COLLAGEN TYPE II

OTHER NAME(S):

Chicken Collagen Type II, Chicken Type II Collagen, Colágeno de Pollo, Collagen II, Collagen Type II, Collagène de Poulet, Collagène de Type II, Collagène de Type II de Cartilage de Poulet, Collagène de Type II Hydrolysé, Hydrolyzed Chicken Collagen Type II, Hydrolyzed Collagen Type II, Type II Collagen.<br/><br/>

Overview

Overview Information

Collagen is a protein that is part of cartilage, bone, and other tissues in animals and humans. People use collagen from chickens for medicine.

Chicken collagen is used to treat joint pain associated with many types of arthritis and surgery, as well as back pain, neck pain, and pain following injury.

How does it work?

Collagen type II is said to work by causing the body to produce substances that fight pain and swelling. But this is unproven.

Uses

Uses & Effectiveness?

Insufficient Evidence for

  • Osteoarthritis. Early research shows that taking a specific product (AR7 Joint Complex by Robinson Pharma) containing collagen type II, methylsulfonylmethane (MSM), cetyl myristoleate, lipase, vitamin C, turmeric, and bromelain by mouth for 12 weeks reduces joint pain and tenderness in people with osteoarthritis. However, it does not seem to improve X-rays of affected joints.
  • Rheumatoid arthritis (RA). Research on the effects of collagen type II in people with RA shows conflicting results. Some research shows that taking collagen type II by mouth for 3 months reduces joint pain, swelling, and time to walk 15 meters in people with RA. However, other research does not show these improvements when collagen type II is taken for longer periods of time or in higher doses. Also, other research suggests that collagen type II is less effective than the drug methotrexate for treating RA.
  • Pain associated with joint pain after surgery, pain after injury, and back and neck pain.
  • Other conditions.
More evidence is needed to rate the effectiveness of collagen type II for these uses.

Side Effects

Side Effects & Safety

Collagen type II is POSSIBLY SAFE when taken by mouth in doses up to 2.5 mg daily for up to 24 weeks. Some people might have stomach problems after taking collagen type II. Headache, difficulty sleeping, dizziness, and liver problems have also occurred. But these events are uncommon.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking collagen type II if you are pregnant or breast-feeding. Stay on the safe side and avoid use.

Egg or chicken allergies: People who are allergic to chicken or eggs should not use collagen type II. Collagen products have been associated with allergic reactions.

Interactions

Interactions?

We currently have no information for COLLAGEN TYPE II Interactions.

Dosing

Dosing

The appropriate dose of collagen type II depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for collagen type II. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

  • Hauselmann, H. J., Caravatti, M., Seifert, B., Wang, K., Bruckner, P., Stucki, G., and Michel, B. A. Can collagen type II sustain a methotrexate-induced therapeutic effect in patients with long-standing rheumatoid arthritis? A double-blind, randomized trial. Br J Rheumatol 1998;37(10):1110-1117. View abstract.
  • McKown, K. M., Carbone, L. D., Kaplan, S. B., Aelion, J. A., Lohr, K. M., Cremer, M. A., Bustillo, J., Gonzalez, M., Kaeley, G., Steere, E. L., Somes, G. W., Myers, L. K., Seyer, J. M., Kang, A. H., and Postlethwaite, A. E. Lack of efficacy of oral bovine type II collagen added to existing therapy in rheumatoid arthritis. Arthritis Rheum 1999;42(6):1204-1208. View abstract.
  • Trentham, D. E., Dynesius-Trentham, R. A., Orav, E. J., Combitchi, D., Lorenzo, C., Sewell, K. L., Hafler, D. A., and Weiner, H. L. Effects of oral administration of type II collagen on rheumatoid arthritis. Science 9-24-1993;261(5129):1727-1730. View abstract.
  • Zhang, L. L., Wei, W., Xiao, F., Xu, J. H., Bao, C. D., Ni, L. Q., and Li, X. F. A randomized, double-blind, multicenter, controlled clinical trial of chicken type II collagen in patients with rheumatoid arthritis. Arthritis Rheum 7-15-2008;59(7):905-910. View abstract.
  • AutoImmune Inc. announces phase III trial results for Colloral. URL http://www.autoimmune.com/clinic/coll.html (Accessed 24 October 1999).
  • Barclay TS, Tsourounis C, McCart GM. Glucosamine. Ann Pharmacother 1998;32:574-9. View abstract.
  • Barnett ML, Combitchi D, Trentham DE. A pilot trial of oral type II collagen in the treatment of juvenile rheumatoid arthritis. Arthritis Rheum 1996;39:623-8. View abstract.
  • Barnett ML, Kremer JM, St.Clair W, et al. Treatment of rheumatoid arthritis with oral type II collagen. Arthritis Rheum 1998;41:290-7. View abstract.
  • Kalden JR, Sieper J. Oral collagen in the treatment of rheumatoid arthritis [editorial]. Arthritis Rheum 1998;41:191-4.
  • Mullins RJ, Richards C, Walker T. Allergic reactions to oral, surgical and topical bovine collagen. Anaphylactic risk for surgeons. Aust N Z J Ophthalmol 1996;24:257-60. View abstract.
  • Trentham DE. Oral tolerization as a treatment of rheumatoid arthritis. Rheum Dis Clin North Am 1998;24:525-36. View abstract.
  • Xie Q, Shi R, Xu G, et al. Effects of AR7 Joint Complex on arthralgia for patients with osteoarthritis: results of a three-month study in Shanghai, China. Nutr J. 2008 Oct 27;7:31. View abstract.

More Resources for COLLAGEN TYPE II

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
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