disease symptoms worse. Do not take octacosanol if you are taking levodopa/carbidopa (Sinemet).



The appropriate dose of octacosanol depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for octacosanol. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References


  • Mas R, Castano G, Fernandez J, et al. Long-term effects of policosanol on obese patients with Type II Hypercholesterolemia. Asia Pac.J Clin Nutr. 2004;13(Suppl):S102.
  • Mas R, Castano G, Illnait J, et al. Effects of policosanol in patients with type II hypercholesterolemia and additional coronary risk factors. Clin.Pharmacol.Ther. 1999;65:439-447. View abstract.
  • Menendez R, Arruzazabala L, Mas R, et al. Cholesterol-lowering effect of policosanol on rabbits with hypercholesterolaemia induced by a wheat starch-casein diet. Br J Nutr 1997;77:923-32. View abstract.
  • Menendez R, Fernandez SI, Del Rio A, et al. Policosanol inhibits cholesterol biosynthesis and enhances low density lipoprotein processing in cultured human fibroblasts. Biol Res 1994;27:199-203. View abstract.
  • Norris FH, Denys EH, Fallat RJ. Trial of octacosanol in amyotrophic lateral sclerosis. Neurology 1986;36:1263-4. View abstract.
  • Norris FH, Denys EH. Nutritional supplements in amyotrophic lateral sclerosis. Adv Exp Med Biol 1987;209:183-9. View abstract.
  • Snider S. Octacosanol in parkinsonism. Ann Neurol 1984;16:723. View abstract.
  • Torres O, Agramonte AJ, Illnait J, et al. Treatment of hypercholesterolemia in NIDDM with policosanol. Diabetes Care 1995;18:393-7. View abstract.
  • Baldwin JL, et al. Pectin-induced occupational asthma. Chest 1993;104:1936-7.
  • Becker B, Kuhn U, Hardewig-Budny B. Double-blind, randomized evaluation of clinical efficacy and tolerability of an apple pectin-chamomile extract in children with unspecific diarrhea. Arzneimittelforschung 2006;56(6):387-393. View abstract.
  • Brouns F, Theuwissen E, Adam A, Bell M, Berger A, Mensink RP. Cholesterol-lowering properties of different pectin types in mildly hyper-cholesterolemic men and women. Eur J Clin Nutr. 2012 May;66(5):591-9. View abstract.
  • Cerda JJ, Robbins FL, Burgin CW, et al. The effects of grapefruit pectin on patients at risk for coronary heart disease without altering diet or lifestyle. Clin Cardiol 1988;11:589-94. View abstract.
  • Cohen AJ, Forse MS, Tarlo SM. Occupational asthma caused by pectin inhalation during the manufacture of jam. Chest 1993;103:309-11. View abstract.
  • Davidson MH, Dugan LD, Stocki J, et al. A low-viscosity soluble-fiber fruit juice supplement fails to lower cholesterol in hypercholesterolemic men and women. J Nutr 1998;128:1927-32. View abstract.
  • Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  • Eliaz I, Hotchkiss AT, Fishman ML, Rode D. The effect of modified citrus pectin on urinary excretion of toxic elements. Phytother Res 2006;20:859-64. View abstract.
  • Federal Register April 17,2003. Anti-Diarrheal Products for over-the-counter human use; final monograph. Available at: http://www.fda.gov/OHRMS/DOCKETS/98fr/03-9380.pdf (Accessed 27 December 2004).
  • Guess BW, Scholz MC, Strum SB, et al. Modified citrus pectin (MCP) increases the prostate-specific antigen doubling time in men with prostate cancer: a phase II pilot study. Prostate Cancer Prostatic Dis 2003;6:301-4. View abstract.
  • Hillman LC, Peters SG, Fisher CA, et al. The effects of the fiber components pectin, cellulose and lignin on serum cholesterol levels. Am J Clin Nutr 1985;42:207-13. View abstract.
  • Jaakkola MS, et al. Asthma caused by occupational exposure to pectin. J Allergy Clin Immunol 1997;100:575-6. View abstract.
  • Jackson CL, Dreaden TM, Theobald LK, et al. Pectin induces apoptosis in human prostate cancer cells: correlation of apoptotic function with pectin structure. Glycobiology 2007;17:805-19. View abstract.
  • Jenkins DJ, Wesson V, Wolever TM, et al. Wholemeal versus wholegrain breads: proportion of whole or cracked grain and the glycaemic response. BMJ 1988;297:958-60. View abstract.
  • Knopp RH, Superko HR, Davidson M, et al. Long-term blood cholesterol-lowering effects of a dietary fiber supplement. Am J Prev Med 1999;17:18-23. View abstract.
  • Kraut A, et al. Christmas candy maker's asthma. IgG4-mediated pectin allergy. Chest 1992;102:1605-7. View abstract.
  • Miyazawa R, Tomomasa T, Kaneko H, Arakawa H, Shimizu N, Morikawa A. Effects of pectin liquid on gastroesophageal reflux disease in children with cerebral palsy. BMC Gastroenterol. 2008 Apr 16;8:11. View abstract.
  • Moriarty PM, Backes J, Dutton JA, He J, Ruisinger JF, Schmelzle K. Apple pectin for the reduction of niacin-induced flushing. J Clin Lipidol. 2013 Mar-Apr;7(2):140-6. View abstract.
  • Nishijima T, Takida Y, Saito Y, Ikeda T, Iwai K. Simultaneous ingestion of high-methoxy pectin from apple can enhance absorption of quercetin in human subjects. Br J Nutr. 2015 May 28;113(10):1531-8. View abstract.
  • Rabbani GH, Teka T, Zaman B, et al. Clinical studies in persistent diarrhea: dietary management with green banana or pectin in Bangladeshi children. Gastroenterology 2001;121:554-60. View abstract.
  • Richter WO, Jacob BG, Schwandt P. Interaction between fibre and lovastatin. Lancet 1991;338:706.
  • Rock CL, Swendseid ME. Plasma beta-carotene response in humans after meals supplemented with dietary pectin. Am J Clin Nutr 1992;55:96-9. View abstract.
  • Veldman FJ, Nair CH, Vorster HH, et al. Dietary pectin influences fibrin network structure in hypercholesterolaemic subjects. Thromb Res 1997;86:183-96. View abstract.
  • Wanders AJ, Feskens EJ, Jonathan MC, Schols HA, de Graaf C, Mars M. Pectin is not pectin: a randomized trial on the effect of different physicochemical properties of dietary fiber on appetite and energy intake. Physiol Behav. 2014 Apr 10;128:212-9. View abstract.
  • Waterhouse ET, Washington C, Washington N. An investigation into the efficacy of the pectin based anti-reflux formulation-Aflurax. Int J Pharm 2000;209:79-85.. View abstract.
  • Westphal W, et al. [Exogenous allergic asthma following pectin exposure-a new occupational allergen]. Pneumologie 1990;44(Suppl 1):337-8. View abstract.
  • Chan PC, Tam SC, Robinson JD, et al. Effect of phosphatidylcholine on ultrafiltration in patients on continuous ambulatory peritoneal dialysis. Nephron 1991;59:100-3. View abstract.
  • Cheatham CL, Goldman BD, Fischer LM, da Costa KA, Reznick JS, Zeisel SH. Phosphatidylcholine supplementation in pregnant women consuming moderate-choline diets does not enhance infant cognitive function: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr 2012;96(6):1465-72. View abstract.
  • Lin Y, Rudrum M, van der Wielen RP, et al. Wheat germ policosanol failed to lower plasma cholesterol in subjects with normal to mildly elevated cholesterol concentrations. Metabolism 2004;53:1309-14. View abstract.
  • Alcocer, L., Fernandez, L., Campos, E., and Mas, R. A comparative study of policosanol Versus acipimox in patients with type II hypercholesterolemia. Int.J.Tissue React. 1999;21(3):85-92. View abstract.
  • Aleman, C. L., Mas, R., Hernandez, C., Rodeiro, I., Cerejido, E., Noa, M., Capote, A., Menendez, R., Amor, A., Fraga, V., and . A 12-month study of policosanol oral toxicity in Sprague Dawley rats. Toxicol.Lett. 1994;70(1):77-87. View abstract.
  • Aleman, C. L., Puig, M. N., Elias, E. C., Ortega, C. H., Guerra, I. R., Ferreiro, R. M., and Brinis, F. Carcinogenicity of policosanol in mice: an 18-month study. Food Chem.Toxicol. 1995;33(7):573-578. View abstract.
  • Arruzazabala, M. L., Carbajal, D., Mas, R., Valdes, S., and Molina, V. Pharmacological Interaction Between Policosanol and Nitroprusside in Rats. J Med Food 2001;4(2):67-70. View abstract.
  • Arruzazabala, M. L., Molina, V., Carbajal, D., Valdes, S., and Mas, R. Effect of policosanol on cerebral ischemia in Mongolian gerbils: role of prostacyclin and thromboxane A2. Prostaglandins Leukot.Essent.Fatty Acids 1993;49(3):695-697. View abstract.
  • Arruzazabala, M. L., Noa, M., Menendez, R., Mas, R., Carbajal, D., Valdes, S., and Molina, V. Protective effect of policosanol on atherosclerotic lesions in rabbits with exogenous hypercholesterolemia. Braz.J Med Biol.Res 2000;33(7):835-840. View abstract.
  • Barocci, S., Ginevri, F., Valente, U., Torre, F., Gusmano, R., and Nocera, A. Correlation between angiotensin-converting enzyme gene insertion/deletion polymorphism and kidney graft long-term outcome in pediatric recipients: a single-center analysis. Transplantation 2-27-1999;67(4):534-538. View abstract.
  • Cabrera, L., Rivero, B., Magraner, J., Sierra, R., Gonzalez, V., Uribarri, E., Laguna, A., Cora, M., Tejeda, Y., Rodriguez, E., and Velazquez, C. Stability studies of tablets containing 5 mg of policosanol. Boll.Chim.Farm. 2003;142(7):277-284. View abstract.
  • Cabrera, L., Uribarri, E., Laguna, A., Sierra, R., Mederos, D., Gonzalez, M., and Gonzalez, V. Study of the interaction between policosanol and excipients. Boll.Chim.Farm. 2002;141(2):138-142. View abstract.
  • Carbajal, D., Arruzazabala, M. L., Mas, R., Molina, V., and Valdes, S. Effect of policosanol on experimental thrombosis models. Prostaglandins Leukot.Essent.Fatty Acids 1994;50(5):249-251. View abstract.
  • Castano, G., Mas, Ferreiro R., Fernandez, L., Gamez, R., Illnait, J., and Fernandez, C. A long-term study of policosanol in the treatment of intermittent claudication. Angiology 2001;52(2):115-125. View abstract.
  • Castano, G., Mas, R., Fernandez, L., Gamez, R., and Illnait, J. Effects of policosanol and lovastatin in patients with intermittent claudication: a double-blind comparative pilot study. Angiology 2003;54(1):25-38. View abstract.

Vitamins Survey

Have you ever purchased OCTACOSANOL?

Did you or will you purchase this product in-store or online?

Where did you or where do you plan to purchase this product?

Where did you or where do you plan to purchase this product?

What factors influenced or will influence your purchase? (check all that apply)

Vitamins Survey

Where did you or where do you plan to purchase this product?

Do you buy vitamins online or instore?

What factors are most important to you? (check all that apply)

More Resources for OCTACOSANOL

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2018.