BA JI TIAN: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Ba ji tian is a plant. The root of the plant is used to make medicine.

Ba ji tian is used for many conditions, but there is no good scientific evidence to support these uses.

Ba ji tian is also stir-fried and eaten as a food.

How does it work ?

Ba ji tian might help treat depression by increasing the effects of serotonin, a chemical found in the brain. Also, ba ji tian contains chemicals that might reduce inflammation and regulate levels of hormones or other chemicals in the body.

Uses & Effectiveness ?

Possibly Effective for

Depression. Some research shows that taking combination products containing extracts of ba ji tian can reduce symptoms of depression in some people.

There is interest in using ba ji tian for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful.

Side Effects

When taken by mouth: There isn't enough reliable information to know if ba ji tian is safe or what the side effects might be.

Special Precautions and Warnings

When taken by mouth: There isn't enough reliable information to know if ba ji tian is safe or what the side effects might be.

Pregnancy and breast-feeding: There isn't enough reliable information to know if ba ji tian is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Diabetes: Ba ji tian might affect blood sugar levels and could interfere with blood sugar control. Don't take ba ji tian if you have diabetes.

Painful urination (dysuria): Ba ji tian is thought to stimulate the kidneys, so it might make painful urination worse. Use with caution if you have this problem.

Surgery: Ba ji tian might affect blood sugar levels and could interfere with blood sugar control during and after surgical procedures. Stop using ba ji tian at least 2 weeks before a scheduled surgery.

Interactions ?

Moderate Interaction

Be cautious with this combination

Medications for diabetes (Antidiabetes drugs) interacts with BA JI TIAN
Ba ji tian might increase or decrease blood sugar. Diabetes medications are used to lower blood sugar. Taking ba ji tian along with diabetes medications might increase or decrease the effects of these medications. Monitor your blood sugar levels closely if you use ba ji tian and take medications for diabetes. The dose of your diabetes medications may need to be changed.

Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, metformin (Glucophage), pioglitazone (Actos), rosiglitazone (Avandia), and others.

Dosing

BY MOUTH:

For depression: Products containing oligosaccharides from the root of ba ji tian have been used at doses of 300-800 mg daily for 6-8 weeks.

View References

REFERENCES:

Choi, J., Lee, K. T., Choi, M. Y., Nam, J. H., Jung, H. J., Park, S. K., and Park, H. J. Antinociceptive anti-inflammatory effect of Monotropein isolated from the root of Morinda officinalis. Biol Pharm Bull 2005;28(10):1915-1918. View abstract.

Kim, I. T., Park, H. J., Nam, J. H., Park, Y. M., Won, J. H., Choi, J., Choe, B. K., and Lee, K. T. In-vitro and in-vivo anti-inflammatory and antinociceptive effects of the methanol extract of the roots of Morinda officinalis. J Pharm Pharmacol 2005;57(5):607-615. View abstract.

Li, N., Qin, L. P., Han, T., Wu, Y. B., Zhang, Q. Y., and Zhang, H. Inhibitory effects of morinda officinalis extract on bone loss in ovariectomized rats. Molecules. 2009;14(6):2049-2061. View abstract.

Li, Y. F., Yuan, L., Xu, Y. K., Yang, M., Zhao, Y. M., and Luo, Z. P. Antistress effect of oligosaccharides extracted from Morinda officinalis in mice and rats. Acta Pharmacol Sin. 2001;22(12):1084-1088. View abstract.

MengYong, Z., CaiJiao, W., HuSheng, Z., XianWu, P., and JianMin, F. Protective effect of polysaccharides from morinda officinalis on bone loss in ovariectomized rats. Int J Biol Macromol. 10-1-2008;43(3):276-278. View abstract.

Soon, Y. Y. and Tan, B. K. Evaluation of the hypoglycemic and anti-oxidant activities of Morinda officinalis in streptozotocin-induced diabetic rats. Singapore Med J 2002;43(2):077-085. View abstract.

Wu, Y. B., Zheng, C. J., Qin, L. P., Sun, L. N., Han, T., Jiao, L., Zhang, Q. Y., and Wu, J. Z. Antiosteoporotic activity of anthraquinones from Morinda officinalis on osteoblasts and osteoclasts. Molecules. 2009;14(1):573-583. View abstract.

Zhang, H. L., Li, J., Li, G., Wang, D. M., Zhu, L. P., and Yang, D. P. Structural characterization and anti-fatigue activity of polysaccharides from the roots of Morinda officinalis. Int J Biol Macromol. 4-1-2009;44(3):257-261. View abstract.

Bao L, Qin L, Liu L, Wu Y, Han T, Xue L, Zhang Q. Anthraquinone compounds from Morinda officinalis inhibit osteoclastic bone resorption in vitro. Chem Biol Interact. 2011 Nov 15;194(2-3):97-105. View abstract.

Cui C, Yang M, Yao Z, et al. [Antidepressant active constituents in the roots of Morinda officinalis how]. Chung Kuo Chung Yao Tsa Chih 1995;20:36-9, 62-3. View abstract.

Du Y, Zheng Q, Ou ZH, et al. Efficacy and safety of Morinda officinalis oligosaccharide capsules for depressive disorder: a systematic review and meta-analysis. Braz J Psychiatry 2021;43(3):306-313. View abstract.

Huang KC. The Pharmacology of Chinese Herbs. 2nd ed. Boca Raton, FL: CRC Press, LLC 1999:267.

Lai ZK, Yin YY, Yan JZ, et al. Inulin-type oligosaccharides of Morinda officinalis exerted antidepressant effects by reducing hippocampal inflammation. Metab Brain Dis. 2023 Aug;38(6):2065-2075. View abstract.

Li S, Ouyang Q, Tan X, et al. [Chemical constituents of Morinda officinalis how]. Chung Kuo Chung Yao Tsa Chih 1991;16:675-6, 703. View abstract.

Li Y, Lü SS, Tang GY, Hou M, Tang Q, Zhang XN, Chen WH, Chen G, Xue Q, Zhang CC, Zhang JF, Chen Y, Xu XY. Effect of Morinda officinalis capsule on osteoporosis in ovariectomized rats. Chin J Nat Med. 2014 Mar;12(3):204-12. View abstract.

Li Z, Chen Z, Chen J, et al. Monotropein attenuates apoptosis and pyroptosis in chondrocytes and alleviates osteoarthritis progression in mice. Chin Med 2023;18(1):42. View abstract.

Liang J, Liang J, Hao H, et al. The extracts of Morinda officinalis and its hairy roots attenuate dextran sodium sulfate-induced chronic ulcerative colitis in mice by regulating inflammation and lymphocyte apoptosis. Front Immunol. 2017;8:905. View abstract.

Qiao ZS, Wu H, Su ZW. [Comparison with the pharmacological actions of Morinda officinalis, Damnacanthus officinarum and Schisandra propinqua]. Chung Hsi I Chieh Ho Tsa Chih 1991;11:390,415-7. View abstract.

Rong K, Chen P, Lang Y, et al. Morinda officinalis polysaccharide attenuates osteoporosis in rats underwent bilateral ovariectomy by suppressing the PGC-1a/PPAR? pathway. J Orthop Surg (Hong Kong) 2022;30(3):10225536221130824. View abstract.

Shen Y, Zhang Q, Wu YB, et al. Pharmacokinetics and tissue distribution of monotropein and deacetyl asperulosidic acid after oral administration of extracts from Morinda officinalis root in rats. BMC Complement Altern Med. 2018;18(1):288. View abstract.

Xu LZ, Xu DF, Han Y, Liu LJ, Sun CY, Deng JH, Zhang RX, Yuan M, Zhang SZ, Li ZM, Xu Y, Li JS, Xie SH, Li SX, Zhang HY, Lu L. BDNF-GSK-3ß-ß-Catenin Pathway in the mPFC Is Involved in Antidepressant-Like Effects of Morinda officinalis Oligosaccharides in Rats. Int J Neuropsychopharmacol. 2016 Nov 11. pii: pyw088. View abstract.

Yang JY, Kim MG, Park JH, Hong ST, Lee HS. Evaluation of benzaldehyde derivatives from Morinda officinalis as anti-mite agents with dual function as acaricide and mite indicator. Sci Rep. 2014 Dec 1;4:7149. View abstract.

Yang L, Ao Y, Li Y, et al. Morinda officinalis oligosaccharides mitigate depression-like behaviors in hypertension rats by regulating Mfn2-mediated mitophagy. J Neuroinflammation 2023;20(1):31. View abstract.

Yang YJ, Shu HY, Min ZD. [Anthraquinones isolated from Morinda officinalis and Damnacanthus indicus]. Yao Hsueh Hsueh Pao 1992;27:358-64. View abstract.

Yoshikawa M, Yamaguchi S, Nishisaka H, et al. Chemical constituents of Chinese natural medicine, morindae radix, the dried roots of morinda officinalis how: structures of morindolide and morofficinaloside. Chem Pharm Bull (Tokyo) 1995;43:1462-5. View abstract.

Yu HH, Zhao W, Zhang BX, Wang Y, Li J, Fang YF. Morinda officinalis extract exhibits protective effects against atopic dermatitis by regulating the MALAT1/miR-590-5p/CCR7 axis. J Cosmet Dermatol. 2023 May;22(5):1602-1612. View abstract.

Zhang L, Zhao X, Wang F, Lin Q, Wang W. Effects of Morinda officinalis Polysaccharide on Experimental Varicocele Rats. Evid Based Complement Alternat Med. 2016;2016:5365291. View abstract.

Chang, M. S., Kim, W. N., Yang, W. M., Kim, H. Y., Oh, J. H., and Park, S. K. Cytoprotective effects of Morinda officinalis against hydrogen peroxide-induced oxidative stress in Leydig TM3 cells. Asian J Androl 2008;10(4):667-674. View abstract.

Chen ZH, Wang GH, and Wang XP et al. Effectiveness and tolerability of warm-supplementing kidney yang added to risperidone in improving cognitive impairment in patients with schizophrenia: An 8-week, multicenter, randomized, double-blind, placebo-controlled clinical trial. Current Therapeutic Research, Clinical and Experimental 2008;69:104-117.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.

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BA JI TIAN - Uses, Side Effects, and More