Beta-1,3-glucan Lentinan, Beta-glucan Lentinan, Lentinane, Polysaccharide dérivé de Lentinus edodes.


Overview Information

Lentinan is a substance that comes from the shiitake mushroom.

Some medical professionals use lentinan to boost the effects of regular medicines used for treating cancer and HIV infection, but there is no good scientific evidence to support these uses.

How does it work?

Lentinan might increase the effects of certain medications that fight viruses and cancer. It might also increase the activity of some of the body's defense (immune) cells.


Uses & Effectiveness?

Insufficient Evidence for

  • Cancer of the esophagus. Early research suggests that lentinan may improve the way regular cancer drugs work in people with cancer of the esophagus.
  • Stomach cancer. Early research suggests that lentinan may improve the way regular cancer drugs work in people with stomach cancer.
  • HIV/AIDS infection. Early research suggests that lentinan may improve the way some HIV drugs work.
  • Lung cancer. Early research suggests that lentinan may improve the way regular cancer drugs work in people with lung cancer.
  • Prostate cancer. Early research suggests that lentinan may improve the way regular cancer drugs work in men with prostate cancer.
  • Other Conditions.
More evidence is needed to rate the effectiveness of lentinan for these uses.

Side Effects

Side Effects & Safety

When taken by mouth: Lentinan is POSSIBLY SAFE. It might cause stomach and intestinal discomfort and rash.

When given as a shot: Lentinan is POSSIBLY SAFE. It might cause rash, muscle pain, and tiredness.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if lentinan is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.



We currently have no information for LENTINAN Interactions.



The appropriate dose of lentinan depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for lentinan. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References


  • Hazama, S., Watanabe, S., Ohashi, M., Yagi, M., Suzuki, M., Matsuda, K., Yamamoto, T., Suga, Y., Suga, T., Nakazawa, S., and Oka, M. Efficacy of orally administered superfine dispersed lentinan (beta-1,3-glucan) for the treatment of advanced colorectal cancer. Anticancer Res 2009;29(7):2611-2617. View abstract.
  • Gordon M, Guralnik M, Kaneko Y, et al. A phase II controlled study of a combination of the immune modulator, lentinan, with didanosine (ddI) in HIV patients with CD4 cells of 200-500/mm3. J Med 1995;26:193-207. View abstract.
  • Nishihira T, Akimoto M, Mori S. [Anti-cancer effects of BRMs associated with nutrition in cancer patients]. Gan To Kagaku Ryoho,1988;15:1615-20. View abstract.
  • Taguchi T. Clinical efficacy of lentinan on patients with stomach cancer: end point results of a four-year follow-up survey. Cancer Detect Prev Suppl 1987;1:333-49. View abstract.
  • Tari K, Satake I, Nakagomi K, et al. [Effect of lentinan for advanced prostate carcinoma]. Hinyokika Kiyo 1994;40:119-23. View abstract.
  • Wada T, Nishide T, Hatayama K, et al. [A comparative clinical trial with tegafur plus lentinan treatment at two different doses in advanced cancer]. Gan To Kagaku Ryoho 1987;14:2509-11. View abstract.
  • Wang H, Cai Y, Zheng Y, Bai Q, Xie D, Yu J. Efficacy of biological response modifier lentinan with chemotherapy for advanced cancer: a meta-analysis. Cancer Med. 2017;6(10):2222-2233. View abstract.
  • Wang JL, Bi Z, Zou JW, Gu XM. Combination therapy with lentinan improves outcomes in patients with esophageal carcinoma. Mol Med Rep. 2012;5(3):745-8. View abstract.
  • Yin X, Ying J, Li L, Zhang H, Wang H. A meta-analysis of lentinan injection combined with chemotherapy in the treatment of nonsmall cell lung cancer. Indian J Cancer. 2015;52 Suppl 1:e29-31. View abstract.
  • Yoshino S, Nishikawa K, Morita S, et al. Randomised phase III study of S-1 alone versus S-1 plus lentinan for unresectable or recurrent gastric cancer (JFMC36-0701). Eur J Cancer. 2016;65:164-71. View abstract.
  • Yoshiyuki T, Onda M, Tokunaga A, et al. [Treatment for peritoneal dissemination of gastric cancer by intraperitoneal administration of CDDP through Infuse-a-Port]. Gan To Kagaku Ryoho 1994;21:2323-5. View abstract.
  • Zhang D, Zheng J, Ni M, et al. Comparative efficacy and safety of Chinese herbal injections combined with the FOLFOX regimen for treating gastric cancer in China: a network meta-analysis. Oncotarget. 2017;8(40):68873-68889. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
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