Calabar bean (Physostigma venenosum) is a plant. It has been traditionally used to make medicine, but the seed is extremely poisonous and can be deadly.

Calabar bean contains a chemical that affects signals between muscles and nerves. This chemical affects many parts of the body.

People use calabar bean for constipation, epilepsy, and many other conditions, but there is no good scientific evidence to support these uses. Using calabar bean is also unsafe.

Uses & Effectiveness ?

We currently have no information for CALABAR BEAN overview.

Side Effects

When taken by mouth: Calabar bean is unsafe. It is extremely toxic and can cause paralysis, seizures, coma, and death.

Special Precautions and Warnings

When taken by mouth: Calabar bean is unsafe. It is extremely toxic and can cause paralysis, seizures, coma, and death.

Pregnancy and breast-feeding: Calabar bean is unsafe when taken by mouth. It may cause severe side effects, including death. Don't use it.

Interactions ?

    Minor Interaction

    Be watchful with this combination

  • Drying medications (Anticholinergic drugs) interacts with CALABAR BEAN

    Calabar bean can increase a chemical in the body called acetylcholine. Acetylcholine plays a big part in many important body functions. Some medications, called anticholinergic drugs, block the effects of acetylcholine in the body. Taking calabar bean might decrease the effects of anticholinergic drugs.


There isn't enough reliable information to know what an appropriate dose of calabar bean might be. Calabar bean might also be unsafe. Speak with a healthcare provider before using.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.