Ornithine ketoglutarate (OKG) is a salt made from the amino acid ornithine and alpha-ketoglutarate, which is a precursor to the amino acid glutamine.

Ornithine ketoglutarate might change the way amino acids, the building blocks of protein, are used in the body. It also increases insulin, a hormone that regulates the amount of sugar in the blood.

People use ornithine ketoglutarate for healing wounds and burns. It is also used for building muscle strength, HIV/AIDS, stroke, and many other purposes, but there is no good scientific evidence to support these uses.

Don't confuse ornithine ketoglutarate with ornithine or another chemical called L-ornithine-L-aspartate (LOLA). These are not the same.

Uses & Effectiveness ?

Possibly Effective for

  • Burns. Taking ornithine ketoglutarate by mouth seems to improve wound healing in people with burns.
  • Wound healing. Taking ornithine ketoglutarate by mouth seems to improve healing time and reduce complications in people undergoing major surgery.
There is interest in using ornithine ketoglutarate for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful.

Side Effects

When taken by mouth: Ornithine ketoglutarate is possibly safe. It's been used safely for up to 3 weeks.

Special Precautions and Warnings

When taken by mouth: Ornithine ketoglutarate is possibly safe. It's been used safely for up to 3 weeks.

Pregnancy and breast-feeding: There isn't enough reliable information to know if ornithine ketoglutarate is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Interactions ?

We currently have no information for ORNITHINE KETOGLUTARATE (OKG) overview.


Ornithine ketoglutarate has most often been used by adults in doses of 10-30 grams by mouth daily for 3 weeks. It has also been given in feeding tubes while under medical supervision. Speak with a healthcare provider to find out what dose might be best for a specific condition.
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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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© Therapeutic Research Faculty 2020.