ORNITHINE KETOGLUTARATE

OTHER NAME(S):

2-Oxopentanedioic Acid L-Ornithine, ACO, Alpha-Cétoglutarate de L-Ornithine, Alpha-Cétoglutarate de L(+)-ornithine, Alpha-Cétoglutarate d'Ornithine, Cétoglutarate d'Ornithine, Di-Ornithine Alpha-Ketogutarate, L-Ornithine Alpha-Ketoglutarate, L(+)-ornithine alpha-ketoglutarate, OAKG, OKG, Ornicetil, Ornithine Alpha-Ceto Glutarate, Ornithine Alpha Ketoglutarate, Ornithine Alpha-Ketoglutarate, Ornithine 2-Oxoglutarate, Ornithine Oxoglutarate, Ornitina Cetoglutarato.<br/><br/>

Overview

Overview Information

Ornithine ketoglutarate is a salt made from the amino acid ornithine and the glutamine precursor alpha-ketoglutarate. People use it as a medicine.

Ornithine ketoglutarate is taken by mouth to build muscle and increase muscle strength. It is also used for HIV/AIDS and for healing wounds, skin pressure ulcers, and burns.

Ornithine ketoglutarate is sometimes included in nutritional formulas that healthcare providers give as an injection into the veins (intravenously, by IV). Ornithine ketoglutarate is added to the formulas to prevent abnormally slow growth in children who are receiving long-term intravenous feeding.

Ornithine ketoglutarate is also given by IV for helping the body make muscle protein after surgery or stroke; and for treating brain change caused by liver disease. It is also used to reduce nausea and vomiting caused by chemotherapy and improving the health of people that have had a stroke.

Don't confuse ornithine ketoglutarate with ornithine or another chemical called L-ornithine-L-aspartate (LOLA).

How does it work?

Ornithine ketoglutarate might change the way amino acids, the building blocks of protein, are used in the body. It also increases insulin, a hormone that regulates the amount of sugar in the blood.

Uses

Uses & Effectiveness?

Possibly Effective for

  • Burns. Taking ornithine ketoglutarate by mouth might improve wound healing in people with burns.
  • Wound healing. Taking ornithine ketoglutarate before plastic surgery or after surgery for throat cancer improves healing time and reduces complications such as the number of infections.

Likely InEffective for

  • Worsening of mental function caused by liver disease. Giving ornithine ketoglutarate intravenously (by IV) does not help treat mental changes caused by liver disease. In fact, it may make this condition worse.

Insufficient Evidence for

  • Nausea and vomiting caused by chemotherapy. Early research suggests that giving ornithine ketoglutarate intravenously (by IV) before and during chemotherapy can reduce the severity of nausea and vomiting similarly to the drug metoclopramide.
  • Abnormally slow growth. Some early research suggests that ornithine ketoglutarate helps prevent abnormally slow growth when added to long-term nutrition that is given to children intravenously (by IV). However, other research suggests that taking ornithine ketoglutarate for one year does not improve growth in short-statured children.
  • HIV/AIDS. Early research suggests that taking ornithine ketoglutarate by mouth for 12 weeks does not improve immune function, strength, or body weight in people with HIV.
  • Pressure ulcers. Taking ornithine ketoglutarate by mouth for 6 weeks seems to improve healing in older people with heel pressure ulcers that are no larger than 8 cm2 at the start of treatment. However, it does not seem to improve healing in people with larger heel pressure ulcers.
  • Stroke. Early research suggests that giving ornithine ketoglutarate intravenously (by IV) for 5 days to people who have had a stroke might improve their ability to respond to stimuli. However, this improvement does not appear to continue once treatment with ornithine ketoglutarate is stopped.
  • Muscle regrowth after surgery. Early research suggests that ornithine ketoglutarate might improve the regrowth of certain muscles after surgery.
  • Complications of surgery or long-term feeding by vein and other conditions.
  • Other conditions.
More evidence is needed to rate the effectiveness of ornithine ketoglutarate for these uses.

Side Effects

Side Effects & Safety

Ornithine ketoglutarate is POSSIBLY SAFE in children and adults when given intravenously or in adults when taken by mouth with appropriate medical supervision.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Not enough is known about the use of ornithine ketoglutarate during pregnancy and breast-feeding. Stay on the safe side and avoid use.

Worsening of mental function caused by liver disease: Taking ornithine ketoglutarate might make this condition worse.

Interactions

Interactions?

We currently have no information for ORNITHINE KETOGLUTARATE Interactions.

Dosing

Dosing

The following doses have been studied in scientific research:

BY MOUTH:

  • For burn wounds: 30 grams of ornithine ketoglutarate daily.
  • For other wounds: 10 grams daily beginning 5 days before and continuing until 10 days after surgery. 20 grams daily for one month.

View References

REFERENCES:

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  • Bouchon, Y., Michon, J., Chanson, L., Merle, M., and Debry, G. [Effect of ornithine oxoglutarate on the duration and quality of wound healing in extensive reparative and plastic surgical methods]. Ann.Chir Plast.Esthet. 1989;34(5):447-449. View abstract.
  • Brocker, P., Vellas, B., Albarede, J. L., and Poynard, T. A two-centre, randomized, double-blind trial of ornithine oxoglutarate in 194 elderly, ambulatory, convalescent subjects. Age Ageing 1994;23(4):303-306. View abstract.
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  • Vaubourdolle, M., Salvucci, M., Coudray-Lucas, C., Agneray, J., Cynober, L., and Ekindjian, O. G. Action of ornithine alpha ketoglutarate on DNA synthesis by human fibroblasts. In Vitro Cell Dev.Biol. 1990;26(2):187-192. View abstract.
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  • Chainuvati T, Plengvanit U, Viranuvatti V. Ornicetil on encephalopathy. Effect of ornicetil (ornithine alpha-ketoglutarate) on encephalopathy in patients with acute and chronic liver disease. Acta Hepatogastroenterol (Stuttg) 1977;24:434-9. View abstract.
  • De Bandt JP, Coudray-Lucas C, Lioret N, et al. A randomized controlled trial of the influence of the mode of enteral ornithine alpha-ketoglutarate administration in burn patients. J Nutr 1998;128:563-9. View abstract.
  • Gay G, Villaume C, Beaufrand MJ, et al. Effects of ornithine alphaketoglutarate on blood insulin, glucagon and aminoacids in alcoholic cirrhosis. Biomedicine 1979;30:173-7. View abstract.
  • Meakins TS, Persaud C, Jackson AA. Dietary supplementation with L-methionine impairs the utilization of urea-nitrogen and increases 5-L-oxoprolinuria in normal women consuming a low protein diet. J Nutr 1998;128:720-7. View abstract.
  • Moukarzel AA, Goulet O, Salas JS, et al. Growth retardation in children receiving long-term total parenteral nutrition: effects of ornithine alpha-ketoglutarate. Am J Clin Nutr 1994;60:408-13. View abstract.
  • Wernerman J, Hammarkvist F, Ali MR, Vinnars E. Glutamine and ornithine-alpha-ketoglutarate but not branched-chain amino acids reduce the loss of muscle glutamine after surgical trauma. Metabolism 1989;38:63-6. View abstract.
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  • Woollard ML, Pearson RM, Dorf G, et al. Controlled trial of ornithine alpha ketoglutarate (OAKG) in patients with stroke. Stroke 1978;9:218-22. View abstract.

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