Lenticus edodes, Lentinan edodes, Lentinane, Lentinula edodes, Lentinus edodes, Polysaccharide dérivé de Lentinus edodes, Polysaccharide derived from Lentinus edodes, Tricholomopsis edodes.<br/><br/>


Overview Information

Lentinan is a substance that comes from the shiitake mushroom.

Medical professionals use lentinan to boost the effects of regular medicines used for treating cancer and HIV infection. They give lentinan intravenously (by IV) or as a shot (by injection).

How does it work?

Lentinan might increase the effects of certain medications that fight viruses and cancer. It might also increase the activity of some of the body’s defense (immune) cells.


Uses & Effectiveness?

Possibly Effective for

Insufficient Evidence for

  • Breast cancer, when given by injection. Developing evidence suggests that lentinan may improve the way regular cancer drugs work in people with breast cancer.
  • Stomach cancer, when given by injection. Developing evidence suggests that lentinan may improve the way regular cancer drugs work in people with stomachcancer. However, lentinan seems less likely to work in stomach cancer patients who are malnourished.
  • Prostate cancer, when given by injection. Developing evidence suggests that lentinan may improve the way regular cancer drugs work in men with prostate cancer.
  • Other conditions.
More evidence is needed to rate the effectiveness of lentinan for these uses.

Side Effects

Side Effects & Safety

There isn't enough information available to know if lentinan is safe. It might cause stomach and intestinal cramps, rash, muscle pain, and tiredness; and it can slow blood clotting.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Not enough is known about the use of lentinan during pregnancy and breast-feeding. Stay on the safe side and avoid use.



We currently have no information for LENTINAN Interactions.



The following doses have been studied in scientific research:


  • Healthcare providers give lentinan as a shot to strengthen the immune system in patients with HIV/AIDS.

View References


  • Gordon M, Guralnik M, Kaneko Y, et al. A phase II controlled study of a combination of the immune modulator, lentinan, with didanosine (ddI) in HIV patients with CD4 cells of 200-500/mm3. J Med 1995;26:193-207. View abstract.
  • Kosaka A, Kuzuoka M, Yamafuji K, et al. [Synergistic action of lentinan (LNT) with endocrine therapy of breast cancer in rats and humans]. Gan To Kagaku Ryoho 1987;14:516-22. View abstract.
  • Nishihira T, Akimoto M, Mori S. [Anti-cancer effects of BRMs associated with nutrition in cancer patients]. Gan To Kagaku Ryoho,1988;15:1615-20. View abstract.
  • Taguchi T. Clinical efficacy of lentinan on patients with stomach cancer: end point results of a four-year follow-up survey. Cancer Detect Prev Suppl 1987;1:333-49. View abstract.
  • Tari K, Satake I, Nakagomi K, et al. [Effect of lentinan for advanced prostate carcinoma]. Hinyokika Kiyo 1994;40:119-23. View abstract.
  • Wada T, Nishide T, Hatayama K, et al. [A comparative clinical trial with tegafur plus lentinan treatment at two different doses in advanced cancer]. Gan To Kagaku Ryoho 1987;14:2509-11. View abstract.
  • Yoshiyuki T, Onda M, Tokunaga A, et al. [Treatment for peritoneal dissemination of gastric cancer by intraperitoneal administration of CDDP through Infuse-a-Port]. Gan To Kagaku Ryoho 1994;21:2323-5. View abstract.

More Resources for LENTINAN

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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© Therapeutic Research Faculty 2018.