INOSINE

OTHER NAME(S):

Hypoxanthine Riboside, Hypoxanthosine, Inosina, 2,3-Diphosphoglycerate, 6-9 Dihydro-9-B-D-ribofuranosyl-1H-puin-6-one, 9-B-D-ribofuranosylhypoxanthine.<br/><br/>

Overview

Overview Information

Inosine is a chemical that can be made in a laboratory. It is used as medicine.

People take inosine for improving their athletic performance. It is also used for multiple sclerosis (MS) and Parkinson's disease.

How does it work?

When people take inosine by mouth it is changed in the body to make a chemical called uric acid. Uric acid acts like an antioxidant and might protect cells in the brain.

Uses

Uses & Effectiveness?

Insufficient Evidence for

  • Improving athletic performance. Early research shows that taking inosine does not help people to run faster or cycle farther.
  • Multiple sclerosis (MS). Some research shows that having low uric acid levels increases the risk of developing MS. Research in adults with MS shows that taking inosine increases the levels of uric acid in the blood. However, it is not clear if this improves the symptoms of MS. More research in larger groups is needed to understand if increased uric acid levels helps to treat MS.
More evidence is needed to rate inosine for these uses.
Side Effects

Side Effects & Safety

Inosine is POSSIBLY SAFE for most people when taken by mouth. Taking inosine can cause high levels of a chemical called uric acid in the blood and urine. These high levels of uric acid might cause kidney or bladder stones in some people.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Not enough is known about the use of inosine during pregnancy and breast-feeding. Stay on the safe side and avoid use.

Gout: Taking inosine might make gout worse.

Interactions

Interactions?

We currently have no information for INOSINE Interactions.

Dosing

Dosing

The appropriate dose of inosine depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for inosine. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

  • Benowitz LI, Goldberg DE, Madsen JR, et al. Inosine stimulates extensive axon collateral growth in the rat corticospinal tract after injury. Proc Natl Acad Sci USA 1999;96:13486-90. View abstract.
  • Gonsette RE, Sindic C, D'hooghe MB, et al. Boosting endogenous neuroprotection in multiple sclerosis: The association of inosine and interferon beta in relapsing-remitting Multiple Sclerosis (ASIIMS) trial. Mult Scler. 2010;16(4):455-62. View abstract.
  • Markowitz CE, Spitsin S, Zimmerman V, et al. The treatment of multiple sclerosis with inosine. J Altern Complement Med. 2009;15(6):619-25. View abstract.
  • Muñoz García D, Midaglia L, Martinez Vilela J, et al. Associated inosine to interferon: results of a clinical trial in multiple sclerosis. Acta Neurol Scand. 2015;131(6):405-10. View abstract.
  • Parkinson Study Group SURE-PD Investigators. Inosine to increase serum and cerebrospinal fluid urate in Parkinson disease: a randomized clinical trial. JAMA Neurol. 2014;71(2):141-50. View abstract.
  • Starling RD, Trappe TA, Short KR, et al. Effect of inosine supplementation on aerobic and anaerobic cycling performance. Med Sci Sports Exerc 1996;28:1193-8. View abstract.
  • Toncev G. Therapeutic value of serum uric acid levels increasing in the treatment of multiple sclerosis. Vojnosanit Pregl. 2006;63(10):879-82. View abstract.
  • Williams MH, Kreider RB, Hunter DW, et al. Effect of inosine supplementation on 3-mile treadmill run performance and VO2 peak. Med Sci Sports Exerc 1990;22:517-22. View abstract.
  • Yamamoto T, Moriwaki Y, Cheng J, Takahashi S, Tsutsumi Z, Ka T, Hada T. Effect of inosine on the plasma concentration of uridine and purine bases. Metabolism. 2002;51(4):438-42. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2018.