Bolet à Couleurs Variées, Bolet Versicolore, Boletus versicolor, Champignon Coriolus, Champignon de Queue de Dinde, Coriolus, Coriolus versicolor, Hongo Coriolus, Kawaratake, Krestin, Polypore à Couleurs Variées, Polypore Versicolor, Polyporus Versicolor, Polysaccharide-K, Polysaccharide Krestin, Polysaccharide Peptide, Polysaccharopeptide, Polystictus versicolor, PSK, PSP, Trametes versicolor, Turkey Tail, Yun Zhi, Yun-Zhi (cloud mushroom).<br/><br/>


Overview Information

Coriolus mushroom is a fungus. People have used the fruiting body and other parts as folk medicine for a long time. Recently, researchers have started to isolate and identify substances in coriolus that might act like pharmaceutical drugs. Two of these substances are polysaccharide peptide (PSP) and polysaccharide krestin (PSK). Scientists think these chemicals might be able to fight cancer and boost the immune system.

Coriolus mushroom, PSP, and PSK are used for stimulating the immune system; treating herpes, chronic fatigue syndrome (CFS), hepatitis, and pulmonary disorders; reducing phlegm; improving bodybuilding results; increasing energy; curing ringworm and a skin condition called impetigo; treating upper respiratory, urinary, and digestive tract infections; curing liver disorders including hepatitis; reducing the toxic effects and pain of chemotherapy and radiation therapy; increasing the effectiveness of chemotherapy; prolonging life and raising the quality of life of cancer patients; and increasing appetite.

How does it work?

Coriolus contains polysaccharide peptide (PSP) and polysaccharide-K (PSK, krestin), which may be able to fight tumor growth as well as boost the immune system.


Uses & Effectiveness?

Possibly Effective for

Insufficient Evidence for

More evidence is needed to rate the effectiveness of coriolus mushroom for these uses.

Side Effects

Side Effects & Safety

Coriolus mushroom is POSSIBLY SAFE for most people when taken by mouth appropriately. There have been no reported side effects so far. However, people who have received chemotherapy and a chemical called PSK (which is extracted from coriolus mushroom) have experienced nausea, low white blood cell counts, and liver problems. It is unclear if these side effects were due to the chemotherapy or PSK.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking coriolus mushroom if you are pregnant or breast-feeding. Stay on the safe side and avoid use.



We currently have no information for CORIOLUS MUSHROOM Interactions.



The following doses have been studied in scientific research:


  • For cancer, in addition to chemotherapy: 3 grams of PSK, the ingredient that is thought to fight cancer, is taken daily.

View References


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  • Nakajima, T., Inokuchi, K., Hattori, T., Inoue, K., Taguchi, T., Kondou, T., Abe, O., Kikuchi, K., Tanabe, T., and Ogawa, N. [Multi-institutional cooperative study of adjuvant immunochemotherapy in gastric cancer--five-year survival rate]. Gan To Kagaku Ryoho 1989;16(4 Pt 1):799-806. View abstract.
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  • Nishiwaki, Y., Furuse, K., Fukuoka, M., Ota, M., Niitani, H., Asakawa, M., Nakai, H., Sakai, S., and Ogawa, N. [A randomized controlled study of PSK combined immuno-chemotherapy for adenocarcinoma of the lung. The Advanced Lung Cancer Immuno-chemotherapy Study Group]. Gan To Kagaku Ryoho 1990;17(1):131-136. View abstract.
  • Nomoto, K., Tsuru, S., Awane, Y., Kamei, H., Ishibiki, H., Sekiguchi, M., Tamada, R., Toge, T., and Nakajima, T. [Changes in nonspecific suppressor factors in the serum of gastric cancer patients after surgery and immunochemotherapy]. Gan To Kagaku Ryoho 1986;13(3 Pt 1):458-463. View abstract.
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  • Ohmura, Y., Matsunaga, K., Motokawa, I., Sakurai, K., and Ando, T. Protective effects of a protein-bound polysaccharide, PSK, against Candida albicans infection in syngeneic tumor-bearing mice via Th1 cell functions. Cancer Biother.Radiopharm. 2003;18(5):769-780. View abstract.
  • Ohno, R., Yamada, K., Masaoka, T., Ohshima, T., Amaki, I., Hirota, Y., Horikoshi, N., Horiuchi, A., Imai, K., Kimura, I., and . A randomized trial of chemoimmunotherapy of acute nonlymphocytic leukemia in adults using a protein-bound polysaccharide preparation. Cancer Immunol Immunother. 1984;18(3):149-154. View abstract.
  • Ohwada, S., Ikeya, T., Yokomori, T., Kusaba, T., Roppongi, T., Takahashi, T., Nakamura, S., Kakinuma, S., Iwazaki, S., Ishikawa, H., Kawate, S., Nakajima, T., and Morishita, Y. Adjuvant immunochemotherapy with oral Tegafur/Uracil plus PSK in patients with stage II or III colorectal cancer: a randomised controlled study. Br.J Cancer 3-8-2004;90(5):1003-1010. View abstract.
  • Ohwada, S., Kawate, S., Ikeya, T., Yokomori, T., Kusaba, T., Roppongi, T., Takahashi, T., Nakamura, S., Kawashima, Y., Nakajima, T., and Morishita, Y. Adjuvant therapy with protein-bound polysaccharide K and tegafur uracil in patients with stage II or III colorectal cancer: randomized, controlled trial. Dis Colon Rectum 2003;46(8):1060-1068. View abstract.
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  • Nakazato H, Koike A, Saji S, et al. Efficacy of immunochemotherapy as adjuvant treatment after curative resection of gastric cancer. Study Group of Immunochemotherapy with PSK for Gastric Cancer. Lancet 1994;343:1122-6. View abstract.
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  • Ogoshi K, Satou H, Isono K, et al. Immunotherapy for esophageal cancer. A randomized trial in combination with radiotherapy and radiochemotherapy. Cooperative Study Group for Esophageal Cancer in Japan. Am J Clin Oncol 1995;18:216-22. View abstract.
  • Qian ZM, Xu MF, Tang PL. Polysaccharide peptide (PSP) restores immunosuppression induced by cyclophosphamide in rats. Am J Chin Med 1997;25:27-35.. View abstract.
  • Sugimachi K, Maehara Y, Ogawa M, et al. Dose intensity of uracil and tegafur in postoperative chemotherapy for patients with poorly differentiated gastric cancer. Cancer Chemother Pharmacol 1997;40:233-8. View abstract.
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  • Toi M, Hattori T, Akagi M, et al. Randomized adjuvant trial to evaluate the addition of tamoxifen and PSK to chemotherapy in patients with primary breast cancer. 5-Year results from the Nishi-Nippon Group of the Adjuvant Chemoendocrine Therapy for Breast Cancer Organization. Cancer 1992;70:2475-83. View abstract.
  • Torisu M, Hayashi Y, Ishimitsu T, et al. Significant prolongation of disease-free period gained by oral polysaccharide K (PSK) administration after curative surgical operation of colorectal cancer. Cancer Immunol Immunother 1990;31:261-8. View abstract.
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  • Wang HX, Ng TB, Liu WK, et al. Polysaccharide-peptide complexes from the cultured mycelia of the mushroom Coriolus versicolor and their culture medium activate mouse lymphocytes and macrophages. Int J Biochem Cell Biol 1996;28:601-7. View abstract.
  • Wasser SP, Weis AL. Therapeutic effects of substances occurring in higher Basidiomycetes mushrooms: a modern perspective. Crit Rev Immunol 1999;19:65-96. View abstract.
  • Yeung JH, Chiu LC, Ooi VE. Effect of polysaccharide peptide (PSP) on glutathione and protection against paracetamol-induced hepatotoxicity in the rat. Methods Find Exp Clin Pharmacol 1994;16:723-9. View abstract.
  • Yokoe T, Iino Y, Takei H, et al. HLA antigen as predictive index for the outcome of breast cancer patients with adjuvant immunochemotherapy with PSK. Anticancer Res 1997;17:2815-8. View abstract.

More Resources for CORIOLUS MUSHROOM

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